Detection of lung cancer by FDG-PET cancer screening program: a nationwide Japanese survey.

abstract：BACKGROUND:This study sought to better define the immunological impact of combining neoadjuvant total androgen suppression (TAS) with radiotherapy (xRT) in treating prostate cancer. MATERIALS AND METHODS:Subjects selected (n = 37) were stage I-II prostate cancer patients meeting the eligibility requirements for RTOG p...

journal_title：Anticancer research

authors： Johnke RM,Edwards JM,Kovacs CJ,Evans MJ,Daly BM,Karlsson UL,Lee TK,Allison RR,Arastu HH,Cariveau MJ,O'Brien KF

更新日期：2005-07-01 00:00:00

abstract：:VP-16 and ICRF-193 are different types of antitumor topoisomerase II inhibitors, being cleavable and non-cleavable complex-stabilizing types, respectively. To examine the possibility of enhancing the efficacy of combination chemotherapy, we carried out simultaneous and sequencial treatment of cells with the two drugs....

journal_title：Anticancer research

authors： Ishida R,Iwai M,Hara A,Andoh T

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Long-acting sandostatin (S-LAR; octreotide acetate) is well tolerated and effective for symptom control and possibly disease control in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). We undertook a retrospective analysis to study the efficacy and tolerability of higher doses (more than 20-30 mg/mon...

journal_title：Anticancer research

authors： Chadha MK,Lombardo J,Mashtare T,Wilding GE,Litwin A,Raczyk C,Gibbs JF,Kuvshinoff B,Javle MM,Iyer RV

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIM:Sarcoma of the oral cavity is rare accounting for around 1% of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma. PATIENTS AND METHODS:The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of...

journal_title：Anticancer research

authors： Sumida T,Otawa N,Kamata YU,Yamada T,Uchida K,Nakano H,Hamakawa H,Yamamoto T,Ueyama Y,Mori Y

更新日期：2015-08-01 00:00:00

abstract：:Hepatocellular carcinoma is one of the most common malignancies in the world, with the liver being the second most frequently involved organ in metastatic disease. Although the gold standard treatment for malignant liver disease is surgical resection, only few patients can undergo such an intervention. This explains t...

journal_title：Anticancer research

authors： Poggi G,Riccardi A,Quaretti P,Teragni C,Delmonte A,Amatu A,Saini G,Mazzucco M,Bernardo A,Palumbo R,Canto A,Bernieri S,Bernardo G

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Neutral endopeptidase 24.11 (NEP) is a cell-surface peptidase that inactivates a variety of neuropeptide substrates. In addition to catalytic activity, NEP can exert biological effects through protein-protein interactions. We previously reported that NEP directly associated with tyrosine-phosphorylated Lyn k...

journal_title：Anticancer research

authors： Shen R,Milowsky MI,Ozaki N,Navarro D,Sumitomo M,Xu Y,Nanus DM

更新日期：2002-09-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) represents the most malignant primary brain tumor in adults with generally dismal prognosis, early clinical deterioration and high mortality. GBM is extremely invasive, characterized by intense and aberrant vascularization and high resistance to multimodal treatment. Standard therapy (sur...

journal_title：Anticancer research

authors： Polivka J Jr,Polivka J,Holubec L,Kubikova T,Priban V,Hes O,Pivovarcikova K,Treskova I

更新日期：2017-01-01 00:00:00

abstract：:Adriamycin (ADM) is an oncostatic of the anthracycline family with confirmed experimental and clinical efficiency. This antitumoral drug has been reported to stimulate macrophage activity and is able to induce apoptosis (AP) in some tumour cells. The objective of the present work was to investigate if in vivo administ...

journal_title：Anticancer research

authors： Dominguez-Rodriguez JR,Gomez-Contreras PC,Hernandez-Flores G,Lerma-Diaz JM,Carranco A,Cervantes-Munguia R,Orbach-Arbouys S,Bravo-Cuella A

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The possibilities and limitations of computer tomography (CT) examination for detecting primary gastric cancer tumors have been poorly understood. The aim of the present study was to evaluate the pre-operative assessment of gastric cancer tumors using 32-multidetector row-CT. PATIENTS AND METHODS:A prospect...

journal_title：Anticancer research

authors： Kikuchi S,Futawatari N,Sakuramoto S,Watanabe M,Kubota K,Sasaki M,Murata K,Kida M

更新日期：2006-11-01 00:00:00

abstract：UNLABELLED:The aim of this study wsa to evaluate the additive effect of valproic acid (VPA) to γδ T-cell cytotoxicity against bladder cancer cells. MATERIALS AND METHODS:Human bladder cancer cell lines TCCSUP and 253J were treated with VPA and mRNA expression of natural killer group 2D (NKG2D) ligands was determined. ...

