Abstract:
:Healthy human brain diffusion anisotropy maps derived from standard spin echo diffusion tensor imaging (DTI) were compared with those using fluid-attenuated inversion recovery (FLAIR) preparation prior to DTI to null the signal from cerebrospinal fluid (CSF). Consistent comparisons entailed development of DTI postprocessing methods, image masking based on fitting quality, and an objective region-of-interest-based method for assessment of white matter extent. FLAIR DTI achieved an extended delineation of major white-matter tracts (genu, splenium, and body of the corpus callosum) close to large CSF-filled spaces (lateral ventricles), but did not affect representation of tracts remote from CSF (internal and external capsules and coronal radiation). This result, which was detectable qualitatively (visual inspection), was verified quantitatively by analyses of the relative anisotropy (RA) distribution over white matter structures for 11 subjects. FLAIR DTI thus suppresses the CSF signal that otherwise masks underlying anisotropic parenchymal tissue through partial volume averaging.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Papadakis NG,Martin KM,Mustafa MH,Wilkinson ID,Griffiths PD,Huang CL,Woodruff PWdoi
10.1002/mrm.10204subject
Has Abstractpub_date
2002-08-01 00:00:00pages
394-8issue
2eissn
0740-3194issn
1522-2594journal_volume
48pub_type
杂志文章abstract:PURPOSE:Diabetic nephropathy (DN) is the leading cause of renal failure; however, current clinical tests are insufficient for assessing this disease. DN is associated with changes in renal metabolites, so we evaluated the utility of chemical exchange saturation transfer (CEST) imaging to detect changes characteristic o...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26045
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:Establishing a high-resolution non-ECG-gated first-pass perfusion (FPP) cardiac MRI technique may improve accessibility and diagnostic capability of FPP imaging. We propose a non-ECG-gated FPP imaging technique using continuous magnetization-driven golden-angle radial acquisition. The main purpose of this preli...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25074
更新日期:2014-12-01 00:00:00
abstract::If magnetic resonance spectroscopy (MRS) is to become a useful tool in clinical medicine, it will be necessary to find reliable methods for analyzing and classifying MRS data. Automated methods are desirable because they can remove user bias and can deal with large amounts of data, allowing the use of all the availabl...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350608
更新日期:1996-06-01 00:00:00
abstract:PURPOSE:To develop a flexible fast spin echo (FSE) triple-echo Dixon (FTED) technique. METHODS:An FSE pulse sequence was modified by replacing each readout gradient with three fast-switching bipolar readout gradients with minimal interecho dead time. The corresponding three echoes were used to generate three raw image...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26186
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:All methods presented to date to map both conductivity and permittivity rely on multiple acquisitions to compute quantitatively the magnitude of radiofrequency transmit fields, B1+. In this work, we propose a method to compute both conductivity and permittivity based solely on relative receive coil sensitivitie...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25399
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:To introduce and evaluate an image registration technique for robust quantification of CEST acquisitions corrupted by motion. METHODS:The proposed iterative algorithm exploits a low-rank approximation of the z-spectrum (LRAZ), to gradually separate the contrast variation due to saturation at different off-reso...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27206
更新日期:2018-11-01 00:00:00
abstract::Image contrast with gradient-recalled echo sequences (GRE) used for fMRI can have both blood oxygen level-dependent (BOLD) and inflow components, and the latter is often undesirable. A dual-echo technique can be used to differentiate these mechanisms, because modulation of signal from inflow is common to both echoes, ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350306
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abstract::The feasibility of reconstructing three-dimensional (3D) MRI data sets from limited-view projections is investigated in phantom and in vivo animal studies to improve the temporal resolution of magnetic resonance angiography without sacrificing spatial resolution. Thirty-two pairs of orthogonal biplane projections are ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20727
更新日期:2006-01-01 00:00:00
abstract::Nuclear Overhauser effect (NOE) enhancements and relaxation times of 31P metabolites in human calf were measured in 12 volunteers (4 men and 8 women) at 1.5 T using a dual tuned four-ring birdcage. The NOE enhancements of inorganic phosphate (Pi), phosphocreatine (PCr), gamma-, alpha-, and beta-nucleoside triphosphate...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910330316
更新日期:1995-03-01 00:00:00
abstract::Phosphorus NMR can measure myocardial tissue pH from the chemical shift of inorganic phosphate (Pi) in isolated buffer-perfused hearts, but in vivo the Pi peak originating from the myocardium is obscured by the resonance of 2,3-diphosphoglycerate (DPG) in the blood, making pH difficult to determine. Taking advantage o...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910170209
更新日期:1991-02-01 00:00:00
abstract::A method is presented that employs the inherent spectral selectivity of the Steady-State Free Precession (SSFP) pulse sequence to provide a spectral band of suppression. At TE = TR/2, SSFP partitions the magnetization into two phase-opposed spectral components. Z-storing one of these components simultaneously further ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20633
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:To characterize and optimize 19 F MRI for different perfluorocarbons (PFCs) at 3T and quantify the loss of acquisition efficiency as a function of different temperature and cellular conditions. METHODS:The T1 and T2 relaxation times of the commonly used PFCs perfluoropolyether (PFPE), perfluoro-15-crown-5-ethe...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26317
更新日期:2017-06-01 00:00:00
abstract::The signals of water in the different compartments of rat sciatic nerve are resolved in the (2)H double-quantum-filtered NMR spectrum, due to their different quadrupolar splittings and relaxation rates. This resolution allowed the independent measurement of the water diffusion coefficients in the different compartment...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199909)42:3<461::aid-mrm8>
更新日期:1999-09-01 00:00:00
