Abstract:
PURPOSE:To achieve highly accelerated submillimeter resolution T 2 -weighted functional MRI at 7T by developing a three-dimensional gradient and spin echo imaging (GRASE) with inner-volume selection and variable flip angles (VFA). METHODS:GRASE imaging has disadvantages in that (a) k-space modulation causes T 2 blurring by limiting the number of slices and (b) a VFA scheme results in partial success with substantial SNR loss. In this work, accelerated GRASE with controlled T 2 blurring is developed to improve a point spread function (PSF) and temporal signal-to-noise ratio (tSNR) with a large number of slices. To this end, the VFA scheme is designed by minimizing a trade-off between SNR and blurring for functional sensitivity, and a new GRASE-optimized random encoding, which takes into account the complex signal decays of T 2 and T 2 ∗ weightings, is proposed by achieving incoherent aliasing for constrained reconstruction. Numerical and experimental studies were performed to validate the effectiveness of the proposed method over regular and VFA GRASE (R- and V-GRASE). RESULTS:The proposed method, while achieving 0.8 mm isotropic resolution, functional MRI compared to R- and V-GRASE improves the spatial extent of the excited volume up to 36 slices with 52%-68% full width at half maximum (FWHM) reduction in PSF but approximately 2- to 3-fold mean tSNR improvement, thus resulting in higher BOLD activations. CONCLUSIONS:We successfully demonstrated the feasibility of the proposed method in T 2 -weighted functional MRI. The proposed method is especially promising for cortical layer-specific functional MRI.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Park S,Torrisi S,Townsend JD,Beckett A,Feinberg DAdoi
10.1002/mrm.28589subject
Has Abstractpub_date
2020-11-24 00:00:00eissn
0740-3194issn
1522-2594pub_type
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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journal_title:Magnetic resonance in medicine
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