Polyamine Analogues of Propanediamine Series Inhibit Prostate Tumor Cell Growth and Activate the Polyamine Catabolic Pathway.

abstract：:To investigate the specific transduction of a suicide gene into human small cell lung carcinoma (SCLC) cells, we explored the promoter region of the neuron specific enolase (NSE) gene as a tumor-specific promoter. In Northern blot analysis, NSE mRNA was expressed more abundantly in the SBC3 human SCLC cell line than i...

journal_title：Anticancer research

authors： Tanaka M,Inase N,Miyake S,Yoshizawa Y

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIM:Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma. We have previously demonstrated that PSK induces apoptosis and inhibites proliferation of promyelomonocytic leukemia ...

journal_title：Anticancer research

authors： Hirahara N,Edamatsu T,Fujieda A,Fujioka M,Wada T,Tajima Y

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Osteoscopy is a minimally-invasive endoscopic technique for inspecting lesions inside bone marrow cavities. We describe the feasibility of osteoscopic surgery of giant cell tumor of bone (GCTB) in order to preserve the proximal fibula, and thereby achieve immediate recovery and avoid complications. PATIENTS...

journal_title：Anticancer research

authors： Futani H,Kumanishi S,Minakawa GO,Yoshiya S

更新日期：2018-05-01 00:00:00

abstract：:Metallothioneins (MT) are low molecular weight cysteine-rich proteins, present in a wide variety of eukaryotes. Although their physiological function is not entirely understood, recently it was found that in vitro human MTs (hMTs) expression prevents apoptosis. In the present study, the apoptosis preventing effect of ...

journal_title：Anticancer research

authors： Tsangaris GT,Vamvoukakis J,Politis I,Kattamis AC,Tzortzatou-Stathopoulou F

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIM:Novel drugs to inhibit insulin receptor substrate (IRS) and focal adhesion kinase (FAK) pathways are emerging and will be sarcoma subtype-specific. As a result, defining expression of proteins in these pathways; in select tumors is important in order to formulate therapeutic approaches to malignant perip...

journal_title：Anticancer research

authors： Shaw CM,Grobmyer SR,Ucar DA,Cance WG,Reith JD,Hochwald SN

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Although paclitaxel was given triweekly in phase II trials prior to its approval for gastric cancer in Japan, it is currently more often delivered by a weekly schedule in the second-line setting. PATIENTS AND METHODS:A phase II trial with response rate as the primary end-point was conducted. Patients with m...

journal_title：Anticancer research

authors： Kodera Y,Ito S,Mochizuki Y,Fujitake S,Koshikawa K,Kanyama Y,Matsui T,Kojima H,Takase T,Ohashi N,Fujiwara M,Sakamoto J,Akimasa N,Chubu Clinical Cancer Group.

更新日期：2007-07-01 00:00:00

abstract：:The Feulgen-DNA content of squamous carcinoma cell nuclei from the human esophagus was assessed in punch biopsies from 47 untreated patients. Forty-four of the 47 biopsies (93.6%) demonstrated aneuploid cell populations, and the remaining 3 (6.4%) were non-diploid. Previous studies have demonstrated that in esophageal...

journal_title：Anticancer research

authors： Munck-Wikland E,Auer G,Kuylenstierna R,Lindholm J,Rubio C

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:To investigate the differences between two rat yolk sac tumor cell lines with different radiosensitivities and p53 status in sensitivity to high-LET heavy-ion beam and in sensitizing effect of etoposide or cisplatin in combination with heavy-ion beam. MATERIALS AND METHODS:NMT-1 (wild-type p53 cell) is a pa...

journal_title：Anticancer research

authors： Takahashi T,Fukawa T,Hirayama R,Yoshida Y,Musha A,Furusawa Y,Ando K,Nakano T

更新日期：2010-06-01 00:00:00

abstract：:Development of an effective therapeutic strategy for refractory pancreatic cancer must consider whether chemosensitivity can be induced in chemoresistant cells. We established a pancreatic cancer stem cell-rich cell line using TIG-1 feeder cells and leukemia inhibitory factor (LIF)-rich SNL76/7 conditioned medium. We ...

journal_title：Anticancer research

authors： Imaizumi A,Onishi H,Yamasaki A,Kawamoto M,Umebayashi M,Morisaki T,Hasumi K

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Aggrecan, the large aggregating proteoglycan, is a major component of the cartilage extracellular matrix. The C-terminal globular domain (G3) of the aggrecan molecule exhibits a pattern of alternative splicing that involves three exons. Each corresponds to a subdomain, epidermal growth factor 1(EGF1), EGF2, ...

journal_title：Anticancer research

authors： Matsui Y,Araki N,Tsuboi H,Tsumaki N,Nakata K,Kawabata H,Eyre DR,Yoshikawa H

