Sodium NMR imaging of lung water in rats.

Abstract:

:Coronal proton and sodium images of control rats and rats with either increased permeability edema produced by intravenous alloxan (300 mg/kg) or increased pressure edema produced by saline infusion (2 ml/min) were obtained. Axial chest CT images were used to monitor the development of pulmonary edema. Immediately after the imaging session compartmental lung water was measured gravimetrically. The sodium and proton imagings were done sequentially in a 31-cm-bore 1.9-T magnet without moving the animal. The anatomical boundaries of the lung on the proton images were transferred to the sodium images for calculation of the average sodium signal intensity which was determined by extrapolating the mean values from five echoes to time zero. The sodium signal intensity was correlated (r = 0.7) with the total water fraction. There was poor correlation (r = 0.56) with the extravascular water due to confounding by the sodium vascular signal.

journal_name

Magn Reson Med

authors

Kundel HL,Shetty A,Joseph PM,Summers RM,Kassab EA,Moore B

doi

10.1002/mrm.1910060403

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

381-9

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

6

pub_type

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