Three-dimensional whole body imaging of spin probes in mice by time-domain radiofrequency electron paramagnetic resonance.

Abstract:

:Imaging of stable paramagnetic spin probes in phantom objects and in vivo was evaluated using a RF time domain EPR spectrometer/imager operating at 300 MHz. Projections were collected using static magnetic field gradients and images were reconstructed using filtered back-projection techniques. Results from phantom objects containing approximately 10(17) spins of stable paramagnetic probes with single narrow EPR spectra provide three-dimensional spatial images with resolution better than 2 mm. When the spin probe was administered to mice, the spin probe accumulation was temporally observed in the thoracic, abdominal, and pelvic regions. A three-dimensional image (from 144 projections) from a live mouse was collected in 5 min. Using fiducial markers, the spin probe accumulation in organs such as liver, kidney, and bladder could be observed. Differences in the oxygen status between liver and kidney were observed from the EPR images from mice administered with spin probe, by treating the time-domain responses with convolution difference approach, prior to image reconstruction. The results from these studies suggest that, with the use of stable paramagnetic spin probes and time-domain RF EPR, it is possible to perform in vivo imaging on animals and also obtain important spatially resolved physiologic information.

journal_name

Magn Reson Med

authors

Afeworki M,van Dam GM,Devasahayam N,Murugesan R,Cook J,Coffin D,Larsen JH,Mitchell JB,Subramanian S,Krishna MC

doi

10.1002/(sici)1522-2594(200003)43:3<375::aid-mrm9>

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

375-82

issue

3

eissn

0740-3194

issn

1522-2594

pii

10.1002/(SICI)1522-2594(200003)43:3<375::AID-MRM9>

journal_volume

43

pub_type

杂志文章
  • Evidence that both fast and slow water ADC components arise from intracellular space.

    abstract::Evaluation of water diffusion in the brain has revealed both fast- and slow-diffusing water populations. It has been suggested that these populations represent extra- and intracellular water, respectively. We have identified and characterized both populations in the intracellular space of the Xenopus oocyte. We have a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10301

    authors: Sehy JV,Ackerman JJ,Neil JJ

    更新日期:2002-11-01 00:00:00

  • CEST MRI quantification procedures for breast cancer treatment-related lymphedema therapy evaluation.

    abstract:PURPOSE:To quantify chemical exchange saturation transfer contrast in upper extremities of participants with lymphedema before and after standardized lymphatic mobilization therapy using correction procedures for B0 and B1 heterogeneity, and T1 relaxation. METHODS:Females with (n = 12) and without (n = 17) breast canc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28031

    authors: Crescenzi R,Donahue PMC,Mahany H,Lants SK,Donahue MJ

    更新日期:2020-05-01 00:00:00

  • Four-dimensional flow MRI using spiral acquisition.

    abstract::Time-resolved three-dimensional phase-contrast MRI is an important tool for physiological as well as clinical studies of blood flow in the heart and vessels. The application of the technique is, however, limited by the long scan times required. In this work, we investigate the feasibility of using spiral readouts to r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23297

    authors: Sigfridsson A,Petersson S,Carlhäll CJ,Ebbers T

    更新日期:2012-10-01 00:00:00

  • MRI reconstruction using deep Bayesian estimation.

    abstract:PURPOSE:To develop a deep learning-based Bayesian estimation for MRI reconstruction. METHODS:We modeled the MRI reconstruction problem with Bayes's theorem, following the recently proposed PixelCNN++ method. The image reconstruction from incomplete k-space measurement was obtained by maximizing the posterior possibili...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28274

    authors: Luo G,Zhao N,Jiang W,Hui ES,Cao P

    更新日期:2020-10-01 00:00:00

  • Generalization of intravoxel incoherent motion model by introducing the notion of continuous pseudodiffusion variable.

    abstract:PURPOSE:A generalized intravoxel incoherent motion (IVIM) model, called the GIVIM, was proposed to better account for complex perfusion present in the tissues having various vessels and flow regimes, such as the liver. THEORY AND METHODS:The notions of continuous pseudodiffusion variable as well as perfusion fraction ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26064

    authors: Kuai ZX,Liu WY,Zhang YL,Zhu YM

    更新日期:2016-11-01 00:00:00

  • Biexponential longitudinal relaxation in white matter: Characterization and impact on T1 mapping with IR-FSE and MP2RAGE.

