Immunohistochemical expression of E-cadherin and beta-catenin in the normal and malignant human endometrium: an inverse correlation between E-cadherin and nuclear beta-catenin expression.

abstract：:The attempts to identify, isolate and characterize cancer stem cell populations are mostly dependent on cell-surface markers. In breast cancer, several putative breast cancer stem cell (BCSC) markers have already been reported, but the agreement on their phenotypic characterization is still absent. In fact, it became ...

journal_title：Anticancer research

authors： DA Cruz Paula A,Lopes C

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Although in vitro and clinical studies indicate that overexpression of P-glycoprotein (Pgp), p53, or metallothionein (MT) is involved in modulating drug resistance/sensitivity of cancer cells, the clinical relevance of the overexpression remains to be elucidated. MATERIALS AND METHODS:In this paper the expr...

journal_title：Anticancer research

authors： Eid H,Géczi L,Mágori A,Bodrogi I,Institoris E,Bak M

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND/AIM:Few studies have examined the genetic role of matrix metalloproteinases (MMPs) to early detection or prediction in gastric cancer development. In this study, the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to gastric cancer risk in Taiwanese was investigated for the first time...

journal_title：Anticancer research

authors： Fu CK,Chien YC,Chuang HY,Wang YC,Hwang JJ,Yang MD,Yu CC,Chen JC,Chang WS,Bau DT,Tsai CW

更新日期：2020-02-01 00:00:00

abstract：AIM:Metastasis of unknown primary (MUP) is commonly treated with radiation therapy (RT) to the entire mucosal surfaces and bilateral neck nodes (LN). We report outcomes of oropharynx-targeted RT, retropharyngeal nodes (RPN) and bilateral LN in this context. PATIENTS AND METHODS:Single-Institution retrospective study o...

journal_title：Anticancer research

authors： Mourad WF,Hu KS,Shasha D,Concert C,Ishihara D,Lin W,Shourbaji RA,Ryniak M,Gamez ME,Lukens JN,Li Z,Culliney BE,Khorsandi AS,Tran T,Jacobson A,Manolidis S,Schantz S,Urken M,Persky MS,Harrison LB

更新日期：2014-01-01 00:00:00

abstract：:To evaluate further the chemopreventive role of motherwort (Leonurus sibiricus L; MW) in lesions of the mammary gland and uterus of GR/A mice, the effects on these lesions of the adsorbed (MW1) and unadsorbed (MW2) fractions of MW separated by ion-exchange resins were studied. The incidence of palpable mammary tumours...

journal_title：Anticancer research

authors： Nagasawa H,Inatomi H,Suzuki M,Mori T

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIM:Small cell lung cancer (SCLC) is still a deadly type of cancer for which there are few effective therapeutic strategies. Development of a new molecule targeting agent is urgently desired. Previously we showed that recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and mastermin...

journal_title：Anticancer research

authors： Onishi H,Ichimiya S,Yanai K,Umebayashi M,Nakamura K,Yamasaki A,Imaizumi A,Nagai S,Murahashi M,Ogata H,Morisaki T

更新日期：2018-08-01 00:00:00

abstract：:The active vitamin D3, 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3), is now well recognized as a potent regulator of cell proliferation and differentiation in addition to possessing a regulatory effect on calcium and phosphorus metabolism. From research on the synthesis of 1,25(OH)2D3 analogs with the goal of separatin...

journal_title：Anticancer research

authors： Kubodera N,Hatakeyama S

更新日期：2009-09-01 00:00:00

abstract：:The iron chelator deferoxamine mesylate has been shown to inhibit the growth of a variety of human malignant cell lines and the rat 13762NF mammary adenocarcinoma cell line. In vivo studies in mice have also demonstrated that an iron deficiency induced by either feeding a low iron diet or injecting the iron chelator d...

journal_title：Anticancer research

authors： Wang F,Elliott RL,Head JF

更新日期：1999-01-01 00:00:00

abstract：:Cases with deletion of part of the long arm of chromosome 5 (5q-) and a myeloid hemopoietic disorder show a marked female preponderance. We analysed the female preponderance of 328 published cases of myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). MDS without clinical or cytogenetic progression shows ...

journal_title：Anticancer research

authors： Pedersen B

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:To investigate the differences between two rat yolk sac tumor cell lines with different radiosensitivities and p53 status in sensitivity to high-LET heavy-ion beam and in sensitizing effect of etoposide or cisplatin in combination with heavy-ion beam. MATERIALS AND METHODS:NMT-1 (wild-type p53 cell) is a pa...

