Abstract:
:T(2) quantification may augment diagnostic T(2)-weighted imaging; to improve cancer detection via auto-segmentation of multi-parametric acquisitions and to potentiate longitudinal studies of prostate cancer. However, robust quantitative techniques are not generally accessible or refined for clinical translation. This research describes the adaptation of a magnetization-prepared spiral imaging technique, termed T2prep for prostate application, providing whole gland coverage within a 5-min interval with considerable insensitivity to radio-frequency (RF) inhomogeneities. Clinical piloting in two cohorts with distinct clinical histories demonstrated the anticipated differences in zonal and tumor T(2), including tumor T(2) shortening compared to peripheral zone, and post-radiotherapy shortening of peripheral zone T(2). SNR calculations were performed for data acquired with or without an endo-rectal coil in tandem with a torso phased array, to judge the potential for voxel-based T(2) mapping and thereby support focal biological characterization of cancer, hypoxia, and response to therapy within regions of dense cancer burden.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Foltz WD,Chopra S,Chung P,Bayley A,Catton C,Jaffray D,Wright GA,Haider MA,Ménard Cdoi
10.1002/mrm.22492subject
Has Abstractpub_date
2010-10-01 00:00:00pages
1155-61issue
4eissn
0740-3194issn
1522-2594journal_volume
64pub_type
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