Abstract:
:Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI-based 3He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vivo mouse lungs. The technique yields accurate, quantitative information about the microstructure and geometry of acinar airways. In this study, the 3He lung morphometry technique is successfully implemented for in vivo studies of mice. Results indicate excellent agreement between in vivo morphometry via 3He MRI and microscopic morphometry after sacrifice. This opens up new avenues for application of the technique as a precise, noninvasive, in vivo biomarker of changes in lung microstructure, within various mouse models of lung disease.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Wang W,Nguyen NM,Yablonskiy DA,Sukstanskii AL,Osmanagic E,Atkinson JJ,Conradi MS,Woods JCdoi
10.1002/mrm.22737subject
Has Abstractpub_date
2011-03-01 00:00:00pages
620-6issue
3eissn
0740-3194issn
1522-2594journal_volume
65pub_type
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