    abstract:PURPOSE:Magnetization transfer in white matter (WM) causes biexponential relaxation, but most quantitative T1 measurements fit data assuming monoexponential relaxation. The resulting monoexponential T1 estimate varies based on scan parameters and represents a source of variation between studies, especially at high fiel...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25729

    authors: Rioux JA,Levesque IR,Rutt BK

    更新日期:2016-06-01 00:00:00

  • Dynamic glucose-enhanced (DGE) MRI in the human brain at 7 T with reduced motion-induced artifacts based on quantitative R1ρ mapping.

    abstract:PURPOSE:Dynamic glucose-enhanced (DGE)-MRI based on chemical exchange-sensitive MRI, that is, glucoCEST and gluco-chemical exchange-sensitive spin-lock (glucoCESL), is intrinsically prone to motion-induced artifacts because the final DGE contrast relies on the difference of images, which were acquired with a time gap o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28112

    authors: Boyd PS,Breitling J,Zimmermann F,Korzowski A,Zaiss M,Schuenke P,Weinfurtner N,Schlemmer HP,Ladd ME,Bachert P,Paech D,Goerke S

    更新日期:2020-07-01 00:00:00

  • A new approach to Z-spectrum acquisition: prospective baseline enhancement (PROBE) for CEST/Nuclear Overhauser Effect.

    abstract:PURPOSE:To develop a prospective baseline enhancement that compensates for intermingled background effects in Z-spectra to achieve sensitivity enhancement of peaks related to CEST and nuclear Overhauser effect. METHODS:An MRI sequence-specific compensation of background effects is achieved through variation of the pul...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27555

    authors: Lenich T,Pampel A,Mildner T,Möller HE

    更新日期:2019-04-01 00:00:00

  • Absolute quantification of myocardial perfusion under adenosine stress.

    abstract::The prebolus technique allows one to quantify perfusion in the human heart with a low variability by means of MRI. In this study the prebolus technique was used to determine quantitative perfusion values in the human heart under adenosine stress and to measure the myocardial perfusion reserve (MPR). Twelve healthy vol...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21020

    authors: Ritter C,Brackertz A,Sandstede J,Beer M,Hahn D,Köstler H

    更新日期:2006-10-01 00:00:00

  • A flexible nested sodium and proton coil array with wideband matching for knee cartilage MRI at 3T.

    abstract:PURPOSE:We describe a 2 × 6 channel sodium/proton array for knee MRI at 3T. Multielement coil arrays are desirable because of well-known signal-to-noise ratio advantages over volume and single-element coils. However, low tissue-coil coupling that is characteristic of coils operating at low frequency can make the potent...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26017

    authors: Brown R,Lakshmanan K,Madelin G,Alon L,Chang G,Sodickson DK,Regatte RR,Wiggins GC

    更新日期:2016-10-01 00:00:00

  • Comparison of prospective head motion correction with NMR field probes and an optical tracking system.

    abstract:PURPOSE:The aim of this study was to compare prospective head motion correction and motion tracking abilities of two tracking systems: Active NMR field probes and a Moiré phase tracking camera system using an optical marker. METHODS:Both tracking systems were used simultaneously on human subjects. The prospective head...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27343

    authors: Eschelbach M,Aghaeifar A,Bause J,Handwerker J,Anders J,Engel EM,Thielscher A,Scheffler K

    更新日期:2019-01-01 00:00:00

  • Measurement of fibrin concentration by fast field-cycling NMR.

    abstract::The relaxation of (1)H nuclei due to their interaction with quadrupolar (14)N nuclei in gel structures is measured using fast field-cycling NMR. This phenomenon called quadrupolar dips has been reported in different (1)H-(14)N bond-rich species. In this study, we have studied quadrupolar dips in fibrin, an insoluble p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23117

    authors: Broche LM,Ismail SR,Booth NA,Lurie DJ

    更新日期:2012-05-01 00:00:00

  • Deuterium magnetic resonance imaging of rabbit eye in vivo.

    abstract::We used deuterium magnetic resonance imaging (2H MRI) to visualize water movement in the rabbit eye. Dynamic 2H MRI was obtained every 3.5 min at 2 tesla by FLASH pulse sequence (TR, 300 ms; TE, 10 ms; alpha = 90 degrees) with a slice thickness of 10 mm using a surface coil (4 cm in diameter). After topical administra...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910330417

    authors: Obata T,Ikehira H,Koga M,Yoshida K,Kimura F,Tateno Y

    更新日期:1995-04-01 00:00:00

  • Fast three-dimensional inner volume excitations using parallel transmission and optimized k-space trajectories.

