Prognostic relevance of p53 in node negative breast cancer.

abstract：METHODS:Induction chemotherapy, consisting of 3 courses of cisplatin (30 mg/m2/i.v. 1st and 2nd day), epirubicin (30 mg/m2/i.v. 1st and 2nd day), etoposide (75 mg/m2/i.v. 1st and 2nd day) and bleomycin (15 mg/i.v. 1st and 2nd day), prior to radical hysterectomy and lymph nodes resection, was used in the primary treatme...

journal_title：Anticancer research

authors： Panetta A,Angelelli B,Martoni A

更新日期：1999-01-01 00:00:00

abstract：:Therapy of patients with metastatic renal cell carcinoma (mRCC) requires sequential use of several agents with different mechanisms and minimal cross-resistance between the different agents. Tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors prolong progression-free survival (PFS) in...

journal_title：Anticancer research

authors： Paule B,Brion N

更新日期：2011-10-01 00:00:00

abstract：:Multiple myeloma (MM) is a clonal plasma cell malignancy, which is currently incurable. Therefore, new mono- or combined therapy treatment regimens in the early and advanced phases of MM are urgently needed to combat this disease. Recently, p38 mitogen-activated protein kinase (MAPK) has been implicated as playing an ...

journal_title：Anticancer research

authors： Medicherla S,Reddy M,Ying J,Navas TA,Li L,Nguyen AN,Kerr I,Hanjarappa N,Protter AA,Higgins LS

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:To understand the molecular response of tumor cells to therapeutic ionizing radiation (IR), we previously reported that human breast cancer cells derived following chronic exposure to fractionated ionizing radiation (MCF+FIR) showed a transient radioresistance. MCF+FIR cells also demonstrated increased activ...

journal_title：Anticancer research

authors： Ozeki M,Tamae D,Hou DX,Wang T,Lebon T,Spitz DR,Li JJ

更新日期：2004-09-01 00:00:00

abstract：:The anti-tumor properties of arsenic trioxide have attracted extensive attention after successfully inducing apoptosis of acute promyelocytic leukemia cells. However, the therapeutic spectrum should not only be restricted to acute promyelocytic leukemia, but should also extend into other types of tumor cells. In this ...

journal_title：Anticancer research

authors： Tsai CW,Chang NW,Tsai RY,Wang RF,Hsu CM,Lin SS,Wu CN,Sun SS,Tsai MH,Bau DT

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The knowledge of direct effects of β-glucans on tumor cells is limited. This study evaluated the impact of a soluble yeast-derived beta-(1-3),(1-6)-d-glucan, containing a fraction of aggregated sugar polymers, on viability, proliferation and expression of CD86 of the human B-cell lymphoma cell lines Daudi an...

journal_title：Anticancer research

authors： Harnack U,Kellermann U,Pecher G

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND/AIM:There is no clear evidence in the literature regarding the regulation of programmed cell death-ligand 1 (PD-L1) expression by cyclo-oxygenase-2 (COX2). In this study, whether PD-L1 expression was regulated by COX2 activity was examined in vitro. MATERIALS AND METHODS:Resected lung cancer specimens were ...

journal_title：Anticancer research

authors： Shimizu K,Okita R,Saisho S,Maeda AI,Nojima Y,Nakata M

更新日期：2018-08-01 00:00:00

abstract：:Upper gastrointestinal malignancies are associated with a high disease burden worldwide, and esophageal and gastric cancers represent the most common entities. Given a lack of early characteristic symptoms and potent screening instruments, the majority of patients present with advanced disease at the time of diagnosis...

journal_title：Anticancer research

authors： Bolm L,Käsmann L,Paysen A,Karapetis C,Rades D,Wellner UF,Keck T,Watson DI,Hummel R,Hussey DJ

更新日期：2018-06-01 00:00:00

abstract：:The adenomatous polyposis coli (APC) gene was investigated in Swedish patients with familial adenomatous polyposis (FAP). A combination of analyses including single stranded conformation polymorphism (SSCP), heteroduplex (HD), protein truncation test (PTT) and direct sequencing was used to enable optimal mutation dete...

journal_title：Anticancer research

authors： Nordling M,Engwall Y,Wahlström J,Wiklund L,Eriksson MA,Gustavsson B,Fasth S,Larsson PA,Martinsson T

更新日期：1997-11-01 00:00:00

abstract：AIM:To report our experience on implementation and preliminary results of a decision-making model based on the recommendations of an Interdisciplinary Oncological Care Group developed for the management of colorectal cancer. PATIENTS AND METHODS:The multidisciplinary team identified a reference guideline using apprais...

journal_title：Anticancer research

authors： Genovesi D,Mazzilli L,Trignani M,DI Tommaso M,Nuzzo A,Biondi E,Tinari N,Martino MT,Innocenti P,DI Sebastiano P,Mazzola L,Lanci C,Neri M,Laterza F,Marino M,Ferrini G,Spadaccini A,Filippone A,DI Giandomenico E,Marulli