journal_title：Anticancer research

authors： Suzuki T,Terao S,Acharya B,Naoe M,Yamamoto S,Okamura H,Gotoh A

更新日期：2010-11-01 00:00:00

abstract：:Intrinsic or acquired resistance of pancreatic cancer to gemcitabine (2'-deoxy-2'-difluorodeoxycytidine) is an important factor in the failure of gemcitabine treatment. Proteomic analysis of gemcitabine-sensitive KLM1 pancreatic cancer cells and -resistant KLM1-R cells identified heat-shock protein-27(HSP27) as a biom...

journal_title：Anticancer research

authors： Kuramitsu Y,Suenaga S,Wang Y,Tokuda K,Kitagawa T,Tanaka T,Akada J,Maehara S,Maehara Y,Nakamura K

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND/AIM:Recent innovations in the treatment of multiple myeloma have enriched our therapeutic repertoire regarding the treatment of multiple myeloma during the last decades. However, despite today's therapies many multiple myeloma (MM) patients experience relapse of disease and eventually remain incurable. Wnt/β...

journal_title：Anticancer research

authors： Schmeel LC,Schmeel FC,Schmidt-Wolf IGH

更新日期：2017-07-01 00:00:00

abstract：:Selective delivery of a high level of Mitomycin C (MMC) in intraperitoneal disseminated lesions was studied using a new dosage form of MMC, called MMC-CH. Intracavitary MMC-CH delivered a much higher level of MMC selectively to intraperitoneal tissues, with a much lower level of MMC in the whole body, in comparison wi...

journal_title：Anticancer research

authors： Hagiwara A,Takahashi T,Lee R,Ueda T,Takeda M,Itoh T

更新日期：1986-09-01 00:00:00

abstract：:Normal resident peritoneal macrophages from BALB/c mice were continuously grown and expanded in vitro as non tumorigenic cells on a confluent layer of mesothelial cells. These peritoneal macrophages expanded in vitro (EPM) were very cytotoxic against EMT6 sarcoma, Abelson myeloma, EL4, and L929S cells in culture. This...

journal_title：Anticancer research

authors： Bartholeyns J,Lombard Y,Poindron P

更新日期：1988-01-01 00:00:00

abstract：:Several signaling pathways have been recognized in normal c-kit-mediated signal transduction following stem cell factor (SCF) stimulation including Janus kinase (JAK)/signal transducer and activator of transcription (STAT), mitogen-activated protein kinase (MAPK) and phosphoinositol 3-kinase (PI-3 K) pathways. In gast...

journal_title：Anticancer research

authors： Paner GP,Silberman S,Hartman G,Micetich KC,Aranha GV,Alkan S

更新日期：2003-05-01 00:00:00

abstract：:A 70-year-old man with a growing liver tumor had undergone subtotal gastrectomy with pancreaticoduodenectomy for gastric cancer (T4b P0 H0 N1, Stage IIIB) 30 months before admission to our hospital. Enhanced computed tomography revealed two hypervascular nodules in segments 4 and 8. After histological diagnosis of sma...

journal_title：Anticancer research

authors： Kinoshita K,Beppu T,Miyata T,Kuramoto K,Yoshida Y,Umesaki N,Kitano Y,Nakagawa S,Okabe H,Nitta H,Imai K,Hayashi H,Yamashita YI,Komori H,Horino K,Misumi A,Baba H

更新日期：2018-03-01 00:00:00

abstract：AIM:The aim of the study was to identify novel biomarkers that are vital for improving management of patients with gastric cancer (GC). MATERIALS AND METHODS:An RNA-sequencing analysis was conducted using gastric tissue from patients with metastatic GC. In vitro cell functions were evaluated by siRNA-mediated knockdow...

journal_title：Anticancer research

authors： Sawaki K,Kanda M,Umeda S,Miwa T,Tanaka C,Kobayashi D,Hayashi M,Yamada S,Nakayama G,Omae K,Koike M,Kodera Y

更新日期：2019-11-01 00:00:00

abstract：:Three monoclonal antiidiotypic antibodies (AIA) to MOPC 315 IgA, G3 (IgG2b), A2 (IgG1) and D10 (a hybrid molecule consisting of gamma 1 and gamma 2a heavy chains), were characterized with respect to their binding constants (Ka) to MOPC 315 mouse myeloma cells. The Ka of G3 and A2 was 10(8)/mole; and that of D10 was 3 ...

journal_title：Anticancer research

authors： Marks A,Baumal R,Lei M,Ahmad A,Liu E

更新日期：1985-07-01 00:00:00

abstract：:Simultaneous administration of medroxyprogesterone acetate (MPA) and tamoxifen markedly elevated the serum alanine and aspartate aminotransferase activities in 4 out of 30 patients with endometrial or ovarian carcinoma; and also slightly increased the activities of gamma-glutamyl transferase in 2 of the patients. Thes...

journal_title：Anticancer research

authors： Riippa P,Kauppila A,Sundström H,Vihko R

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen and predominant target for cancer immunotherapy. Its detection is only established based on gene expression. In this study, we established a monoclonal antibody against KK-LC-1 to detect its protein expression in formalin-fixed samples. ...

