Monitoring bone marrow-originated mesenchymal stem cell traffic to myocardial infarction sites using magnetic resonance imaging.

Abstract:

:How stem cells promote myocardial repair in myocardial infarction (MI) is not well understood. The purpose of this study was to noninvasively monitor and quantify mesenchymal stem cells (MSC) from bone marrow to MI sites using magnetic resonance imaging (MRI). MSC were dual-labeled with an enhanced green fluorescent protein and micrometer-sized iron oxide particles prior to intra-bone marrow transplantation into the tibial medullary space of C57Bl/6 mice. Micrometer-sized iron oxide particles labeling caused signal attenuation in T(2)*-weighted MRI and thus allowed noninvasive cell tracking. Longitudinal MRI demonstrated MSC infiltration into MI sites over time. Fluorescence from both micrometer-sized iron oxide particles and enhanced green fluorescent protein in histology validated the presence of dual-labeled cells at MI sites. This study demonstrated that MSC traffic to MI sites can be noninvasively monitored in MRI by labeling cells with micrometer-sized iron oxide particles. The dual-labeled MSC at MI sites maintained their capability of proliferation and differentiation. The dual-labeling, intra-bone marrow transplantation, and MRI cell tracking provided a unique approach for investigating stem cells' roles in the post-MI healing process. This technique can potentially be applied to monitor possible effects on stem cell mobilization caused by given treatment strategies.

journal_name

Magn Reson Med

authors

Yang Y,Schumacher A,Yang Y,Liu J,Shi X,Hill WD,Hu TC

doi

10.1002/mrm.22735

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

1430-6

issue

5

eissn

0740-3194

issn

1522-2594

journal_volume

65

pub_type

杂志文章
  • A unique anisotropic R2 of collagen degeneration (ARCADE) mapping as an efficient alternative to composite relaxation metric (R2 -R1 ρ ) in human knee cartilage study.

    abstract:PURPOSE:Anisotropic transverse R2 (1/T2 ) relaxation of water proton is sensitive to cartilage degenerative changes. The purpose is to develop an efficient method to extract this relaxation metric in clinical studies. METHODS:Anisotropic R2 can be measured inefficiently by standard R2 mapping after removing an isotrop...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27621

    authors: Pang Y,Palmieri-Smith RM,Malyarenko DI,Swanson SD,Chenevert TL

    更新日期:2019-06-01 00:00:00

  • Wavelet-space correlation imaging for high-speed MRI without motion monitoring or data segmentation.

    abstract:PURPOSE:This study aims to (i) develop a new high-speed MRI approach by implementing correlation imaging in wavelet-space, and (ii) demonstrate the ability of wavelet-space correlation imaging to image human anatomy with involuntary or physiological motion. METHODS:Correlation imaging is a high-speed MRI framework in ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25546

    authors: Li Y,Wang H,Tkach J,Roach D,Woods J,Dumoulin C

    更新日期:2015-12-01 00:00:00

  • The importance of correcting for signal drift in diffusion MRI.

    abstract:PURPOSE:To investigate previously unreported effects of signal drift as a result of temporal scanner instability on diffusion MRI data analysis and to propose a method to correct this signal drift. METHODS:We investigated the signal magnitude of non-diffusion-weighted EPI volumes in a series of diffusion-weighted imag...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26124

    authors: Vos SB,Tax CM,Luijten PR,Ourselin S,Leemans A,Froeling M

    更新日期:2017-01-01 00:00:00

  • A comparison of static and dynamic ∆B0 mapping methods for correction of CEST MRI in the presence of temporal B0 field variations.

    abstract:PURPOSE:To assess the performance, in the presence of scanner instabilities, of three dynamic correction methods which integrate ∆B0 mapping into the chemical exchange saturation transfer (CEST) measurement and three established static ∆B0 -correction approaches. METHODS:A homogeneous phantom and five healthy voluntee...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27750

    authors: Poblador Rodriguez E,Moser P,Dymerska B,Robinson S,Schmitt B,van der Kouwe A,Gruber S,Trattnig S,Bogner W

    更新日期:2019-08-01 00:00:00

  • Dual-polarity slice-GRAPPA for concurrent ghost correction and slice separation in simultaneous multi-slice EPI.