abstract::Since contrast in magnetic resonance imaging (MRI) is so sensitive to the magnetic relaxation rates of tissue protons, the use of paramagnetic ions to alter contrast in a tissue-specific fashion is an alluring prospect. The influence of these ions on the proton relaxation rates in homogeneous solutions is known to var...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910020206
更新日期:1985-04-01 00:00:00
abstract::A novel method for detecting neural activity in functional magnetic resonance imaging (fMRI) data is introduced. It is based on canonical correlation analysis (CCA), which is a multivariate extension of the univariate correlation analysis widely used in fMRI. To detect homogeneous regions of activity, the method combi...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200102)45:2<323::aid-mrm1041>3.0
更新日期:2001-02-01 00:00:00
abstract::The interactive use of magnetic resonance imaging (MRI) techniques is increasing in operating theaters. A study was performed on 17 male company volunteers to assess the neurobehavioral effects of exposure to magnetic fields from a 1.5 Tesla MRI system. The subjects' neurobehavioral performances on a neurobehavioral t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10604
更新日期:2003-10-01 00:00:00
abstract::Deuterium (2H) double-quantum filtered (DQF) NMR spectroscopy of nucleus pulposus (NP) tissues from human intervertebral discs is reported. The DQF spectral intensities, DQ build-up rates, and DQF-detected rotating-frame spin-lattice relaxation times are sensitive to the degree of hydration of the NP tissue, and displ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21231
更新日期:2007-06-01 00:00:00
abstract::Longitudinal and transverse relaxation rates for the 11B resonances in sodium borocaptate (BSH) at varying concentrations were measured in undiluted horse serum in a 4.7 Tesla field. The results could be fit by a model that assumes fast exchange of the BSH molecule between a free and a bound state, using values of 0.7...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390314
更新日期:1998-03-01 00:00:00
abstract::The aim of this study was to detect salvageable peri-infarction myocardium by MRI in rats after infarction, using with a double contrast agent (CA) protocol at 7 Tesla. Intravascular superparamagnetic iron oxide (SPIO) nanoparticles and an extracellular paramagnetic CA (Gd-DOTA) were used to characterize the peri-infa...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20210
更新日期:2004-10-01 00:00:00
abstract::Steady-state free precession (SSFP) methods have been very successful due to their high signal and short imaging times. These properties make them good candidates for applications that intrinsically suffer from low signal such as low gamma nuclei imaging. A new chemical shift imaging (CSI) technique based on the SSFP ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10279
更新日期:2002-10-01 00:00:00
abstract::Trifluoroacetate and trifluoroacetamide, when added to a suspension of human red blood cells, give rise to separate 19F NMR signals from the intra- and extracellular species. This phenomenon has recently been exploited for measuring the membrane potential of erythrocytes. However, the separation of the peaks was incor...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910180119
更新日期:1991-03-01 00:00:00
abstract::Measuring T(2) at 7.0 T is not trivial due to RF inhomogeneity effects, however, gradient echo sampling of a spin echo is insensitive to RF pulse errors, does not suffer from significant distortions, and allows T'(2) and T(2) to be estimated simultaneously. Gradient echo sampling of a spin echo results are relatively ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22522
更新日期:2010-11-01 00:00:00
abstract::A novel center-out 3D trajectory for sampling magnetic resonance data is presented. The trajectory set is based on a single Fermat spiral waveform, which is substantially undersampled in the center of k-space. Multiple trajectories are combined in a "stacked cone" configuration to give very uniform sampling throughout...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22918
更新日期:2011-11-01 00:00:00
abstract::In active catheter tracking, small RF coils are attached to the catheter for localization. For interactive catheter steering at vessel branchings, it is necessary to visualize not only a single point near the catheter tip but also the entire shape and orientation of the catheter's distal end. Therefore, a 35-mm-long t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20108
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:Fluorescence lifetime imaging microscopy (FLIM) of endogenous fluorescent metabolites permits the measurement of cellular metabolism in cell, tissue and animal models. In parallel, magnetic resonance spectroscopy (MRS) of dynamic nuclear (hyper)polarized (DNP) 13 C-pyruvate enables measurement of metabolism at ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27644
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To investigate the uncertainties on relative Cramér-Rao lower bound (rCRB) estimates and demonstrate their biasing effects in MRS quantification. THEORY AND METHODS:Simulations were performed to calculate the distribution of the computed rCRB (noted rCRB*) for several rCRB levels. One hundred thousand simulati...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27415
更新日期:2019-02-01 00:00:00
abstract::Generating flow-specific images (arteriograms, venograms) with optimal signal-to-noise ratios for time-resolved MR angiography is a conditional maximum problem, and its solutions are generalized matched filters. We have investigated six matched filters, corresponding to all possible combinations of three flow suppress...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910300511
更新日期:1993-11-01 00:00:00
abstract:PURPOSE:The primary purpose of this study is to propose a method for the simultaneous quantitative three-dimensional (3D) mapping of conductivity and susceptibility using double-echo ultrashort echo time (UTE) imaging. The secondary purpose is to investigate the changes of these properties over time during in vitro hem...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25869
更新日期:2016-07-01 00:00:00
abstract::Changes in the exchange rate of water across the blood-brain barrier, denoted k(w), may indicate blood-brain barrier dysfunction before the leakage of large-molecule contrast agents is observable. A previously proposed approach for measuring k(w) is to use diffusion-weighted arterial spin labeling to measure the vascu...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.23104
更新日期:2012-05-01 00:00:00
abstract::With standard spectroscopic imaging, high spatial resolution is achieved at the price of a large number of phase-encoding steps, leading to long acquisition times. Fast spatial encoding methods reduce the minimum total acquisition time. In this article, a k-space scanning scheme using a continuous series of growing an...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.10622
更新日期:2003-12-01 00:00:00