Influence of cell membrane potential, and selectivity of the Na+/H+ exchanger and Cl-/HCO3- exchanger on the intracellular accumulation of adriamycin.

abstract：BACKGROUND:Antioxidants have the potential to protect normal tissues against radiation-induced damage, but must not protect tumor cells during radiotherapy. The major objectives were to determine whether a metalloporphyrin antioxidant affects prostate tumor response to radiation and identify possible mechanisms of inte...

journal_title：Anticancer research

authors： Gridley DS,Makinde AY,Luo X,Rizvi A,Crapo JD,Dewhirst MW,Moeller BJ,Pearlstein RD,Slater JM

更新日期：2007-09-01 00:00:00

abstract：:In order to improve the treatment of advanced H&N cancer we must consider to adopt new strategies as: new/better cytostatic agents; new combinations of present cytostatic agents and; potentiation of radiotherapy and cytostatic agents by biochemical modulation, which we define as potentiation of therapy by non-chemothe...

journal_title：Anticancer research

authors： Wennerberg J,Kjellén E,Lybak S,Rydell R,Pero R

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Nuclear morphometry can be expected to improve the distinction between benign and malignant lesions. PATIENTS AND METHODS:Forty fine-needle aspiration biopsy (FNAB) samples fixed in 50% ethanol were collected at the African Oncology Institute, Sabratha, Libya, during the period 2004-2007. All diagnoses repo...

journal_title：Anticancer research

authors： Abdalla F,Boder J,Buhmeida A,Hashmi H,Elzagheid A,Collan Y

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:The proportion of geriatric gastric cancer (GC) patients with comorbidities has been increasing in Japan. This study was designed to evaluate the prognostic influence of the extent of lymph node dissection (END) and perioperative morbidities in patients with GC. PATIENTS AND METHODS:Between 2008 and 2013, t...

journal_title：Anticancer research

authors： Kawaguchi T,Komatsu S,Ichikawa D,Kimura YU,Komiyama S,Konishi H,Kin S,Kawakami S,Kosuga T,Okamoto K,Otsuji E

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND/AIM:The Aspartate aminotransaminase/Alanine aminotransaminase ratio (AST/ALT ratio) has been identified as a prognostic marker for several malignancies. In this study, we evaluated the prognostic value of the AST/ALT ratio in a large cohort of non-metastatic colorectal cancer patients (CRC). PATIENTS AND ME...

journal_title：Anticancer research

authors： Scheipner L,Smolle MA,Barth D,Posch F,Stotz M,Pichler M,StÖger H,Gerger A,Riedl JM

更新日期：2021-01-01 00:00:00

abstract：:The macrolide antibiotic erythromycin has recently been shown to overcome the resistance to anticancer drugs that results from overexpression of P-glycoprotein. The present study, using erythromycin lactobionic acid as a model drug, investigated the inhibitory effects of erythromycin on the efflux of doxorubicin from ...

journal_title：Anticancer research

authors： Kiso S,Cai SH,Kitaichi K,Furui N,Takagi K,Takagi K,Nabeshima T,Hasegawa T

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND/AIM:Bone metastases are associated with increased morbidity and poor prognosis in a variety of cancers. The present study investigated the effects of targeted radionuclide therapy with α-emitting, bone-seeking radium-224 (224Ra) on osteolytic bone metastasis of MDA-MB-231(SA)-GFP human breast cancer cells in...

journal_title：Anticancer research

authors： Juzeniene A,Bernoulli J,Suominen M,Halleen J,Larsen RH

更新日期：2018-04-01 00:00:00

abstract：:P44 Ro (Mel) is a human malignant melanoma cell line derived from a testicular metastasis in a DNA repair deficient, xeroderma pigmentosum patient. This line harbors a N-ras gene mutated in codon 61. To investigate other cellular genes possibly contributing to the expression of its transformed phenotype, four XP44 rev...

journal_title：Anticancer research

authors： Lafarge-Frayssinet C,Daya-Grosjean L,Estrade S,Frezouls G,Sarasin A,Cassingena R

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Lung cancer cells often express vimentin. However, the function of vimentin in lung cancer cells has not been fully evaluated. MATERIALS AND METHODS:We evaluated the association between vimentin expression in resected non-small cell lung cancer (NSCLC) specimens and prognosis. Short-interfering RNA targetin...

journal_title：Anticancer research

authors： Tadokoro A,Kanaji N,Liu D,Yokomise H,Haba R,Ishii T,Takagi T,Watanabe N,Kita N,Kadowaki N,Bandoh S

