Diffusion dispersion imaging: Mapping oscillating gradient spin-echo frequency dependence in the human brain.

Abstract:

PURPOSE:Oscillating gradient spin-echo (OGSE) diffusion MRI provides information about the microstructure of biological tissues by means of the frequency dependence of the apparent diffusion coefficient (ADC). ADC dependence on OGSE frequency has been explored in numerous rodent studies, but applications in the human brain have been limited and have suffered from low contrast between different frequencies, long scan times, and a limited exploration of the nature of the ADC dependence on frequency. THEORY AND METHODS:Multiple frequency OGSE acquisitions were acquired in healthy subjects at 7T to explore the power-law frequency dependence of ADC, the "diffusion dispersion." Furthermore, a method for optimizing the estimation of the ADC difference between different OGSE frequencies was developed, which enabled the design of a highly efficient protocol for mapping diffusion dispersion. RESULTS:For the first time, evidence of a linear dependence of ADC on the square root of frequency in healthy human white matter was obtained. Using the optimized protocol, high-quality, full-brain maps of apparent diffusion dispersion rate were also demonstrated at an isotropic resolution of 2 mm in a scan time of 6 min. CONCLUSIONS:This work sheds light on the nature of diffusion dispersion in the healthy human brain and introduces full-brain diffusion dispersion mapping at clinically relevant scan times. These advances may lead to new biomarkers of pathology or improved microstructural modeling.

journal_name

Magn Reson Med

authors

Arbabi A,Kai J,Khan AR,Baron CA

doi

10.1002/mrm.28083

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

2197-2208

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

83

pub_type

杂志文章
  • Ultra-rapid gradient echo imaging.

    abstract::A novel ultra-rapid gradient echo (URGE) NMR imaging technique is introduced, which is capable of continuous high resolution 3D scanning while neither subject to fast gradient switching nor excessive RF power deposition. Sampling free induction decays instead of creating spin echoes enables maintaining a workable stea...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910330123

    authors: Heid O,Deimling M,Huk WJ

    更新日期:1995-01-01 00:00:00

  • Quantitative chemical exchange saturation transfer MRI of intervertebral disc in a porcine model.

    abstract:PURPOSE:Previous studies have associated low pH in intervertebral discs (IVDs) with discogenic back pain. The purpose of this study was to determine whether quantitative CEST (qCEST) MRI can be used to detect pH changes in IVDs in vivo. METHODS:The exchange rate ksw between glycosaminoglycan (GAG) protons and water pr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26457

    authors: Zhou Z,Bez M,Tawackoli W,Giaconi J,Sheyn D,de Mel S,Maya MM,Pressman BD,Gazit Z,Pelled G,Gazit D,Li D

    更新日期:2016-12-01 00:00:00

  • Echo-volume imaging.

    abstract::Two single-shot volume imaging techniques are described. The first, single-echo echo-volume imaging, is essentially the echo-volume imaging (EVI) sequence suggested by Mansfield (J. Phys. C. 10, L55 (1977)). The second is a multi-spin-echo approach in which one plane of k-space is collected during each spin echo. In b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320518

    authors: Song AW,Wong EC,Hyde JS

    更新日期:1994-11-01 00:00:00

  • One-minute whole-brain magnetization transfer ratio imaging with intrinsic B1-correction.

    abstract:PURPOSE:Magnetization transfer ratio (MTR) histograms are used widely for the assessment of diffuse pathological changes in the brain. For broad clinical application, MTR scans should not only be fast, but confounding factors should also be minimized for high reproducibility. To this end, a 1-minute whole-brain spiral ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28618

    authors: Afshari R,Santini F,Heule R,Meyer CH,Pfeuffer J,Bieri O

    更新日期:2020-12-08 00:00:00

  • Interindividual reproducibility of glutamate quantification using 1.5-T proton magnetic resonance spectroscopy.

    abstract::The goal of this study was to measure the interindividual reproducibility of glutamate quantification in 1.5-T (1)H MRS of human brains. To determine the effective echo time (TE) for glutamate quantification, spectra from a phantom and 12 participants were obtained with TE = 30, 35, 40, and 144 ms (repetition time (TR...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20387

    authors: Jang DP,Lee JM,Lee E,Park S,Kim JJ,Namkoong K,Yoon KJ,Kim IY,Kim SI

    更新日期:2005-03-01 00:00:00

  • Simultaneous spin-echo refocusing.

