Abstract:
:High polarization of nuclear spins in liquid state through hyperpolarized technology utilizing dynamic nuclear polarization has enabled the direct monitoring of (13)C metabolites in vivo at a high signal-to-noise ratio. Acquisition time limitations due to T(1) decay of the hyperpolarized signal require accelerated imaging methods, such as compressed sensing, for optimal speed and spatial coverage. In this paper, the design and testing of a new echo-planar (13)C three-dimensional magnetic resonance spectroscopic imaging (MRSI) compressed sensing sequence is presented. The sequence provides up to a factor of 7.53 in acceleration with minimal reconstruction artifacts. The key to the design is employing x and y gradient blips during a fly-back readout to pseudorandomly undersample k(f)-k(x)-k(y) space. The design was validated in simulations and phantom experiments where the limits of undersampling and the effects of noise on the compressed sensing nonlinear reconstruction were tested. Finally, this new pulse sequence was applied in vivo in preclinical studies involving transgenic prostate cancer and transgenic liver cancer murine models to obtain much higher spatial and temporal resolution than possible with conventional echo-planar spectroscopic imaging methods.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Hu S,Lustig M,Balakrishnan A,Larson PE,Bok R,Kurhanewicz J,Nelson SJ,Goga A,Pauly JM,Vigneron DBdoi
10.1002/mrm.22233subject
Has Abstractpub_date
2010-02-01 00:00:00pages
312-21issue
2eissn
0740-3194issn
1522-2594journal_volume
63pub_type
杂志文章abstract::For time-resolved background-subtracted contrast-enhanced magnetic resonance angiography, the bright and sparse arterial signal allows unique identification of contrast bolus arrival in the arteries. This article presents an automatic filtering algorithm using such arterial characterization for selecting arterial phas...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10358
更新日期:2002-12-01 00:00:00
abstract::MnCl(2) was injected intrathecally through the cisterna magna in rats, allowing infusion of divalent manganese ions (Mn(++)) into the CSF space and thence into the brain, without breaking the blood-brain barrier (BBB). Mn(++) uptake and washout dynamics in the brain were measured by serial T(1)-weighted MRI and EPI T(...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20047
更新日期:2004-05-01 00:00:00
abstract::Genetically engineered mouse models provide enormous potential for investigation of the underlying mechanisms of atherosclerotic disease, but noninvasive imaging methods for analysis of atherosclerosis in mice are currently limited. This study aimed to demonstrate the feasibility of MRI to noninvasively visualize athe...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10500
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:To develop a three-dimensional, free-breathing, late gadolinium enhancement (3D FB-LGE) cardiovascular magnetic resonance (CMR) technique, and to compare it with clinically used two-dimensional breath-hold LGE (2D BH-LGE). METHODS:The proposed 3D FB-LGE method consisted of inversion preparation, inversion dela...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26234
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To optimize 3D radial ultrashort echo time MRI for high resolution whole-lung imaging. METHODS:3D radial ultrashort echo time was implemented on a 3T scanner to investigate the effects of: (1) limited field-of-view excitation, (2) variable density readouts, and (3) radial oversampling. Improvements in noise pe...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24570
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:MR elastography (MRE) of the brain is being explored as a biomarker of neurodegenerative disease such as dementia. However, MRE measures for healthy brain have varied widely. Differing wave delivery methodologies may have influenced this, hence finite element-based simulations were performed to explore this pos...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26333
更新日期:2017-07-01 00:00:00
abstract::Fucose is believed to be a marker for cancer that may be detectable by the 2D proton NMR (COSY) of human plasma. However, the COSY technique is time consuming and prone to error. These problems may be alleviated by using the SUPERCOSY pulse sequence; this technique shows that there are many other cross peaks in the re...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910150102
更新日期:1990-07-01 00:00:00
abstract::Direct measurement of neural currents by means of MRI can potentially open a high temporal resolution (10-100 ms) window applicable for monitoring dynamics of neuronal activity without loss of the high spatial resolution afforded by MRI. Previously, we have shown that the alternating balanced steady state imaging affo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.23105
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:The purpose of this study is to increase the robustness of MR fingerprinting (MRF) toward subject motion. METHODS:A novel reconstruction algorithm, MOtion insensitive MRF (MORF), was developed, which uses an iterative reconstruction based retrospective motion correction approach. Each iteration loops through t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27227
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:As the premiere modality for brain imaging, MRI could find wider applicability if lightweight, portable systems were available for siting in unconventional locations such as intensive care units, physician offices, surgical suites, ambulances, emergency rooms, sports facilities, or rural healthcare sites. METH...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25147
更新日期:2015-02-01 00:00:00
abstract::A robust postprocessing method to detect regions of magnetic field change is presented. High resolution gradient echo data is acquired to create a complex baseline image. From this image, two low resolution images are obtained by applying a low pass filter on the magnitude image and the complex image, respectively. Su...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910360518
更新日期:1996-11-01 00:00:00
abstract:PURPOSE:To demonstrate the feasibility of a novel, ellipse fitting approach, named PLANET, for simultaneous estimation of relaxation times T1 and T2 from a single 3D phase-cycled balanced steady-state free precession (bSSFP) sequence. METHODS:A method is presented in which the elliptical signal model is used to descri...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26717
更新日期:2018-02-01 00:00:00
abstract::Stejskal and Tanner's ingenious pulsed field gradient design from 1965 has made diffusion NMR and MRI the mainstay of most studies seeking to resolve microstructural information in porous systems in general and biological systems in particular. Methods extending beyond Stejskal and Tanner's design, such as double diff...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章,评审
doi:10.1002/mrm.25901
