Multimodal Anti-tumor Approaches Combined with Immunotherapy to Overcome Tumor Resistance in Esophageal and Gastric Cancer.

abstract：:Megakaryocyte polyploidization is an advantageous and regulated mechanism which leads to an increase in platelet production. In megakaryocyte cell lines, polyploidization can be obtained by using cytochalasin B, an inhibitor of the actin polymerization. The Nucleolar Organizer Regions (AgNORs) are parts of nucleolar D...

journal_title：Anticancer research

authors： Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIM:The clinicopathological significance and prognostic value of insulin-like growth factor binding protein 1 (IGFBP1) in gastric cancer have not been investigated to date. This study aimed to investigate the relationship of IGFBP1 expression with clinicopathological variables and prognosis. MATERIALS AND M...

journal_title：Anticancer research

authors： Sato Y,Inokuchi M,Takagi Y,Kojima K

更新日期：2019-06-01 00:00:00

abstract：:P-glycoprotein (P-gp) and multidrug resistance related protein (MRP) overexpression is often responsible of the development of multidrug resistance in cancer therapy. These proteins are also expressed in normal tissues, where their physiological role is related to the extrusion of endogenous toxins or to secretory fun...

journal_title：Anticancer research

authors： Rosati A,Decorti G,Klugmann FB,Candussio L,Granzotto M,Melato M,Giraldi T

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The prognostic significance of angiogenesis, proliferation and apoptosis after interferon (IFN) was investigated in 96 patients with renal cell carcinoma (RCC). MATERIALS AND METHODS:Microvessel density in the tumor(MVD), proliferative index(PI) and apoptotic index(AI) were quantified using immunohistochemi...

journal_title：Anticancer research

authors： Yoshino S,Kato M,Okada K

更新日期：2000-01-01 00:00:00

abstract：:The growth and amino acid utilization of a mouse macrophage-like cell line J774.1 was investigated in two different culture media supplemented with 10% fetal bovine serum (FBS). The J774.1 cells grew faster, and consumed glutamine and serine at higher rates in DMEM than in RPMI1640 medium. The consumption of other ami...

journal_title：Anticancer research

authors： Thet MM,Yokote Y,Chu Q,Wang QT,Kishino K,Tamura N,Shimada J,Amano O,Kanda Y,Kunii S,Takekawa F,Hatano H,Shimada C,Hasegawa H,Sakagami H

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the progression-free survival (PFS) and toxicity associated with adjuvant administration of carboplatin and pemetrexed for completely resected patients with stage IB, II and IIIA non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Forty-five eligible NSCLC patient...

journal_title：Anticancer research

authors： Karapanagiotou EM,Boura PG,Papamichalis G,Konstantinou M,Sepsas E,Chamalakis G,Simsiris P,Gkiozos I,Syrigos KN

更新日期：2009-10-01 00:00:00

abstract：:The development and maintenance of testicular interstitial cell (IC) tumors under the conditions of low LH levels were examined in aged Fischer 344 rats, and the enzyme activities for androgen synthesis in the tumors were estimated. Sixty-week old rats received injections of an LH-RH agonist (LH-RHa) for 28 weeks or w...

journal_title：Anticancer research

authors： Chatani F,Nonoyama T,Sudo K,Miyajima H,Takeyama M,Takatsuka D,Mori H,Matsumoto K

更新日期：1990-03-01 00:00:00

abstract：:P-glycoprotein has been identified in mast cells stabilized in culture as well as in rat peritoneal mast cells, and is primarily concentrated on the granular membrane. This study aimed to define the role of this protein in the transport and accumulation of doxorubicin in mast cell granules and in its histamine releasi...

journal_title：Anticancer research

authors： Candussio L,Decorti G,Crivellato E,Rosati AM,Traversa U,Klugmann FB

更新日期：1999-03-01 00:00:00

abstract：:Bisphosphonates are strong inhibitors of osteoclastic bone resorption in both benign and malignant bone diseases. The nitrogen-containing bisphosphonates (N-BPs) have strong cytotoxicity via inhibition of protein prenylation in the mevalonate pathway, and also demonstrate direct cytostatic and proapoptotic effects on ...

journal_title：Anticancer research

authors： Tanaka T,Kawashima H,Ohnishi K,Matsumura K,Yoshimura R,Matsuyama M,Kuratsukuri K,Nakatani T

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Laparoscopic surgery in patients with endometrial cancer has been more widely used in the last 5-10 years, and numerous reports concerning recurrence rate and the surgical technique, laparoscopic vs. open, have been published. However, no data are available concerning the surgical technique of an open or clo...

journal_title：Anticancer research

authors： Kohlberger P,Nowotny G,Speiser P,Joura E,Sliutz G,Hefler L,Reinthaller A

