Lack of prognostic significance of neuroendocrine differentiation and stem cell antigen co-expression in resected early-stage non-small cell lung cancer.

Abstract:

BACKGROUND:Neuroendocrine (NE) carcinomas of the lung exhibit expression of various stem cell antigens, and except for carcinoid tumours, carry a poor prognosis. Despite the fact that 10%-30% of all non-small cell lung carcinomas (NSCLC) which are not classified as NE carcinomas also show expression of NE markers, data on their prognostic significance are conflicting and analyses of the expression and relevance of stem cell antigens in this subgroup are lacking. MATERIALS AND METHODS:Tissue specimens of 100 resected early-stage NSCLC were analyzed by immunohistochemistry for the expression and prognostic significance of NE markers. Moreover, the subgroup of NSCLC with NE differentiation (ND) were assessed for the expression and prognostic significance of the stem cell antigens CD117, CD133 and breast cancer resistance protein-1 (ABCG2). RESULTS:ND correlated significantly with adenocarcinoma histology (p=0.035), but not with prognosis. In the subgroup of ND-NSCLC (n=80), the stem cell antigens CD117, CD133 and ABCG2 were expressed in 51%, 14% and 33% of the cases, but likewise, showed no association with prognosis or clinicopathological characteristics. CONCLUSION:This study indicates that neither ND, nor co-expression of the stem cell antigens CD117, CD133 or ABCG2, have a prognostic significance in resected early-stage NSCLC.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Gottschling S,Jensen K,Herth FJ,Thomas M,Schnabel PA,Herpel E

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

981-90

issue

3

eissn

0250-7005

issn

1791-7530

pii

33/3/981

journal_volume

33

pub_type

杂志文章
  • Dexamethasone enhances expression of membrane and soluble interleukin-6 receptors by prostate carcinoma cell lines.

    abstract:BACKGROUND:Primary prostate carcinoma cells constitutively secrete interleukin-6 (IL-6), and high levels of IL-6 receptor are detected in prostate carcinoma tissues. These findings have implicated IL-6 in the growth and differentiation of prostate carcinomas. Herein, we examined the regulation of IL-6 receptor complex ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Mori S,Murakami-Mori K,Bonavida B

    更新日期:1998-11-01 00:00:00

  • Release kinetics of 5-fluorouracil-loaded microspheres on an experimental rat glioma.

    abstract:BACKGROUND:Biodegradable loaded systems are promising devices for controlled and sustained release of anticancer drugs to brain tumours. We investigated the influence of drug-release profiles of 5-fluorouracil-loaded microspheres designed for the treatment of malignant gliomas. MATERIALS AND METHODS:2.5 mg 5-FU delive...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Roullin VG,Lemaire L,Venier-Julienne MC,Faisant N,Franconi F,Benoit JP

    更新日期:2003-01-01 00:00:00

  • Lapatinib Inhibits Amphiregulin-induced BeWo Choriocarcinoma Cell Proliferation by Reducing ERK1/2 and AKT Signaling Pathways.

    abstract:BACKGROUND:Human choriocarcinoma is the most aggressive type of gestational trophoblastic neoplasia. The expression of epidermal growth factor receptor (EGFR) in choriocarcinomas is significantly higher than those of trophoblastic cells in healthy placentas. Lapatinib is a potent EGFR and human epidermal growth factor ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13355

    authors: Pires LV,Yi Y,Cheng JC,Pizzolato LS,Cordero E,Leung PCK,Brum IS

    更新日期:2019-05-01 00:00:00

  • Steroid hormone receptors and tumorigenicity of sublines from breast tumor metastatic MDA-MB 231 cell line.

    abstract::Ten cell sublines the MDA-MB 231 human breast cell line were analyzed for their phenotypic diversity: morphology, karyotype, growth rate, clonogenicity in semisolid medium, tumorigenicity in nude mice, number and affinity of nuclear receptors for oestradiol, progesterone and glucocorticoids. Karyotypic analysis showed...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Crépin M,Salle V,Raux H,Berger R,Hamelin R,Brouty-Boyé D,Israel L

