Decomposition of inflow and blood oxygen level-dependent (BOLD) effects with dual-echo spiral gradient-recalled echo (GRE) fMRI.

Abstract:

:Image contrast with gradient-recalled echo sequences (GRE) used for fMRI can have both blood oxygen level-dependent (BOLD) and inflow components, and the latter is often undesirable. A dual-echo technique can be used to differentiate these mechanisms, because modulation of signal from inflow is common to both echoes, whereas susceptibility and diffusion-related signal losses are larger in the second echo. An efficient dual-echo interleaved spiral sequence was developed for use with a conventional scanner. It uses a k-space trajectory that spirals out from the origin while the first echo is collected, then spirals back in while collecting the second echo. Decomposition of the data provides separate images of the inflow and T2-weighted components. Results demonstrate the decomposition with phantom experiments and with photic stimulation in normal volunteers.

journal_name

Magn Reson Med

authors

Glover GH,Lemieux SK,Drangova M,Pauly JM

doi

10.1002/mrm.1910350306

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

299-308

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

35

pub_type

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