Abstract:
BACKGROUND/AIM:Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma. We have previously demonstrated that PSK induces apoptosis and inhibites proliferation of promyelomonocytic leukemia HL-60 cells, but the signaling pathway for this action remains to be elucidated. In HL-60 cells, the mitogen-activated protein kinase (MAPK) pathway has been reported to be involved in stimuli-induced apoptosis. Therefore, involvement of the p38 MAPK pathway in PSK-induced apoptosis was herein investigated. MATERIALS AND METHODS:HL-60 cells were used in this study. Western blotting was performed to detect phosphorylated p38 MAPK. A p38 MAPK inhibitor, SB203580, was used to examine the roles of p38 MAPK in PSK-induced apoptosis and growth inhibition. RESULTS:PSK induced p38 MAPK phosphorylation. Co-treatment with SB203580 blocked PSK-induced apoptosis, caspase-3 activation and growth inhibition. CONCLUSION:The p38 MAPK pathway plays an important role in PSK-induced apoptosis.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Hirahara N,Edamatsu T,Fujieda A,Fujioka M,Wada T,Tajima Ysubject
Has Abstractpub_date
2012-07-01 00:00:00pages
2631-7issue
7eissn
0250-7005issn
1791-7530pii
32/7/2631journal_volume
32pub_type
杂志文章abstract:BACKGROUND/AIM:Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis and tumorigenicity. We previously assessed the role of cytokine gene polymorphisms in gastric cancer risk in Chile. In the present study, we aimed to analyze whether these polym...
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doi:
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doi:
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