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Because of the low chemosensitivity of gastric cancer to conventional antitumor agents, the role of adjuvant chemotherapy for patients with advanced gastric cancer is controversial. We have previously proposed the necessity to evaluate the appropriateness of particular adjuvant cancer chemotherapies in indiv...

journal_title：Anticancer research

authors： Kubota T,Egawa T,Otani Y,Furukawa T,Saikawa Y,Yoshida M,Watanabe M,Kumai K,Kitajima M

更新日期：2003-01-01 00:00:00

abstract：AIM:The purpose of this study was to identify patient-, facility-, disease-, and treatment-specific characteristics that increase mortality in patients with upper limb osteosarcoma. PATIENTS AND METHODS:The National Cancer Data Base (NCDB) was queried for bone cancer. With Cox regression, the demographic, facility, tu...

journal_title：Anticancer research

authors： Restrepo DJ,Huayllani MT,Boczar D,Sisti A,Spaulding AC,Carter RE,Moran SL,Parker AS,Perdikis G,Forte AJ

更新日期：2019-09-01 00:00:00

abstract：:Poly(ADP-ribose) is a naturally occurring nuclear macromolecule resembling nucleic acids. It is synthesized from NAD+ on histones and a few other nuclear proteins. Its function, although not completely understood, might be to alter chromatin structure and to regulate the activity of proteins involved in the metabolism...

journal_title：Anticancer research

authors： Boulikas T

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Tumor cells expressing excessive anionic-charged sialic acid can be potentially targeted by cationic polymers which may inhibit tumor growth. In the present study, three new families of cationic polymers were synthesized to assess their effects on prostate cancer cells. MATERIALS AND METHODS:Cationic polyme...

journal_title：Anticancer research

authors： Gakhar G,Liu H,Shen R,Scherr D,Wu D,Nanus D,Chu CC

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this study was to determine the molecular and clinicopathological features, as well as the prognosis of patients with endometrial cancer (EC) having prior malignancy (second primary EC: SPEC) compared with those without a history of prior malignancy (first primary EC: FPEC). MATERIALS A...

journal_title：Anticancer research

authors： Haraga J,Nakamura K,Haruma T,Nyuya A,Nagasaka T,Masuyama H

更新日期：2020-07-01 00:00:00

abstract：UNLABELLED:BACKGROND/AIM: Recent evidence indicates that inflammation is a hallmark of cancer. Tumor-associated neutrophils (TANs) contribute to tumor invasion. However, whether TANs and lymph node metastasis are related is unknown. Intranodal lymphatic vessel density (LVD) is significantly correlated with tumor progre...

journal_title：Anticancer research

authors： Tokumoto M,Tanaka H,Ohira M,Go Y,Okita Y,Sakurai K,Toyokawa T,Kubo N,Muguruma K,Maeda K,Sawada T,Hirakawa K

更新日期：2014-12-01 00:00:00

abstract：:The usefulness of lymphocyte subset change as an indicator for predicting survival time and the effectiveness of combined treatment with an immunopotentiator, lentinan, and carboplatin (CBDCA) were investigated. Of 13 patients with advanced unresectable cancer entered in this study, 9 were administered 2 mg/body lenti...

journal_title：Anticancer research

authors： Matsuoka H,Yano K,Seo Y,Saito T,Tomoda H,Tsurumoto S

更新日期：1995-09-01 00:00:00

abstract：:The poor response of pancreatic adenocarcinoma to conventional chemotherapy has prompted us to search for innovative treatment approaches. Verapamil, a calcium channel blocker, has been reported to increase the doxorubicin sensitivity of several tumor models with acquired resistance, often in association with decrease...

journal_title：Anticancer research

authors： Chang BK,Brenner DE,Gutman R

更新日期：1989-03-01 00:00:00

abstract：:Vascularized bone graft (VBG) is a form of vascularized bone marrow transplant in which the bone marrow is surgically grafted with its microenvironment intact. Due to the preservation of cellular viability, VBG have significant advantages over non-vascularized bone grafts. Free vascularized fibula grafts have superior...

journal_title：Anticancer research

authors： Muramatsu K,Hashimoto T,Tominaga Y,Taguchi T

更新日期：2014-06-01 00:00:00

abstract：:The reverse transcriptase polymerase chain reaction (RT-PCR) can be of clinical relevance in identifying malignant melanoma cells in blood or tissues of patients at risk for disseminated melanoma. The diagnostic value of this marker however, is still controversial. The objective of this study was to compare and quanti...

journal_title：Anticancer research

authors： Calogero A,Hospers GA,Timmer-Bosscha H,Koops HS,Mulder NH

更新日期：2000-09-01 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) (CDDP) is the most active anticancer agent. It has been reported that intracellular accumulation of CDDP is an important step as a determinant for resistance to CDDP, which may be modulated by Na+, K(+)-ATPase activity. In this study, the significance of membrane Na+, K(+)-ATPase activ...

