Abstract:
:How stem cells promote myocardial repair in myocardial infarction (MI) is not well understood. The purpose of this study was to noninvasively monitor and quantify mesenchymal stem cells (MSC) from bone marrow to MI sites using magnetic resonance imaging (MRI). MSC were dual-labeled with an enhanced green fluorescent protein and micrometer-sized iron oxide particles prior to intra-bone marrow transplantation into the tibial medullary space of C57Bl/6 mice. Micrometer-sized iron oxide particles labeling caused signal attenuation in T(2)*-weighted MRI and thus allowed noninvasive cell tracking. Longitudinal MRI demonstrated MSC infiltration into MI sites over time. Fluorescence from both micrometer-sized iron oxide particles and enhanced green fluorescent protein in histology validated the presence of dual-labeled cells at MI sites. This study demonstrated that MSC traffic to MI sites can be noninvasively monitored in MRI by labeling cells with micrometer-sized iron oxide particles. The dual-labeled MSC at MI sites maintained their capability of proliferation and differentiation. The dual-labeling, intra-bone marrow transplantation, and MRI cell tracking provided a unique approach for investigating stem cells' roles in the post-MI healing process. This technique can potentially be applied to monitor possible effects on stem cell mobilization caused by given treatment strategies.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Yang Y,Schumacher A,Yang Y,Liu J,Shi X,Hill WD,Hu TCdoi
10.1002/mrm.22735subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1430-6issue
5eissn
0740-3194issn
1522-2594journal_volume
65pub_type
杂志文章abstract:PURPOSE:Anisotropic transverse R2 (1/T2 ) relaxation of water proton is sensitive to cartilage degenerative changes. The purpose is to develop an efficient method to extract this relaxation metric in clinical studies. METHODS:Anisotropic R2 can be measured inefficiently by standard R2 mapping after removing an isotrop...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27621
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:This study aims to (i) develop a new high-speed MRI approach by implementing correlation imaging in wavelet-space, and (ii) demonstrate the ability of wavelet-space correlation imaging to image human anatomy with involuntary or physiological motion. METHODS:Correlation imaging is a high-speed MRI framework in ...
journal_title:Magnetic resonance in medicine
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更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To investigate previously unreported effects of signal drift as a result of temporal scanner instability on diffusion MRI data analysis and to propose a method to correct this signal drift. METHODS:We investigated the signal magnitude of non-diffusion-weighted EPI volumes in a series of diffusion-weighted imag...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26124
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To assess the performance, in the presence of scanner instabilities, of three dynamic correction methods which integrate ∆B0 mapping into the chemical exchange saturation transfer (CEST) measurement and three established static ∆B0 -correction approaches. METHODS:A homogeneous phantom and five healthy voluntee...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27750
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:A ghost correction strategy for Simultaneous Multi-Slice (SMS) EPI methods that provides improved ghosting artifact reduction compared to conventional methods is presented. Conventional Nyquist ghost correction methods for SMS-EPI rely on navigator data that contain phase errors from all slices in the simultane...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27113
更新日期:2018-10-01 00:00:00
abstract::A magnetic resonance imaging (MRI) method is presented to detect, localize, and quantify myocardial kinematics by measuring the material rate-of-strain tensor at each pixel in gated NMR images of the heart. The immediate, local effect of muscular activity is self-deformation, and the strain tensor is the basic mathema...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910270107
更新日期:1992-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25016
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To develop a postprocessing algorithm that corrects geometric distortions due to spatial variations of the static magnetic field amplitude, B0 , and effects from relaxation during signal acquisition in EPI. THEORY AND METHODS:An analytic, complex point-spread function is deduced for k-space trajectories of EPI...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28591
更新日期:2020-11-21 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21129
更新日期:2007-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200102)45:2<323::aid-mrm1041>3.0
更新日期:2001-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21834
更新日期:2009-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199912)42:6<1089::aid-mrm1
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:This study aims to identify work-related and personal factors associated with workers' exposure to static magnetic fields (SMF) and motion-induced time-varying magnetic fields (TVMF) from MRI scanners. METHODS:Measurements of personal exposure to SMF and TVMF were performed among MRI staff during 439 work shif...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25720
更新日期:2016-05-01 00:00:00
abstract::To investigate the dependency of T(1) relaxation on mechanical strain in articular cartilage, quantitative magnetic resonance T(1) imaging experiments were carried out on cartilage before/after the tissue was immersed in gadolinium contrast agent and when the tissue was being compressed (up to ∼ 48% strains). The spat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22933
更新日期:2011-06-01 00:00:00
