Abstract:
PURPOSE:The aims of this study were (i) to establish a robust and fast method to quantify hepatocellular phosphorus compounds in molar concentration on a 3T clinical scanner, (ii) to evaluate its reproducibility, and (iii) to test its feasibility for a use in large cohort studies. METHOD:Proton-decoupled (31) P magnetic resonance spectroscopy of liver (31) P compounds were acquired on 85 healthy subjects employing image selected in-vivo spectroscopy localization in 13 min of acquisition at 3T. Absolute quantification was achieved using an external reference and double-matching phantoms (inorganic phosphates and adenosine triphosphate (ATP) solutions). Reproducibility of the method was also examined. RESULTS:This method showed a high intra- and interday as well as inter- and intraobserver reproducibility (r > 0.98; P < 0.001), with a high signal to noise ratio (SNR) (i.e., mean SNR of γ-ATP: 16). The mean liver concentrations of 85 healthy subjects were assessed to be 1.99 ± 0.51 and 2.74 ± 0.55 mmol/l of wet tissue volume for Pi and γ-ATP, respectively. CONCLUSION:This method reliably quantified molar concentrations of liver (31) P compounds on 85 subjects with a short total examination time (∼25 min) on a 3T clinical scanner. Thus, the current method can be readily utilized for a clinical study, such as a large cohort study.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Laufs A,Livingstone R,Nowotny B,Nowotny P,Wickrath F,Giani G,Bunke J,Roden M,Hwang JHdoi
10.1002/mrm.24835subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1670-5issue
5eissn
0740-3194issn
1522-2594journal_volume
71pub_type
杂志文章abstract:PURPOSE:To reduce the influence of tidal volume on fractional ventilation (FV) derived by Fourier decomposition (FD). METHODS:Twelve volunteers were examined on a 1.5 Tesla scanner. Spoiled gradient echo imaging of coronal and sagittal slices of the lung were performed. The tidal volume variations between different ac...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.26047
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abstract::A method for volume selective proton spectroscopy is presented based on a multiecho sequence with short refocusing interval tcp. It is demonstrated, that by appropriate choice of tcp on the order of 4-6 ms, signals from overlapping multiplets like the glutamine and glutamate (Glu/Gln) resonances in spectra of the huma...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910370603
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abstract:PURPOSE:To compare experimental transverse relaxivities of iron oxide nanocrystals (IONC) as a function of clustering and magnetic field strength with different theoretical model predictions. THEORY AND METHODS:Well-defined IONC clusters in nanoemulsions (NEs) of which both size and IONC loading could be judiciously t...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25465
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10692
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abstract::A potential relationship between structural compartments in neural tissue and NMR parameters may increase the specificity of MRI in diagnosing diseases. Nevertheless, our understanding of MR of nerves and white matter is limited, particularly the influence of various water compartments on the MR signal is not known. I...
journal_title:Magnetic resonance in medicine
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更新日期:1999-11-01 00:00:00
abstract::MRI after a constant infusion (CI) of Gd-DTPA has been used to identify the extent of myocardial infarction (MI). However, Gd-DTPA-enhanced "viability" imaging is more commonly performed with a bolus (for "delayed-enhancement" (DE) imaging). This study sought to determine how image delay time and time postinfarction i...
journal_title:Magnetic resonance in medicine
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abstract::Magnetic resonance (MR) can offer a unique window on the structure/function relationships in the brain, by utilizing the established link between tissue function, metabolism, and hemodynamics. This report focuses on recent applications of MR-based cerebral blood volume (CBV) imaging in humans. Our methodology uses hig...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25455
更新日期:2015-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390604
更新日期:1998-06-01 00:00:00
abstract::The assessment of myocardial fibrosis and extracellular volume requires accurate estimation of myocardial T1 s. While image acquisition using the modified Look-Locker inversion recovery technique is clinically feasible for myocardial T1 mapping, respiratory motion can limit its applicability. Moreover, the conventiona...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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abstract:PURPOSE:Dipole antennas in ultrahigh field MRI have demonstrated advantages over more conventional designs. In this study, the fractionated dipole antenna is presented: a dipole where the legs are split into segments that are interconnected by capacitors or inductors. METHODS:A parameter study has been performed on di...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25596
更新日期:2016-03-01 00:00:00
abstract::Localized 1H NMR homonuclear J editing spectroscopy was used to measure the concentration of 2-pyrrolidinone (PRDN) in the human occipital lobe of five normal and six epileptic subjects taking vigabatrin. PRDN is a lactam cyclization product of gamma-aminobutyric acid (GABA). From a localized volume of 13.5 cm3 in the...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
abstract::The fast spin-echo (FSE) sequence is frequently used as a fast data-readout technique in conjunction with other pulse sequence elements, such as in fluid-attenuated inversion-recovery (FLAIR) and double inversion-recovery (DIR) sequences. In order to implement those pulse sequences, an understanding is required of how...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1995-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27439
更新日期:2019-01-01 00:00:00
abstract::Optimal control theory has been applied in the past for the design of RF pulses for selective excitation. This was the outcome of having established the controllability of the MR spin system for the selective excitation problem. "Minimum distance" was the main formulation used for the solution. Because of their robust...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910360311
更新日期:1996-09-01 00:00:00
abstract::We have demonstrated that echo-planar imaging can be used to produce high-quality snapshot images of the human fetus in utero in a fraction of a second. These images are free of motional artifact or blurring and allow detailed depiction of fetal structures in normal and pathological pregnancies. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910130214
更新日期:1990-02-01 00:00:00
abstract:PURPOSE:Lung pO2 mapping with (3)He MRI assumes that the sources of signal decay with time during a breath-hold are radiofrequency depolarization and oxygen-dependent T1 relaxation, but the method is sensitive to other sources of spatio-temporal signal change such as diffusion. The purpose of this work was to assess th...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24779
更新日期:2014-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.28665
更新日期:2021-01-21 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21585
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abstract::The changes in the response of skeletal muscle to maximal dynamic exercise were investigated in going from a fasted state to a refed state by means of 31P NMR spectroscopy. It was found that in the fasted state, exercise-induced changes in Pi/PCr and in pH were both inhibited, in comparison with those in the refed sta...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910030616
更新日期:1986-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25790
更新日期:2016-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26864
更新日期:2018-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25366
更新日期:2015-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1996-02-01 00:00:00
abstract:PURPOSE:Reference region models (RRMs) can quantify tumor perfusion in dynamic contrast-enhanced MRI without an arterial input function. Inspection of the RRM reveals that one of the free parameters in the fit is uniquely linked to the reference region and is common to all voxels. A two-step approach is proposed that t...
journal_title:Magnetic resonance in medicine
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更新日期:2017-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2019-01-01 00:00:00
abstract::Compressed sensing has been of great interest to speed up the acquisition of MR images. The k-t group sparse (k-t GS) method has recently been introduced for dynamic MR images to exploit not just the sparsity, as in compressed sensing, but also the spatial group structure in the sparse representation. k-t GS achieves ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24333
更新日期:2013-04-01 00:00:00