Abstract:
:The course of pulmonary edema formation after an intratracheal (i.t.) instillation of ovalbumin was followed noninvasively by magnetic resonance imaging (MRI) in actively sensitized Brown Norway (BN) rats. Changes in edema volume assessed by MRI mimicked the results from the analysis of the number and activation of inflammatory cells recovered from the broncho-alveolar lavage (BAL) fluid. Rats treated with budesonide did not develop edema following challenge with ovalbumin, and these animals showed a significant decrease in BAL fluid inflammatory cell numbers and eosinophil peroxidase and myeloperoxidase activities. Thus, following lung edema formation by MRI provides a reliable means of assessing pulmonary inflammation after allergen challenge. Unlike BAL fluid analysis, which requires killing animals at each time point, this method is noninvasive. MRI could be of importance for the noninvasive profiling of anti-inflammatory drugs in animal models of asthma and in the clinic. Magn Reson Med 45:88-95, 2001.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Beckmann N,Tigani B,Ekatodramis D,Borer R,Mazzoni L,Fozard JRdoi
10.1002/1522-2594(200101)45:1<88::aid-mrm1013>3.0.subject
Has Abstractpub_date
2001-01-01 00:00:00pages
88-95issue
1eissn
0740-3194issn
1522-2594pii
10.1002/1522-2594(200101)45:1<88::AID-MRM1013>3.0.journal_volume
45pub_type
杂志文章abstract:PURPOSE:Continuously moving table (CMT) MRI is a high throughput technique that has multiple applications in whole-body imaging. In this work, CMT MRI based on golden angle (GA, 111.246° azimuthal step) radial sampling is developed at 3 Tesla (T), with the goal of increased flexibility in image reconstruction using arb...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25531
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:Multi-slice radiofrequency (RF) pulses have higher specific absorption rates, more peak RF power, and longer pulse durations than single-slice RF pulses. Gradient field design techniques using a z-gradient array are investigated for exciting multiple slices with a single-band RF pulse. THEORY AND METHODS:Two d...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27031
更新日期:2018-07-01 00:00:00
abstract::The relaxivities (R-values) of the gadolinium diethylene triamine pentaacetic acid (Gd(DTPA)2-) ions in a series of skim-milk solutions at 0-40% milk concentrations were measured using NMR spectroscopy. The R-value was found to be approximately linearly proportional to the concentration of the solid component in the m...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22169
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To demonstrate the feasibility of a novel, ellipse fitting approach, named PLANET, for simultaneous estimation of relaxation times T1 and T2 from a single 3D phase-cycled balanced steady-state free precession (bSSFP) sequence. METHODS:A method is presented in which the elliptical signal model is used to descri...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26717
更新日期:2018-02-01 00:00:00
abstract::Specialized receiver coils having a small sensitive region can provide an improvement in SNR for MR imaging and spectroscopy, at the expense of limiting the usable field of view. This work presents a technique for designing coil arrays that allows the size and location of the sensitive region to be selected remotely. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910170128
更新日期:1991-01-01 00:00:00
abstract::Magnetic resonance (MR) can offer a unique window on the structure/function relationships in the brain, by utilizing the established link between tissue function, metabolism, and hemodynamics. This report focuses on recent applications of MR-based cerebral blood volume (CBV) imaging in humans. Our methodology uses hig...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910220227
更新日期:1991-12-01 00:00:00
abstract::Hyperpolarized gases ((129)Xe and (3)He) are being used increasingly in both MRI and NMR spectroscopy studies. However, it has been shown that carrier agents are required to preserve the long relaxation times of gases in biological fluids. Optimized gas transport can be achieved through controlled T(1) and T(2) measur...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10476
更新日期:2003-06-01 00:00:00
abstract::Optimization of experimental settings of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), like the contrast administration protocol, is of great importance for reliable quantification of the microcirculatory properties, such as the volume transfer-constant K(trans). Using system identification theory an...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21575
更新日期:2008-05-01 00:00:00
abstract::The Shinnar-Le Roux (SLR) radiofrequency (RF) pulse design algorithm is widely used for designing slice-selective RF pulses due to its intuitiveness, optimality, and speed. SLR is limited, however, in that it is only capable of designing one-dimensional pulses played along constant gradients. We present a nonuniform S...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.23269
更新日期:2012-09-01 00:00:00
abstract::The purpose of this study was to determine the value of a blood-pool contrast media (NC100150, Nycomed Imaging (now Amersham Health) Oslo, Norway) for evaluation of venous thrombosis of the deep veins of the pelvis and lower extremities. Twelve patients were prospectively evaluated with conventional X-ray venography (...