    更新日期:1990-11-01 00:00:00

  • Limited-sampling models for estimation of the carboplatin area under the curve.

    abstract:BACKGROUND:The area under the curve (AUC) of free carboplatin, is a major determinant of toxicity and response. A conventional pharmacokinetic study to determine AUC requires frequent blood sampling. One strategy for overcoming this problem is to apply a limited sampling model (LSM). MATERIALS AND METHODS:We developed...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Miyazaki M,Fujiwara Y,Takahashi T,Isobe T,Ohune T,Tsuya T,Yamakido M

    更新日期:1997-11-01 00:00:00

  • Similar patterns of loss of heterozygosity in serum of adenocarcinoma of the distal oesophagus and the cardia in early diagnosis.

    abstract:BACKGROUND:Loss of heterozygosity (LOH) may be a valuable tool for detection of malignant proceedings. The aim of our study was to investigate LOH in the serum of patients with adenocarcinoma of the distal oesophagus and the cardia for diagnostic and prognostic utility. PATIENTS AND METHODS:Matched tumour and serum sa...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Wachowiak R,Kaifi JT,Schurr PG,Merkert P,Yekebas E,Schwarzenbach H,Strate T,Sauter G,Izbicki JR

    更新日期:2007-01-01 00:00:00

  • Clinical evaluation of response or escape to chemotherapy and of survival of patients with multiple myeloma. A prospective study of 202 patients (1975-1982).

    abstract::Between 1975 and 1982, 202 previously untreated patients with multiple myeloma (MM) and clinical evidence of disease progression received intensive chemotherapy every 3-5 weeks to induce remission. Treatment regimen included intermittent courses of a combination of cycle non-specific drugs (melphalan, cyclophosphamide...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Bataille R,Souteyrand P,Sany J

    更新日期:1984-11-01 00:00:00

  • Amplified increase in signal transduction activity in cancer cells.

    abstract:AIM:To elucidate the behavior of 1 phosphatidylinositol 4,5 bisphosphate (PIP2) 5 phosphatase (PIP2 5-Pase, EC 3.1.3.36) and 1 phosphatidylinositol 4 phosphate (PIP) 4-phosphatase (PIP 4-Pase) in cancer cells, the steady state activities of PIP2 5-Pase and PIP 4-Pase were determined in the particulate fractions of rat ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yang H,Shen F,Weber G

    更新日期:1999-11-01 00:00:00

  • Surgical outcomes of anatomical resection for solitary recurrent hepatocellular carcinoma.

    abstract:BACKGROUND:For eradicating portal venous tumor extension and intrahepatic metastasis in hepatocellular carcinoma (HCC), anatomical resection is, in theory, preferable. PATIENTS AND METHODS:We carried-out a retrospective cohort study in 110 patients who underwent curative hepatic resection (anatomical resection; n=20, ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yamashita Y,Imai D,Bekki Y,Takeishi K,Tsujita E,Ikegami T,Yoshizumi T,Ikeda T,Shirabe K,Ishida T,Maehara Y

    更新日期:2014-08-01 00:00:00

  • Human bladder carcinoma cells with an unusual pattern of in vitro growth: transition from nonproliferative spheroids to active monolayer growth upon interaction with tumor-derived fibroblasts.

    abstract::A new transitional cell carcinoma cell line, BCCA-1, derived from a primary urinary bladder carcinoma, was characterized with respect to the growth patterns of in vitro culture, xenotransplantability in SCID mice and immunophenotypic profile. The most unusual finding was a strong tendency of forming many aggregates (m...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Chuang CK,Liao SK

    更新日期:2000-03-01 00:00:00

  • Prognostic value of acquired resistance-related molecules in Japanese patients with NSCLC treated with an EGFR-TKI.