更新日期：2016-04-01 00:00:00

abstract：:Advanced or metastatic pancreatic cancer is an incurable disease. The main treatment is chemotherapy with cytotoxic agents. On the basis of our experience in clinical trials, the objectives have been to determine response rate, life prolongation and clinical benefit. In our trials and in those of other authors, all of...

journal_title：Anticancer research

authors： Stathopoulos GP,Androulakis N,Souglakos J,Stathopoulos J,Georgoulias V

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND/AIM:Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis and tumorigenicity. We previously assessed the role of cytokine gene polymorphisms in gastric cancer risk in Chile. In the present study, we aimed to analyze whether these polym...

journal_title：Anticancer research

authors： Gonzalez-Hormazabal P,Romero S,Musleh M,Bustamante M,Stambuk J,Pisano R,Lanzarini E,Chiong H,Rojas J,Castro VG,Jara L,Berger Z

更新日期：2018-10-01 00:00:00

abstract：:Thirty advanced breast cancer patients received Vinorelbine (VNB) according to two different schedules: a weekly i.v. bolus of 30 mg/m (14 patients) or a continuous infusion (CI) schedule comprising 8 mg i.v. bolus on day 1 followed by 8 mg/m2/die CI day 1 to 4, q 21 days (16 patients). 36% of patients had received at...

journal_title：Anticancer research

authors： Gasco M,Gardin G,Repetto L,Campora E,Rosso R

更新日期：1997-03-01 00:00:00

abstract：AIM:To develop potent HIF-1α inhibitors for potential treatment of cancer. MATERIALS AND METHODS:Chemical synthesis, HIF-luciferase assay, cytotoxic assay, platelet aggregation assay, western blot analysis, quantitative real-time PCR, aqueous solubility, protein binding, metabolic stability, and metabolic pathways. R...

journal_title：Anticancer research

authors： Chen J,Wang J,Schwab LP,Park KT,Seagroves TN,Jennings LK,Miller DD,Li W

更新日期：2014-08-01 00:00:00

abstract：:We investigated the in vitro effects of heparin on the growth and interaction of SW480 colon adenocarcinoma cells with the extracellular matrix proteins laminin, fibronectin and collagen IV. Cell adhesion assays were performed in wells precoated with the proteins mentioned. Tumor cell migration and invasiveness were a...

journal_title：Anticancer research

authors： Antachopoulos CT,Iliopoulos DC,Gagos S,Agapitos MV,Karayannacos PE,Roboli SK,Skalkeas GD

更新日期：1995-07-01 00:00:00

abstract：:The effect on liver tissue of glutathione administration to rats treated for 7-14 days with 2-acetylaminofluorene was investigated. The DNA damage induced by the hepatotoxic agent and evaluated by the alkaline elution technique was significantly reduced by glutathione. Furthermore, GSH administration maintained liver ...

journal_title：Anticancer research

authors： Cesarone CF,Scarabelli L,Orunesu M

更新日期：1986-11-01 00:00:00

abstract：:Cases with deletion of part of the long arm of chromosome 5 (5q-) and a myeloid hemopoietic disorder show a marked female preponderance. We analysed the female preponderance of 328 published cases of myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). MDS without clinical or cytogenetic progression shows ...

journal_title：Anticancer research

authors： Pedersen B

更新日期：1997-09-01 00:00:00

abstract：:Nineteen patients with locally advanced inoperable carcinoma of the uterine cervix (8 with stage IIb, 8 with stage IIIb and 3 with stage IV) were treated with a cisplatin (100 mg/m2), aclacinomycin (30 mg/m2) and bleomycin (20 mg/m2) combination using balloon occluded arterial infusion (BOAI), and 5 patients (2 stage ...

journal_title：Anticancer research

authors： Sawada T,Yoshimura Y,Kawakami S

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly SV40 or more likely cytomegalovirus (CMV). One report indicate...

journal_title：Anticancer research

authors： Lehrer S,Labombardi V,Green S,Pessin-Minsley MS,Germano IM,Rosenzweig KE

更新日期：2011-03-01 00:00:00

abstract：:Metals and metal compounds have been used in medicine for several thousands of years. In this review we summarized the anti-cancer activities of the ten most active metals: arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium and platinum. The first reviewed metal, arsenic, presents the anomaly...

journal_title：Anticancer research

authors： Desoize B

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIM:High-mobility group box 1 (HMGB1) is a nuclear DNA-binding protein that exerts a range of proinflammatory actions when it is secreted extracellularly. We hypothesized that HMGB1 released from damaged cells in pituitary apoplexy would exacerbate the neurological symptoms due to acute inflammation. PATIEN...

