Triple diffusion encoding MRI predicts intra-axonal and extra-axonal diffusion tensors in white matter.

Abstract:

PURPOSE:To demonstrate how triple diffusion encoding (TDE) MRI can be applied to separately estimate the intra-axonal and extra-axonal diffusion tensors in white matter (WM). METHODS:Using a TDE pulse sequence with an axially symmetric b-matrix, diffusion MRI data were acquired at 3T for 3 healthy adults with an axial b-value of 4000 s/mm2 , a radial b-value of 307 s/mm2 , and 64 diffusion encoding directions. This acquisition was then repeated with the radial b-value set to 0. A previously proposed theory was applied to these data in order to estimate the intra-axonal diffusivity and axonal water fraction for each WM voxel. Conventional single diffusion encoding data were also obtained with b-values of 1000 and 2000 s/mm2 , which provided additional information sufficient for determining both the intra-axonal and extra-axonal diffusion tensors. RESULTS:From the TDE data, the average intra-axonal diffusivity in WM was found to be 2.24 ± 0.18 µm2 /ms, and the average axonal water fraction was found to be 0.60 ± 0.11. From the 2 diffusion tensors, average WM values were estimated for several compartment-specific diffusion parameters. In particular, the extra-axonal mean diffusivity was 1.09 ± 0.19 µm2 /ms, the intra-axonal fractional anisotropy was 0.50 ± 0.14, and the extra-axonal fractional anisotropy was 0.23 ± 0.13. CONCLUSION:By using a simple TDE pulse sequence with an axially symmetric b-matrix, the diffusion tensors for the intra-axonal and extra-axonal spaces can be separately estimated in adult WM. This allows one to determine compartment-specific diffusion properties for these 2 water pools.

journal_name

Magn Reson Med

authors

Ramanna S,Moss HG,McKinnon ET,Yacoub E,Helpern JA,Jensen JH

doi

10.1002/mrm.28084

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

2209-2220

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

83

pub_type

杂志文章
  • Online correction of respiratory-induced field disturbances for continuous MR-thermometry in the breast.

    abstract::MR-thermometry allows monitoring of the local temperature evolution during minimally invasive interventional therapies. However, for the particular case of MR-thermometry in the human breast, magnetic field variations induced by the respiratory cycle lead to phase fluctuations requiring a suitable correction strategy ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21954

    authors: Hey S,Maclair G,de Senneville BD,Lepetit-Coiffe M,Berber Y,Köhler MO,Quesson B,Moonen CT,Ries M

    更新日期:2009-06-01 00:00:00

  • In vivo differentiation of two vessel wall layers in lower extremity peripheral vein bypass grafts: application of high-resolution inner-volume black blood 3D FSE.

    abstract::Lower extremity peripheral vein bypass grafts (LE-PVBG) imaged with high-resolution black blood three-dimensional (3D) inner-volume (IV) fast spin echo (FSE) MRI at 1.5 Tesla possess a two-layer appearance in T1W images while only the inner layer appears visible in the corresponding T2W images. This study quantifies t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22037

    authors: Mitsouras D,Owens CD,Conte MS,Ersoy H,Creager MA,Rybicki FJ,Mulkern RV

    更新日期:2009-09-01 00:00:00

  • Ischemia-induced ADC changes are larger than osmotically-induced ADC changes in a neonatal rat hippocampus model.

    abstract::Diffusion-weighted imaging (DWI) is frequently used to diagnose stroke. However, the origin of the observed reduction in the apparent diffusion coefficient (ADC) in the acute phase following ischemia is not well understood. Although cell swelling is considered to play an important role, it is unclear whether this can ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20353

    authors: van Pul C,Jennekens W,Nicolay K,Kopinga K,Wijn PF

    更新日期:2005-02-01 00:00:00

  • Self-navigated 4D cartesian imaging of periodic motion in the body trunk using partial k-space compressed sensing.

    abstract:PURPOSE:To enable fast and flexible high-resolution four-dimensional (4D) MRI of periodic thoracic/abdominal motion for motion visualization or motion-corrected imaging. METHODS:We proposed a Cartesian three-dimensional k-space sampling scheme that acquires a random combination of k-space lines in the ky/kz plane. A p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26406

    authors: Küstner T,Würslin C,Schwartz M,Martirosian P,Gatidis S,Brendle C,Seith F,Schick F,Schwenzer NF,Yang B,Schmidt H

    更新日期:2017-08-01 00:00:00

  • Correction for partial volume errors in MR heart perfusion imaging.

