Abstract：
BACKGROUND/AIM:The transcription factor Y-box-binding protein 1 (YB1) is overexpressed in many types of human cancers. YB1 regulates the G1 phase of the cell cycle by controlling transcription of G1 regulators. Here, we report that YB1 is also involved in regulating G2/M phase. MATERIALS AND METHODS:YB1-depleted TKO cells were subjected to quantitative reverse transcription-polymerase chain reaction and cell-cycle analysis. RNA immunoprecipitation (RIP)-chip assay was performed using anti-YB1 antibodies. Precipitated RNAs were subjected to microarray analysis. RESULTS:Silencing YB1 inhibited the proliferation of TKO cells, which lost the machinery required for G1 phase arrest. Cell-cycle analysis showed that silencing YB1 caused G2/M phase cell-cycle arrest. RIP-chip assay showed that YB1 associated with mRNA of multiple cell-cycle-related genes, including G2/M phase regulators. CONCLUSION:YB1 positively regulates not only the G1 phase but also G2/M phase by regulating multiple cell-cycle-related genes.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kotake Y,Arikawa N,Tahara K,Maru H,Naemura Mdoi
10.21873/anticanres.11490subject
Has Abstractpub_date
2017-04-01 00:00:00pages
1603-1608issue
4eissn
0250-7005issn
1791-7530pii
37/4/1603journal_volume
37pub_type
杂志文章abstract：:It has been shown recently that various myeloid leukemia cells can be induced by numerous compounds to differentiate terminally into non-growing mature cells. Furthermore, some of these compounds have been found to be clinically useful for the therapy of certain types of myeloid leukemia. To improve this new method of...
journal_title：Anticancer research
pub_type： 杂志文章,评审
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journal_title：Anticancer research
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