Should We Cease to Perform Salvage Hysterectomy After Chemoradiation and Brachytherapy in Locally Advanced Cervical Cancer?

abstract：BACKGROUND/AIM:The oxazaphosphorines, ifosfamide and cyclophosphamide, represent a class of alkylating agents. The aim of the present in vitro study was to compare antileukemic activity of 4-hydroperoxyifosfamide (4-OOH-IF) and 4-hydroperoxycyclophosphamide (4-OOH-CP). MATERIALS AND METHODS:The experiments were perfor...

journal_title：Anticancer research

authors： Opydo-Chanek M,Śladowska K,Blicharski K,Mikeš J,Fedoročko P,Niemeyer U,Mazur L

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND/AIM:Vanek's tumor is an inflammatory fibroid polyp (IFP) of very low incidence, which originates in the submucosa of the stomach, duodenum, jejunum and ileum. The etiology of this tumor is still unknown. Histologically, IFP is characterized by submucosal spindle cell proliferation in fibromyxoid stroma with ...

journal_title：Anticancer research

authors： Jukic Z,Ferencic Z,Radulovic P,Mijic A,Fucic A

更新日期：2014-12-01 00:00:00

abstract：AIM:To determine the predictive value of HIF-1α and VEGF-C in primary neuroendocrine breast cancers (NEBC) and their correlation with other clinico-pathological characteristics of NEBC. MATERIALS AND METHODS:HIF-1α and VEGF-C were determined immunohistochemically in tissue samples from 31 cases of NEBC. RESULTS:The H...

journal_title：Anticancer research

authors： Marton I,Knezevic F,Ramic S,Milosevic M,Tomas D

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND/AIM:Forodesine inhibits purine nucleoside phosphorylase, resulting in an accumulation of intracellular dGTP and consequently cell death. 9-β-D-Arabinofuranosylguanine (ara-G) is an active compound of nelarabine that is intracellularly phosphorylated to a triphosphate form, which inhibits DNA synthesis. Both ...

journal_title：Anticancer research

authors： Yamauchi T,Uzui K,Nishi R,Tasaki T,Ueda T

更新日期：2014-09-01 00:00:00

abstract：:The effect of treatment schedule on the antitumor activity of a new platinum derivative, glycolate-0,0'-diammineplatinum (II) (254S) compared with cis- diamminedichloroplatinum (II) (CDDP) was investigated using ascites L1210 leukemia and solid Lewis lung carcinoma. The drugs were given i.p. by three treatments: as a ...

journal_title：Anticancer research

authors： Suzumura Y,Kato T,Ueda R,Ota K

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) plays a role in carcinogenesis and carcinoma progression. In this study we investigated the expression of HB-EGF in human colonic non-neoplastic and neoplastic tissues. MATERIALS AND METHODS:We performe...

journal_title：Anticancer research

authors： Ito Y,Higashiyama S,Takeda T,Okada M,Matsuura N

更新日期：2001-03-01 00:00:00

abstract：:Several lines of evidence have postulated that reduction in the activity of lipoprotein lipase (LPL) is involved in cachexia induction in cancer patients. Recently we have demonstrated that murine melanoma B16 has the ability to reduce the LPL activity and thereby induce cachexia symptoms in mice following intraperito...

journal_title：Anticancer research

authors： Tsujimoto S,Kawamura I,Inami M,Lacey E,Nishigaki F,Naoe Y,Manda T,Goto T

更新日期：2000-09-01 00:00:00

abstract：:The CSEIL/CAS protein (CAS) is a Ran-binding protein with a function as a nuclear transport (export) factor. CSEIL/CAS, similar to Ran and other ran-binding proteins, plays at the same time an important role in the mitotic spindle checkpoint, which assures genomic stability during cell division. This checkpoint is fre...

journal_title：Anticancer research

authors： Behrens P,Brinkmann U,Fogt F,Wernert N,Wellmann A

更新日期：2001-07-01 00:00:00

abstract：:Evidence exists that estrogen metabolism has a role in the pathogenesis of recurrent respiratory papillomatosis (RRP). This disease has a papillomavirus etiology and is characterized by recurrent benign tumors with a significant propensity to become malignant. We have measured the systemic transformation of estrogen u...

journal_title：Anticancer research

authors： Auborn K,Abramson A,Bradlow HL,Sepkovic D,Mullooly V

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Gingival squamous cell carcinoma (SCC) cells frequently invade mandibular bone, and this destruction is associated with a worse prognosis. However, the relationship between bone destruction and associated factors is unclear. In this study, the role and diagnostic utility of transforming growth factor-beta (T...

journal_title：Anticancer research

authors： Goda T,Shimo T,Yoshihama Y,Hassan NM,Ibaragi S,Kurio N,Okui T,Honami T,Kishimoto K,Sasaki A

