The standpoint of AIDS research and therapy programs.

Abstract:

:Considerable progress has recently been achieved in understanding the pathogenesis of human immunodeficiency virus type 1 (HIV-1), and in improving the efficacy of antiretroviral therapies for the treatment of patients with the acquired immunodeficiency syndrome (AIDS). The pharmacological properties of new drugs are very effective in establishing a long-term suppression of HIV-1 replication, and have remarkably increased the survival period of patients with AIDS. However, current antiretroviral therapies are still far from eradicating HIV-1 from patients, and do not prevent the development of AIDS-related malignancies, which affect 40% of individuals infected by HIV-1. The malignancies that are considered AIDS-related are: Kaposi's sarcoma, non-Hodgkin lymphoma, intraepithelial cervical carcinoma and anal neoplasia. Their incidence is expected to increase as the survival period of patients with AIDS lengthens. Also, the cost of antiretroviral therapies poses a limit to the development of successful global intervention to tackle the worldwide spreading of AIDS, that, by the year 2000, will affect 40 million individuals. Some 90% of these new infections are occurring in developing countries, which can not afford the cost of antiretroviral therapies, and are not able to ensure a proper follow up of patients with AIDS. In addition, cultural and ethical problems make difficult the achievement of an adequate education of how to prevent the spreading of AIDS among populations of poorer countries. On these grounds, the field of AIDS research is evaluating alternative therapeutic approaches for the treatment and prevention of AIDS.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Romano G,Massi D,Giordano A

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

2763-78

issue

4B

eissn

0250-7005

issn

1791-7530

journal_volume

18

pub_type

杂志文章,评审
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    authors: Kaibuchi T,Furuya Y,Akakura K,Masai M,Ito H

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    authors: DA Cruz Paula A,Marques O,Rosa AM,DE Fátima Faria M,Rêma A,Lopes C

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  • Adjuvant docetaxel, cisplatin and 5-fluorouracil (TPF) in locally advanced squamous cell carcinoma of the head and neck.

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    authors: Baghi M,Hambek M,May A,Radeloff A,Gstoettner W,Knecht R

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    journal_title:Anticancer research

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    authors: Takenawa T,Kuramitsu Y,Wang Y,Okada F,Tokuda K,Kitagawa T,Ueyama Y,Nakamura K

    更新日期:2013-01-01 00:00:00

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    journal_title:Anticancer research

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    doi:

    authors: Sugeno H,Takebayashi Y,Higashimoto M,Ogura Y,Shibukawa G,Kanzaki A,Terada K,Sugiyama T,Watanabe K,Katoh R,Nitta Y,Fukushima T,Koyama Y,Inoue N,Sekikawa K,Ogawa K,Sato Y,Takenoshita S

    更新日期:2004-03-01 00:00:00

  • Intermediate stage Hodgkin's disease: preliminary results on 210 patients treated with four ABVD chemotherapy cycles plus extended versus involved field radiotherapy.

    abstract:BACKGROUND:To improve long-term survival by reducing toxicity in intermediate stage Hodgkin's disease patients, we compared the effects of involved field (IF) versus extended field (EF) irradiation administered after four cycles of ABVD regimen. MATERIALS AND METHODS:Two hundred and ten Hodgkin's disease patients, at ...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Anselmo AP,Cavalieri E,Osti FM,Cantonetti M,De Sanctis V,Alfo M,Amadori S,Enrici RM

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  • Metastases of human tumors in experimental animals.

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    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Doré JF,Bailly M,Bertrand S

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  • E-cadherin and alpha-catenin expression in normal, hyperplastic and neoplastic endometrium.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Carico E,Atlante M,Giarnieri E,Raffa S,Bucci B,Giovagnoli MR,Vecchione A

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  • Screening for prostatic carcinoma with prostate specific antigen.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Waidelich R,Jansen HM,Stieber P,Schmeller N,Lamerz R,Werdan K,Fateh-Moghadam A

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  • Effect of glutathione on alterations of liver DNA structure and metabolic activities induced in vivo by 2-acetylaminofluorene.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Cesarone CF,Scarabelli L,Orunesu M

    更新日期:1986-11-01 00:00:00

  • A KIT-negative, DOG1-positive epithelioid GIST of the stomach harboring a novel PDGFRA exon 14 single nucleotide deletion.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Rizzardi C,Marzinotto S,Avellini C,Melato M,Mariuzzi L

    更新日期:2012-05-01 00:00:00

  • Prognostic role of angiogenesis in colorectal cancer.

