Ascorbyl stearate inhibits cell proliferation and tumor growth in human ovarian carcinoma cells by targeting the PI3K/AKT pathway.

abstract：BACKGROUND:DNA topoisomerase II alpha (topo II alpha) is associated with active cell proliferation of mammalian cells. Topo II alpha overexpression has been reported in a number of human malignancies and is considered to be related to their biological behaviors. MATERIALS AND METHODS:We examined the expression of topo...

journal_title：Anticancer research

authors： Ohashi Y,Sasano H,Yamaki H,Shizawa S,Kikuchi A,Shineha R,Akaishi T,Satomi S,Nagura H

更新日期：1999-05-01 00:00:00

abstract：:The relationship between production of Colony-Stimulating Factor (CSF) and metastasis has been investigated in the TS/A murine model. CSF production was determined in TS/A cell variants isolated through serial in vivo selection of lung metastatic nodules induced by intravenous or subcutaneous injection of tumor cells ...

journal_title：Anticancer research

authors： Nicoletti G,Lollini PL,Bagnara GP,De Giovanni C,Del Re B,Bons L,Prodi G,Nanni P

更新日期：1987-07-01 00:00:00

abstract：AIM:We report on a rare case of appendiceal primary neuroendocrine carcinoma (NEC) and discuss three cases previously described. CASE REPORT:A 58-year-old woman presented with acute abdominal pain and a low-grade fever. She was diagnosed with acute appendicitis and underwent laparoscopic appendectomy. Pathological exa...

journal_title：Anticancer research

authors： Tomioka K,Fukoe Y,Lee Y,Lee M,Wada Y,Aoki T,Murakami M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND/AIM:Up-regulation of metallo-proteinase (MMP) proteins has been shown in various types of solid cancers and the genotype of MMP1 has been associated with the risk of solid cancers. The contribution of MMP1 genotype to lung cancer has been investigated in various countries, though, to our knowledge, not in Ta...

journal_title：Anticancer research

authors： Shen TC,Chang WS,Tsai CW,Chao CY,Lin YT,Hsiao CL,Hsu CL,Chen WC,Hsia TC,Bau DT

更新日期：2018-01-01 00:00:00

abstract：:The Fiber Hypothesis which had its origins in the work of Burkitt and others in the early 1970's, focussed largely on fiber's beneficial effects on colon cancer and disorders of the gastric intestinal tract. In the 1980's it was proposed that fiber may also have beneficial effects on breast cancer and a rational for t...

journal_title：Anticancer research

authors： Cohen LA

更新日期：1999-09-01 00:00:00

abstract：:Immunohistochemical analysis of the p53 tumor suppressor gene was performed in 69 human pancreatic ductal adenocarcinomas, using a highly specific anti-p53 antibody. Nuclear immunoreactivity was found in 40 tumors, yielding an overall frequency of 58%. Immunoblotting confirmed that nuclear immunoreactivity was associa...

journal_title：Anticancer research

authors： Yokoyama M,Yamanaka Y,Friess H,Buchler M,Korc M

更新日期：1994-11-01 00:00:00

abstract：:MDL 103,323, an enclomiphene analog, was tested for binding to the estrogen receptor, inhibition of human tumor xenografts and prevention of carcinogen-induced mammary tumors. MDL 103,323 had 5-6 fold greater affinity for the human estrogen receptor than did either tamoxifen or enclomiphene. Consistent with enhanced b...

journal_title：Anticancer research

authors： Bitonti AJ,Baumann RJ,Bush TL,Cashman EA,Wright CL,Prakash NJ

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND/AIM:The impact of testosterone or obesity on the pathological grade of prostate cancer remains controversial. Therefore, in this study, we investigated the relationship of serum testosterone and body mass index (BMI) to Gleason score at biopsy. PATIENTS AND METHODS:This study included 128 Japanese patients ...

journal_title：Anticancer research

authors： Shiota M,Takeuchi A,Sugimoto M,Dejima T,Kashiwagi E,Kiyoshima K,Inokuchi J,Tatsugami K,Yokomizo A

更新日期：2015-11-01 00:00:00

abstract：:Angiogenesis, the process of generating new capillary blood vessels, is a fundamental requirement for normal physiological processes including embryogenesis, reproductive function and wound healing. Angiogenesis is also implicated in various pathological conditions including age-related retinal macular degeneration, d...

journal_title：Anticancer research

authors： Salesi N,Bossone G,Veltri E,Di Cocco B,Marolla P,Pacetti U,Larosa G,Muni R,Vecchione A

更新日期：2005-09-01 00:00:00

abstract：:BRCA1 acts as a tumour suppressor and germ-line mutations within this gene are found in a large proportion of families with breast cancer. The aim of our study was to unravel the mechanism of action of genistein, the major soy phytoestrogen, in BRCA1-mutant human breast cancer cell lines. Four breast cancer cell lines...

