Abstract：
:In acute coronary syndromes such as unstable angina and myocardial infarction, serum concentration of brain natriuretic peptide, a cardiac hormone with potent vasodilatatory, natriuretic and diuretic activities, is elevated. Little is known about the effect of elevated BNP plasma concentration on free radical-mediated tissue damage in these states. We investigated the influence of human BNP 32 and its fragment BNP 7-32 on the production of superoxide anion by PMN, a major cause for myocardial damage. Although BNP showed itself no stimulatory potential on superoxide anion release in PMN, it enhanced significantly the stimulatory potential of cell stimuli such as fMLP or phorbol 12-myristate 13-acetate (PMA) in PMN. Thus our data show that the cardiac-derived hormone BNP influences an important function of PMN. This 'priming' effect of BNP on PMN may contribute to the tissue damage occuring during acute coronary syndromes.
journal_name
Life Scijournal_title
Life sciencesauthors
Garlichs CD,Zhang H,Schmeisser A,Daniel WGdoi
10.1016/s0024-3205(99)00333-1subject
Has Abstractpub_date
1999-01-01 00:00:00pages
1027-33issue
10eissn
0024-3205issn
1879-0631pii
S0024320599003331journal_volume
65pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The involvement of atriopeptin in hypertension was investigated in spontaneously hypertensive rats (SHR). It was found that intravenous injection of atriopeptin III (20-80 nmol/kg) markedly decreased the mean arterial pressure in anesthetized SHR in a dose dependent manner. The heart rate was not significantly affecte...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90238-9
更新日期：1986-03-17 00:00:00
abstract：:DL-alpha-difluoromethylornithine (DFMO), 4-deoxypyridoxine (4-DOP), and methylglyoxal bis (guanylhydrazone) (MGBG) were tested as inhibitors of acute skin graft rejection. Proximal full thickness tail skins were exchanged between C57BL/6 and Balb/C mice. Distal autografts were placed to monitor healing. Inhibitors wer...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90349-g
更新日期：1991-01-01 00:00:00
abstract：:11Beta-hydroxyglucocorticoids (HGCs) are known to induce apoptosis in immature T cells. Here we show that 11-oxoglucocorticoids (OGCs), which are oxidized metabolites of HGCs, counteract the apoptosis-inducing effects of HGC in murine thymocytes in vitro. Corticosterone at concentrations ranging from 0.1-100 microM in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01069-4
更新日期：2001-05-18 00:00:00
abstract：:It is well established that reperfusion of heart is the optimal method for salvaging ischemic myocardium, however, the success of this therapy could be limited by reperfusion injury, which is involved in inflammatory responses. High density lipoprotein (HDL) has an anti-inflammatory function and can protect the heart ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.06.021
更新日期：2007-08-09 00:00:00
abstract：:Two types of plasma membranes isolated from rat brain cortex were used to study the membrane-perturbing properties of ethanol. Rats administered ethanol in the form of a liquid diet showed an increase in levels of phosphatidylserines, phosphatidylinositols and phosphatidic acids as compared to controls. The results pr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90512-5
更新日期：1984-11-19 00:00:00
abstract：:The objective of this study was to determine the primary event that occurs in Ca2+-regulatory sarcoplasmic-reticular (SR) proteins during subacute transition from concentric/mechanically-compensated left ventricular (LV) hypertrophy to eccentric/decompensated hypertrophy. Using Dahl salt-sensitive rats with hypertensi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01383-2
更新日期：2001-11-30 00:00:00
abstract：AIMS:To characterize the effects of a calorie matched high-fat diet (HFD) on spontaneous physical activity (SPA), body weight, inflammatory status and expression of genes related to energy homeostasis in hypothalamus of mice. MAIN METHODS:C57Bl/6 mice (n=5 per group) were fed a control diet (16.5% calories from fat) -...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.04.017
更新日期：2017-06-15 00:00:00
abstract：BACKGROUND:Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide. For advanced-stage patients, chemotherapeutic drugs are the best treatment option; however, their adverse effects and high cost are still major obstacles for effecti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118827
更新日期：2021-01-15 00:00:00
abstract：:Immunoreactive (ir) beta-endorphin (b-END) and dynorphin (DYN) in rat brain and pituitary were measured after food and water deprivation and from brains taken during either day or night. In other rats, eating and drinking were measured following lesions in the arcuate n. Ir-DYN levels are higher in hypothalamus and lo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90221-1
更新日期：1982-10-18 00:00:00
abstract：:The present study analyses the expression and distribution of neuronal nitric oxide synthase (nNOS) in the brainstem of animals pre-treated with Escherichia coli or Helicobacter pylori LPS, at doses that modulate gastric motor function. Systemic administration of H. pylori LPS prevented in a dose-dependent manner (5, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.03.007
更新日期：2005-07-15 00:00:00
abstract：AIMS:Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period. MAIN METHODS:A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.033
更新日期：2018-09-15 00:00:00
abstract：:The purpose of this study was to investigate the involvement of calcium in K+ currents and its effects on amino acid accumulation and on the membrane potential regulated by tri-iodo-L-thyronine (T3) in Sertoli cells. Immature rat testes were pre-incubated for 30 min in Krebs-Ringer bicarbonate buffer and incubated for...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.08.005
更新日期：2004-01-23 00:00:00
abstract：:There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00097-1
更新日期：1999-01-01 00:00:00
abstract：:Previous experiments have shown that epinephrine-induced renin secretion in vivo apparently is initiated by activation of extrarenal adrenoceptors. However the location of these receptors has not been determined despite considerable search. The present experiments were designed to evaluate the hypothesis that epinephr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90747-8