journal_title：Anticancer research

authors： Takahashi T,Fukawa T,Hirayama R,Yoshida Y,Musha A,Furusawa Y,Ando K,Nakano T

更新日期：2010-06-01 00:00:00

abstract：:The antitumor effect of endogenous tumor necrosis factor (en-TNF) with cyclophosphamide (CY) was analyzed using the murine Meth A tumor model. En-TNF was induced by the administration of interferon-gamma (4 micrograms/kg: 1 x 10(4) units/ mouse) as a primer and Streptococcus preparation OK-432 (100 KE/kg) as a trigger...

journal_title：Anticancer research

authors： Inagawa H,Ohshiro S,Nishizawa T,Goto S,Soma G,Mizuno D

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIM:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) plays an important role in the adhesion, invasion, and metastasis of tumor cells. Although emerging evidence suggests that IMP3 promotes tumor progression in several malignancies, the expression of IMP3 and its prognostic implication in adenocar...

journal_title：Anticancer research

authors： Kim HG,Park MS,Sung JY,Kim YW,Kim HS,Na K

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To analyze the prognostic value of DNA multiploidy in a prospective study on frozen surgical tissue samples from primary colorectal cancer. SUMMARY BACKGROUND DATA:Survival data from eleven prospective studies collectively comprising about thirteen hundred patients showed that aneuploidy correlated with a 5-...

journal_title：Anticancer research

authors： Cosimelli M,D'Agnano I,Tedesco M,D'Angelo C,Botti C,Giannarelli D,Vasselli S,Cavaliere F,Zupi G,Cavaliere R

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Zoledronic acid is a new member of the bisphosphonate (BP) class of compounds, a family of closely related synthetic molecules originally derived from the naturally occurring pyrophosphate. These compounds that are potent inhibitors of bone resorption, have been shown to reduce the growth of several cancer c...

journal_title：Anticancer research

authors： Bäckman U,Svensson A,Christofferson RH,Azarbayjani F

更新日期：2008-05-01 00:00:00

abstract：:Malignant human urothelial cell lines propagated in vitro have previously been demonstrated to express low amounts of monomorphic HLA-A,B,C as compared to premalignant urothelial cells. In this study the expression of polymorphic HLA-A,B epitopes in human urothelial cell lines have been investigated in greater detail....

journal_title：Anticancer research

authors： Ottesen SS,Kieler J

更新日期：1991-01-01 00:00:00

abstract：:During the last 50 years median survival for metastatic breast cancer has not varied and remains 2-3.5 years. To assess the clinical benefit of salvage systemic therapy a retrospective analysis of metastatic breast cancer patients all homogeneously treated with a commonly used first-line anthacycline-containing cytoto...

journal_title：Anticancer research

authors： Campora E,Gardin G,Gasco M,Rosso R,Santi L

更新日期：1999-07-01 00:00:00

abstract：:To activate the cancerous genetic information in the cell one has either to activate oncogenes or to inactivate antioncogenes (cancerous growth suppressing genes). These processes usually happen in the cell with the aid of external factors, especially chemical carcinogens' and radiations. It was shown with the aid of ...

journal_title：Anticancer research

authors： Ladik JJ

更新日期：1994-01-01 00:00:00

abstract：:We examined 11 patients (9 male and 2 female, age 41 +/- 13) presenting astrocytomas of different malignancy grade (WHO) with single voxel (PRESS) and double voxel (STABLE) spectroscopy techniques. The content of choline in the tumors was determined as a function of their grade of malignity and a significant correlati...

journal_title：Anticancer research

authors： Speck O,Thiel T,Hennig J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Resistance to multiple chemotherapeutic agents results from a variety of factors including a lack of apoptosis in tumor cells. To induce apoptosis in two types of tumor cells, RPMI-8226 and MG-63, a combination of chemotherapeutic agents and retroviral transduction of TRAIL was employed. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Suzuki H,Hotta T,Koyama T,Komagata M,Imakiire A,Yanase N,Yoshimoto T,Mizuguchi J

更新日期：2003-07-01 00:00:00

abstract：:During postnatal development, the formation of new blood vessels is possible only through angiogenesis. The initial growth of solid neoplasms, including childhood brain tumors, during the genetically determined stages of carcinogenesis, even at clinically undetectable sizes (a few mm3), depends upon the continuous for...

journal_title：Anticancer research

authors： Bodey B,Bodey B Jr,Siegel SE,Kaiser HE

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND/AIM:Cytological analysis for diagnosing malignant pleural effusion associated with lung adenocarcinoma (Ad-MPE) shows limited sensitivity and novel diagnostic biomarkers are needed. The aim of this study was to evaluate the profile of four microRNAs (miRNAs) in exosomes in Ad-MPE and benign (non-neoplastic) ...