更新日期：2007-05-01 00:00:00

abstract：:Tumor growth delay (TGD) is a widely accepted method for in situ assessment of tumor treatment modalities. However, it has some drawbacks: (1) dependency on arbitrary endpoints and, even more serious, (2) lack of alterations of the tumor-growth pattern after treatment. In the present study a generalization of TGD is p...

journal_title：Anticancer research

authors： Bassukas ID

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND/AIM:Oxysterol plays important physiological roles in diverse biological processes including apoptosis. However, the mechanisms underlying oxysterol-induced apoptosis remain unknown. 25-hydroxycholesterol (25-HC) is an oxysterol synthesized by cholesterol 25-hydroxylase from cholesterol during sterol metaboli...

journal_title：Anticancer research

authors： You JS,Lim H,Kim TH,Oh JS,Lee GJ,Seo YS,Kim DK,Yu SK,Kim HJ,Kim CS,Kim JS

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Breast cancer grows in a hormone-rich environment which influences its biological features and thus, ultimately, its clinical behavior. Circulating hormone levels were measured in premenopausal and postmenopausal breast cancer patients prior to surgery, and correlated with all available clinical and biologic...

journal_title：Anticancer research

authors： Hernández L,Nuñez-Villarl MJ,Martínez-Arribas F,Pollán M,Schneider J

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this phase I study was to determine the maximum-tolerated dose (MTD) and recommended dose (RD) of combination therapy with weekly nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and cyclophosphamide (CPA) in metastatic breast cancer (MBC) patients. PATIENTS AND METHODS:Five patie...

journal_title：Anticancer research

authors： Ota D,Akatsuka S,Nishi T,Kato T,Takeuchi M,Tsuji M,Fukuuchi A

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The effectiveness and improvement in quality of life (QOL) of a long-acting formulation of octreotide (LAR) administration for cancer patients, with chronic loperamide-refractory diarrhea not attributed to medical therapy, were investigated. PATIENTS AND METHODS:Twenty-nine patients with chronic loperamide-r...

journal_title：Anticancer research

authors： Mystakidou K,Katsouda E,Tsilika E,Smyrniotis V,Vassiliou I,Tsiatas M,Vlahos L

更新日期：2006-05-01 00:00:00

abstract：:Our recent in vitro findings for suppression of thrombospondin-1 (TSP1; an antiangiogenic factor) expression by wild-type (wt) p53 in a p53-null thyroid carcinoma cell line, FRO, prompted us to investigate the in vivo effect of exogenous wt-p53 and TSP1 expression on tumor growth and angiogenesis of FRO xenografts in ...

journal_title：Anticancer research

authors： Nagayama Y,Shigematsu K,Namba H,Zeki K,Yamashita S,Niwa M

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Molecular alterations such as DNA microsatellite instability (MSI/RER), single nucleotide polymorphism (SNP) and loss of heterozygosity (LOH) can occur throughout the genome and be associated with different types of cancer. In the present study, we aimed at detecting molecular alterations within the mismatch...

journal_title：Anticancer research

authors： Arzimanoglou II,Hansen LL,Chong D,Li Z,Psaroudi MC,Dimitrakakis C,Jacovina AT,Shevchuk M,Reid L,Hajjar KA,Vassilaros S,Michalas S,Gilbert F,Chervenak FA,Barber HR

更新日期：2002-03-01 00:00:00

abstract：UNLABELLED:The present study evaluated the frequency of the polymorphism of Interleukin-6 (IL6) in women positive for E6/E7 Human Papillomavirus (HPV) (n=152) and women negative for HPV (n=238), 390 women in total. Material for analysis was obtained at the Federal University of São Paulo. Interleukin-6 polymorphism was...

journal_title：Anticancer research

authors： Porto CR,De Oliveira Kleine JP,Longatto Filho A,Da Silva ID

更新日期：2014-07-01 00:00:00

abstract：:The melastatin-like transient receptor potential M2 (TRPM2) channel is a Ca2+ permeable channel that is activated by reactive oxygen species (ROS), and its activation induces necrotic cell death. The effect of insertion of TRPM2 into A172 human glioblastoma cells (A172 cells) was investigated. The insertion of TRPM2 c...

journal_title：Anticancer research

authors： Ishii M,Oyama A,Hagiwara T,Miyazaki A,Mori Y,Kiuchi Y,Shimizu S

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIM:The transcription factor Y-box-binding protein 1 (YB1) is overexpressed in many types of human cancers. YB1 regulates the G1 phase of the cell cycle by controlling transcription of G1 regulators. Here, we report that YB1 is also involved in regulating G2/M phase. MATERIALS AND METHODS:YB1-depleted TKO c...