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND/AIM:The identification of a series of oxadiazole-based compounds, as promising antiproliferative agents, has been previously reported. The aim of this study was to explore the SAR of newly-synthesized oxadiazole derivatives and identify their molecular targets. MATERIALS AND METHODS:A small library of 1,2,5...

journal_title：Anticancer research

authors： Gelain A,Mori M,Meneghetti F,Porta F,Basile L,Marverti G,Asai A,Hyeraci M,García-Argáez AN,Via LD,Guccione S,Villa S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:Cancer incidence and mortalities are growing worldwide, therefore research and development of more effective and less invasive treatments, such as photodynamic therapy, are needed. Herein, we investigated the methylene blue (MB) photoactivation effects in lung epithelial cells (BEAS-2B) and lung adenocar...

journal_title：Anticancer research

authors： Rodríguez-Córdova RJ,Gutiérrez-Valenzuela CA,Bojang P,Esquivel R,Hernández P,Ramos KS,Guzmán-Zamudio R,Lucero-Acuña A

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Satraplatin (JM216; bis-acetatoammine-dichlorocyclohexylamine platinum (IV)) is a platinum (Pt) complex developed in an attempt to circumvent tumour resistance and which can be administered by the oral route. The fate of platinum delivered by this oral formulation administered at various doses under the 5 or...

journal_title：Anticancer research

authors： Vouillamoz-Lorenz S,Buclin T,Lejeune F,Bauer J,Leyvraz S,Decosterd LA

更新日期：2003-05-01 00:00:00

abstract：:Thirty-two patients (30 men, 2 women), median age 68 years (range 47-85) with histologically confirmed advanced bladder carcinoma (Stages T3 and T4 according to the International Union Against Cancer staging system), who were poor surgical candidates, were prospectively treated with 1-6 (median 4) cycles of intra-arte...

journal_title：Anticancer research

authors： Mantadakis E,Panagiotidis C,Delakas D,Samonis G

更新日期：2003-11-01 00:00:00

abstract：AIM:To retrospectively compare the efficacy of two irinotecan-based chemotherapy regimens combined with bevacizumab in first-line therapy of metastatic colorectal cancer (mCRC). PATIENTS AND METHODS:The data of 558 patients with mCRC treated with first-line bevacizumab plus irinotecan-containing regimen were obtained ...

journal_title：Anticancer research

authors： Kocakova I,Melichar B,Kocak I,Bortlicek Z,Büchler T,Dusek L,Petruzelka L,Kohoutek M,Prausová J,Finek J,Mohelnikova-Duchonova B,Vyzula R

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Pemetrexed and erlotinib represent different agents commonly used for the second-line treatment of patients with advanced-stage non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We analyzed data of 137 patients with advanced-stage non-squamous NSCLC treated with pemetrexed or erlotinib in the second ...

journal_title：Anticancer research

authors： Fiala O,Pesek M,Finek J,Svaton M,Minarik M,Benesova L,Bortlicek Z,Kucera R,Topolcan O

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Chagas disease patients with longstanding megaesophagus have a significantly increased risk for esophageal carcinoma. MATERIALS AND METHODS:PCR-SSCP analysis and DNA sequencing of esophageal mucosa from Chagas disease patients (with or without megaesophagus) in the exons of the TP53, CDKN2A and FHIT genes w...

journal_title：Anticancer research

authors： DA Silva Manoel-Caetano F,Silveira AF,Silva AE

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Molecular mechanisms responsible for carcinogenesis in upper urinary tract urothelial carcinoma (UUTUC) are not yet clear. This study aimed to examine and correlate the subcellular localization of activin A, maspin, and the androgen receptor (AR) with demographic characteristics, pathological grade, and stag...

journal_title：Anticancer research

authors： Rau KM,Chen YJ,Sun MT,Kang HY

更新日期：2011-05-01 00:00:00

abstract：:Malignant gliomas are often treated with cisplatin (cis-diamminedichloroplatinum(II), CDDP) and radiation but results remain unsatisfactory. To investigate whether CDDP induces radioresistance in glioma, T98G human glioblastoma cells were pretreated 5 times with 10(-6)M CDDP for 24 hours and then the sensitivity of wi...

journal_title：Anticancer research

authors： Poppenborg H,Münstermann G,Knüpfer MM,Hotfilder M,Hacker-Klom U,Wolff JE

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND/AIM:Glioblastoma multiforme (GBM) is a malignant primary brain tumor with high rates of recurrence. This study aimed to investigate the effect of repurposed drug combinations on GBM. MATERIALS AND METHODS:Viability of U87 MG and 11ST patient-derived GMB cell lines, after valproic acid, tranylcypromine or ri...