    abstract:PURPOSE:A ghost correction strategy for Simultaneous Multi-Slice (SMS) EPI methods that provides improved ghosting artifact reduction compared to conventional methods is presented. Conventional Nyquist ghost correction methods for SMS-EPI rely on navigator data that contain phase errors from all slices in the simultane...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27113

    authors: Hoge WS,Setsompop K,Polimeni JR

    更新日期:2018-10-01 00:00:00

  • Magnetic resonance imaging of myocardial kinematics. Technique to detect, localize, and quantify the strain rates of the active human myocardium.

    abstract::A magnetic resonance imaging (MRI) method is presented to detect, localize, and quantify myocardial kinematics by measuring the material rate-of-strain tensor at each pixel in gated NMR images of the heart. The immediate, local effect of muscular activity is self-deformation, and the strain tensor is the basic mathema...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910270107

    authors: Wedeen VJ

    更新日期:1992-09-01 00:00:00

  • Shaped saturation with inherent radiofrequency-power-efficient trajectory design in parallel transmission.

    abstract:PURPOSE:A target-pattern-driven (TD) trajectory design is introduced in combination with parallel transmit (pTX) radiofrequency (RF) pulses to provide localized suppression of unwanted signals. The design incorporates target-pattern and B1+ information to adjust denser sampling and coverage in k-space regions where the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25016

    authors: Schneider R,Haueisen J,Pfeuffer J

    更新日期:2014-10-01 00:00:00

  • Deconvolution-based distortion correction of EPI using analytic single-voxel point-spread functions.

    abstract:PURPOSE:To develop a postprocessing algorithm that corrects geometric distortions due to spatial variations of the static magnetic field amplitude, B0 , and effects from relaxation during signal acquisition in EPI. THEORY AND METHODS:An analytic, complex point-spread function is deduced for k-space trajectories of EPI...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28591

    authors: Patzig F,Mildner T,Schlumm T,Müller R,Möller HE

    更新日期:2020-11-21 00:00:00

  • Inability to directly detect magnetic field changes associated with neuronal activity.

    abstract::The ability to directly detect neuronal magnetic fields by MRI would help investigators achieve the "holy grail" of neuroimaging, namely both high spatial and temporal resolution. Both positive and negative findings have been reported in the literature, with no clear consensus as to the feasibility of direct detection...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21129

    authors: Parkes LM,de Lange FP,Fries P,Toni I,Norris DG

    更新日期:2007-02-01 00:00:00

  • Detection of neural activity in functional MRI using canonical correlation analysis.

    abstract::A novel method for detecting neural activity in functional magnetic resonance imaging (fMRI) data is introduced. It is based on canonical correlation analysis (CCA), which is a multivariate extension of the univariate correlation analysis widely used in fMRI. To detect homogeneous regions of activity, the method combi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200102)45:2<323::aid-mrm1041>3.0

    authors: Friman O,Cedefamn J,Lundberg P,Borga M,Knutsson H

    更新日期:2001-02-01 00:00:00

  • Broadband slab selection with B1+ mitigation at 7T via parallel spectral-spatial excitation.

    abstract::Chemical shift imaging benefits from signal-to-noise ratio (SNR) and chemical shift dispersion increases at stronger main field such as 7 Tesla, but the associated shorter radiofrequency (RF) wavelengths encountered require B1+ mitigation over both the spatial field of view (FOV) and a specified spectral bandwidth. Th...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21834

    authors: Setsompop K,Alagappan V,Gagoski BA,Potthast A,Hebrank F,Fontius U,Schmitt F,Wald LL,Adalsteinsson E

    更新日期:2009-02-01 00:00:00

  • Fast multislice T(1) and t(1sat) imaging using a phase acquisition of composite echoes (PACE) technique.

    abstract::An optimized multislice data acquisition scheme for phase acquisition of composite echoes (PACE) imaging is presented. This new scheme uses a repetition time equal to the mixing time and an appropriate phase cycling scheme, which allows for more efficient exploitation of all composite echoes. These modifications provi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199912)42:6<1089::aid-mrm1

    authors: Ropele S,Stollberger R,Kapeller P,Hartung HP,Fazekas F

    更新日期:1999-12-01 00:00:00

  • Work-related factors associated with occupational exposure to static magnetic stray fields from MRI scanners.

    abstract:PURPOSE:This study aims to identify work-related and personal factors associated with workers' exposure to static magnetic fields (SMF) and motion-induced time-varying magnetic fields (TVMF) from MRI scanners. METHODS:Measurements of personal exposure to SMF and TVMF were performed among MRI staff during 439 work shif...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25720

    authors: Schaap K,Christopher-De Vries Y,Cambron-Goulet É,Kromhout H

    更新日期:2016-05-01 00:00:00

  • Strain-dependent T1 relaxation profiles in articular cartilage by MRI at microscopic resolutions.

