Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI.

Abstract:

:Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI-based 3He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vivo mouse lungs. The technique yields accurate, quantitative information about the microstructure and geometry of acinar airways. In this study, the 3He lung morphometry technique is successfully implemented for in vivo studies of mice. Results indicate excellent agreement between in vivo morphometry via 3He MRI and microscopic morphometry after sacrifice. This opens up new avenues for application of the technique as a precise, noninvasive, in vivo biomarker of changes in lung microstructure, within various mouse models of lung disease.

journal_name

Magn Reson Med

authors

Wang W,Nguyen NM,Yablonskiy DA,Sukstanskii AL,Osmanagic E,Atkinson JJ,Conradi MS,Woods JC

doi

10.1002/mrm.22737

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

620-6

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

65

pub_type

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