Medical history and lifestyle factors contributing to Epstein-Barr virus-associated gastric carcinoma and conventional gastric carcinoma in Korea.

abstract：BACKGROUND/AIM:We have previously reported that alternate-day S-1 had comparable effects and milder adverse events than the respective consecutive-day regimen in head and neck cancer (HNC) patients. The aim of this study was to investigate the anticancer effects of both regimens and underlying mechanisms in vitro. MAT...

journal_title：Anticancer research

authors： Moro Y,Kogashiwa Y,Sakurai H,Takahashi R,Kimura T,Hirasaki M,Matsumoto Y,Sugasawa M,Kohno N

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) is a multifactorial neoplasm related to tobacco smoke, alcohol consumption and molecular genetic changes such as p53 mutations. The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid cod...

journal_title：Anticancer research

authors： Drummond SN,De Marco L,Pordeus Ide A,Barbosa AA,Gomez RS

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Postoperative pancreatic fistula (POPF) remains a major complication after pancreaticoduodenectomy (PD), and the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) after PD is poor. PATIENTS AND METHODS:A multi-institutional retrospective study was performed in 174 patients who underwent PD ...

journal_title：Anticancer research

authors： Yamashita Y,Yoshizumi T,Fukuzawa K,Nishizaki T,Tsujita E,Kajiyama K,Soejima Y,Yamagata M,Yamamoto K,Adachi E,Sugimachi K,Ikeda Y,Uchiyama H,Maeda T,Itoh S,Harimoto N,Ikegami T,Maehara Y

更新日期：2016-05-01 00:00:00

abstract：:Cytochrome P450 CYP2D6 polymorphism is an autosomal recessive trait leading to impaired sparteine/ debrisoquine metabolism in 5-10% of the Caucasian population. Previous studies have associated affected individuals (poor metabolizers = PM) with susceptibility to bladder cancer and various forms of leukemia. In many ot...

journal_title：Anticancer research

authors： Wundrack I,Sasiadek M,Blin N

更新日期：1997-11-01 00:00:00

abstract：:This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the...

journal_title：Anticancer research

authors： Yoon WK,Kim HJ,Son HY,Jeong KS,Park SJ,Kim TH,Kim SH,Kim SR,Ryu SY

更新日期：2004-07-01 00:00:00

abstract：:Multidrug resistance (mdr) constitutes the major obstacle to successful cancer treatment. The ability of fifteen newly-synthesised N-acylphenothiazine derivatives to inhibit the transport activity of P-glycoprotein was studied by flow cytometry in a resistant mouse lymphoma cell line. A standard functional assay with ...

journal_title：Anticancer research

authors： Wesolowska O,Molnár J,Motohashi N,Michalak K

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The number of patients with second malignancies is growing and they represent about one in six out of all new cancers. Second malignancies can be categorized into three major groups according to the predominant etiological factor(s): (i) treatment-related, (ii) part of a syndrome and (iii) those due to share...

journal_title：Anticancer research

authors： Mahmood S,Vu K,Tai P,Joseph K,Koul R,Dubey A,Yu E

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Parathyroid hormone-related protein (PTHrP) is a key regulator of osteolytic metastasis of breast cancer (BC) cells, but its targets and mechanisms of action are not fully understood. This study investigated whether/how PTHrP (1-34) signaling regulates expression of vascular endothelial growth factor (VEGF) ...

journal_title：Anticancer research

authors： Isowa S,Shimo T,Ibaragi S,Kurio N,Okui T,Matsubara K,Hassan NM,Kishimoto K,Sasaki A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The E-cadherin/beta-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. We previously reported aberrant expression of beta-catenin in endometrial carcinomas. However, the expression and correlation of E-cadherin and beta-catenin in normal and m...

journal_title：Anticancer research

authors： Shih HC,Shiozawa T,Miyamoto T,Kashima H,Feng YZ,Kurai M,Konishi I

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids. A recent report has indicated a selective COX-2 inhibitor resulted in increased apoptosis and down-regulated bcl-2 expression in the androgen-sensitive human prostate cancer cell. We investigat...

journal_title：Anticancer research

authors： Tanji N,Kikugawa T,Yokoyama M

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND/AIM:The mechanism responsible for B-cell translocation gene 1 (BTG1) down-regulation in breast carcinoma remains unknown. We examined the BTG1 expression status in breast carcinoma cells and investigated the mechanism underlying the observed alterations. MATERIALS AND METHODS:Four breast carcinoma cell line...