journal_title：Anticancer research

authors： Privat M,Aubel C,Arnould S,Communal Y,Ferrara M,Bignon YJ

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND/AIM:Metabolomics is widely used for biomarker discovery, but conventional mass-spectrometry extraction procedures lose the spatial localization of metabolites. In this study, we directly analyzed breast carcinoma tissues embedded in frozen tissue microarrays (fTMAs) using MALDI mass-spectrometry imaging (MAL...

journal_title：Anticancer research

authors： Torata N,Kubo M,Miura D,Ohuchida K,Mizuuchi Y,Fujimura Y,Hayakawa E,Kai M,Oda Y,Mizumoto K,Hashizume M,Nakamura M

更新日期：2018-07-01 00:00:00

abstract：:The usefulness of lymphocyte subset change as an indicator for predicting survival time and the effectiveness of combined treatment with an immunopotentiator, lentinan, and carboplatin (CBDCA) were investigated. Of 13 patients with advanced unresectable cancer entered in this study, 9 were administered 2 mg/body lenti...

journal_title：Anticancer research

authors： Matsuoka H,Yano K,Seo Y,Saito T,Tomoda H,Tsurumoto S

更新日期：1995-09-01 00:00:00

abstract：:The antioxidative activity and antimutagenic effects of the water-soluble beta-(1-3)-D-glucan derivatives from biotechnologically important species, in particular carboxymethyl-glucan (CM-G) and sulfoethyl-glucan (SE-G) both from the baker's yeast Saccharomyces cerevisiae, and carboxymethyl-chitin-glucan (CM-CG) from ...

journal_title：Anticancer research

authors： Krizková L,Duracková Z,Sandula J,Slamenová D,Sasinková V,Sivonová M,Krajcovic J

更新日期：2003-05-01 00:00:00

abstract：:From 1980 to 1987, 243 evaluable patients with pT1, pT2 (less than 3 centimeters in diameter), N0, M0, invasive breast cancer were treated with "quadrantectomy" with axillary dissection followed by electron beam radiation therapy (QUART) at the St. Bortolo Hospital, Vicenza. Stage II patients received adjuvant chemoth...

journal_title：Anticancer research

authors： Gasparini G,Panizzoni GA,Dal Fior S,Germani B,Dall'Antonia F,Segato G,Meli S,Pozza F

更新日期：1991-07-01 00:00:00

abstract：:P53 mutation, through defects in repairing DNA damages, is associated with genomic instability. In 24 adult patients with relapsed acute lymphoblastic leukemia (ALL), the status of the p53 gene at different stages was serially followed by cytogenetic and polymerase-chain reaction/single strand conformation polymorphis...

journal_title：Anticancer research

authors： Tang JL,Tien HF,Lin MT,Chen PJ,Chen YC

更新日期：1998-03-01 00:00:00

abstract：AIM:To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2). PATIENTS AND METHODS:We treated 13 dogs with 18 natural TVTs with IL-2. The tumors were treated with intratumoral application of 2×10(6) units IL-2. RESULTS:Three months after injection o...

journal_title：Anticancer research

authors： Den Otter W,Hack M,Jacobs JJ,Tan JF,Rozendaal L,Van Moorselaar RJ

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND/AIM:FAM92A1-289 is recognized as one of the newly-discovered putative oncogenes. This study was performed to reveal its oncogenic functions in human cervical carcinoma cells. MATERIALS AND METHODS:The FAM92A1-289+ cell line was established with knock-in technique and selected by puromycin-resistance screeni...

journal_title：Anticancer research

authors： Gui H,Guo XR,Fang J,Ma SN,Wu G,Shen JH,Tu HJ,Li DS,Dai LJ,Ruan XZ

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Treatment for advanced pancreatic cancer is still very unsatisfactory. Treosulfan is an alkylating agent used for conventional, as well as high-dose chemotherapy regimens, whereby plasma concentrations over 500 μg/ml can be achieved. We investigated the effects of treosulfan on pancreatic cancer cell lines. ...

journal_title：Anticancer research

authors： Nitsch E,Mina S,Brammer I,Pace A,Schuch G,Bokemeyer C,Zander A,Kröger N,Ayuk F

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The rearrangement of actin cytoskeleton is being increasingly considered a marker of cancer cell activity, but the fine structure and remodeling of microfilaments within tumor tissue still remains unclear. MATERIALS AND METHODS:We used the recently introduced silicon-rhodamine (SiR)-actin dye to visualize e...

journal_title：Anticancer research

authors： Klementieva NV,Snopova LB,Prodanets NN,Furman OE,Dudenkova VV,Zagaynova EV,Lukyanov KA,Mishin AS

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND/AIM:Basaloid squamous cell carcinoma of the oesophagus (BSCCE) is a variant of oesophageal squamous cell carcinoma (ESCC), that has a more aggressive biological behaviour than that of typical ESCC. miR-3687 has been previously identified to be highly expressed in BSCCE. This study aimed to evaluate the progn...