journal_title：Anticancer research

authors： Tamiya H,Mitani A,Saito A,Ishimori T,Saito M,Isago H,Jo T,Yamauchi Y,Tanaka G,Nagase T

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND/AIM:Typical carcinoids (TC) and atypical carcinoids (AC) are rare diseases. A paucity of randomized studies and disagreements among various guidelines makes the management challenging. PATIENTS AND METHODS:Using codes for TC (8240) and AC (8249) in the National Cancer Database (NCDB), all surgically resecte...

journal_title：Anticancer research

authors： Gosain R,Groman A,Yendamuri SS,Iyer R,Mukherjee S

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The development of synthetic taxanes targets at increasing solubility of the drug, improved clinical efficacy and reduced side-effects. We evaluated the sensitivity of head and neck squamous cell carcinoma cell lines to BMS-184476 and BMS-188797 in vitro. MATERIALS AND METHODS:The effects of paclitaxel and ...

journal_title：Anticancer research

authors： Raitanen M,Pulkkinen J,Kulmala J,Grénman R

更新日期：2004-11-01 00:00:00

abstract：:We describe herein a brother and sister diagnosed with xeroderma pigmentosum variant (XP-V) in early adult life, who presented with increased sensitivity to sunlight and with cutaneous carcinomas on sun-damaged skin. The 27-year-old male farmer (Case 1.) was diagnosed with advanced squamous cell carcinoma (SCC) and mu...

journal_title：Anticancer research

authors： Somos S,Farkas B,Schneider I

更新日期：1999-05-01 00:00:00

abstract：:Menogaril is an antitumor agent active after oral administration, and unlike other anthracyclines, extravasation cannot occur. When the IC90 values of menogaril were plotted versus exposure time on a double-logarithmic scale, the regression lines had slopes between -0.64 and -0.80. These results showed that the mode o...

journal_title：Anticancer research

authors： Yoshida M,Kobunai T,Nakano K,Saito H,Toko T,Takeda S,Unemi N

更新日期：1996-09-01 00:00:00

abstract：:Ascorbyl stearate is a lipophilic, vitamin C derivative with antitumorigenic properties. The molecular mechanism(s) underlying the anticarcinogenic effect of this compound have not been well documented. The effect of ascorbyl stearate was studied in a panel of human ovarian epithelial cancer cells. Treatment with asco...

journal_title：Anticancer research

authors： Fang Q,Naidu KA,Naidu KA,Zhao H,Sun M,Dan HC,Nasir A,Kaiser HE,Cheng JQ,Nicosia SV,Coppola D

更新日期：2006-01-01 00:00:00

abstract：:Four sorts of tumor proliferation-related markers were studied in 50 papillary carcinomas of the thyroid, and the results were correlated with the histologic subtypes of papillary thyroid carcinoma, which have been shown to be associated with the prognosis of the disease. The mitotic count analyzed by light microscopy...

journal_title：Anticancer research

authors： Mizukami Y,Nonomura A,Michigishi T,Noguchi M,Nakamura S,Hashimoto T

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Primary small cell carcinoma of the ovary (SCCO) is rare, making prognosis and outcomes largely undefined. PATIENTS AND METHODS:Using case listing session of SEER 18 (1973-2010), we examined outcomes for patients with SCCO. Analyses were conducted with SEER(*)Stat 8.1.2, Microsoft Excel 2007 and GraphPad Pr...

journal_title：Anticancer research

authors： Jamy O,Yaghmour G,Hare F,Martin MG

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Immunotherapy has become an attractive new strategy in the treatment of cancer. The laboratory and clinical study of cancer immunotherapy is rapidly advancing. However, in the clinical setting, the results of cancer immunotherapy are mixed. We therefore contend that cancer immunotherapy should be customized ...

journal_title：Anticancer research

authors： Inui T,Kuchiike D,Kubo K,Mette M,Uto Y,Hori H,Sakamoto N

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND/AIM:The aim of the study was to evaluate the necessity of gastrectomy including endoscopic submucosal dissection (ESD) scar with margin-negative early gastric cancer (EGC). PATIENTS AND METHODS:We analyzed 83 patients with EGC who received additional gastrectomy after non-curative ESD and evaluated the risk...

journal_title：Anticancer research

authors： Ishida R,Kanaji S,Maehara R,Hasegawa H,Yamamoto M,Matsuda Y,Yamashita K,Matsuda T,Oshikiri T,Sumi Y,Nakamura T,Suzuki S,Kakeji Y

更新日期：2018-09-01 00:00:00