    abstract::Myocardial MR first-pass perfusion time courses are contaminated by signals from the ventricles (spillover) as a consequence of partial volume effects and motion. An early increase in the signal intensity from the myocardium is an indicator of contamination. This contamination leads to under- or overestimation of perf...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20015

    authors: Köstler H,Ritter C,Reiss-Zimmermann M,Beer M,Hahn D,Sandstede J

    更新日期:2004-04-01 00:00:00

  • Detection of liver fibrosis with magnetic cross-relaxation.

    abstract::The utility of MRI using magnetization transfer (MT) enhanced pulse sequences to diagnose hepatic cirrhosis in a rat model was investigated. Hepatic T1 was measured with and without MT off-resonance RF pulses in 17 treated and six control rats. The livers were evaluated histologically, and the hydroxyproline content q...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310513

    authors: Aisen AM,Doi K,Swanson SD

    更新日期:1994-05-01 00:00:00

  • NMR determination of myocardial pH in vivo: separation of tissue inorganic phosphate from blood 2,3-DPG.

    abstract::Phosphorus NMR can measure myocardial tissue pH from the chemical shift of inorganic phosphate (Pi) in isolated buffer-perfused hearts, but in vivo the Pi peak originating from the myocardium is obscured by the resonance of 2,3-diphosphoglycerate (DPG) in the blood, making pH difficult to determine. Taking advantage o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910170209

    authors: Zahler R,Majumdar S,Frederick B,Laughlin M,Barrett E,Gore JC

    更新日期:1991-02-01 00:00:00

  • Radiofrequency pulse design for the selective excitation of dissolved 129Xe.

    abstract:PURPOSE:To optimize radiofrequency (RF) pulses for the selective excitation of dissolved phase (129)Xe that take into account the very short T2*, while simultaneously, minimally exciting the much larger gas signal. METHODS:Numerical simulations of Shinnar le-Roux pulses and binomial coefficient composite-element pulse...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25089

    authors: Leung G,Norquay G,Schulte RF,Wild JM

    更新日期:2015-01-01 00:00:00

  • Improved data reconstruction method for GRAPPA.

    abstract::This paper presents an improved data reconstruction method for generalized autocalibrating partially parallel acquisitions (GRAPPA) using multicolumn multiline interpolation (MCMLI). Both nearest acquired line (ky) neighboring points and column (kx) neighboring points from all components of an array coil were used to ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20601

    authors: Wang Z,Wang J,Detre JA

    更新日期:2005-09-01 00:00:00

  • Advantage of sampling density weighted apodization over postacquisition filtering apodization for sodium MRI of the human brain.

    abstract::For sodium imaging of the human brain, Gibbs' ringing can degrade image appearance and confound image analysis; k-space filtering is generally required. In this work, the signal to noise ratio (SNR) advantage of sampling density weighted apodization (SDWA) over uniform k-space sampling with postacquisition filtering a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21738

    authors: Stobbe R,Beaulieu C

    更新日期:2008-10-01 00:00:00

  • Quantitative susceptibility mapping using single-shot echo-planar imaging.

    abstract:PURPOSE:To perform quantitative susceptibility mapping (QSM) in negligible acquisition time and apply it to measuring iron-rich subcortical gray matter. METHODS:Whole brain QSM was performed using single-shot gradient echo-planar imaging (EPI) in under 7 seconds on a standard 1.5 T system for imaging brain iron in sub...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25316

    authors: Sun H,Wilman AH

    更新日期:2015-05-01 00:00:00

  • Restricted field of view magnetic resonance imaging of a dynamic time series.

    abstract::A restricted field of view (rFOV) approach for imaging a dynamic time series of volumes of limited spatial extent within a larger subject is described. The shorter readout with rFOV-MRI can be exploited to either limit image artifacts or increase spatial resolution. To accomplish rFOV imaging of a multislice volume fo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21115

    authors: Pisani L,Bammer R,Glover G

    更新日期:2007-02-01 00:00:00

  • Compressed Sensing 3D-GRASE for faster High-Resolution MRI.

    abstract:PURPOSE:High-resolution three-dimensional (3D) structural MRI is useful for delineating complex or small structures of the body. However, it requires long acquisition times and high SAR, limiting its clinical use. The purpose of this work is to accelerate the acquisition of high-resolution images by combining compresse...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27789

    authors: Cristobal-Huerta A,Poot DHJ,Vogel MW,Krestin GP,Hernandez-Tamames JA

    更新日期:2019-09-01 00:00:00

  • Diffusion/perfusion MR imaging of acute cerebral ischemia.