    abstract:PURPOSE:To design short parallel transmission (pTx) pulses for excitation of arbitrary three-dimensional (3D) magnetization patterns. METHODS:We propose a joint optimization of the pTx radiofrequency (RF) and gradient waveforms for excitation of arbitrary 3D magnetization patterns. Our optimization of the gradient wav...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26021

    authors: Davids M,Schad LR,Wald LL,Guérin B

    更新日期:2016-10-01 00:00:00

  • Solvate structures in water-methanol solutions of MRI contrast agents: electron spin echo envelope modulation in gadolinium chelates.

    abstract::Electron Spin Echo Envelope Modulation (ESEEM) data are reported for three gadolinium (III) chelates, Gd-EDTA, Gd-DTPA, and Gd-TTHA, in frozen D2O/CH3OD glasses. This series includes Gd-DTPA, an MRI contrast agent that is in clinical use. Three-pulse electron spin echo modulation patterns can be modeled to yield geome...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290414

    authors: Clarkson RB,Hwang JH,Belford RL

    更新日期:1993-04-01 00:00:00

  • Arterial spin labeling perfusion fMRI with very low task frequency.

    abstract::Functional magnetic resonance imaging (fMRI) has become the most widely used modality for visualizing regional brain activation in response to sensorimotor or cognitive tasks. While the majority of fMRI studies have used blood oxygenation level-dependent (BOLD) contrast as a marker for neural activation, baseline drif...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10437

    authors: Wang J,Aguirre GK,Kimberg DY,Roc AC,Li L,Detre JA

    更新日期:2003-05-01 00:00:00

  • A cylindrically symmetric magnetic shield for a large-bore 3.0 Tesla magnet.

    abstract::A 3.0 Tesla, 0.80-m bore magnet replaced our previous 1.9 Tesla, 0.76-m magnet. The 3.0 Tesla replacement magnet had a dipole moment of 1.7 with respect to that of the 1.9 Tesla magnet. The pre-existing cylindrically symmetric passive steel shielding was modified to confine the fringe fields of the replacement magnet ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290319

    authors: Ewing JR,Warner R,Helpern JA

    更新日期:1993-03-01 00:00:00

  • Nuclear magnetic resonance parameters for monitoring coagulation of liver tissue.

    abstract::A new NMR parameter is suggested as a sensitive tool for monitoring thermal coagulation of liver tissue. That parameter is the proton magnetization exchange time (tau(MEX)) between water and the proteins. tau(MEX) was very sensitive to coagulation and insensitive to temperature, therefore representing only damage to t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20693

    authors: Carasso D,Eliav U,Navon G

    更新日期:2005-11-01 00:00:00

  • Local specific absorption rate in brain tumors at 7 tesla.

    abstract:PURPOSE:MR safety at 7 Tesla relies on accurate numerical simulations of transmit electromagnetic fields to fully assess local specific absorption rate (SAR) safety. Numerical simulations for SAR safety are currently performed using models of healthy patients. These simulations might not be useful for estimating SAR in...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25653

    authors: Restivo MC,van den Berg CA,van Lier AL,Polders DL,Raaijmakers AJ,Luijten PR,Hoogduin H

    更新日期:2016-01-01 00:00:00

  • Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T.

    abstract:PURPOSE:To test the hypothesis that a noninvasive dynamic contrast enhanced MRI (DCE-MRI) derived interstitial volume fraction (ve ) and/or distribution volume (VD ) were correlated with tumor cellularity in cerebral tumor. METHODS:T1 -weighted DCE-MRI studies were performed in 18 athymic rats implanted with U251 xeno...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24873

    authors: Aryal MP,Nagaraja TN,Keenan KA,Bagher-Ebadian H,Panda S,Brown SL,Cabral G,Fenstermacher JD,Ewing JR

    更新日期:2014-06-01 00:00:00

  • Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 Tesla.

    abstract::MRI has become an important tool to noninvasively assess global and regional cardiac function, infarct size, or myocardial blood flow in surgically or genetically modified mouse models of human heart disease. Constraints on scan time due to sensitivity to general anesthesia in hemodynamically compromised mice frequent...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22605

    authors: Schneider JE,Lanz T,Barnes H,Stork LA,Bohl S,Lygate CA,Ordidge RJ,Neubauer S

    更新日期:2011-01-01 00:00:00

  • Water in tendon: orientational analysis of the free induction decay.

    abstract::The orientation dependence of the free induction decay (FID) of 1H NMR water signal in ex vivo bovine digital flexor tendon at the native level of hydration is reported. Residual dipolar coupling due to the overall tissue anisotropy produces a 6:1 change in the signal intensity as an angle between the long axis of a s...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20540

    authors: Krasnosselskaia LV,Fullerton GD,Dodd SJ,Cameron IL

    更新日期:2005-08-01 00:00:00

  • Abnormal brain anatomical topological organization of the cognitive-emotional and the frontoparietal circuitry in major depressive disorder.