    abstract::A new approach to spin-echo imaging is presented in which the 180 degrees RF pulse refocuses two or more spin-echoes at different positions in the readout period. When simultaneous echo refocusing (SER) is implemented using multiple 180 degrees pulses, an undesirable mixing of stimulated echoes and primary echoes from...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20587

    authors: Günther M,Feinberg DA

    更新日期:2005-09-01 00:00:00

  • Real-time magnetic resonance imaging of laser heat deposition in tissue.

    abstract::We applied diffusion-sensitive echo planar (Instascan) imaging to study thermal changes caused by a Nd:YAG laser. Images of phantom materials and normal rabbit brain tissue in vivo, acquired in 150 ms, every 2s, clearly showed the dynamics of temperature-related signal intensity changes in the regions irradiated by th...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910210116

    authors: Bleier AR,Jolesz FA,Cohen MS,Weisskoff RM,Dalcanton JJ,Higuchi N,Feinberg DA,Rosen BR,McKinstry RC,Hushek SG

    更新日期:1991-09-01 00:00:00

  • Liver stiffness assessment by tagged MRI of cardiac-induced liver motion.

    abstract::Cirrhosis is an important and growing public health problem, affecting millions of Americans and many more people internationally. A pathological hallmark of the progression to cirrhosis is the development of liver fibrosis, so that monitoring the appearance and progression of liver fibrosis can be used to guide thera...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22785

    authors: Chung S,Breton E,Mannelli L,Axel L

    更新日期:2011-04-01 00:00:00

  • Analysis and correction of biases in cross-relaxation MRI due to biexponential longitudinal relaxation.

    abstract:PURPOSE:Cross-relaxation imaging (CRI) is a family of quantitative magnetization transfer techniques that utilize images obtained with off-resonance saturation and longitudinal relaxation rate (R1) maps reconstructed by the variable flip angle (VFA) method. It was demonstrated recently that a significant bias in an app...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24677

    authors: Mossahebi P,Yarnykh VL,Samsonov A

    更新日期:2014-02-01 00:00:00

  • Contrast-enhanced MRI of brown adipose tissue after pharmacological stimulation.

    abstract::A non-invasive method for studying the modifications induced in lipid depots by hormonal stimulation could extend knowledge of adipose tissues. We studied the effect of adrenergic stimulation on interscapular brown adipose tissue (IBAT) of rats using contrast-enhanced MRI. Controls and rats pre-treated with adrenaline...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20851

    authors: Sbarbati A,Cavallini I,Marzola P,Nicolato E,Osculati F

    更新日期:2006-04-01 00:00:00

  • Ischemia-induced ADC changes are larger than osmotically-induced ADC changes in a neonatal rat hippocampus model.

    abstract::Diffusion-weighted imaging (DWI) is frequently used to diagnose stroke. However, the origin of the observed reduction in the apparent diffusion coefficient (ADC) in the acute phase following ischemia is not well understood. Although cell swelling is considered to play an important role, it is unclear whether this can ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20353

    authors: van Pul C,Jennekens W,Nicolay K,Kopinga K,Wijn PF

    更新日期:2005-02-01 00:00:00

  • Insights into tissue microstructure using a double diffusion encoding sequence on a clinical scanner: Validation and application to experimental tumor models.

    abstract:PURPOSE:To present a double diffusion encoding MRI sequence on a clinical scanner to analyze micro-structure and micro-vasculature of tumors. METHODS:The sequence was tested on phantoms, asparaguses, and 2 tumors allografts in a rodent. Results were analyzed using an adapted VERDICT model to estimate microstructural p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28012

    authors: Duchêne G,Abarca-Quinones J,Leclercq I,Duprez T,Peeters F

    更新日期:2020-04-01 00:00:00

  • Non-ECG-gated myocardial perfusion MRI using continuous magnetization-driven radial sampling.

    abstract:PURPOSE:Establishing a high-resolution non-ECG-gated first-pass perfusion (FPP) cardiac MRI technique may improve accessibility and diagnostic capability of FPP imaging. We propose a non-ECG-gated FPP imaging technique using continuous magnetization-driven golden-angle radial acquisition. The main purpose of this preli...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25074

    authors: Sharif B,Dharmakumar R,Arsanjani R,Thomson L,Bairey Merz CN,Berman DS,Li D

    更新日期:2014-12-01 00:00:00

  • Fast, three-dimensional free-breathing MR imaging of myocardial infarction: a feasibility study.