journal_title：Anticancer research

authors： Hagio K,Furuya S,Nakamura J,Maruyama S,Shiraishi K,Shimizu H,Akaike H,Hosomura N,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the outcomes of laparoscopic surgery in colorectal cancer patients with dialysis. PATIENTS AND METHODS:Fourteen dialysis (dialysis group) and 567 non-dialysis (non-dialysis group) patients who underwent laparoscopic and open surgery for colorectal cancer between April 2008 and December 20...

journal_title：Anticancer research

authors： Higashino N,Matsuda T,Hasegawa H,Yamashita K,Sakamoto H,Fujikawa M,Yamamoto M,Kanaji S,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated patients undergoing salvage hysterectomy after brachytherapy (BT) following concomitant chemoradiation (CRT) for locally advanced cervical cancers (LACC), when residual disease was suspected. PATIENTS AND METHODS:From 2004 to 2013, 29 patients had a radical hysterectomy at the Gustave Rouss...

journal_title：Anticancer research

authors： Gosset M,Chargari C,Bentivegna E,Leary A,Genestie C,Maulard A,Morice P,Gouy S

更新日期：2019-06-01 00:00:00

abstract：:Our recent in vitro findings for suppression of thrombospondin-1 (TSP1; an antiangiogenic factor) expression by wild-type (wt) p53 in a p53-null thyroid carcinoma cell line, FRO, prompted us to investigate the in vivo effect of exogenous wt-p53 and TSP1 expression on tumor growth and angiogenesis of FRO xenografts in ...

journal_title：Anticancer research

authors： Nagayama Y,Shigematsu K,Namba H,Zeki K,Yamashita S,Niwa M

更新日期：2000-07-01 00:00:00

abstract：:Lymphocytes isolated from the peripheral blood of patients with chronic lymphocytic leukemia (CLL) and from healthy donors were studied for membrane fluidity and lipid phase separation. The degree of fluidity of the surface membrane lipids was estimated by fluorescence polarization analysis using the probe 1,6-dipheny...

journal_title：Anticancer research

authors： Deliconstantinos G,Daefler S,Krueger GR

更新日期：1987-05-01 00:00:00

abstract：:TRAIL, Tumor necrosis factor-related apoptosis-inducing ligand), a member of the TNF family, is known to be cytotoxic for a high proportion of tumor cell lines. However, successful application of TRAIL in tumor therapy may depend on finding other agents that can potentiate its antitumor effects. The present study show...

journal_title：Anticancer research

authors： Młynarczuk I,Hoser G,Grzela T,Stokłosa T,Wójcik C,Malejczyk J,Jakóbisiak M

更新日期：2001-03-01 00:00:00

abstract：:Tumor-associated glycoprotein (TAG) 72 is a mucin-like protein of high molecular weight (220-400 kd). Elevated serum levels of TAG72 are preferentially observed in patients suffering from gastric cancer. Additionally the determination of TAG72 may be a helpful tool in the management of patients suffering from mucinous...

journal_title：Anticancer research

authors： Filella X,Friese S,Roth HJ,Nussbaum S,Wehnl B

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIM:The lipophilic, orally bioavailable camptothecin analogue gimatecan is characterized by improved efficacy over conventional camptothecins on human tumor xenografts. Gimatecan produced excellent outcomes orally with prolonged, low-dose, daily treatments. The aim of this study was to assess the antitumor e...

journal_title：Anticancer research

authors： DE Cesare M

更新日期：2018-10-01 00:00:00

abstract：:Important strategies against cancer are based on the understanding of the mechanisms of tumor progression. To elucidate alterations regarding tumor progression, we have performed proteomic differential display analysis for the expression of intracellular proteins in the regressive murine fibrosarcoma cell clone QR-32 ...

journal_title：Anticancer research

authors： Takenawa T,Kuramitsu Y,Wang Y,Okada F,Tokuda K,Kitagawa T,Ueyama Y,Nakamura K

更新日期：2013-01-01 00:00:00

abstract：AIM:The purpose of this prospective evaluation was to assess the late neurologic adverse events and Karnofsky performance status (KPS) in patients with at least two brain metastases from non-small cell lung cancer treated with whole-brain radiotherapy (WBRT) with or without sequential systemic chemotherapy. PATIENTS A...

journal_title：Anticancer research

authors： Nieder C,Astner ST,Grosu AL,Molls M

更新日期：2007-05-01 00:00:00

abstract：:Pseudomyxoma peritonei (PMP) is a clinical condition characterized by diffuse intraabdominal spread of mucinous tumor implants that form on peritoneal surfaces. To complement the efficacy of cytoreductive surgery, an effective cytotoxic drug is required as an intraperitoneal agent for microscopic cytoreduction locoreg...

journal_title：Anticancer research

authors： Chua TC,Akther J,Yao P,Morris DL

更新日期：2009-10-01 00:00:00