Abstract：
:Intrinsic or acquired resistance of pancreatic cancer to gemcitabine (2'-deoxy-2'-difluorodeoxycytidine) is an important factor in the failure of gemcitabine treatment. Proteomic analysis of gemcitabine-sensitive KLM1 pancreatic cancer cells and -resistant KLM1-R cells identified heat-shock protein-27(HSP27) as a biomarker protein which is involved in gemcitabine resistance. However, a knock-down experiment showed that HSP27 was not the only protein implicated with gemcitabine-resistance. Finding further candidate proteins is necessary for achieving effective gemcitabine therapy for patients with pancreatic cancer. DDX39 is an Asp-Glu-Ala-Asp (DEAD)-box RNA helicase reported to be overexpressed in tumor cells, such as lung squamous cell cancer, gastrointestinal stromal tumor, urinary bladder cancer and malignant pleural mesothelioma. In urinary bladder cancer cells, overexpression of this protein is intimately bound with tumorigenesis and poor prognosis. In the present study, the expression of DDX39 in gemcitabine-sensitive KLM1 and -resistant KLM1-R cells was compared. It was found that DDX39 was significantly up-regulated in gemcitabine-resistant KLM1-R cells compared to sensitive KLM1 cells. The ratio of expression of DDX39 to that of actin was significantly up-regulated in KLM1-R cells compared to KLM1 cells (p=0.0072 by Student's t-test). These results suggest that DDX39 is a possible candidate biomarker for predicting the response of patients with pancreatic cancer to treatment with gemcitabine.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kuramitsu Y,Suenaga S,Wang Y,Tokuda K,Kitagawa T,Tanaka T,Akada J,Maehara S,Maehara Y,Nakamura Ksubject
Has Abstractpub_date
2013-08-01 00:00:00pages
3133-6issue
8eissn
0250-7005issn
1791-7530pii
33/8/3133journal_volume
33pub_type
杂志文章abstract：AIM:The aim of the present study was to determine if febuxostat could prevent tumor lysis syndrome (TLS) in children who received induction chemotherapy for hematologic malignancies. PATIENTS AND METHODS:A retrospective analysis was performed in 45 pediatric patients with hematological malignancies who received febuxo...
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pub_type： 杂志文章
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journal_title：Anticancer research
pub_type： 杂志文章
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
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doi：
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doi：
更新日期：2001-11-01 00:00:00
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journal_title：Anticancer research
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doi：
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doi：
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journal_title：Anticancer research
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