Abstract:
:Skeletal muscle triglycerides are markers for insulin resistance in type 2 diabetes. Recently, MR spectroscopy was adapted for in vivo measurement of triglycerides in animal models and for the characterization of new therapeutic approaches. Because of small MR spectroscopy voxel sizes used in skeletal muscles, surface coils are used for signal reception. Furthermore, to obtain well-resolved and undistorted lipid spectra, muscle fibers must be aligned parallel to the magnetic field. Consequently, to achieve a high signal-to-noise ratio and spectral quality, a coil setup must combine high sensitivity with a reliable and reproducible positioning of muscle and voxel. These demands are difficult to match using surface coils. Here, a coil platform is described, which uses inductively coupled Helmholtz coil setup combined with a leg retainer system for rats. The new system allows for measurement of intramyocellular lipids with high signal-to-noise ratio and for significantly improved animal handling, positioning, and throughput.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Neumaier M,Niessen HG,Kaulisch T,Stiller Ddoi
10.1002/mrm.22149subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1036-41issue
4eissn
0740-3194issn
1522-2594journal_volume
62pub_type
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更新日期:2020-08-01 00:00:00
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