更新日期:2016-01-01 00:00:00
abstract::Proton T(1rho)-dispersion MRI is demonstrated for indirect, in vivo detection of (17)O in the brain. This technique, which may be readily implemented on any clinical MRI scanner, is applied towards high-resolution, quantitative mapping of cerebral blood flow (CBF) in the rat by monitoring the clearance of (17)O-enrich...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10403
更新日期:2003-03-01 00:00:00
abstract::We have demonstrated that echo-planar imaging can be used to produce high-quality snapshot images of the human fetus in utero in a fraction of a second. These images are free of motional artifact or blurring and allow detailed depiction of fetal structures in normal and pathological pregnancies. ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910130214
更新日期:1990-02-01 00:00:00
abstract::Imaging of stable paramagnetic spin probes in phantom objects and in vivo was evaluated using a RF time domain EPR spectrometer/imager operating at 300 MHz. Projections were collected using static magnetic field gradients and images were reconstructed using filtered back-projection techniques. Results from phantom obj...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(200003)43:3<375::aid-mrm9>
更新日期:2000-03-01 00:00:00
abstract::An implementation is reported of an imaging method to obtain MUltiple Resolutions along Phase-encode and Slice-select dimensions (MURPS), which enables dynamic imaging of focal changes using a graded, multiresolution approach. MURPS allows one to trade spatial resolution in part of the volume for improved temporal res...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1126
更新日期:2001-06-01 00:00:00
abstract::Generalized MR interferography allows the measurement of parameters which affect the phase of the MR signal. Interference is generated by the simultaneous generation of two echoes in one excitation cycle. Local variations of the signal phase are transformed into displacement of the stripe pattern generated by interfer...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910160305
更新日期:1990-12-01 00:00:00
abstract::A novel tagging method is introduced that increases the spatial resolution of estimates of myocardial radial thickening. The separation of adjacent parallel tag planes is customized to match the expected motion of specific regions of the heart wall. In regions in which the tags increase their separation over systole (...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390421
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:To develop a deep learning-based Bayesian estimation for MRI reconstruction. METHODS:We modeled the MRI reconstruction problem with Bayes's theorem, following the recently proposed PixelCNN++ method. The image reconstruction from incomplete k-space measurement was obtained by maximizing the posterior possibili...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28274
更新日期:2020-10-01 00:00:00
abstract::The water proton resonance frequency (PRF) is temperature dependent and can thus be used for magnetic resonance (MR) thermometry. Since lipid proton resonance frequencies do not depend on temperature, fat suppression is essential for PRF-based temperature mapping. The efficacy of echo-shifted (TE > TR) gradient-echo i...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199907)42:1<53::aid-mrm9>3
更新日期:1999-07-01 00:00:00
abstract::This study investigates the potential of in vivo 31P magnetic resonance spectroscopy (MRS) to characterize musculoskeletal tumors and to determine preoperative levels of histological necrosis, which is an important clinical indicator of patient response. Pretherapy MRS was performed on 28 patients with large musculosk...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910270204
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:Human connectomics necessitates high-throughput, whole-brain reconstruction of multiple white matter fiber bundles. Scaling up tractography to meet these high-throughput demands yields new fiber tracking challenges, such as minimizing spurious connections and controlling for gyral biases. The aim of this study ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27471
更新日期:2019-02-01 00:00:00
abstract::The preovulatory rat follicle reaches a diameter of 1 mm with no internal blood vessels. Nutrient supply to the enclosed oocyte depends solely on passive diffusion across the follicular wall and the follicular fluid. Spin-echo and stimulated-echo NMR microscopy experiments were applied here for studying modulations in...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910340212
更新日期:1995-08-01 00:00:00
abstract:PURPOSE:To design, construct, and evaluate quantitative MR phantoms that mimic MRI signals from the liver with simultaneous control of three parameters: proton-density fat fraction (PDFF), R 2 ∗ ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28452
更新日期:2021-02-01 00:00:00
abstract::Deuterium (2H) double-quantum filtered (DQF) NMR spectroscopy of nucleus pulposus (NP) tissues from human intervertebral discs is reported. The DQF spectral intensities, DQ build-up rates, and DQF-detected rotating-frame spin-lattice relaxation times are sensitive to the degree of hydration of the NP tissue, and displ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21231
更新日期:2007-06-01 00:00:00
abstract::In this study undersampled projection reconstruction (PR) was used for rapid catheter imaging in the heart, employing steady-state free precession (SSFP) contrast. Active catheters and phased-array coils were used for combined imaging of anatomy and catheter position in swine. Real-time imaging of catheter position wa...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10390
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:To develop an MRI acquisition and reconstruction framework for volumetric cine visualization of the fetal heart and great vessels in the presence of maternal and fetal motion. METHODS:Four-dimensional (4D) depiction was achieved using a highly-accelerated multi-planar real-time balanced steady-state free prece...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27798
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:To examine the detection sensitivity for the rapidly exchanging hydroxyl protons of D-glucose using the recently developed on-resonance variable delay multi-pulse (onVDMP) chemical exchange saturation transfer (CEST) technique. METHODS:The onVDMP method was applied for the detection of water signal changes upo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27364
更新日期:2019-01-01 00:00:00
abstract::In the recently proposed technique Sweep Imaging with Fourier Transform (SWIFT), frequency-modulated radiofrequency pulses are used in concert with simultaneous acquisition to facilitate MRI of samples with very short transverse relaxation time. In the present work, sweep MRI is reviewed from a reconstruction perspect...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22516
更新日期:2010-12-01 00:00:00