journal_title：Anticancer research

authors： Kondo Y,Fukuyama T,Yamamura R,Futawatari N,Ichiki Y,Tanaka Y,Nishi Y,Takahashi Y,Yamazaki H,Kobayashi N,Watanabe M

更新日期：2018-10-01 00:00:00

abstract：:The expression of the HMG-CoA-reductase and LDL-receptor genes was examined in primary human embryonic tumours and in normal human first trimester foetal tissues. All embryonic and extra-embryonic tissues examined contained RNA that hybridized with the HMG-CoA-reductase and LDL-receptor cDNA-probes. However, the trans...

journal_title：Anticancer research

authors： Engström W,Schofield PN

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND/AIM:The amino acid positron emission tomography (PET) tracer [(18)F]-3-fluoro-alpha-methyltyrosine ((18)F-FAMT) is known to be highly specific for malignancies. We evaluated the accumulation of (18)F-FDG or (18)F-FAMT in lymph nodes (LN) prior to definitive chemoradiotherapy (CRT) for esophageal cancer. PAT...

journal_title：Anticancer research

authors： Sohda M,Miyazaki T,Honjyo H,Hara K,Ozawa D,Suzuki S,Tanaka N,Sano A,Sakai M,Yokobori T,Nakajima M,Fukuchi M,Kato H,Higuchi T,Tsushima Y,Kuwano H

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND/AIM:Variations in cell phenotype in a single-cell-derived clone may result from asymmetric cell divisions that lead to different cell fate in a homogenous microenvironment. The aim of this study was to demonstrate the extent of cell variety in single-cell-derived clones and propose a different strategy in tr...

journal_title：Anticancer research

authors： Khan GN,Kim EJ,Shin TS,Lee SH

更新日期：2017-05-01 00:00:00

abstract：AIM:The primary aim of the study was to assess the association between risk of recurrence and HER2 equivocal gene status through immunohistochemistry in patients with early breast cancer. PATIENTS AND METHODS:We retrospectively analyzed clinical and pathological data of 455 consecutive patients with early breast cance...

journal_title：Anticancer research

authors： Criscitiello C,Bagnardi V,Viale G,Disalvatore D,Rotmensz N,Esposito A,Goldhirsch A,Curigliano G

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND/AIM:Combining an anticancer agent fenretinide (HPR) or C6-pyridinium ceramide (LCL29) with Foscan-mediated photodynamic therapy (FoscanPDT) is expected to augment anticancer benefits of each substance. We showed that treatment with FoscanPDT+HPR enhanced accumulation of C16-dihydroceramide, and that fumonisi...

journal_title：Anticancer research

authors： Boppana NB,Kraveka JM,Rahmaniyan M,Li LI,Bielawska A,Bielawski J,Pierce JS,Delor JS,Zhang K,Korbelik M,Separovic D

更新日期：2017-02-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to assess the extent of the systemic absorption of cisplatin during intraoperative hyperthermic peritoneal lavage (IHPL) in patients with locally advanced gastric cancer. MATERIALS AND METHODS:The pharmacokinetics and nephrotoxicity of cisplatin were analyzed in patients receiv...

journal_title：Anticancer research

authors： Kern W,Braess J,Kotschofsky M,Samel S,Becker H,Hiddemann W,Schleyer E

更新日期：2002-09-01 00:00:00

abstract：:Hypoxia, a condition of reduced oxygen concentration, is observed in many physiological and pathophysiological states. However, there is rather limited information regarding hypoxic effects in the processes of immortalization and senescence of human cells. Here, the effects of hypoxia induced by either 1.5% O2, or by ...

journal_title：Anticancer research

authors： Poulios E,Trougakos IP,Gonos ES

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Malignant melanoma is a life-threatening disease with a poor prognosis due to its capacity for rapid metastasis and resistance to radio- and chemo-therapy. A pharmacological compound, CP-31398, was recently found to be able to stabilize wild-type p53 and rescue mutant p53 to enhance its transcriptional activ...

journal_title：Anticancer research

authors： Luu Y,Li G

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the role of radiation therapy alone, employing standard fractionation, in stage III-IV hypopharyngeal carcinoma. MATERIALS AND METHODS:Fourteen (38.9%) stage III and 22 (61.1%) stage IV patients with hypopharyngeal carcinoma were submitted, with curative intent, to excl...

journal_title：Anticancer research

authors： Tombolini V,Santarelli M,Raffetto N,Donato V,Valeriani M,Ferretti A,Enrici RM

更新日期：2004-01-01 00:00:00

abstract：:In vivo investigations on oncogene action may provide new findings on the toxicology of potential carcinogens. In this study we investigated the early effects of different cytostatic protocols on early oncogene expression in CBA/Ca mice. Most of the examined protocols showed detectable early changes, especially those ...

journal_title：Anticancer research

authors： Ember I,Raposa T,Varga C,Kiss I

更新日期：1995-07-01 00:00:00