    abstract:BACKGROUND:Most patients with lung cancer experience relapse, although epidermal growth factor receptor (EGFR) of tyrosine kinase inhibitor (TKI) has an astounding effect on tumors with EGFR-activating mutations. It is therefore critical to determine the mechanisms of resistance against agents and the prognostic value ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Uramoto H,Yamada T,Yano S,Kondo N,Hasegawa S,Tanaka F

    更新日期:2012-09-01 00:00:00

  • Metastases of human tumors in experimental animals.

    abstract::A large variety of models of both artificial and spontaneous metastases have been developed in experimental animals. These models have enabled the characterization of metastatic cancer cells and have helped in understanding the metastatic process. Studies of experimental metastases of human tumors have so far been rat...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Doré JF,Bailly M,Bertrand S

    更新日期:1987-09-01 00:00:00

  • Reconsideration of macrophage and dendritic cell classification.

    abstract::It is well known that the activation of innate immune cells, especially antigen-presenting cells such as macrophages and dendritic cells, can ameliorate or exacerbate various diseases, including cancer. Currently, the macrophages and dendritic cells are categorized into several groups by their cell surface and intrace...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Kadowaki T,Shimada M,Inagawa H,Kohchi C,Hirashima M,Soma G

    更新日期:2012-06-01 00:00:00

  • Keishi-ka-kei-to, a traditional Chinese herbal medicine, inhibits pulmonary metastasis of B16 melanoma.

    abstract::Keishi-ka-kei-to, a traditional Chinese herbal medicine composed of a mixture of crude extracts from five medicinal plants (Cinnamomi cortex, Paeoniae radix, Zizyphi fructus, Zingiberis rhizoma and Glycyrrhizae radix), inhibited experimental pulmonary metastasis in mice implanted with B16F10 melanoma cells. When 136 t...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Suzuki F,Kobayashi M,Komatsu Y,Kato A,Pollard RB

    更新日期:1997-03-01 00:00:00

  • Clinical trial of photodynamic therapy using acridine orange with/without low dose radiation as new limb salvage modality in musculoskeletal sarcomas.

    abstract::Most patients with musculoskeletal sarcoma do not recover satisfactory limb function after limb salvage surgery. To achieve satisfactory improvement of limb function, we developed a unique surgical modality of photodynamic therapy using acridine orange (AO-PDT) and clinically applied it to patients with musculoskeleta...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kusuzaki K,Murata H,Matsubara T,Miyazaki S,Okamura A,Seto M,Matsumine A,Hosoi H,Sugimoto T,Uchida A

    更新日期:2005-03-01 00:00:00

  • Ferric nitrilotriacetate induced DNA and protein damage: inhibitory effect of a fermented papaya preparation.

    abstract::The carcinogen Fe-NTA catalyzes the hydrogen peroxide-derived production of free radicals and possibly acts through a mechanism involving oxidative stress. Fermented papaya preparation (FPP) has been reported as a natural antioxidant able to prevent lipid peroxidation in vitro and in vivo. However, little is known abo...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Rimbach G,Guo Q,Akiyama T,Matsugo S,Moini H,Virgili F,Packer L

    更新日期:2000-09-01 00:00:00

  • Effect of lipoprotein lipase activators bezafibrate and NO-1886, on B16 melanoma-induced cachexia in mice.

    abstract::Our recent study has demonstrated that B16 melanoma-induced cachexia in mice is inhibited by ponalrestat, an aldose reductase inhibitor, which has the ability to activate lipoprotein lipase (LPL) activity both in vitro and in vivo. In this study, the effect of bezafibrate and NO-1886, LPL activators, on B16 melanoma-i...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kawamura I,Yamamoto N,Sakai F,Yamazaki H,Goto T

    更新日期:1999-09-01 00:00:00

  • Visualization of the metastatic process by green fluorescent protein expression.