    abstract::To investigate the dependency of T(1) relaxation on mechanical strain in articular cartilage, quantitative magnetic resonance T(1) imaging experiments were carried out on cartilage before/after the tissue was immersed in gadolinium contrast agent and when the tissue was being compressed (up to ∼ 48% strains). The spat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22933

    authors: Xia Y,Wang N,Lee J,Badar F

    更新日期:2011-06-01 00:00:00

  • Implementation of vascular-space-occupancy MRI at 7T.

    abstract::Vascular-space-occupancy (VASO) MRI exploits the difference between blood and tissue T1 to null blood signal and measure cerebral blood volume changes using the residual tissue signal. VASO imaging is more difficult at higher field because of sensitivity loss due to the convergence of tissue and blood T1 values and in...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24334

    authors: Hua J,Jones CK,Qin Q,van Zijl PC

    更新日期:2013-04-01 00:00:00

  • Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone.

    abstract::Advances in modern magnetic resonance imaging (MRI) pulse sequences have enabled clinically practical cortical bone imaging. Human cortical bone is known to contain a distribution of T(1) and T(2) components attributed to bound and pore water, although clinical imaging approaches have yet to discriminate bound from po...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24186

    authors: Horch RA,Gochberg DF,Nyman JS,Does MD

    更新日期:2012-12-01 00:00:00

  • Dynamic imaging with multiple resolutions along phase-encode and slice-select dimensions.

    abstract::An implementation is reported of an imaging method to obtain MUltiple Resolutions along Phase-encode and Slice-select dimensions (MURPS), which enables dynamic imaging of focal changes using a graded, multiresolution approach. MURPS allows one to trade spatial resolution in part of the volume for improved temporal res...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1126

    authors: Panych LP,Zhao L,Jolesz FA,Mulkern RV

    更新日期:2001-06-01 00:00:00

  • Orientational dependence of T2 relaxation in articular cartilage: A microscopic MRI (microMRI) study.

    abstract::The experiments reported herein are the first MRI investigations of the orientational dependence of T(2) relaxation in articular cartilage at microscopic resolution over the 360 degrees angular space. For each of six canine cartilage specimens, 48 independent T(2)-weighted proton images were acquired for 12 different ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10216

    authors: Xia Y,Moody JB,Alhadlaq H

    更新日期:2002-09-01 00:00:00

  • Accelerated MR parameter mapping with low-rank and sparsity constraints.

    abstract:PURPOSE:To enable accurate magnetic resonance (MR) parameter mapping with accelerated data acquisition, utilizing recent advances in constrained imaging with sparse sampling. THEORY AND METHODS:A new constrained reconstruction method based on low-rank and sparsity constraints is proposed to accelerate MR parameter map...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25421

    authors: Zhao B,Lu W,Hitchens TK,Lam F,Ho C,Liang ZP

    更新日期:2015-08-01 00:00:00

  • Combined geometric and algebraic solutions for removal of bSSFP banding artifacts with performance comparisons.

    abstract:PURPOSE:Balanced steady state free precession (bSSFP) imaging suffers from off-resonance artifacts such as signal modulation and banding. Solutions for removal of bSSFP off-resonance dependence are described and compared, and an optimal solution is proposed. THEORY AND METHODS:An Algebraic Solution (AS) that complemen...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26150

    authors: Hoff MN,Andre JB,Xiang QS

    更新日期:2017-02-01 00:00:00

  • Use of high temperature superconductor in a receiver coil for magnetic resonance imaging.

    abstract::A planar YBa2Cu3Ox (YBCO) coil has been used as a pick-up coil in a nuclear magnetic resonance imager. It was found that the quality factor (Q) of the YBCO coil was greater than its copper counterpart by approaching 50% even in a field of 0.15 T. The Q of the copper coil at 77 K and in a field of 0.15 T was 1200 while...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910200218

    authors: Hall AS,Alford NM,Button TW,Gilderdale DJ,Gehring KA,Young IR

    更新日期:1991-08-01 00:00:00

  • Iterative Next-Neighbor Regridding (INNG): improved reconstruction from nonuniformly sampled k-space data using rescaled matrices.

