Abstract:
:A new strategy for a quantitative measurement of regional pulmonary ventilation using hyperpolarized helium-3 (3He) MRI has been developed. The method employs the build-up of the signal intensity after a variable number of (3)He breaths. A mathematical model of the signal dynamics is presented, from which the local ventilation, defined as the fraction of gas exchanged per breath within a given volume, is calculated. The model was used to create ventilation maps of coronal slices of guinea pig lungs. Ventilation values very close to 1 were found in the trachea and the major airways. In the lung parenchyma, regions adjacent to the hilum showed values of 0.6-0.8, whereas 0.2-0.4 was measured in peripheral regions. Monte Carlo simulations were used to investigate the accuracy of the method and its limitations. The simulations revealed that, at presently attainable signal-to-noise ratios, the ventilation parameter can be determined with a relative uncertainty of <5% over a wide range of values.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Deninger AJ,Månsson S,Petersson JS,Pettersson G,Magnusson P,Svensson J,Fridlund B,Hansson G,Erjefeldt I,Wollmer P,Golman Kdoi
10.1002/mrm.10206subject
Has Abstractpub_date
2002-08-01 00:00:00pages
223-32issue
2eissn
0740-3194issn
1522-2594journal_volume
48pub_type
杂志文章abstract:PURPOSE:The oxygen extraction fraction (OEF) is an important biomarker for tissue-viability. MRI enables noninvasive estimation of the OEF based on the blood-oxygenation-level-dependent (BOLD) effect. Quantitative OEF-mapping is commonly applied using least-squares regression (LSR) to an analytical tissue model. Howeve...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26749
更新日期:2018-02-01 00:00:00
abstract::The magnetization subtraction technique (MS), which is equivalent to the inversion recovery technique in strong magnetic fields, has been implemented in dynamic nuclear polarization-enhanced magnetic resonance imaging (DNPI). The general theoretical basis of the MS method, which can be applied to DNPI or to prepolariz...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350316
更新日期:1996-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2004-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2017-03-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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abstract::A modified high-speed stimulated-echo acquisition mode (STEAM) diffusion sequence (90 degrees-TE/2-90 degrees-TM-[alpha-TE/2-STE]n) incorporating bipolar diffusion gradients that are less sensitive to macroscopic motion-induced artifacts is presented. Diffusion encoding was performed only during the first echo interva...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910350620
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910400621
更新日期:1998-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2016-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2016-07-01 00:00:00
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更新日期:2008-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2013-06-01 00:00:00
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更新日期:2019-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2016-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2003-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199904)41:4<824::aid-mrm23
更新日期:1999-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25531
更新日期:2015-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910320206
更新日期:1994-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910380307
更新日期:1997-09-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:1985-08-01 00:00:00
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更新日期:2020-04-01 00:00:00
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更新日期:2010-01-01 00:00:00
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更新日期:2003-08-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1987-04-01 00:00:00
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更新日期:2018-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1992-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2005-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:1988-05-01 00:00:00
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更新日期:2008-05-01 00:00:00
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更新日期:1991-04-01 00:00:00