    abstract:PURPOSE:Despite the increasing understanding of major depressive disorder (MDD) using neuroimaging techniques, the topological organization of anatomical networks underlying MDD remains unclear. METHODS:The topological organization of brain anatomical networks was explored using complex network approaches. Diffusion t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25036

    authors: Qin J,Wei M,Liu H,Yan R,Luo G,Yao Z,Lu Q

    更新日期:2014-11-01 00:00:00

  • In vivo 3.0-tesla magnetic resonance T1rho and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms.

    abstract::The purpose of this study is (1) to determine the correlation between T(1rho) and T(2) and degenerative grade in intervertebral discs using in vivo 3.0-T MRI, and (2) to determine the association between T(1rho) and T(2) and clinical findings as quantified by the SF-36 Questionnaire and Oswestry Disability Index. Sixt...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22362

    authors: Blumenkrantz G,Zuo J,Li X,Kornak J,Link TM,Majumdar S

    更新日期:2010-05-01 00:00:00

  • Optimization of survey protocols for MRI.

    abstract::A method for evaluating the sensitivity of MRI protocols to changes in an arbitrary number of tissue parameters over a broad range of parameter values is presented. This analysis is useful for choosing an optimal basis set of images for either a "survey" protocol or tissue segmentation algorithms. A survey protocol is...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910130202

    authors: McVeigh ER,Henkelman RM,Bronskill MJ

    更新日期:1990-02-01 00:00:00

  • A pitfall associated with lactate detection using stimulated-echo proton spectroscopy.

    abstract::At TE values of 136 ms, it has recently been shown that the lactate methyl signal, when obtained with a stimulated-echo (STE) sequence, is modulated at the zero-quantum (ZQ) frequency when TM is varied. Here we describe an additional modulation of the ZQ lactate signal, due to spin-spin coupling, that results in a 10-...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910170223

    authors: Sotak CH,Alger JR

    更新日期:1991-02-01 00:00:00

  • Dynamic slice-dependent shim and center frequency update in 3 T breast diffusion weighted imaging.

    abstract:PURPOSE:To demonstrate dynamic slice-dependent shim update as a simple method to reduce susceptibility-induced B0 inhomogeneity and associated pixel shift artifacts in diffusion-weighted echo planar imaging (DW-EPI) in 3 T breast imaging. METHODS:Dynamic slice-dependent update of linear shim and center frequency was i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24824

    authors: Lee SK,Tan ET,Govenkar A,Hancu I

    更新日期:2014-05-01 00:00:00

  • In vivo detection of a pH-sensitive nitroxide in the rat stomach by low-field ESR-based techniques.

    abstract::A study was made of the in vivo detectability of a pH-sensitive, imidazolidine spin probe, and the efficacy of low-frequency electron spin resonance (ESR)-based techniques for pH measurement in vitro and in vivo in rats. The techniques used were longitudinally-detected ESR (LODESR) and field-cycled dynamic nuclear pol...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10392

    authors: Foster MA,Grigor'ev IA,Lurie DJ,Khramtsov VV,McCallum S,Panagiotelis I,Hutchison JM,Koptioug A,Nicholson I

    更新日期:2003-03-01 00:00:00

  • Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON).

    abstract::In proton magnetic resonance imaging (MRI) metallic substances lead to magnetic field distortions that often result in signal voids in the adjacent anatomic structures. Thus, metallic objects and superparamagnetic iron oxide (SPIO)-labeled cells appear as hypointense artifacts that obscure the underlying anatomy. The ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21399

    authors: Stuber M,Gilson WD,Schär M,Kedziorek DA,Hofmann LV,Shah S,Vonken EJ,Bulte JW,Kraitchman DL

    更新日期:2007-11-01 00:00:00

  • High-resolution 1H NMR spectroscopy in rat liver using magic angle turning at a 1 Hz spinning rate.

    abstract::It is demonstrated that a high-resolution (1)H NMR spectrum of excised rat liver can be obtained using the technique of magic angle turning (MAT) at a sample spinning rate of 1 Hz. A variant of the phase-corrected MAT (PHORMAT) pulse sequence that includes a water suppression segment was developed for the investigatio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10139

    authors: Hu JZ,Rommereim DN,Wind RA

    更新日期:2002-05-01 00:00:00