    abstract::The reconstruction of MR images from nonrectilinearly sampled data is complicated by the fact that the inverse 2D Fourier transform (FT) cannot be performed directly on the acquired k-space data set. k-Space gridding is commonly used because it is an efficient reconstruction method. However, conventional gridding requ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10692

    authors: Moriguchi H,Duerk JL

    更新日期:2004-02-01 00:00:00

  • Interleaved diffusion-weighted improved by adaptive partial-Fourier and multiband multiplexed sensitivity-encoding reconstruction.

    abstract:PURPOSE:We report a series of techniques to reliably eliminate artifacts in interleaved echo-planar imaging (EPI) based diffusion-weighted imaging (DWI). METHODS:First, we integrate the previously reported multiplexed sensitivity encoding (MUSE) algorithm with a new adaptive Homodyne partial-Fourier reconstruction alg...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25318

    authors: Chang HC,Guhaniyogi S,Chen NK

    更新日期:2015-05-01 00:00:00

  • Carotid-CNS MR flow imaging.

    abstract::The authors present their 1-year experience with the use of 3DFT, time-of-flight MR angiography for the evaluation of vascular diseases of the head and neck. Their experience with over 150 patients indicates that this examination may be performed in conjunction with standard spin-echo imaging with only a minimal incre...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910140215

    authors: Masaryk TJ,Laub GA,Modic MT,Ross JS,Haacke EM

    更新日期:1990-05-01 00:00:00

  • Fast and accurate calculation of myocardial T1 and T2 values using deep learning Bloch equation simulations (DeepBLESS).

    abstract:PURPOSE:To propose and evaluate a deep learning model for rapid and accurate calculation of myocardial T1 /T2 values based on a previously proposed Bloch equation simulation with slice profile correction (BLESSPC) method. METHODS:Deep learning Bloch equation simulations (DeepBLESS) models are proposed for rapid and ac...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28321

    authors: Shao J,Ghodrati V,Nguyen KL,Hu P

    更新日期:2020-11-01 00:00:00

  • A flexible fast spin echo triple-echo Dixon technique.

    abstract:PURPOSE:To develop a flexible fast spin echo (FSE) triple-echo Dixon (FTED) technique. METHODS:An FSE pulse sequence was modified by replacing each readout gradient with three fast-switching bipolar readout gradients with minimal interecho dead time. The corresponding three echoes were used to generate three raw image...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26186

    authors: Son JB,Hwang KP,Madewell JE,Bayram E,Hazle JD,Low RN,Ma J

    更新日期:2017-03-01 00:00:00

  • Whole-heart steady-state free precession coronary artery magnetic resonance angiography.

    abstract::Current implementations of coronary artery magnetic resonance angiography (MRA) suffer from limited coverage of the coronary arterial system. Whole-heart coronary MRA was implemented based on a free-breathing steady-state free-precession (SSFP) technique with magnetization preparation. The technique was compared to a ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10653

    authors: Weber OM,Martin AJ,Higgins CB

    更新日期:2003-12-01 00:00:00

  • Improved estimation of velocity and flow rate using regularized three-point phase-contrast velocimetry.

    abstract::We improved the three-point phase-contrast method by regularization of MR velocity data after acquisition of a low velocity-to-noise ratio (VNR) velocity image and a high VNR aliased velocity image. The phase unwrapping algorithm is based on the assumed correlation of the velocity of adjacent flow voxels on the low VN...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200007)44:1<122::aid-mrm18>3.0.c

    authors: Herment A,Mousseaux E,Jolivet O,DeCesare A,Frouin F,Todd-Pokropek A,Bittoun J

    更新日期:2000-07-01 00:00:00

  • Dynamic changes in water ADC, energy metabolism, extracellular space volume, and tortuosity in neonatal rat brain during global ischemia.

    abstract::To obtain a better understanding of the mechanisms underlying early changes in the brain water apparent diffusion coefficient (ADC) observed in cerebral ischemia, dynamic changes in the ADC of water and in the energy status were measured at postnatal day 8 or 9 in neonatal rat brains after cardiac arrest using 1H MRS/...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360110

    authors: van der Toorn A,Syková E,Dijkhuizen RM,Vorísek I,Vargová L,Skobisová E,van Lookeren Campagne M,Reese T,Nicolay K

    更新日期:1996-07-01 00:00:00

  • Combined dynamic contrast-enhanced liver MRI and MRA using interleaved variable density sampling.

    abstract:PURPOSE:To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent. METHODS:An interleaved variable density (IVD) undersampling pattern was implemented i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25195

    authors: Salmani Rahimi M,Korosec FR,Wang K,Holmes JH,Motosugi U,Bannas P,Reeder SB

    更新日期:2015-03-01 00:00:00