Abstract:
:Proton-electron double-resonance imaging (PEDRI) was used to assess renal function by monitoring the flow of the exogenous nitroxide free radical proxyl carboxylic acid (PCA) through normal and injured kidneys in the living rat. Kidney damage was induced by treatment with 2-bromoethylamine (BEA), which provides a well established model for human analgesic nephropathy. PCA clearance rates for liver, abdominal blood vessels, and renal tissues were determined from serial PEDRI images of normal rats (n = 6) and rats treated with BEA (n = 21). Different groups of BEA-treated animals were imaged on day 4 (n = 6), day 6 (n = 6), and day 9 (n = 9) after treatment. In BEA-treated rats, there was an increase in PCA half-life in all tissues studied. This increase was greatest in the kidney tissues and the effect progressed with time after treatment. The effect is probably due to BEA-induced damage to the tubules in the renal cortex and may not be related to the primary lesions in the renal medulla.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Seimenis I,Foster MA,Lurie DJ,Hutchison JM,Whiting PH,Payne Sdoi
10.1002/mrm.1910400214subject
Has Abstractpub_date
1998-08-01 00:00:00pages
280-6issue
2eissn
0740-3194issn
1522-2594journal_volume
40pub_type
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