Abstract:
AIM:To investigate the protein kinase B (Akt) signalling proteins phosphatase and tensin homolog (PTEN), phosphorylated-Akt (p-Akt) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in non-seminomatous germ cell tumors (NST) with a view to future investigative approaches. MATERIALS AND METHODS:The expressions of PTEN, p-Akt and p27(Kip1) were immunohistochemically assessed in 17 teratomas, 27 embryonal cell carcinomas, 6 yolk sac tumors and 24 benign testicular parenchymas. The cytoplasmic and corresponding nuclear expressions were compared and correlated to tumor entity. RESULTS:PTEN was dramatically reduced in all the NST subgroups. Concentrated nuclear p27(Kip1) and loss of the cytoplasmic form was found in teratomas and embryonal cell carcinomas. Neither altered expression nor negative Akt regulation was found. The yolk sac tumors showed late cytoplasmic shift of PTEN and p27(Kip1). CONCLUSION:Both, the absence of overexpression of p-Akt and of negative correlations to PTEN and p27(Kip1) suggest that signalling of these parameters in NST might include additional mechanisms such as crosstalk to other pathways rather than classical Akt activation.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Hennenlotter J,Amend B,Vogel U,Renninger M,Springer C,Kuehs U,Stenzl A,Bedke Jsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
3783-8issue
11eissn
0250-7005issn
1791-7530pii
31/11/3783journal_volume
31pub_type
杂志文章abstract:AIM:The aim of the study was to evaluate the long-term oncology outcomes of prostate cancer patients receiving robotic-assisted radical prostatectomy (RARP). PATIENTS AND METHODS:We retrospectively evaluated 111 patients with clinically-localized prostate cancer receiving RARP with a mean follow-up of 103.43 months. ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.11803
更新日期:2017-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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journal_title:Anticancer research
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更新日期:1999-03-01 00:00:00
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journal_title:Anticancer research
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更新日期:2015-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
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journal_title:Anticancer research
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更新日期:1995-11-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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journal_title:Anticancer research
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更新日期:2010-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2009-10-01 00:00:00
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journal_title:Anticancer research
pub_type:
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
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更新日期:2017-06-01 00:00:00
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更新日期:2016-10-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2016-06-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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