更新日期：2010-07-01 00:00:00

abstract：AIM:To investigate the protein kinase B (Akt) signalling proteins phosphatase and tensin homolog (PTEN), phosphorylated-Akt (p-Akt) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in non-seminomatous germ cell tumors (NST) with a view to future investigative approaches. MATERIALS AND METHODS:The expressions of PT...

journal_title：Anticancer research

authors： Hennenlotter J,Amend B,Vogel U,Renninger M,Springer C,Kuehs U,Stenzl A,Bedke J

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND/AIM:The differentiation of the mouse breast epithelial cell line HC11 is known to require confluence as well as the addition of hydrocortisone, insulin and prolactin. MATERIALS AND METHODS:Since confluence, which triggers the engagement of the cell-to-cell adhesion molecule E-cadherin, induces a dramatic in...

journal_title：Anticancer research

authors： Niit M,Geletu M,Taha Z,Arulanandam R,Cass J,Hoskin V,Elliott B,Gunning P,Raptis L

更新日期：2019-06-01 00:00:00

abstract：:The feasibility of using low-dose carboplatin (CBDCA) as a radiopotentiator in radiotherapy(RT) for non-small cell lung cancer(NSCLC) patients with unfavorable factors was studied. Fifteen patients with locally advanced and inoperable NSCLC were treated with RT in combination with daily 20 mg/m2 CBDCA. Twelve patients...

journal_title：Anticancer research

authors： Satoh H,Ohara K,Fuji H,Ishikawa H,Yamashita YT,Kamma H,Ohtsuka M,Hasegawa S

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIM:Leiomyosarcoma is an extremely rare, small bowel neoplasm (2% of all gastrointestinal tumours). Early diagnosis is challenging due to the slow growth of the cancer. The biological behaviour of this group of tumours is aggressive, and the first-line treatment is surgical resection. PATIENTS AND METHODS:T...

journal_title：Anticancer research

authors： Ferrari C,DI Domenico S,Mascherini M,Santoliquido M,Mastracci L,DE Cian F

更新日期：2020-07-01 00:00:00

abstract：AIM:To investigate the expression and significance of glypican-3 (GPC3) in human hepatocellular carcinoma (HCC). MATERIALS AND METHODS:DNA chips were used to measure the expression of mRNAs for members of the glypican and syndecan families of heparan sulfate proteoglycans (HSPGs) in normal liver tissue, non-tumor tiss...

journal_title：Anticancer research

authors： Suzuki M,Sugimoto K,Tanaka J,Tameda M,Inagaki Y,Kusagawa S,Nojiri K,Beppu T,Yoneda K,Yamamoto N,Ito M,Yoneda M,Uchida K,Takase K,Shiraki K

更新日期：2010-12-01 00:00:00

abstract：:Measurement of CA125 is well established in the diagnosis and follow-up of ovarian cancer. CA125 determination is usually performed with the monoclonal antibodies OC125 and M11. For the IMMULITE OM-MA chemoluminsence assay (DPC Biermann, Bad Nauheim, Germany) the monoclonal antibody OV185 is used. We analysed CA125 se...

journal_title：Anticancer research

authors： Gebauer G,Rieger M,Jäger W,Lang N

更新日期：1999-07-01 00:00:00

abstract：AIM:The present study aimed to examine the survival benefit of adjuvant chemotherapy for the patients with stage IB gastric cancer according to the second English edition of the Japanese Classification of Gastric Carcinoma (2nd JCGC). PATIENTS AND METHODS:In total, 201 consecutive patients who underwent curative surge...

journal_title：Anticancer research

authors： Toyokawa T,Ohira M,Sakurai K,Kubo N,Tanaka H,Muguruma K,Hirakawa K

更新日期：2015-07-01 00:00:00

abstract：:We examined 11 patients (9 male and 2 female, age 41 +/- 13) presenting astrocytomas of different malignancy grade (WHO) with single voxel (PRESS) and double voxel (STABLE) spectroscopy techniques. The content of choline in the tumors was determined as a function of their grade of malignity and a significant correlati...

journal_title：Anticancer research

authors： Speck O,Thiel T,Hennig J

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Late developing breast cancer metastases are common and lethal despite treatment with adjuvant chemotherapy at the time of primary tumor excision. Stimulation of an antitumor immune response is an alternative strategy for preventing this devastating development. MATERIALS AND METHODS:A mouse model of the hu...

journal_title：Anticancer research

authors： Gao Y,Bergman I

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND/AIM:Novel treatment strategies aiming to eliminate or attenuate the invasive phenotype of glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, could offer a profound therapeutic benefit to patients. We previously demonstrated one method to create invasive sub-populations of GBM ...

