Abstract:
AIM:We report on a rare case of appendiceal primary neuroendocrine carcinoma (NEC) and discuss three cases previously described. CASE REPORT:A 58-year-old woman presented with acute abdominal pain and a low-grade fever. She was diagnosed with acute appendicitis and underwent laparoscopic appendectomy. Pathological examination of the resected specimen revealed NEC. Immunohistochemical analyses were positive for synaptophysin, chromogranin, and CD-56. The tumour was high grade and the Ki-67 index was >20%. Primary NEC of the appendix is extremely rare. To our knowledge, this is the first case report of an appendiceal NEC that meets the 2010 diagnostic criteria of the World Health Organization. CONCLUSION:Due to its non-specific clinical presentation, NEC is often misdiagnosed as appendicitis; however, it can advance rapidly and carries a very poor prognosis, despite chemotherapy. In the future, a treatment protocol for immunohistochemical analyses should be established to improve the survival rate.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Tomioka K,Fukoe Y,Lee Y,Lee M,Wada Y,Aoki T,Murakami Msubject
Has Abstractpub_date
2013-06-01 00:00:00pages
2635-8issue
6eissn
0250-7005issn
1791-7530pii
33/6/2635journal_volume
33pub_type
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journal_title:Anticancer research
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journal_title:Anticancer research
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更新日期:1997-05-01 00:00:00
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journal_title:Anticancer research
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更新日期:2003-01-01 00:00:00
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journal_title:Anticancer research
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更新日期:2005-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
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journal_title:Anticancer research
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更新日期:2008-03-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
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更新日期:2016-04-01 00:00:00
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doi:
更新日期:2000-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:
更新日期:2015-12-01 00:00:00
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更新日期:2012-01-01 00:00:00
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doi:
更新日期:1998-09-01 00:00:00
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