    abstract::We demonstrate here the visualization of the cancer metastatic process in live tissue in vivo by green fluorescent protein (GFP) expression. The human lung adenocarcinoma cell-line Anip 973 was transfected with the humanized GFP-S65T cDNA and stable high-level GFP-expressing transfectants were established. GFP transfe...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Chishima T,Miyagi Y,Wang X,Tan Y,Shimada H,Moossa A,Hoffman RM

    更新日期:1997-07-01 00:00:00

  • Microbial conversion of methyl- and methoxy- substituted derivatives of 5H-indolo[2,3-b]quinoline as a method of developing novel cytotoxic agents.

    abstract::In furtherance of our structure-activity relationship studies on the antitumor activity of indolo[2,3-b]quinolines, novel cytotoxic derivatives bearing methyl groups at N-5, C-11, C-2 and/or C-9, as well as methoxy-groups at C-2 and/or C-9, were synthesized by the modified Graebe-Ullmann reaction. To elucidate the met...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Osiadacz J,Kaczmarek L,Opolski A,Wietrzyk J,Marcinkowska E,Biernacka K,Radzikowski C,Jon M,Peczyńska-Czoch W

    更新日期:1999-07-01 00:00:00

  • The Use of Styrene Maleic Acid Nanomicelles Encapsulating the Synthetic Cannabinoid Analog WIN55,212-2 for the Treatment of Cancer.

    abstract:UNLABELLED:Synthetic cannabinoid WIN55,212-2 (WIN) has shown a promise as an anticancer agent but causes psychoactive side-effects. In the present study, nano-micelles of styrene maleic acid (SMA)-conjugated WIN were synthesized to reduce side-effects and increase drug efficacy. SMA-WIN micelles were characterised and ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Xian S,Parayath NN,Nehoff H,Giles NM,Greish K

    更新日期:2015-09-01 00:00:00

  • Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis.

    abstract::Induction of apoptosis by green tea polyphenols has been observed in various tumor cell systems, but whether green tea polyphenol-induced apoptosis requires caspase 3 for execution has not been confirmed. We previously reported that green tea polyphenol-induced apoptosis involved Apaf-1 accumulation and caspase 3 acti...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Hsu S,Lewis J,Singh B,Schoenlein P,Osaki T,Athar M,Porter AG,Schuster G

    更新日期:2003-03-01 00:00:00

  • An Unbalanced Chromosome Translocation Between 7p22 and 12q13 Leads to ACTB-GLI1 Fusion in Pericytoma.

    abstract:BACKGROUND/AIM:Since the first description of five pericytomas with the t(7;12)/ACTB-GLI1 fusion gene, only three new tumors were studied by both cytogenetics and molecular techniques. We report here genetic data on another case of this rare tumor. MATERIALS AND METHODS:Cytogenetic, fluorescence in situ hybridization ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14065

    authors: Panagopoulos I,Gorunova L,Rise TV,Andersen K,Micci F,Heim S

    更新日期:2020-03-01 00:00:00

  • Transmission electron microscopy study of the effects produced by wide-band low-power millimeter waves on MCF-7 human breast cancer cells in culture.

    abstract::Our previous work showed that low-power wide-band millimeter waves (MMW) inhibit the growth of the MCF-7 human breast carcinoma cell line, also causing a marked reduction of the density of microvilli at the apical membrane of the MCF-7 cells, as revealed by scanning electron microscopy. The aim of the present work was...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Beneduci A,Chidichimo G,Tripepi S,Perrotta E

    更新日期:2005-03-01 00:00:00

  • Surveillance and treatment of hereditary non-polyposis colorectal cancer.

    abstract::Hereditary Non-polyposis Colorectal Cancer (HNPCC) has only recently been found to be linked to genetic loci. Clinical means of characterizing subjects at increased familial risk remain valid. If conservative criteria for HNPCC are not met, there remains a sufficiently high risk to first-degree relatives of colorectal...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Lynch PM