journal_title：Anticancer research

authors： Kotake Y,Arikawa N,Tahara K,Maru H,Naemura M

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Lymph node metastases from squamous cell carcinoma (SCC) can reach 20% in some high risk subgroups, and while early detection of metastasis may potentially improve overall and/or disease-specific survival, techniques for early detection have not been established. One such technique is the use of sentinel lym...

journal_title：Anticancer research

authors： Liu YY,Rozen WM,Rahdon R

更新日期：2011-04-01 00:00:00

abstract：AIM:The aim of this study was to analyze the lung cancer detection rate in asymptomatic individuals by the Fluorine-18 fluorodeoxyglucose-positron emission tomography FDG-PET cancer screening program in Japan. MATERIALS AND METHODS:A total of 153,775 asymptomatic individuals underwent the FDG-PET cancer screening prog...

journal_title：Anticancer research

authors： Minamimoto R,Senda M,Jinnouchi S,Terauchi T,Yoshida T,Uno K,Iinuma T,Murano T,Nakashima R,Inoue T

更新日期：2014-01-01 00:00:00

abstract：:Antisense inhibition of the RelA subunit but not the NFKB1 subunit of NK-kappa B transcription factor results in a block of cellular adhesion and inhibition of tumor cell growth in vitro and in vivo. Studies aimed at dissecting the molecular mechanism of antisense relA action led to our identification of a kappa B-lik...

journal_title：Anticancer research

authors： Sharma HW,Higgins-Sochaski K,Perez JR,Narayanan R

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Monoclonal Antibody (MAb) 29-13 reacts with the human sarcoma-associated antigen (SAA) p200. We report here engineering and primary characterization of a single chain antibody (scFV2913). MATERIALS AND METHODS:The scFV2913 recombinant gene, consisting of VH-linker-VK, was constructed with RT-PCR. This gene ...

journal_title：Anticancer research

authors： Chen H,Wang P,Stastny JJ,Shilkaitis A,Liao X,Das Gupta TK

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND/AIM:γδ T cells mediate cytotoxicity against prostate cancer (PCa) cells in vitro; however, the clinical efficacy of γδ T cell-targeted immunotherapy for recurrent and metastatic PCa is unsatisfactory. We hypothesized that the resistance of recurrent and metastatic PCa to γδ T cells is related to the presence...

journal_title：Anticancer research

authors： Miyashita M,Tomogane M,Nakamura Y,Shimizu T,Fujihara A,Ukimura O,Ashihara E

更新日期：2020-10-01 00:00:00

abstract：:Peptides extracted from tumor cells after mild acid treatment can function as antigenic epitopes when presented by cultured dendritic cells. Peptides were extracted from four tumors syngeneic to C3H mice, three weakly immunogenic tumors (FSA, MCAK, HCA) and one non-immunogenic tumor (NFSA). Dendritic cells pulsed with...

journal_title：Anticancer research

authors： Ribas A,Bui LA,Butterfield LH,Vollmer CM,Jilani SM,Dissette VB,Glaspy JA,McBride WH,Economou JS

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays a role in carcinogenesis and carcinoma progression. In this study we investigated the expression of HB-EGF in human colonic non-neoplastic and neoplastic tissues. MATERIALS AND METHODS:We performe...

journal_title：Anticancer research

authors： Ito Y,Higashiyama S,Takeda T,Okada M,Matsuura N

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND/AIM:For cases of musculoskeletal sarcoma of the knee presenting to our institute, we prioritize joint preservation whenever possible. To investigate patient satisfaction and desire for joint preservation, a questionnaire survey was performed. PATIENTS AND METHODS:Surveys were mailed to 62 patients with musc...

journal_title：Anticancer research

authors： Abe K,Yamamoto N,Hayashi K,Takeuchi A,Kato S,Miwa S,Igarashi K,Inatani H,Aoki YU,Higuchi T,Taniguchi Y,Tsuchiya H

更新日期：2019-04-01 00:00:00

abstract：:Intravenous administration of sodium benzylideneascorbate (SBA) rapidly necrotized inoperable human lung cancer, and induced degeneration of 3'-methyl-4-dimethylaminoazobenzene-induced rat hepatocellular carcinoma (vacuolar, eosinophilic degeneration, nuclear debris) without affecting the serum glutamic oxaloacetic tr...

journal_title：Anticancer research

authors： Sakagami H,Asano K,Fukuchi K,Gomi K,Ota H,Kazama K,Tanuma S,Kochi M

更新日期：1991-07-01 00:00:00

abstract：:Colorectal cancers are often preceded by noninvasive neoplasias arising in the surface epithelium, namely tubular, tubulovillous and villous adenomas. That neoplasias may also arise in the colorectal crypts is less well known. Between 1998 and 2002, colonoscopies, rectoscopies and colorectal surgical specimens from 86...

journal_title：Anticancer research

authors： Rubio CA

更新日期：2005-11-01 00:00:00