Radiotherapy in the treatment of stage III-IV hypopharyngeal carcinoma.

abstract：BACKGROUND:Lung cancer is the second leading cause of mortality among men and women in the U.S. Among different varieties of lung cancer, the non-small cell lung cancer (NSCLC) has the highest frequency comprising about 85% of cases. We evaluated 1-methyl-4-phenylpyridinium ion (MPP(+)) for cytotoxicity against human l...

journal_title：Anticancer research

authors： Badisa RB,Mina DA,Latinwo LM,Soliman KF

更新日期：2014-10-01 00:00:00

abstract：AIM:We hypothesized that a nomogram can accurately predict overall survival (OS) for patients with intrahepatic cholangiocarcinoma (ICC) after hepatectomy. MATERIALS AND METHODS:A nomogram to predict OS based was developed using data from 185 ICC patients who had undergone hepatectomy. The nomogram was evaluated by co...

journal_title：Anticancer research

authors： Yeh CN,Wang SY,Chen YY,Chen MH,Chiang KC,Cheng CT,Tsai CY,Wang CC,Yeh TS,Chen TC

更新日期：2016-08-01 00:00:00

abstract：:Annexins belong to a family of the calcium-dependent phospholipid binding proteins. They are also substrates of receptor tyrosine kinases. Overexpression of Annexin II, which has been reported in various carcinomas, is thought to be associated with cell proliferation, differentiation and cell-cell adhesion in the path...

journal_title：Anticancer research

authors： Emoto K,Sawada H,Yamada Y,Fujimoto H,Takahama Y,Ueno M,Takayama T,Uchida H,Kamada K,Naito A,Hirao S,Nakajima Y

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:In breast carcinomas, prolonged signalling through the TGF-beta receptor promotes latent tumour progression, metastasis and the epithelial-to-mesenchymal transition of tumour cells. Previously, it has been found that the 154 amino acid RING finger protein, RNF11, was overexpressed in high-grade breast tumour...

journal_title：Anticancer research

authors： Azmi PB,Seth AK

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIM:Vimentin3 (Vim3) was recently described as a tumour marker for the direct discrimination between benign and malignant kidney tumours. Here, we examined its expression in prostate cancer (PCa) cell lines and the regulation of its expression by endothelin receptors. MATERIALS AND METHODS:Prostate cancer c...

journal_title：Anticancer research

authors： KÖditz B,Stog A,GÖbel H,Heidegger I,Fries J,Heidenreich A,VON Brandenstein M

更新日期：2021-01-01 00:00:00

abstract：AIM:Modern radiotherapy (RT) technique and therapy de-escalation have led to encouraging results in lymphoma management. In this study, we aimed to describe the oncological and toxicity outcome in patients with ocular adnexal lymphoma. PATIENTS AND METHODS:A total of 45 patients with 52 orbital lesions who were treate...

journal_title：Anticancer research

authors： Rehn S,Elsayad K,Oertel M,Baehr A,Eter N,Haverkamp U,Lenz G,Eich HT

更新日期：2020-07-01 00:00:00

abstract：:Ovarian cancer is the most lethal malignancy among gynaecological cancers. Although many anticancer agents have been developed for the treatment of ovarian cancer, it continues to have an extremely poor prognosis. Heparin-binding epidermal growth factor-like grown factor (HB-EGF) has been reported to be a rational the...

journal_title：Anticancer research

authors： Miyata K,Yotsumoto F,Fukagawa S,Kiyoshima C,Ouk NS,Urushiyama D,Ito T,Katsuda T,Kurakazu M,Araki R,Sanui A,Miyahara D,Murata M,Shirota K,Yagi H,Takono T,Kato K,Yaegashi N,Akazawa K,Kuroki M,Yasunaga S,Miyamoto S

更新日期：2017-07-01 00:00:00

abstract：:Phorbol ester, 12-0-Tetradecanoyl-13-Phorbol-Acetate (TPA), induces a terminal macrophage-like differentiation of cells from human acute myelogenous leukemia cell lines. We report here that blastoid cells obtained from acute nonlymphocytic leukemia (M1-M2) undergo differentiation-related changes characteristic of macr...

journal_title：Anticancer research

authors： Joshi KS,Rao SG,Joshi DS,Advani SH,Bhisey AN

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Urocortin and corticotropin-releasing factors (CRFs) and their receptors are expressed in many organs, including the central nervous system. In this study, the expression of mRNAs of urocortin 1, 2, 3, and CRF and CRF receptors 1 and 2 in malignant glioma, was examined. MATERIALS AND METHODS:The RNAs of hum...

journal_title：Anticancer research

authors： Kamada M,Ikeda K,Fujioka K,Akiyama N,Akiyoshi K,Inoue Y,Hanada S,Yamamoto K,Tojo K,Manome Y