    abstract::In vivo echo-planar MR imaging was used to measure apparent diffusion coefficients (ADC) of cerebral tissues in a comprehensive noninvasive evaluation of early ischemic brain damage induced by occlusion of the middle cerebral artery (MCA) in a cat model of acute regional stroke. Within 10 min after arterial occlusion,...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910190220

    authors: Kucharczyk J,Mintorovitch J,Asgari HS,Moseley M

    更新日期:1991-06-01 00:00:00

  • In vivo evaluation of intracellular pH and high-energy phosphate metabolites during regional myocardial ischemia in cats using 31P nuclear magnetic resonance.

    abstract::Phosphorus-31 nuclear magnetic resonance spectroscopy (31P NMR) was used to assess the temporal changes of high-energy phosphate metabolites in the region of acute myocardial ischemia of open-chest cats. Eight anesthetized cats were studied following ligation of the left anterior descending coronary artery. Creatine p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910030209

    authors: Stein PD,Goldstein S,Sabbah HN,Liu ZQ,Helpern JA,Ewing JR,Lakier JB,Chopp M,LaPenna WF,Welch KM

    更新日期:1986-04-01 00:00:00

  • Atraumatic quantitation of cerebral perfusion in cats by 19F magnetic resonance imaging.

    abstract::We have noninvasively produced low-resolution, quantitative nuclear magnetic resonance images of cerebral blood flow in 2-ml voxels in eight cats. Typical signal-to-noise of 4 to 1 was obtained in cerebral voxels in 16.5-s epochs. Mean flow during normocapnia (paCO2 = 39 +/- 4 mm Hg) and hypercapnia (paCO2 = 62 +/- 4 ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910280105

    authors: Branch CA,Ewing JR,Helpern JA,Ordidge RJ,Butt S,Welch KM

    更新日期:1992-11-01 00:00:00

  • Selective excitation of two-dimensional arbitrarily shaped voxels with parallel excitation in spectroscopy.

    abstract::Parallel excitation is being studied intensively for applications in MR imaging and in particular for selecting arbitrary shapes as regions of interest. In this work, parallel excitation was applied to arbitrarily shaped voxel selection in spectroscopy and investigated for different excitation k-space trajectories (ra...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23018

    authors: Snyder J,Haas M,Hennig J,Zaitsev M

    更新日期:2012-02-01 00:00:00

  • Proton NMR spectroscopy of solvent-saturable resonances: a new approach to study pH effects in situ.

    abstract::It is shown that the effect of pH changes can be measured in proton NMR spectra through the pH sensitivity of the signal intensities of metabolite protons exchanging with water. To observe this phenomenon, pulse sequences must be used that can sensitively observe these exchangeable protons under physiological conditio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910400105

    authors: Mori S,Eleff SM,Pilatus U,Mori N,van Zijl PC

    更新日期:1998-07-01 00:00:00

  • Model-based mapping of fat unsaturation and chain length by chemical shift imaging--phantom validation and in vivo feasibility.

    abstract::Knowledge about the triglyceride (fat) (1)H spectrum enables quantitative determination of several triglyceride characteristics. This work describes a model-based chemical shift imaging method that separates water and fat signal and provides maps of three triglyceride quantities: fatty acid carbon chain length, unsatu...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24196

    authors: Berglund J,Ahlström H,Kullberg J

    更新日期:2012-12-01 00:00:00

  • Automatic in-line quantitative myocardial perfusion mapping: Processing algorithm and implementation.

    abstract:PURPOSE:Quantitative myocardial perfusion mapping has advantages over qualitative assessment, including the ability to detect global flow reduction. However, it is not clinically available and remains a research tool. Building upon the previously described imaging sequence, this study presents algorithm and implementat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27954

    authors: Xue H,Brown LAE,Nielles-Vallespin S,Plein S,Kellman P

    更新日期:2020-02-01 00:00:00

  • Single-shot localized echo-planar imaging (STEAM-EPI) at 4.7 tesla.

    abstract::The resolution and homogeneity limitations of echo-planar imaging (EPI) are overcome by zoom imaging of an easily shimmed localized volume. Use of the stimulated echo enables single-shot localization. In vivo 0.5-mm resolution EPI images of selected regions of a cat brain at 4.7 T are presented. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910140225

    authors: Turner R,von Kienlin M,Moonen CT,van Zijl PC

    更新日期:1990-05-01 00:00:00

  • Transceive phase mapping using the PLANET method and its application for conductivity mapping in the brain.