journal_title：Anticancer research

authors： Koo S,Martin G,Toussaint LG

更新日期：2015-06-01 00:00:00

abstract：:Throughout the world, breast cancer is among the major causes of cancer-related death and is the most common cancer found in women. The development of cancer molecular knowledge has surpassed the novel concept of cancer biology and unraveled principle targets for anticancer drug developments and treatment strategies. ...

journal_title：Anticancer research

authors： Tungsukruthai S,Petpiroon N,Chanvorachote P

更新日期：2018-05-01 00:00:00

abstract：:The aim of our study was to investigate the role of electroporation in the treatment of cisplatin resistant tumor cells in vitro. For this purpose we used well characterized human ovarian carcinoma IGROV I cells and their resistant subclone IGROV 1/DDP. The cells were either continuously exposed to cisplatin or treate...

journal_title：Anticancer research

authors： Cemazar M,Sersa G,Miklavcic D

更新日期：1998-11-01 00:00:00

abstract：:Para-aminobenzoic acid (PABA) has been previously reported as being an inhibitor of DDP toxicity, and its use did not result in any observable loss in antitumor activity of DDP. The following studies investigated the effect of PABA on the pharmacokinetics and urinary excretion of cis-diamminedichloroplatinum(II) (DDP)...

journal_title：Anticancer research

authors： Esposito M,Vannozzi M,Viale M,Pellecchia C,Civalleri D,Gogioso L

更新日期：1995-11-01 00:00:00

abstract：:Several signaling pathways have been recognized in normal c-kit-mediated signal transduction following stem cell factor (SCF) stimulation including Janus kinase (JAK)/signal transducer and activator of transcription (STAT), mitogen-activated protein kinase (MAPK) and phosphoinositol 3-kinase (PI-3 K) pathways. In gast...

journal_title：Anticancer research

authors： Paner GP,Silberman S,Hartman G,Micetich KC,Aranha GV,Alkan S

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Small cell neuroendocrine cervical carcinoma (SCNCC) is a rare tumor that comprises 1-3% of cervical tumors. SCNCC exhibits clinical and biological characteristics of both cervical neoplasm (such as local aggressiveness and involvement of papillomavirus) and neuroendocrine small cell cancer of any site (such...

journal_title：Anticancer research

authors： Bifulco G,Mandato VD,Giampaolino P,Piccoli R,Insabato L,De Rosa N,Nappi C

更新日期：2009-02-01 00:00:00

abstract：:Carcinoembryonic antigen was measured in serum and in extracts from 37 colorectal tumors and we found a poor correlation between circulating and tumor CEA. Monoclonal antiCEA antibodies were used in indirect immunoperoxidase staining of the corresponding formalin fixed tissue sections. We found that serum CEA measurem...

journal_title：Anticancer research

authors： Pagé M,Dalifard I,Bertrand G,Bocquillon PG,Daver A

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND/AIM:Metastases involving the adrenal glands can be treated surgically or with radiation therapy. Retrospective studies indicate that radiotherapy for this indication is safe, well-tolerated and associated with symptom palliation and good local control. We conducted this analysis to report on patterns and out...

journal_title：Anticancer research

authors： Buergy D,Rabe L,Siebenlist K,Stieler F,Fleckenstein J,Giordano FA,Wenz F,Boda-Heggemann J

更新日期：2018-08-01 00:00:00

abstract：:Telomerase activity is associated with most malignant tumors. To evaluate the role of telomerase reactivation as a diagnostic and prognostic marker in oral carcinogenesis activity was investigated in mortal and immortal cell lines in eight oral leukoplakias (OL) and 46 oral squamous cell carcinomas (OSCC). Activity wa...

journal_title：Anticancer research

authors： Ries JC,Hassfurther E,Steininger H,Kloss FR,Wiltfang J,Girod SC,Neukam FW

更新日期：2001-03-01 00:00:00

abstract：:ADCP is a dimeric glycoprotein of about 200KD, for which the physiological role is still obscure. This protein occurs mainly in a membrane bound form in various human tissues. In this paper we review the current literature on ADCP in cancer studies. Soluble ADCP was described to be consistently decreased or absent in ...

journal_title：Anticancer research

authors： Ten Kate J,Dinjens WN,Meera Khan P,Bosman FT

更新日期：1986-09-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of oxaliplatin (L-OHP) fractionated over two days with bimonthly 5-fluorouracil (5-FU) and leucovorin (LV), as first-line treatment of metastatic colorectal cancer (MCC) patients. PATIENTS AND METHODS:Fifty-four patients with inoperable MCC (median age, 60 years) were entere...

journal_title：Anticancer research

authors： Recchia F,Rea S,Nuzzo A,Lalli A,Di Lullo L,De Filippis S,Saggio G,Biondi E,Massa E,Mantovani G

更新日期：2004-05-01 00:00:00