更新日期：2012-12-01 00:00:00

abstract：:Eighteen patients with advanced melanoma of the limbs underwent a single isolation perfusion with melphalan under normothermic conditions, i.e. tissue temperatures between 37.0 and 38.0 degrees C. There were no major complications. In 7 patients complete remission was achieved and in 8 the remission was partial, i.e. ...

journal_title：Anticancer research

authors： Kroon BB,Van Geel AN,Benckhuijsen C,Wieberdink J

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Experimental data at the molecular, cellular and organismal levels have implicated dietary components in cancer. Exposure to numerous growth factors, hormones and environmental agents, that can regulate signaling events, is involved in carcinogenesis. Research targets on gene-nutrient interactions may give u...

journal_title：Anticancer research

authors： Updike MS,Sawdy JC,Wang LS,Liu S,Huang YW,Ye W,Farrar WB,Lin YC,Wick M

更新日期：2007-01-01 00:00:00

abstract：:This study was designed to determine whether circulating cancer cells in patients with gastric cancer can be identified by a RT-PCR method and to assess the clinical significance of the hematogenic dissemination of cancer cell in gastric cancer patients. A total of 41 patients with gastric cancer were enrolled in this...

journal_title：Anticancer research

authors： Nishida S,Kitamura K,Ichikawa D,Koike H,Tani N,Yamagishi H

更新日期：2000-05-01 00:00:00

abstract：UNLABELLED:The aim of this study was to investigate the apoptosis resulting from NSC 95397, brefeldin A, bortezomib and sanguinarine in neuroendocrine tumor cell lines. MATERIALS AND METHODS:A multiparametric high-content screening assay for measurement of apoptosis was used. The human pancreatic carcinoid cell line, ...

journal_title：Anticancer research

authors： Larsson DE,Wickström M,Hassan S,Oberg K,Granberg D

更新日期：2010-01-01 00:00:00

abstract：:Paclitaxel has been approved as second-line therapy after anthracyclines in AIDS-Kaposi's sarcoma (KS) patients. To date, only one patient with classical KS and treated with standard dose (175 mg/m2) 3-weekly paclitaxel as first line therapy has been reported in the literature. Herein, the first case is presented of a...

journal_title：Anticancer research

authors： Silvestris N,Galetta D,Colucci G

更新日期：2009-02-01 00:00:00

abstract：:The suitability of CK20 mRNA expression as a marker for the detection of minimum residual disease in patients with cancer of epithelial origin was evaluated. A sensitive nested RT-PCR assay with multiple replicates was optimised to detect a minimum number of circulating tumor cells expressing cytokeratin 20 (CK20) mRN...

journal_title：Anticancer research

authors： Champelovier P,Mongelard F,Seigneurin D

更新日期：1999-05-01 00:00:00

abstract：:The number of silver stained nucleolar organiser regions (AgNORs) was assessed in biopsy specimens of 78 patients with prostatic adenocarcinoma followed up for a mean of 15.6 years. The number of Ag-NORs was related to histological features, clinical stage, DNA ploidy, S-phase fraction (SPF) and clinical outcome. In 3...

journal_title：Anticancer research

authors： Eskelinen M,Lipponen P,Syrjänen K

更新日期：1992-09-01 00:00:00

abstract：:In furtherance of our structure-activity relationship studies on the antitumor activity of indolo[2,3-b]quinolines, novel cytotoxic derivatives bearing methyl groups at N-5, C-11, C-2 and/or C-9, as well as methoxy-groups at C-2 and/or C-9, were synthesized by the modified Graebe-Ullmann reaction. To elucidate the met...

journal_title：Anticancer research

authors： Osiadacz J,Kaczmarek L,Opolski A,Wietrzyk J,Marcinkowska E,Biernacka K,Radzikowski C,Jon M,Peczyńska-Czoch W

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this study was to determine the molecular and clinicopathological features, as well as the prognosis of patients with endometrial cancer (EC) having prior malignancy (second primary EC: SPEC) compared with those without a history of prior malignancy (first primary EC: FPEC). MATERIALS A...

journal_title：Anticancer research

authors： Haraga J,Nakamura K,Haruma T,Nyuya A,Nagasaka T,Masuyama H

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND/AIM:γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Hanada E,Kageyama S,Murai R,Kubota S,Ii H,Nakata S,Kita H,Kawauchi A,Chano T

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Melanoma is characterized by high resistance to chemotherapy. The aim of this study was to investigate combined effects of doxorubicin and parthenolide on melanoma cells. MATERIALS AND METHODS:Thiazolyl blue tetrazolium bromide (MTT) assay and flow cytometry were used to evaluate viability. The p53 levels a...