更新日期：1987-10-19 00:00:00
abstract：:Since Oct-1 is a ubiquitous DNA binding protein shown to play an important role in regulating cell proliferation and possess structural characteristics consistent with a nitric oxide (NO) target, we studied NO regulation of the DNA binding activity of Oct-1 in the A7R5 vascular smooth muscle cell (VSMC) line. Two NO d...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01172-7
更新日期：1998-01-01 00:00:00
abstract：AIMS:This study evaluated the role of cyclophilin A (CyPA) in early phase of atherosclerosis and also examined the atheroprotective effects of melatonin due to its antioxidant properties. MAIN METHODS:APOE null mice at 6 and 15weeks of age were treated with melatonin at a dose of 0.1mg/kg/day or 10mg/kg/day. We evalua...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.11.011
更新日期：2013-05-20 00:00:00
abstract：:Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00053-9
更新日期：1995-02-17 00:00:00
abstract：:To characterize the mechanism of the analgesic action of H1 antihistaminics the effects of a new, highly selective agonist, 2-(3-trifluoromethylphenyl)histamine dihydrogenmaleate (FMPH), and of the better known H1 agonist, 2-thiazolylethylamine (2-TEA), were studied on pain threshold by means of three different kinds ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00295-1
更新日期：1998-01-01 00:00:00
abstract：:Alpha adrenergic receptors are identified on basolateral plasma membranes derived from proximal tubular epithelial cells. The density of alpha 2 receptors was over two-fold greater than alpha 1 receptors. The basolateral membranes were devoid of beta receptors. These results support previous demonstrations of alpha ad...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90259-7
更新日期：1988-01-01 00:00:00
abstract：:Aim Furowanin A (Fur A) is a flavonoid isolated from Millettia pachycarpa Benth. Studies show its potent anti-neoplastic effects against leukemia cells. The aim of the present study was to determine the potential therapeutic effect of Fur A against colorectal cancer (CRC), and elucidate the underlying mechanism. MATE...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.12.027
更新日期：2019-02-01 00:00:00
abstract：:This study was designed to evaluate the effects of roxithromycin (RXM), a newly synthesized macrolide antibiotic on allergic responses in mice. RXM was orally administered into BALB/c mice once a day for 42 days in a single dose of 5 mg/kg body weight. Spleen cells (Sp C) collected from mice on day 7, 14, 28 and 42 po...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90154-u
更新日期：1993-01-01 00:00:00
abstract：:[3H]ET (etorphine), which is considered either as an "universal" ligand or a mu agonist, interacts with identical affinities KD = 0.33-0.38 nM to hybrid cells and rabbit cerebellum, pure delta and mu-enriched opioid receptor preparations, respectively. In rat brain tissue, [3H]ET binding is inhibited by DAGO (Tyr-D-Al...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90452-8
更新日期：1987-08-10 00:00:00
abstract：:Leukocyte interactions with endothelial cell monolayers (ECM) and smooth muscle cells (SMC) play an important role during inflammatory processes. Several studies describe an inhibitory effect of dexamethasone on polymorphonuclear leukocytes (PMNL), endothelial cell function, and interleukin-1 (IL-1) release. Aim of th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00609-2
更新日期：1999-01-01 00:00:00
abstract：:To investigate the difference of metabolic pharmacokinetics between pure glycyrrhizin (GZ) and GZ in licorice decoction, six New Zealand White rabbits were orally given pure GZ and licorice decoction containing equivalent content of GZ in a randomized crossover design. HPLC methods were used for the quantitation of GZ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.020
更新日期：2005-01-21 00:00:00
abstract：:We investigated the mechanism by which glucose refeeding can reverse the enhancement of glycolysis caused by glucose starvation. Human fibroblasts were deprived of glucose for 18 hr and then refed for 1 hr with either (a) medium from sister glucose-starved cultures (controls), (b) fresh, glucose-containing medium (fre...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90057-x
更新日期：1989-01-01 00:00:00
abstract：:Accumulation of excess fluoride in the environment poses serious health risks to plants, animals, and humans. This endangers human health, affects organism growth and development, and negatively impacts the food chain, thereby affecting ecological balance. In recent years, numerous studies focused on the molecular mec...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.02.001
更新日期：2018-04-01 00:00:00
abstract：:Concanavalin A enhanced the rat rectal absorption of phenol red and cefoxitin at pH 7.4 and the uptake of cefoxitin into brush border membrane vesicles prepared from rat rectal membrane. The enhancing action of concanavalin A demonstrated a sodium ion dependency and was inhibited by the presence of 4,4'-diisothiocyano...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90496-x
更新日期：1984-01-30 00:00:00
abstract：:The binding of the D2-like agonists, (+)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin (7-OH-DPAT) and [3H]pramipexole (2-amino-4,5,6-tetrahydro-6-propylaminobenzthiazole; MIRAPEX) were determined in membranes from adult male Sprague-Dawley and Fischer-344 rats. Saturation analysis, which optimized binding to D3 recep...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00446-9
更新日期：1998-01-01 00:00:00
abstract：:An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90175-0
更新日期：1988-01-01 00:00:00
abstract：:In saturation binding experiments, (+)pentazocine, (+)3-(3-hydroxyphenyl)-N-propylpiperidine (3-PPP), haloperidol and rimcazole did not inhibit the binding of [3H]DTG in a purely competitive fashion. Although Scatchard analysis indicated that [3H]DTG bound to a single site, the inhibition curves of some, but not all, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90255-n
更新日期：1992-01-01 00:00:00