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    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Papamichael D

    更新日期:2001-11-01 00:00:00

  • Expression of metallopanstimulin and oncogenesis in human prostatic carcinoma.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Fernandez-Pol JA,Fletcher JW,Hamilton PD,Klos DJ

    更新日期:1997-05-01 00:00:00

  • Evaluation of tartrate-resistant acid phosphatase (TRAP) 5b as serum marker of bone metastases in human breast cancer.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Capeller B,Caffier H,Sütterlin MW,Dietl J

    更新日期:2003-03-01 00:00:00

  • Oxaliplatin fractionated over two days with bimonthly leucovorin and 5-fluorouracil in metastatic colorectal cancer.

    abstract:PURPOSE:To evaluate the efficacy and safety of oxaliplatin (L-OHP) fractionated over two days with bimonthly 5-fluorouracil (5-FU) and leucovorin (LV), as first-line treatment of metastatic colorectal cancer (MCC) patients. PATIENTS AND METHODS:Fifty-four patients with inoperable MCC (median age, 60 years) were entere...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Recchia F,Rea S,Nuzzo A,Lalli A,Di Lullo L,De Filippis S,Saggio G,Biondi E,Massa E,Mantovani G

    更新日期:2004-05-01 00:00:00

  • Prognostic value of serum CA9 in patients with metastatic clear cell renal cell carcinoma under targeted therapy.

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    journal_title:Anticancer research

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Gigante M,Li G,Ferlay C,Perol D,Blanc E,Paul S,Zhao A,Tostain J,Escudier B,Negrier S,Genin C

    更新日期:2012-12-01 00:00:00

  • Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats.

    abstract::The effects of silybinin, an antioxidant, on the pharmacokinetics of tamoxifen and its metabolite, 4-hydroxytamoxifen, were investigated in rats. A single dose of tamoxifen was administered intravenously (2 mg/kg) and orally (10 mg/kg) without or with silybinin (0.5, 2.5 and 10 mg/kg) to rats. Silybinin significantly ...

    journal_title:Anticancer research

    pub_type: 杂志文章

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    authors: Kim CS,Choi SJ,Park CY,Li C,Choi JS

    更新日期:2010-01-01 00:00:00

  • Oxazolinodoxorubicin - a promising new anthracycline.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Lukawska M,Klopotowska D,Milczarek M,Wietrzyk J,Studzian K,Szmigiero L,Porebska A,Oszczapowicz I

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  • The prognostic significance of autoantibodies against dsDNA in patients with colorectal adenocarcinoma.

    abstract:BACKGROUND:The tumors of the gastrointestinal system have been associated with various immune disorders. The goal of this study was to correlate the presence of the anti-dsDNA autoantibodies in the serum of patients with colorectal adenocarcinoma suffering from the prognosis of their disease. PATIENTS AND METHODS:We i...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Syrigos KN,Charalambopoulos A,Pliarchopoulou K,Varsamidakis N,Machairas A,Mandrekas D

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  • Lentinan potentiates immunity and prolongs the survival time of some patients.

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    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Matsuoka H,Seo Y,Wakasugi H,Saito T,Tomoda H

    更新日期:1997-07-01 00:00:00

  • Serrated adenomas of the cardia.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Rubio CA,Lagergren J

    更新日期:2004-05-01 00:00:00

  • Cytotoxic and anti-metastatic activities of phenolic compounds from Dendrobium ellipsophyllum.

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tanagornmeatar K,Chaotham C,Sritularak B,Likhitwitayawuid K,Chanvorachote P

    更新日期:2014-11-01 00:00:00

  • Procalcitonin: A New Biomarker for Medullary Thyroid Cancer? A Systematic Review.

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    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Karagiannis AK,Girio-Fragkoulakis C,Nakouti T

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    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Taniguchi Y,Yoshioka N,Nishizawa T,Inagawa H,Kohchi C,Soma G

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  • Recent developments in radiosensitization.

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    pub_type: 杂志文章,评审

    doi:

    authors: Linam J,Yang LX

    更新日期:2015-05-01 00:00:00

  • Clinical Impact of Escalating Relative High-dose-rate Intracavitary Brachytherapy Dose in Stage IIB Cervical Cancer.

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  • The Role of Prophylactic Cranial Irradiation for Non-small Cell Lung Cancer.

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    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:10.21873/anticanres.12185

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  • Is the tumor marker CASA dependent on the menstrual cycle?

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    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Meisel M,Römer T,Straube W

    更新日期:1997-07-01 00:00:00