    更新日期:1994-07-01 00:00:00

  • In vivo inhibition by antioxidants of adriamycin-induced apoptosis in murine peritoneal macrophages.

    abstract::Adriamycin (ADM) is an oncostatic of the anthracycline family with confirmed experimental and clinical efficiency. This antitumoral drug has been reported to stimulate macrophage activity and is able to induce apoptosis (AP) in some tumour cells. The objective of the present work was to investigate if in vivo administ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Dominguez-Rodriguez JR,Gomez-Contreras PC,Hernandez-Flores G,Lerma-Diaz JM,Carranco A,Cervantes-Munguia R,Orbach-Arbouys S,Bravo-Cuella A

    更新日期:2001-05-01 00:00:00

  • Synchronous Large Gastrointestinal Stromal Tumor and Adenocarcinoma in the Stomach Treated with Imatinib Mesylate Followed by Total Gastrectomy.

    abstract::Herein we report on a case of synchronous large gastrointestinal stromal tumor (GIST) and adenocarcinoma of the stomach treated with radical surgery following neoadjuvant therapy with imatinib mesylate. A 58-year-old man was referred to our hospital with a large mass in the peritoneal cavity. Abdominal computed tomogr...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Namikawa T,Munekage E,Munekage M,Maeda M,Yatabe T,Kitagawa H,Sakamoto K,Obatake M,Kobayashi M,Hanazaki K

    更新日期:2016-04-01 00:00:00

  • Kinetic radical scavenging activity and cytotoxicity of 2-methoxy- and 2-t-butyl-substituted phenols and their dimers.

    abstract::The dimers bis-EUG, bis-MMP, bis-BHA, bis-BMP and bis-DBP were synthesized from the monomers 4-allyl-2-methoxyphenol (EUG), 2-methoxy-4-methylphenol (MMP), 2-t-butyl-4-methoxyphenol (BHA), 2-t-butyl-4-methylphenol (BMP) and 2,4-di-t-butylphenol (DBP), respectively. The stoichiometric factors (n; number of free radical...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Fujisawa S,Atsumi T,Kadoma Y,Ishihara M,Ito S,Yokoe I

    更新日期:2004-09-01 00:00:00

  • Phase I pharmacokinetic study of S-1 granules and nedaplatin for advanced head and neck cancer.

    abstract:AIM:We performed a pharmacokinetic phase I trial of the combination of S-1 granules and nedaplatin for head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS:Patients were treated with both nedaplatin on day 1 at a dose starting at 80 mg/m(2) (level 1) escalating up to 90 mg/m(2) (level 2), and S-1 granul...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Hayashi H,Okamoto I,Ueda S,Tanaka K,Okamoto K,Kawakami H,Nishina S,Takeda M,Fujisaka Y,Satoh T,Terao K,Nishimura Y,Doi K,Nakagawa K

    更新日期:2013-12-01 00:00:00

  • The role of growth factors in central nervous system tumours.

    abstract::The role of growth factors in tumour growth and progression has increasingly been studied over the last few years. This review summarizes the available data and discusses their limitations as well as their potential influence on future therapeutic strategies. A large body of data suggests an important role of EGF, TGF...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Nieder C,Schlegel J,Andratschke N,Thamm R,Grosu AL,Molls M

    更新日期:2003-03-01 00:00:00

  • Pleural effusion as a significant prognostic factor in non-small cell lung cancer.

    abstract:UNLABELLED:In non-small cell lung cancer (NSCLC), pleural effusion is a frequently observed complication, and often provides a treatment difficulties. The aim of this study is to evaluate prognostic significance of pleural effusion in patients with NSCLC. MATERIALS AND METHODS:Seven hundred and eight untreated patient...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Naito T,Satoh H,Ishikawa H,Yamashita YT,Kamma H,Takahashi H,Ohtsuka M,Hasegawa S

    更新日期:1997-11-01 00:00:00