Compartment size estimation with double wave vector diffusion-weighted imaging.

Abstract:

:Double wave vector diffusion weighting uses gradients along two different directions between excitation and acquisition. It has been shown theoretically that for restricted diffusion the signal amplitude in such an experiment can depend on the angle between the two gradient vectors. The highest amplitude is obtained with antiparallel orientation, and the amplitude difference between parallel and antiparallel gradient orientations depends on the compartment size. The validity of this description is experimentally tested for water between polymer beads, for radish, and for porcine spinal cord, using a clinical MR system with limited gradient strength. The results indicate that the phenomenon is observable; however, the size of the signal difference is considerably diminished when compared with theory. This is attributed to violations of the approximating conditions underlying the theoretical description and to free diffusion contributions. It is concluded that the effect could successfully be used as a basis for developing a new noninvasive method for assessing cell size.

journal_name

Magn Reson Med

authors

Koch MA,Finsterbusch J

doi

10.1002/mrm.21514

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

90-101

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

60

pub_type

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