journal_title：Anticancer research

authors： Bando T,Fujimura M,Kasahara K,Matsuda T

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Primary serous-papillary peritoneal carcinoma is able to spread to the retroperitoneal lymph nodes, but there is no evidence of the pattern of lymphatic metastasis. Because of the fact that this tumor entity is indistinguishable histologically from primary serous-papillary ovarian carcinoma, its taxonomic po...

journal_title：Anticancer research

authors： Steinhagen PR,Sehouli J

更新日期：2011-04-01 00:00:00

abstract：AIM:Modern radiotherapy (RT) technique and therapy de-escalation have led to encouraging results in lymphoma management. In this study, we aimed to describe the oncological and toxicity outcome in patients with ocular adnexal lymphoma. PATIENTS AND METHODS:A total of 45 patients with 52 orbital lesions who were treate...

journal_title：Anticancer research

authors： Rehn S,Elsayad K,Oertel M,Baehr A,Eter N,Haverkamp U,Lenz G,Eich HT

更新日期：2020-07-01 00:00:00

abstract：:From 1980 to 1987, 243 evaluable patients with pT1, pT2 (less than 3 centimeters in diameter), N0, M0, invasive breast cancer were treated with "quadrantectomy" with axillary dissection followed by electron beam radiation therapy (QUART) at the St. Bortolo Hospital, Vicenza. Stage II patients received adjuvant chemoth...

journal_title：Anticancer research

authors： Gasparini G,Panizzoni GA,Dal Fior S,Germani B,Dall'Antonia F,Segato G,Meli S,Pozza F

更新日期：1991-07-01 00:00:00

abstract：:Paclitaxel has been approved as second-line therapy after anthracyclines in AIDS-Kaposi's sarcoma (KS) patients. To date, only one patient with classical KS and treated with standard dose (175 mg/m2) 3-weekly paclitaxel as first line therapy has been reported in the literature. Herein, the first case is presented of a...

journal_title：Anticancer research

authors： Silvestris N,Galetta D,Colucci G

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND/AIM:Twenty-four 2-azolylchromones were subjected to quantitative structure-activity relationship (QSAR) analysis based on their cytotoxicity and tumor specificity, in order to find their new biological activities. MATERIALS AND METHODS:Cytotoxicity against two human oral squamous cell carcinoma cell lines a...

journal_title：Anticancer research

authors： Sakagami H,Okudaira N,Uesawa Y,Takao K,Kagaya H,Sugita Y

更新日期：2018-02-01 00:00:00

abstract：:The role of intensive pre- and postoperative chemotherapy in unresectable nonmetastatic neuroblastoma is still controversial. A preoperative regimen that included deferoxamine, cyclophosphamide, etoposide, carboplatin and thiotepa (D-CECaT) was evaluated in 10 children over one year of age at diagnosis, and this was f...

journal_title：Anticancer research

authors： Donfrancesco A,Deb G,Dominici C,De Sio L,Inserra A,Boglino C,Takahashi M,Uchino J,Helson L

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Studies have recommended a 21-gene recurrence score (RS) to optimize adjuvant treatment for patients with early-stage breast cancer (EBC) with hormone receptor-positive (HR+) and human epidermal growth factor receptor-2 negative (HER2-) tumors. This study aimed to prospectively evaluate the impact of this RS...

journal_title：Anticancer research

authors： Zeng Y,Li Q,Qin T,Li S,Jin L,Wu J,Chen K,Deng H,Rao N,Liu Q,Su F,Jia W,Yao H

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND/AIM:The matrix metalloproteinase (MMP) family of enzymes are in charge of degradation of various components of the extracellular matrix and their functional genetic polymorphisms may be associated with cancer susceptibility. The functional polymorphisms in the promoter region of MMP7 (A-181G and C-153T) have...

journal_title：Anticancer research

authors： Chou AK,Hsiao CL,Shih TC,Wang HC,Tsai CW,Chang WS,Liu LC,Way TD,Chung JG,Bau DT

更新日期：2017-09-01 00:00:00

abstract：:In screening cytotoxic agents in morphine alkaloids [TE1-10], codeinone [TE8] was cytotoxic against two human oral tumor cells lines (HSC-2 and HSG). The cytotoxic activity of codeinone (CC50=1.0-1.2 microg/mL) against HSC-2 or HSG cells was higher than that of doxorubicin (CC50=1.9-2.0 microg/mL). Human oral gingival...

journal_title：Anticancer research

authors： Kawase M,Sakagami H,Furuya K,Kikuchi H,Nishikawa H,Motohashi N,Morimoto Y,Varga A,Molnár J

更新日期：2002-01-01 00:00:00