Exosomal MicroRNA Expression Profiling in Patients with Lung Adenocarcinoma-associated Malignant Pleural Effusion.

Abstract:

BACKGROUND/AIM:Cytological analysis for diagnosing malignant pleural effusion associated with lung adenocarcinoma (Ad-MPE) shows limited sensitivity and novel diagnostic biomarkers are needed. The aim of this study was to evaluate the profile of four microRNAs (miRNAs) in exosomes in Ad-MPE and benign (non-neoplastic) pleural effusion (BPE). MATERIALS AND METHODS:A total of 56 pleural effusion samples from patients with lung adenocarcinoma and benign diseases were collected. Exosomal miRNA expressions were evaluated using real-time quantitative reverse transcription polymerase chain reaction (RT-PCR). RESULTS:The expression levels of miR-182 and miR-210 were significantly higher in the Ad-MPE than in the BPE samples. The receiver operating characteristics curve analyses of miR-182 and miR-210 for diagnosis of Ad-MPE yielded areas under the receiver operating characteristic curves of 0.87 and 0.81, respectively. CONCLUSION:These miRNA signatures may have a diagnostic potential for differentiating Ad-MPE from BPE.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Tamiya H,Mitani A,Saito A,Ishimori T,Saito M,Isago H,Jo T,Yamauchi Y,Tanaka G,Nagase T

doi

10.21873/anticanres.13039

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

6707-6714

issue

12

eissn

0250-7005

issn

1791-7530

pii

38/12/6707

journal_volume

38

pub_type

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