journal_title：Anticancer research

authors： Sachkova A,Sperling S,Mielke D,Schatlo B,Rohde V,Ninkovic M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:Previous studies have shown discrepancies between patient's desired and actual death place. As planning of family support and involvement of palliative home care teams seem to improve the chance to meet patients preferences, geographical availability of specialized palliative home care could influence pl...

journal_title：Anticancer research

authors： Nilsson J,Axelsson B,Holgersson G,Carlsson T,Bergqvist M,Bergstrom S

更新日期：2020-07-01 00:00:00

abstract：:The number of silver stained nucleolar organiser regions (AgNORs) was assessed in biopsy specimens of 78 patients with prostatic adenocarcinoma followed up for a mean of 15.6 years. The number of Ag-NORs was related to histological features, clinical stage, DNA ploidy, S-phase fraction (SPF) and clinical outcome. In 3...

journal_title：Anticancer research

authors： Eskelinen M,Lipponen P,Syrjänen K

更新日期：1992-09-01 00:00:00

abstract：:In the study of 65 matched pairs of lung tumor tissue and normal lung parenchyma, cathepsin B (CB) activity was found to be increased about 4.6-fold, when regarding median levels. CB activity was found to be insignificantly higher in adenocarcinoma compared to the other histologic cell types. CB levels did not correla...

journal_title：Anticancer research

authors： Ebert W,Knoch H,Werle B,Trefz G,Muley T,Spiess E

更新日期：1994-05-01 00:00:00

abstract：:Glioblastoma multiforme (GBM), a grade IV glioma, appears to harbor therapy-resistant cancer stem cells (CSCs) that are the major cause of recurrence. All-trans retinoic acid (ATRA), a derivative of retinoid, is capable of differentiating a variety of stem cells, as well as normal neural progenitor cells, and down-reg...

journal_title：Anticancer research

authors： Karsy M,Albert L,Tobias ME,Murali R,Jhanwar-Uniyal M

更新日期：2010-12-01 00:00:00

abstract：:We examined the antitumor effect of lipopolysaccharide extracted from Pantoea agglomerans, a Gram-negative bacterium, using intradermal administration on murine syngeneic tumors, Meth A fibrosarcoma, MH134 hepatoma and Lewis lung (LL) carcinoma. The latter two tumors are known to be relatively low in immunogenicity, h...

journal_title：Anticancer research

authors： Inagawa H,Nishizawa T,Noguchi K,Minamimura M,Takagi K,Goto S,Soma G,Mizuno D

更新日期：1997-05-01 00:00:00

abstract：:In pancreatic neoplasias mutations in the first exon (codon 12) of K-ras gene occur at high frequency and seem to have a diagnostic significance. We set up the DGGE conditions to search for these mutations in pancreatic tumor sample DNAs. All samples were directly classified by simply comparing their DGGE patterns wit...

journal_title：Anticancer research

authors： Pellegata NS,Losekoot M,Fodde R,Pugliese V,Saccomanno S,Renault B,Bernini LF,Ranzani GN

更新日期：1992-09-01 00:00:00

abstract：AIM:The suitability of Papanicolaou staining and of hematoxylin staining for DNA single-cell cytometry was investigated in comparison to Feulgen staining. MATERIALS AND METHODS:Ten normal cervical smears and ten cervical smears containing cells of a squamous cell carcinoma in situ were analyzed. The integrated optical...

journal_title：Anticancer research

authors： Biesterfeld S,Beckers S,Del Carmen Villa Cadenas M,Schramm M

更新日期：2011-01-01 00:00:00

abstract：:22 patients with advanced non-small-cell lung cancer were randomized to receive chemotherapy (ifosfamide) or chemotherapy followed by thymosin alpha1 + low-dose IFNalpha. Chemo-immunotherapy induced an enhanced response rate compared with chemotherapy alone (33% and 10% respectively). Although these differences were n...

journal_title：Anticancer research

authors： Salvati F,Rasi G,Portalone L,Antilli A,Garaci E

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND/AIM:Polyamines are important for the growth of eukaryotic cells. At high levels, they promote proliferation, invasion and migration of tumour cells. Polyamine metabolism is an important new target for anticancer therapy. Some polyamine analogues can have an inhibitory effect on tumour cells. The aim of this ...

journal_title：Anticancer research

authors： Ploskonos MV,Syatkin SP,Neborak EV,Hilal A,Sungrapova KY,Sokuyev RI,Blagonravov ML,Korshunova AY,Terentyev AA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this report was to summarize the real-world experience with lipegfilgrastim as a neutropenia prophylaxis in a large cohort of lymphoma patients receiving immuno-, chemo-therapy. PATIENTS AND METHODS:Observational clinical data were derived from two phase IV studies (NADIR and LEOS) with simil...

journal_title：Anticancer research

authors： Pettengell R,Wolff T,Goehler T,Cascavilla N

更新日期：2021-01-01 00:00:00