journal_title：Anticancer research

authors： Wozniak M,Szulawska-Mroczek A,Hartman ML,Nejc D,Czyz M

更新日期：2013-08-01 00:00:00

abstract：:The CSEIL/CAS protein (CAS) is a Ran-binding protein with a function as a nuclear transport (export) factor. CSEIL/CAS, similar to Ran and other ran-binding proteins, plays at the same time an important role in the mitotic spindle checkpoint, which assures genomic stability during cell division. This checkpoint is fre...

journal_title：Anticancer research

authors： Behrens P,Brinkmann U,Fogt F,Wernert N,Wellmann A

更新日期：2001-07-01 00:00:00

abstract：AIM:Brucea javanica was studied to identify nuclear factor kappaB (NF-κB) inhibitors exhibiting reactive oxygen species (ROS) intracellular amplification. MATERIAL AND METHODS:Eight compounds were evaluated for selective cytotoxicity using HT-29, HeLa, and HL-60 cells, and in a NF-κB assay. Active compounds were then ...

journal_title：Anticancer research

authors： Kim JA,Lau EK,Pan L,De Blanco EJ

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the usefulness of reverse transcription-polymerase chain reaction (RT-PCR) for detecting anaplastic lymphoma kinase (ALK) translocations using cytology samples from lung cancer patients. MATERIALS AND METHODS:We analyzed ALK translocations by RT-PCR in cytology samples from lung cancer pati...

journal_title：Anticancer research

authors： Nakamichi S,Seike M,Miyanaga A,Chiba M,Matsuda K,Kobayashi K,Takahashi A,Takeuchi S,Minegishi Y,Kubota K,Gemma A

更新日期：2017-06-01 00:00:00

abstract：:Approximately 85% of patients with advanced ovarian cancer will experience recurrence of the disease. In 311 patients CA125 serum levels were determined at follow up investigation in our department. A sensitivity of 92% and specificity of 89% were calculated. Reflecting the further course of disease, specificity could...

journal_title：Anticancer research

authors： Meier W,Baumgartner L,Stieber P,Hasholzner U,Fateh-Moghadam A

更新日期：1997-07-01 00:00:00

abstract：:Despite progress in chemotherapeutic agents, non-small cell lung cancers (NSCLC) still have a poor survival rate. Thus, development of new therapeutic strategies, specifically against cancer cells is still required. For this purpose, we treated the non-small cell lung cancer cell line NSCLC-N6 with the natural product...

journal_title：Anticancer research

authors： Jacquot C,Rousseau B,Carbonnelle D,Chinou I,Malleter M,Tomasoni C,Roussakis C

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND/AIM:New anticancer drugs are usually tested on cancer cells in culture in a standard medium. We stimulated immune polynuclear cells by lipopolysaccharides to obtain an enriched medium (EM) containing inflammatory cytokines more closely reflecting the tumor microenvironment and tested a rhenium-diselenium (Re...

journal_title：Anticancer research

authors： Veena V,Harikrishnan A,Lakshmi B,Khanna S,Desmaele D,Collery P

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND/AIM:Gefitinib and erlotinib were shown to be particularly effective in a clinically selected subpopulation of non-small cell lung cancer patients (NSCLC): adenocarcinoma histology, non-smoking status, Asian origin and female gender have been associated with improved clinical benefit compared to the unselecte...

journal_title：Anticancer research

authors： Bonanno L,Schiavon M,Nardo G,Bertorelle R,Bonaldi L,Galligioni A,Indraccolo S,Pasello G,Rea F,Favaretto A

更新日期：2010-12-01 00:00:00

abstract：AIM:To evaluate the role of low mechanical index (MI) contrast-enhanced sonography (CEUS) for the characterization of small hepatocellular carcinomas (HCC) in cirrhotic patients by comparing the results to ultrafast dynamic gadolinium-enhanced magnetic resonance imaging (MRI) studies. MATERIALS AND METHODS:Between Sep...

journal_title：Anticancer research

authors： Giorgio A,De Stefano G,Coppola C,Ferraioli G,Esposito V,Di Sarno A,Giorgio V,De Stefano M,Sangiovanni V,Liorre G,Del Viscovo L

更新日期：2007-11-01 00:00:00

abstract：:The sodium iodide symporter (NIS) is a plasma membrane protein that mediates active uptake of inorganic iodide from plasma into thyroid cells. Expression of the NIS gene in tumor cells may provide a novel mechanism for treating cancer. Previously, we cloned cDNA of rat NIS into the retroviral vector LXSN, transduced h...

journal_title：Anticancer research

authors： Mitrofanova E,Hagan C,Qi J,Seregina T,Link C Jr

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:The standard treatment of epithelial ovarian cancer is tumor debulking by surgery, followed by six cycles of chemotherapy consisting of cisplatinum and paclitaxel. However, this therapy protocol is not satisfactory, since about 50% of the treated patients eventually experience recurrence within a few years o...

journal_title：Anticancer research

authors： Law KS,Chen HC,Liao SK

更新日期：2007-03-01 00:00:00