journal_title：Anticancer research

authors： Woo HY,DO SI,Kim SH,Song SY,Kim HS

更新日期：2019-10-01 00:00:00

abstract：:Renal Cell Carcinoma (RCC) is characterized by high intratumoral microvascular density (iMVD) and significantly elevated serologic titers of angiogenesis factors, basic fibroblast growth factor (bFGF), vascular endothelial growth factor (vEGF) and angiogenin (Ag). The goal of the present study was to find whether a co...

journal_title：Anticancer research

authors： Wechsel HW,Feil G,Bichler KH,Beiter T,Gleichmann R

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIM:The clinicopathological significance and prognostic value of insulin-like growth factor binding protein 1 (IGFBP1) in gastric cancer have not been investigated to date. This study aimed to investigate the relationship of IGFBP1 expression with clinicopathological variables and prognosis. MATERIALS AND M...

journal_title：Anticancer research

authors： Sato Y,Inokuchi M,Takagi Y,Kojima K

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Osteoscopy is a minimally-invasive endoscopic technique for inspecting lesions inside bone marrow cavities. We describe the feasibility of osteoscopic surgery of giant cell tumor of bone (GCTB) in order to preserve the proximal fibula, and thereby achieve immediate recovery and avoid complications. PATIENTS...

journal_title：Anticancer research

authors： Futani H,Kumanishi S,Minakawa GO,Yoshiya S

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:Pyruvate kinase M2 (PKM2) is an enzyme that is predominantly overexpressed in various types of cancer. The role of PKM2 in liver fluke-associated cholangiocarcinoma (CCA) remains unclear. This study aimed to investigate the antitumor activity of shikonin, a PKM2 inhibitor, in CCA cells. MATERIALS AND ME...

journal_title：Anticancer research

authors： Thonsri U,Seubwai W,Waraasawapati S,Wongkham S,Boonmars T,Cha'on U,Wongkham C

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The potential of MTp53 knockout by oligodesoxyribonucleotide phosphothioates (ODNs) to affect proliferation, apoptosis and chemosensitivity in undifferentiated thyroid cancer (UTC) cells with a recessive MTp53 mutation was evaluated. MATERIALS AND METHODS:Transient transfections with ODNs complementary to p...

journal_title：Anticancer research

authors： Hassan I,Wunderlich A,Burchert A,Hoffmann S,Zielke A

更新日期：2006-03-01 00:00:00

abstract：:Adenovirus(ADV) mediated thymidine kinase(TK) gene therapy followed by ganciclovir(GCV) administration is widely used in different types of cancer. ACV shares the same mechanism of selective cell killing in ADV/TK positive cells as GCV and can be used at 4.5 times higher doses in patients without significant side effe...

journal_title：Anticancer research

authors： Tong XW,Engehausen DG,Kaufman RH,Agoulnik I,Contant C,Freund CT,Oehler MK,Kim TE,Hasenburg A,Woo SL,Kieback DG

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Early detection before scintigraphic appearance of osseous metastatic spread might improve the outcome of breast cancer patients. The amino-terminal propeptide (PINP) of type I collagen as an indicator of bone formation is a very promising candidate among all markers of bone metabolism. We investigated the u...

journal_title：Anticancer research

authors： Lüftner D,Jozereau D,Schildhauer S,Geppert R,Müller C,Fiolka G,Wernecke KD,Possinger K

更新日期：2005-05-01 00:00:00

abstract：:The in vitro antioxidative activity of benzylideneascorbate (SBA) and the in vivo effect on adriamycin (ADR)-induced cardiotoxicity in a mouse model were investigated. The radical-scavenging activity of SBA was assayed in terms of reduction of chemiluminescence induced by O2-, generated in xanthine/xanthine oxidase an...

journal_title：Anticancer research

authors： Kojima S,Iizuka H,Yamaguchi H,Tanuma S,Kochi M,Ueno Y

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIM:Oxysterol plays important physiological roles in diverse biological processes including apoptosis. However, the mechanisms underlying oxysterol-induced apoptosis remain unknown. 25-hydroxycholesterol (25-HC) is an oxysterol synthesized by cholesterol 25-hydroxylase from cholesterol during sterol metaboli...

journal_title：Anticancer research

authors： You JS,Lim H,Kim TH,Oh JS,Lee GJ,Seo YS,Kim DK,Yu SK,Kim HJ,Kim CS,Kim JS

更新日期：2020-02-01 00:00:00

abstract：:We report a case of secondary chondrosarcoma arising in the ilium showing spontaneous regression after frequent local tumor recurrences followed by multiple surgeries of marginal or intralesional excision. The patient was a 16-year-old boy who had been diagnosed as having multiple exostosis from 9 years of age. He exp...

