Abstract:
:Phase-contrast magnetic resonance imaging is subject to numerous sources of error, which decrease clinical confidence in the reported measures. This work outlines how stationary perivascular fat can impart a significant chemical shift induced phase-contrast magnetic resonance imaging measurement error using computational simulations, in vitro, and in vivo experiments. This chemical shift error does not subtract in phase difference processing, but can be minimized with proper parameter selection. The chemical shift induced phase errors largely depend on both the receiver bandwidth and the TE. Both theory and an in vivo comparison of the maximum difference in net forward flow between vessels with and without perivascular fat indicated that the effects of chemically shifted perivascular fat are minimized by the use of high bandwidth (814 Hz/px) and an in-phase TE (high BW-TE(IN)). In healthy volunteers (N = 10) high BW-TE(IN) significantly improves intrapatient net forward flow agreement compared with low bandwidth (401 Hz/px) and a mid-phase TE as indicated by significantly decreased measurement biases and limits of agreement for the ascending aorta (1.8 ± 0.5 mL vs. 6.4 ± 2.8 mL, P = 0.01), main pulmonary artery (2.0 ± 0.9 mL vs. 11.9 ± 5.8 mL, P = 0.04), the left pulmonary artery (1.3 ± 0.9 mL vs. 5.4 ± 2.5 mL, P = 0.003), and all vessels (1.7 ± 0.8 mL vs. 7.2 ± 4.4 mL, P = 0.001).
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Middione MJ,Ennis DBdoi
10.1002/mrm.24262subject
Has Abstractpub_date
2013-02-01 00:00:00pages
391-401issue
2eissn
0740-3194issn
1522-2594journal_volume
69pub_type
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journal_title:Magnetic resonance in medicine
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更新日期:2017-05-01 00:00:00
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