    abstract::Imaging delayed hyperenhancement of myocardial infarction is most commonly performed using an inversion recovery (IR) prepared 2D breathhold segmented k-space gradient echo (FGRE) sequence. Since only one slice is acquired per breathhold in this technique, 12-16 successive breathholds are required for complete anatomi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20061

    authors: Saranathan M,Rochitte CE,Foo TK

    更新日期:2004-05-01 00:00:00

  • High resolution quantitative relaxation and diffusion MRI of three different experimental brain tumors in rat.

    abstract::The potential of quantitative parameter images of the relaxation times T1 and T2, the proton density rho and the apparent diffusion coefficient (ADC) to characterize three different experimental rat brain tumors (F98 glioma, RN6 Schwannoma, and E376 neuroblastoma) was studied. All parameter values, as determined in hi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910340608

    authors: Eis M,Els T,Hoehn-Berlage M

    更新日期:1995-12-01 00:00:00

  • Evaluation of hepatic steatosis before liver transplantation in ex vivo by volumetric quantitative PDFF-MRI.

    abstract:PURPOSE:Over the last two decades, extended criteria have promoted an increased number of donor livers available for liver transplantation. But posttransplant graft loss is still a major concern. Macrovesicular hepatic steatosis (MHS) is recognized as the most significant prognostic histologic parameter in predicting p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28592

    authors: Chen G,Jiang J,Wang X,Yang M,Xie Y,Guo H,Tang H,Zhou L,Hu D,Kamel IR,Chen Z,Li Z

    更新日期:2020-11-16 00:00:00

  • Modification of embolic-PVA particles with MR contrast agents.

    abstract::We report the synthesis and characterization of polyvinyl alcohol (PVA) embolic particles modified with a clinically approved magnetic resonance (MR) contrast agent. PVA particles are used during transcatheter arterial embolization (TAE) procedures and this minimally invasive technique is a widely employed treatment f...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21518

    authors: Cilliers R,Song Y,Kohlmeir EK,Larson AC,Omary RA,Meade TJ

    更新日期:2008-04-01 00:00:00

  • Quantitative and qualitative fat analysis in human leg muscle of neuromuscular diseases by 1H MR spectroscopy in vivo.

    abstract::1H MR spectra were recorded from human gastrocnemius muscle at 63.86 MHz using the body coil of the Signa scanner as transmitter and a 3-in. surface coil as receiver. The fat content of the muscle was quantified relative to that of water in a selected volume or slice. The fat/water ratio was 0.05-0.07 for normal muscl...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910100206

    authors: Bárány M,Venkatasubramanian PN,Mok E,Siegel IM,Abraham E,Wycliffe ND,Mafee MF

    更新日期:1989-05-01 00:00:00

  • Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 Tesla.

    abstract::MRI has become an important tool to noninvasively assess global and regional cardiac function, infarct size, or myocardial blood flow in surgically or genetically modified mouse models of human heart disease. Constraints on scan time due to sensitivity to general anesthesia in hemodynamically compromised mice frequent...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22605

    authors: Schneider JE,Lanz T,Barnes H,Stork LA,Bohl S,Lygate CA,Ordidge RJ,Neubauer S

    更新日期:2011-01-01 00:00:00

  • Input parameter sensitivity analysis and comparison of quantification models for continuous arterial spin labeling.

    abstract::The regional cerebral blood flow (rCBF) values determined using continuous arterial spin labeling (CASL) are subject to several sources of variability, including natural physiologic variations, sensitivity to the input parameters, and the use of different quantification models. To date, a thorough analysis of the impa...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20440

    authors: Steger TR,White RA,Jackson EF

    更新日期:2005-04-01 00:00:00

  • Fast diffusion tensor imaging and tractography of the whole cervical spinal cord using point spread function corrected echo planar imaging.

    abstract::Diffusion tensor imaging has been used in a number of spinal cord studies, but severe distortions caused by susceptibility induced field inhomogeneities limit its applicability to investigate small volumes within acceptable acquisition times. A way to evaluate image distortions is to map the point spread function of t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24235

    authors: Lundell H,Barthelemy D,Biering-Sørensen F,Cohen-Adad J,Nielsen JB,Dyrby TB

    更新日期:2013-01-01 00:00:00

  • Correction of motion-induced susceptibility artifacts and B0 drift during proton resonance frequency shift-based MR thermometry in the pelvis with background field removal methods.