journal_title:Magnetic resonance in medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/mrm.10607
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:For ultrahigh field (UHF) MRI, the expected local specific absorption rate (SAR) distribution is usually calculated by numerical simulations using a limited number of generic body models and adding a safety margin to take into account intersubject variability. Assessment of this variability with a large model d...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27518
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To achieve rapid, high resolution whole-brain gray matter (GM) imaging by developing a novel, single-slab three-dimensional dual-echo fast-spin-echo pulse sequence and GM-selective reconstruction. METHODS:Unlike conventional GM imaging that uses time-consuming double-inversion-recovery preparation, the propose...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26910
更新日期:2017-11-01 00:00:00
abstract::Each k-space segment in multishot diffusion-weighted MRI is affected by a different spatially varying phase which is caused by unavoidable motions and amplified by the diffusion-encoding gradients. A proper image reconstruction therefore requires phase maps for each segment. Such maps are commonly derived from two-dim...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22126
更新日期:2009-11-01 00:00:00
abstract::A simple theoretical model was developed to compare the sensitivities (i.e., signal-to-noise ratios per unit imaging time) of two-dimensional (2D) multislice and 3D imaging sequences. The model shows that the sensitivities of 3D and 2D multislice MRI sequences are usually similar. Sensitivities are identical in T2-wei...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199904)41:4<824::aid-mrm23
更新日期:1999-04-01 00:00:00
abstract::Volume-localized proton NMR spectroscopy was used to estimate bone marrow cellularity in the posterior iliac crests of patients undergoing treatment with hematopoietic growth factors for a variety of hematologic and neoplastic disorders. Twelve patients were accrued, six of whom were studied more than once, yielding a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910190108
更新日期:1991-05-01 00:00:00
abstract::Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI-based 3He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vivo mouse lungs. The technique yiel...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22737
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To present a new method that can simultaneously and efficiently measure T1 and B1 (+) maps using reference region variable flip angle (RR-VFA) imaging. METHODS:Assuming T1 relaxation time in a reference region such as fat is well characterized, and the reference region sufficiently covers smoothly varying B1 (...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24904
更新日期:2013-10-01 00:00:00
abstract::Human brain white matter exhibits an uncommonly strong dispersion of 1/T1 at high fields. An additional relaxation pathway via the myelin lipids, which are not directly visible to medical NMR due to their fast T2 decay, is proposed. Relaxation dispersion data are successfully analyzed on the basis of this model. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910090319
更新日期:1989-03-01 00:00:00
abstract::A method for calculating quantitative three-dimensional susceptibility maps from field measurements acquired using gradient echo imaging at high field is presented. This method is based on division of the three-dimensional Fourier transforms of high-pass-filtered field maps by a simple function that is the Fourier tra...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22334
更新日期:2010-05-01 00:00:00
abstract::A new method is presented for the quantitative determination of regional blood volumes in vivo. It is based on rapid quantitative T1 mapping by Snapshot FLASH MRI combined with the injection of an intravascular MR contrast agent. Regional blood volumes in four different tissues of the rat (skeletal muscle, heart, live...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910290521
更新日期:1993-05-01 00:00:00
abstract::The differential effects of high temperature on 9L rat gliosarcoma cells cultured in two distinctive forms, namely, anchored monolayer cells and multicellular spheroids, were investigated using 31P nuclear magnetic resonance spectroscopy. The critical temperatures resulting in irreversible changes in cellular energeti...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910190233
更新日期:1991-06-01 00:00:00
abstract:PURPOSE:Imaging of [2-13 C]lactate, a metabolic product of [2-13 C]pyruvate, is over considerable interest in hyperpolarized 13 C studies. However, artifact-free imaging of a J-coupled nuclear spin species can be challenging due to the peak-splitting induced by the spin-spin interactions. In this work, two new techniqu...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28532
更新日期:2021-03-01 00:00:00
abstract::A method is presented for measuring myocardial deformation in a breath-hold with tagged cine MRI. Tagged cine images of human hearts are obtained in arbitrary oblique planes on a standard imager with as few as four heartbeats. The scan time has been reduced 16- to 64-fold from previous techniques. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910280214
更新日期:1992-12-01 00:00:00
abstract::The effects of macroscopic background field gradients upon 2D gradient echo images of inhaled (3)He in the human lung were investigated at 1.5 T. Effective compensation of in-slice signal loss in (3)He gradient echo images was then demonstrated using a multiple acquisition interleaved single gradient echo sequence. Th...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10549
更新日期:2003-08-01 00:00:00
abstract::Hyperpolarized (HP) 129Xe can be dissolved in biologically compatible lipid emulsions while maintaining sufficient polarization for in vivo vascular imaging. For xenon in Intralipid 30%, in vitro spectroscopy at 2 T yielded a chemical shift of 197 +/- 1 ppm with reference to xenon gas, a spin-lattice relaxation time T...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199905)41:5<1058::aid-mrm2
更新日期:1999-05-01 00:00:00
abstract::The soft tissue contrast obtained in fast imaging using rapidly repeated partial saturation sequences is usually based on differences in T1. We describe here an extension of the method which results in the development of clinically useful T2-based contrast. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910040404
更新日期:1987-04-01 00:00:00
abstract:PURPOSE:A multi-turn transmit surface coil design was presented to improve B1 efficiency when used with current source amplification. METHODS:Three different coil designs driven by an on-coil current-mode class-D amplifier with current envelope feedback were tested on the benchtop and through imaging in a 1.5 T scanne...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24612
更新日期:2013-04-01 00:00:00
abstract::The assessment of myocardial fibrosis and extracellular volume requires accurate estimation of myocardial T1 s. While image acquisition using the modified Look-Locker inversion recovery technique is clinically feasible for myocardial T1 mapping, respiratory motion can limit its applicability. Moreover, the conventiona...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24385
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To compare the performance of an 8-channel surface coil/clamshell transmitter and 32-channel head array coil/birdcage transmitter for hyperpolarized 13 C brain metabolic imaging. METHODS:To determine the field homogeneity of the radiofrequency transmitters, B1 + mapping was performed on an ethylene glycol head...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27743
更新日期:2019-08-01 00:00:00
abstract::Phased-array coils distribute the high signal-to-noise ratio (SNR) performance of their small component surface coils over the larger area covered by the entire array. The inhomogeneous sensitivity profiles of the component surface coils result in images with very high signal near the phased-array and decreased signal...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350419
更新日期:1996-04-01 00:00:00