Comparison of diffusion- and T2-weighted MRI for the early detection of cerebral ischemia and reperfusion in rats.

Abstract:

:The sensitivity of diffusion-weighted MRI was compared to that of T2-weighted MRI following temporary middle cerebral artery occlusion (MCA-O) for 33 min followed by 4 h of reperfusion in rats. Diffusion-weighted spin-echo images using strong gradients (b value of 1413 s/mm2) demonstrated a significant increase in signal intensity in ischemic regions as early as 14 min after onset of ischemia in comparison to the normal, contralateral hemisphere (p less than 0.05). This hyperintensity returned to baseline levels during reperfusion. T2-weighted images showed no evidence of brain injury during the temporary occlusion. In three rats subjected to permanent MCA-O, diffusion-weighted MRI demonstrated an increased signal intensity on the first image following occlusion and continued to increase during the 4-h observation period. T2-weighted images failed to demonstrate significant injury until approximately 2 h after MCA-O. Signal intensity ratios of ischemic to normal tissues were greater in the diffusion-weighted images than in the T2-weighted MR images at all time points (p less than 0.05). Close anatomical correlation was found between the early and sustained increase in diffusion-weighted MRI signal intensity and localization of infarcts seen on post-mortem histopathology.

journal_name

Magn Reson Med

authors

Mintorovitch J,Moseley ME,Chileuitt L,Shimizu H,Cohen Y,Weinstein PR

doi

10.1002/mrm.1910180106

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

39-50

issue

1

eissn

0740-3194

issn

1522-2594

journal_volume

18

pub_type

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