journal_title：Anticancer research

authors： Okuda T,Fujita M,Kato A

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The prognostic significance of age in ovarian cancer has not been clarified. We investigated the characteristics of ovarian cancer presenting in ages > 70 years and assessed the prognostic significance of advanced age. PATIENTS AND METHODS:Four hundred and fifty-three patients with stage IIC-IV ovarian canc...

journal_title：Anticancer research

authors： Efstathiou E,Dimopoulos MA,Bozas G,Kastritis E,Moulopoulos LA,Rodolakis A,Vlahos G,Gika D,Papadimitriou C,Bamias A

更新日期：2007-01-01 00:00:00

abstract：:22 patients with advanced non-small-cell lung cancer were randomized to receive chemotherapy (ifosfamide) or chemotherapy followed by thymosin alpha1 + low-dose IFNalpha. Chemo-immunotherapy induced an enhanced response rate compared with chemotherapy alone (33% and 10% respectively). Although these differences were n...

journal_title：Anticancer research

authors： Salvati F,Rasi G,Portalone L,Antilli A,Garaci E

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Primary prostate carcinoma cells constitutively secrete interleukin-6 (IL-6), and high levels of IL-6 receptor are detected in prostate carcinoma tissues. These findings have implicated IL-6 in the growth and differentiation of prostate carcinomas. Herein, we examined the regulation of IL-6 receptor complex ...

journal_title：Anticancer research

authors： Mori S,Murakami-Mori K,Bonavida B

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Neuroendocrine (NE) carcinomas of the lung exhibit expression of various stem cell antigens, and except for carcinoid tumours, carry a poor prognosis. Despite the fact that 10%-30% of all non-small cell lung carcinomas (NSCLC) which are not classified as NE carcinomas also show expression of NE markers, data...

journal_title：Anticancer research

authors： Gottschling S,Jensen K,Herth FJ,Thomas M,Schnabel PA,Herpel E

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the expression of thymidine phosphorylase (TP), a known angiogenic factor for endothelial cells, in gastric carcinoma cells and tumor-associated stromal cells. MATERIALS AND METHODS:Sixty-six gastric carcinomas were studied. TP expression was assessed with the P-GF.4...

journal_title：Anticancer research

authors： Liakakos T,Troupis T,Ghiconti I,Triantafyllidis S,Macheras A,Karatzas G,Pavlakis K

更新日期：2006-09-01 00:00:00

abstract：:Nonterminal cellular differentiation has recently been shown to induce transformed cells to revert to a benign state and to become resistant to retransformation by chemical and physical carcinogens without limiting their proliferative potential. Nonterminal differentiation also induces native 3T3 T mesenchymal stem ce...

journal_title：Anticancer research

authors： Tzen CY,Maercklein PB,Scott RE

更新日期：1990-09-01 00:00:00

abstract：UNLABELLED:The pharmacology of progestins includes actions initiated by various cellular targets, including classic receptors characterized as nuclear transcription factors (nPR), G-protein-coupled membrane receptors (mPR), enzymes, membrane channels and transporters. The effects initiated by targets other than nPR are...

journal_title：Anticancer research

authors： Fjelldal R,Moe BT,Ørbo A,Sager G

更新日期：2010-12-01 00:00:00

abstract：:The melastatin-like transient receptor potential M2 (TRPM2) channel is a Ca2+ permeable channel that is activated by reactive oxygen species (ROS), and its activation induces necrotic cell death. The effect of insertion of TRPM2 into A172 human glioblastoma cells (A172 cells) was investigated. The insertion of TRPM2 c...

journal_title：Anticancer research

authors： Ishii M,Oyama A,Hagiwara T,Miyazaki A,Mori Y,Kiuchi Y,Shimizu S

更新日期：2007-11-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is one of the few tumour types metastatic to the pancreas. In order to evaluate the outcome following resection of pancreatic metastases of RCC a retrospective review of surgical patients was performed. The initial histopathological staging, disease-free interval, surgical outcome and surviv...

journal_title：Anticancer research

authors： Schauer M,Vogelsang H,Siewert JR

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Several studies have supported the hypothesis that the concept of immuno-surveillance would not be effective in cancer patients. One reason for suppression of antitumor immunity may be attributed to immune impairment of T-lymphocytes, which extends beyond the tumor-microenvironment and might effect the perip...

journal_title：Anticancer research

authors： Gruber IV,El Yousfi S,Dürr-Störzer S,Wallwiener D,Solomayer EF,Fehm T

更新日期：2008-03-01 00:00:00