    abstract:PURPOSE:To demonstrate feasibility of transceive phase mapping with the PLANET method and its application for conductivity reconstruction in the brain. METHODS:Accuracy and precision of transceive phase (ϕ± ) estimation with PLANET, an ellipse fitting approach to phase-cycled balanced steady state free precession (bSS...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27958

    authors: Gavazzi S,Shcherbakova Y,Bartels LW,Stalpers LJA,Lagendijk JJW,Crezee H,van den Berg CAT,van Lier ALHMW

    更新日期:2020-02-01 00:00:00

  • An analytic expression for the ultimate intrinsic SNR in a uniform sphere.

    abstract:PURPOSE:The ultimate intrinsic signal-to-noise ratio (UISNR) is normally calculated using electrodynamic simulations with a complete basis of modes. Here, we provide an exact solution for the UISNR at the center of a dielectric sphere and assess how accurately this solution approximates UISNR away from the center. MET...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27207

    authors: Lee HH,Sodickson DK,Lattanzi R

    更新日期:2018-11-01 00:00:00

  • Deconvolution-based distortion correction of EPI using analytic single-voxel point-spread functions.

    abstract:PURPOSE:To develop a postprocessing algorithm that corrects geometric distortions due to spatial variations of the static magnetic field amplitude, B0 , and effects from relaxation during signal acquisition in EPI. THEORY AND METHODS:An analytic, complex point-spread function is deduced for k-space trajectories of EPI...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28591

    authors: Patzig F,Mildner T,Schlumm T,Müller R,Möller HE

    更新日期:2020-11-21 00:00:00

  • Contributions of chemical exchange to T1ρ dispersion in a tissue model.

    abstract::Variations in T(1ρ) with locking-field strength (T(1ρ) dispersion) may be used to estimate proton exchange rates. We developed a novel approach utilizing the second derivative of the dispersion curve to measure exchange in a model system of cross-linked polyacrylamide gels. These gels were varied in relative compositi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22947

    authors: Cobb JG,Xie J,Gore JC

    更新日期:2011-12-01 00:00:00

  • Measuring extracellular volume fraction by MRI: First verification of values given by clinical sequences.

    abstract:PURPOSE:To verify MR measurements of myocardial extracellular volume fraction (ECV) based on clinically applicable T1-mapping sequences against ECV measurements by radioisotope tracer in pigs and to relate the results to those obtained in volunteers. METHODS:Between May 2016 and March 2017, 8 volunteers (25 ± 4 years,...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27938

    authors: Nordlund D,Xanthis C,Bidhult S,Jablonowski R,Kanski M,Kopic S,Carlsson M,Engblom H,Aletras AH,Arheden H

    更新日期:2020-02-01 00:00:00

  • Commutator filter: a novel technique for the identification of structures producing significant susceptibility inhomogeneities and its application to functional MRI.

    abstract::A robust postprocessing method to detect regions of magnetic field change is presented. High resolution gradient echo data is acquired to create a complex baseline image. From this image, two low resolution images are obtained by applying a low pass filter on the magnitude image and the complex image, respectively. Su...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360518

    authors: Lai S,Reichenbach JR,Haacke EM

    更新日期:1996-11-01 00:00:00

  • Prospective real-time head motion correction using inductively coupled wireless NMR probes.

    abstract:PURPOSE:Head motion continues to be a major source of artifacts and data quality degradation in MRI. The goal of this work was to develop and demonstrate a novel technique for prospective, 6 degrees of freedom (6DOF) rigid body motion estimation and real-time motion correction using inductively coupled wireless nuclear...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25001

    authors: Sengupta S,Tadanki S,Gore JC,Welch EB

    更新日期:2014-10-01 00:00:00

  • Interleaved diffusion-weighted improved by adaptive partial-Fourier and multiband multiplexed sensitivity-encoding reconstruction.

    abstract:PURPOSE:We report a series of techniques to reliably eliminate artifacts in interleaved echo-planar imaging (EPI) based diffusion-weighted imaging (DWI). METHODS:First, we integrate the previously reported multiplexed sensitivity encoding (MUSE) algorithm with a new adaptive Homodyne partial-Fourier reconstruction alg...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25318

    authors: Chang HC,Guhaniyogi S,Chen NK

    更新日期:2015-05-01 00:00:00

  • Fast maximum intensity projection algorithm using shear warp factorization and reduced resampling.

    abstract::Maximal intensity projection (MIP) is routinely used to view MRA and other volumetric angiographic data. The straightforward implementation of MIP is ray casting that traces a volumetric data set in a computationally expensive manner. This article reports a fast MIP algorithm using shear warp factorization and reduced...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10114

    authors: Fang L,Wang Y,Qiu B,Qian Y

    更新日期:2002-04-01 00:00:00