    abstract:PURPOSE:The linear change of the water proton resonance frequency shift (PRFS) with temperature is used to monitor temperature change based on the temporal difference of image phase. Here, the effect of motion-induced susceptibility artifacts on the phase difference was studied in the context of mild radio frequency hy...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28302

    authors: Wu M,Mulder HT,Baron P,Coello E,Menzel MI,van Rhoon GC,Haase A

    更新日期:2020-11-01 00:00:00

  • Fast acquisition-weighted three-dimensional proton MR spectroscopic imaging of the human prostate.

    abstract::The clinical application of 3D proton spectroscopic imaging (3D SI) of the human prostate requires a robust suppression of periprostatic lipid signal contamination, minimal intervoxel signal contamination, and the shortest possible measurement time. In this work, a weighted elliptical sampling of k-space, combined wit...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20103

    authors: Scheenen TW,Klomp DW,Röll SA,Fütterer JJ,Barentsz JO,Heerschap A

    更新日期:2004-07-01 00:00:00

  • Mapping of redox status in a brain-disease mouse model by three-dimensional EPR imaging.

    abstract::Electron paramagnetic resonance imaging using nitroxides is a powerful method for visualizing the redox status modulated by oxidative stress in vivo. Typically, however, data acquisition times have been too slow to obtain a sufficient number of projections for three-dimensional images, when using continuous wave-elect...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22598

    authors: Fujii H,Sato-Akaba H,Kawanishi K,Hirata H

    更新日期:2011-01-01 00:00:00

  • Counter rotating current local coils for high-resolution magnetic resonance imaging.

    abstract::A type of local coil (or surface coil) for magnetic resonance imaging and spectroscopy is described in which two circular loops of the same diameter are disposed axially with respect to each other and in which counter rotating currents (CRC) are supported in the two loops. This type of coil has been used for localized...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910030412

    authors: Froncisz W,Jesmanowicz A,Kneeland JB,Hyde JS

    更新日期:1986-08-01 00:00:00

  • Comprehensive approach for correction of motion and distortion in diffusion-weighted MRI.

    abstract::Patient motion and image distortion induced by eddy currents cause artifacts in maps of diffusion parameters computed from diffusion-weighted (DW) images. A novel and comprehensive approach to correct for spatial misalignment of DW imaging (DWI) volumes acquired with different strengths and orientations of the diffusi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10677

    authors: Rohde GK,Barnett AS,Basser PJ,Marenco S,Pierpaoli C

    更新日期:2004-01-01 00:00:00

  • Factors influencing the accuracy and precision of velocity-encoded phase imaging.

    abstract::Velocity-encoded phase contrast imaging is being used increasingly in clinical imaging for quantization of blood flow. In this study, the accuracy and precision of ascending aorta flow measurements were found to depend on several subtle aspects of the scan prescription and image analysis. While the usual scan paramete...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910260115

    authors: Buonocore MH,Bogren H

    更新日期:1992-07-01 00:00:00

  • Generalized matched filtering for time-resolved MR angiography of pulsatile flow.

    abstract::Generating flow-specific images (arteriograms, venograms) with optimal signal-to-noise ratios for time-resolved MR angiography is a conditional maximum problem, and its solutions are generalized matched filters. We have investigated six matched filters, corresponding to all possible combinations of three flow suppress...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300511

    authors: Wang Y,Weber DM,Korosec FR,Mistretta CA,Grist TM,Swan JS,Turski PA

    更新日期:1993-11-01 00:00:00

  • A comprehensive approach for correcting voxel-wise b-value errors in diffusion MRI.

    abstract:PURPOSE:In diffusion MRI, the actual b-value played out on the scanner may deviate from the nominal value due to magnetic field imperfections. A simple image-based correction method for this problem is presented. METHODS:The apparent diffusion constant (ADC) of a water phantom was measured voxel-wise along 64 diffusio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28078

    authors: Lee Y,Kettinger AO,Wilm BJ,Deichmann R,Weiskopf N,Lambert C,Pruessmann KP,Nagy Z

    更新日期:2020-06-01 00:00:00

  • High-resolution quantitative sodium imaging at 9.4 Tesla.

    abstract:PURPOSE:Investigation of the feasibility to perform high-resolution quantitative sodium imaging at 9.4 Tesla (T). METHODS:A proton patch antenna was combined with a sodium birdcage coil to provide a proton signal without compromising the efficiency of the X-nucleus coil. Sodium density weighted images with a nominal r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25096

    authors: Mirkes CC,Hoffmann J,Shajan G,Pohmann R,Scheffler K

    更新日期:2015-01-01 00:00:00