High-resolution quantitative sodium imaging at 9.4 Tesla.

Abstract:

PURPOSE:Investigation of the feasibility to perform high-resolution quantitative sodium imaging at 9.4 Tesla (T). METHODS:A proton patch antenna was combined with a sodium birdcage coil to provide a proton signal without compromising the efficiency of the X-nucleus coil. Sodium density weighted images with a nominal resolution of 1 × 1 × 5 mm(3) were acquired within 30 min with an ultrashort echo time sequence. The methods used for signal calibration as well as for B0, B1, and off-resonance correction were verified on a phantom and five healthy volunteers. RESULTS:An actual voxel volume of roughly 40 μL could be achieved at 9.4T, while maintaining an acceptable signal-to-noise ratio (8 for brain tissue and 35 for cerebrospinal fluid). The measured mean sodium concentrations for gray and white matter were 36 ± 2 and 31 ± 1 mmol/L of wet tissue, which are comparable to values previously reported in the literature. CONCLUSION:The reduction of partial volume effects is essential for accurate measurement of the sodium concentration in the human brain. Ultrahigh field imaging is a viable tool to achieve this goal due to its increased sensitivity.

journal_name

Magn Reson Med

authors

Mirkes CC,Hoffmann J,Shajan G,Pohmann R,Scheffler K

doi

10.1002/mrm.25096

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

342-51

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

73

pub_type

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