journal_title：Anticancer research

authors： Nakamura S,Kusuzaki K,Murata H,Takeshita H,Hirata M,Hashiguchi S,Hirasawa Y

更新日期：2000-09-01 00:00:00

abstract：:The electrophysiological effects of gallium chloride (Ga ) and its activity on arrhythmias induced by digitalis were investigated in guinea pig papillary muscle. KCl microelectrodes were used to record transmembrane electrical activity from Purkinje cells from the papillary muscle of guinea pig hearts during superfusi...

journal_title：Anticancer research

authors： Kantelip JP,Millart H,Leperre A,Mougin F,Didier JM

更新日期：1996-01-01 00:00:00

abstract：:The response of the blood-forming and supportive stromal compartments of the marrow to a localized, fractionated course of radiotherapy [FxRT; 2.0 Gy (q24 h x 5)-->74 Gy] was examined in the C57Bl/6 mouse using the hematopoietic progenitor and the cobblestone-forming cell (CAFC) assays as end-points for the blood-form...

journal_title：Anticancer research

authors： Kovacs CJ,Evans MJ,Daly BM

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND/AIM:Hypoxia offers resistance to therapy in human solid tumors. The aim of the study was to investigate whether SN-38, the active metabolite of irinotecan, acts as a radiosensitizer through inhibition of hypoxia-inducible factor (HIF)-1α in the human colorectal cancer (CRC) cells. MATERIALS AND METHODS:HT29...

journal_title：Anticancer research

authors： Okuno T,Kawai K,Hata K,Murono K,Emoto S,Kaneko M,Sasaki K,Nishikawa T,Tanaka T,Nozawa H

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:Primary Non-Hodgkin's lymphoma of the gallbladder (PNHL-GB) is extremely rare and data on clinical characteristics, optimal management and outcomes of these patients are limited to anecdotal reporting. We, therefore, sought to examine these patients using a population-based database. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Ayub A,Rehmani S,Al-Ayoubi AM,Lewis E,Santana-Rodríguez N,Raad W,Bhora F,Kim G

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Circulating nucleosomes are valuable biomarkers for therapy monitoring and estimation of prognosis in cancer disease. While epigenetic and genetic modifications of DNA have been reported in blood of cancer patients, little is known about modifications of histones on circulating nucleosomes. PATIENTS AND MET...

journal_title：Anticancer research

authors： Leszinski G,Gezer U,Siegele B,Stoetzer O,Holdenrieder S

更新日期：2012-05-01 00:00:00

abstract：:The prognostic and predictive role of p53 overexpression in breast cancer samples is usually investigated by using molecular biology or immunohistochemical methods. However, the results are to date controversial, and this is in part due to the methodological pitfalls of both the methods. To study the possibility of ov...

journal_title：Anticancer research

authors： Dittadi R,Brazzale A,Mione R,Di Fresco S,Gatti C,Vinante O,Bassan F,Nascimben O,Gion M

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Positron emission tomography-computed tomography (PET-CT) is currently not established in the management of recurrent ovarian cancer. Here, its value in diagnosis and therapy planning was evaluated. PATIENTS AND METHODS:Seventy patients received PET-CT for suspicion of recurrent ovarian cancer. PET-CT and s...

journal_title：Anticancer research

authors： Lenhard MS,Burges A,Johnson TR,Stieber P,Kümper C,Ditsch N,Linke R,Friese K

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND/AIM:Pancreatic neuroendocrine tumors (pNETs) are rare pancreatic neoplasms, and therapeutic options for pNETs are limited. Metformin is an anti-hypoglycemic drug that appears to have anticancer effects. However, little is known about the effect of metformin on pNETs. In this study, we investigated the anti-p...

journal_title：Anticancer research

authors： Yamana H,Kato K,Kobara H,Fujihara S,Fujita K,Namima D,Fujita N,Kobayashi K,Kamada H,Morishita A,Tsutsui K,Iwama H,Masaki T

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Radiotherapy (RT) with or without chemotherapy (CT) plays an important role as exclusive treatment in patients with head and neck squamous cell cancer (HNSCC). Unfortunately, in some cases, benefit for patients is not recorded and only treatment-related complications are registered. MATERIALS AND METHODS:Da...

journal_title：Anticancer research

authors： Pasqualetti F,Bocci G,Mey V,Menghini V,Montrone S,Cocuzza P,Ferrazza P,Seccia V,Delishaj D,Orlandini C,Fabrini MG,Danesi R

更新日期：2015-01-01 00:00:00