Quantitative measurement of regional lung ventilation using 3He MRI.

Abstract:

:A new strategy for a quantitative measurement of regional pulmonary ventilation using hyperpolarized helium-3 (3He) MRI has been developed. The method employs the build-up of the signal intensity after a variable number of (3)He breaths. A mathematical model of the signal dynamics is presented, from which the local ventilation, defined as the fraction of gas exchanged per breath within a given volume, is calculated. The model was used to create ventilation maps of coronal slices of guinea pig lungs. Ventilation values very close to 1 were found in the trachea and the major airways. In the lung parenchyma, regions adjacent to the hilum showed values of 0.6-0.8, whereas 0.2-0.4 was measured in peripheral regions. Monte Carlo simulations were used to investigate the accuracy of the method and its limitations. The simulations revealed that, at presently attainable signal-to-noise ratios, the ventilation parameter can be determined with a relative uncertainty of <5% over a wide range of values.

journal_name

Magn Reson Med

authors

Deninger AJ,Månsson S,Petersson JS,Pettersson G,Magnusson P,Svensson J,Fridlund B,Hansson G,Erjefeldt I,Wollmer P,Golman K

doi

10.1002/mrm.10206

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

223-32

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

48

pub_type

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