abstract::Vascular-space-occupancy (VASO) MRI exploits the difference between blood and tissue T1 to null blood signal and measure cerebral blood volume changes using the residual tissue signal. VASO imaging is more difficult at higher field because of sensitivity loss due to the convergence of tissue and blood T1 values and in...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24334
更新日期:2013-04-01 00:00:00
abstract::Advances in modern magnetic resonance imaging (MRI) pulse sequences have enabled clinically practical cortical bone imaging. Human cortical bone is known to contain a distribution of T(1) and T(2) components attributed to bound and pore water, although clinical imaging approaches have yet to discriminate bound from po...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24186
更新日期:2012-12-01 00:00:00
abstract::An implementation is reported of an imaging method to obtain MUltiple Resolutions along Phase-encode and Slice-select dimensions (MURPS), which enables dynamic imaging of focal changes using a graded, multiresolution approach. MURPS allows one to trade spatial resolution in part of the volume for improved temporal res...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1126
更新日期:2001-06-01 00:00:00
abstract::The experiments reported herein are the first MRI investigations of the orientational dependence of T(2) relaxation in articular cartilage at microscopic resolution over the 360 degrees angular space. For each of six canine cartilage specimens, 48 independent T(2)-weighted proton images were acquired for 12 different ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10216
更新日期:2002-09-01 00:00:00
abstract:PURPOSE:To enable accurate magnetic resonance (MR) parameter mapping with accelerated data acquisition, utilizing recent advances in constrained imaging with sparse sampling. THEORY AND METHODS:A new constrained reconstruction method based on low-rank and sparsity constraints is proposed to accelerate MR parameter map...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25421
更新日期:2015-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26150
更新日期:2017-02-01 00:00:00
abstract::A planar YBa2Cu3Ox (YBCO) coil has been used as a pick-up coil in a nuclear magnetic resonance imager. It was found that the quality factor (Q) of the YBCO coil was greater than its copper counterpart by approaching 50% even in a field of 0.15 T. The Q of the copper coil at 77 K and in a field of 0.15 T was 1200 while...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910200218
更新日期:1991-08-01 00:00:00
abstract::The reconstruction of MR images from nonrectilinearly sampled data is complicated by the fact that the inverse 2D Fourier transform (FT) cannot be performed directly on the acquired k-space data set. k-Space gridding is commonly used because it is an efficient reconstruction method. However, conventional gridding requ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10692
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:We report a series of techniques to reliably eliminate artifacts in interleaved echo-planar imaging (EPI) based diffusion-weighted imaging (DWI). METHODS:First, we integrate the previously reported multiplexed sensitivity encoding (MUSE) algorithm with a new adaptive Homodyne partial-Fourier reconstruction alg...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25318
更新日期:2015-05-01 00:00:00
abstract::The authors present their 1-year experience with the use of 3DFT, time-of-flight MR angiography for the evaluation of vascular diseases of the head and neck. Their experience with over 150 patients indicates that this examination may be performed in conjunction with standard spin-echo imaging with only a minimal incre...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910140215
更新日期:1990-05-01 00:00:00
abstract:PURPOSE:To propose and evaluate a deep learning model for rapid and accurate calculation of myocardial T1 /T2 values based on a previously proposed Bloch equation simulation with slice profile correction (BLESSPC) method. METHODS:Deep learning Bloch equation simulations (DeepBLESS) models are proposed for rapid and ac...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28321
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To develop a flexible fast spin echo (FSE) triple-echo Dixon (FTED) technique. METHODS:An FSE pulse sequence was modified by replacing each readout gradient with three fast-switching bipolar readout gradients with minimal interecho dead time. The corresponding three echoes were used to generate three raw image...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26186
更新日期:2017-03-01 00:00:00
abstract::Current implementations of coronary artery magnetic resonance angiography (MRA) suffer from limited coverage of the coronary arterial system. Whole-heart coronary MRA was implemented based on a free-breathing steady-state free-precession (SSFP) technique with magnetization preparation. The technique was compared to a ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10653
更新日期:2003-12-01 00:00:00
abstract::We improved the three-point phase-contrast method by regularization of MR velocity data after acquisition of a low velocity-to-noise ratio (VNR) velocity image and a high VNR aliased velocity image. The phase unwrapping algorithm is based on the assumed correlation of the velocity of adjacent flow voxels on the low VN...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200007)44:1<122::aid-mrm18>3.0.c
更新日期:2000-07-01 00:00:00
abstract::To obtain a better understanding of the mechanisms underlying early changes in the brain water apparent diffusion coefficient (ADC) observed in cerebral ischemia, dynamic changes in the ADC of water and in the energy status were measured at postnatal day 8 or 9 in neonatal rat brains after cardiac arrest using 1H MRS/...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910360110
更新日期:1996-07-01 00:00:00
abstract:PURPOSE:To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent. METHODS:An interleaved variable density (IVD) undersampling pattern was implemented i...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25195
更新日期:2015-03-01 00:00:00