Abstract：
BACKGROUND:Prognosis of renal cell carcinoma (RCC) differs within the same stage and grade. Our aim was to investigate the incidence of COX-2 in primary RCC tumors at different stages according to the occurrence of metastasis, and the impact of this biomarker on the survival of RCC patients. PATIENTS AND METHODS:The cytoplasmic/membranous COX-2 protein expression was examined by immunohistochemistry in RCC tumors from 102 patients. The patients were divided into those with: no metastasis during 7.5 years' follow-up (nm), no metastasis at the time of nephrectomy but who later developed metastases (lm), and those with metastasis at presentation (pm). The immunoreactivity of COX-2 was classified as none (absent/weak intensity in fewer than 10% of the cancer cells), low (weak intensity in over 10% of the cancer cells) or high immunostaining (strong intensity in the majority of the cancer cells). In addition p53 and Ki-67 immunostaining was also assessed in tumors. RESULTS:Percentages of COX-2 reaction were (no/low/high): 78/16/7 in the nm, 53/28/19 in the lm, 92/8/0 in the pm groups (p=0.014). Median metastasis-free survival was shorter in lm patients with COX-2-negative tumors when compared to those with COX-2-positive ones (15 vs. 46 months; p=0.020). Median overall survival was shorter in pm/lm patients with COX-2-negative tumors when compared to those with COX-2-positive ones (28 vs. 94 months; p=0.027), and with COX-2-negative/Ki-67-positive tumors when compared to COX-2-positive/Ki-67-negative ones (19 vs. 97 months; p=0.004). Findings for patients with COX-2-negative/p53-positive tumors were similar, with shorter survival compared to those with COX-2-positive/p53-negative ones (19 vs. 97; p=0.006). CONCLUSION:COX-2 protein expression is associated with slow development of metastases, and favourable prognosis in metastatic RCC.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kankuri-Tammilehto MK,Söderström KO,Pelliniemi TT,Vahlberg T,Pyrhönen SO,Salminen EKsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
3023-30issue
7eissn
0250-7005issn
1791-7530pii
30/7/3023journal_volume
30pub_type
杂志文章abstract：:The prognosis of patients with pancreatic cancer is very poor because of late diagnosis and the lack of response to various therapies. Pancreatic cancer is generally resistant to chemotherapy and is highly fatal. Gemcitabine (GEM) appears to be the only effective agent for treatment of pancreatic cancer. However, a hi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND/AIM:Human lectins translate sugar-encoded signals of cell surface glycoconjugates into biological effects, and this is what is known for the adhesion/growth-regulatory galectins. In addition, the multifunctional members of this group can be intracellular, binding to distinct proteins. The presence of galecti...
journal_title：Anticancer research
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doi：
更新日期：2013-08-01 00:00:00
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pub_type： 杂志文章
doi：10.21873/anticanres.14125
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journal_title：Anticancer research
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更新日期：2009-07-01 00:00:00
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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doi：
更新日期：2015-09-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
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更新日期：1998-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：2002-09-01 00:00:00
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doi：
更新日期：2010-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
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更新日期：2014-12-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,随机对照试验
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更新日期：2019-10-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
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doi：
更新日期：2002-03-01 00:00:00
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更新日期：2006-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：2010-09-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
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更新日期：2003-03-01 00:00:00
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