Abstract:
BACKGROUND/AIM:The presence of ascites in ovarian cancer patients is considered a negative prognostic factor. The underlying mechanisms are not clearly understood. MATERIALS AND METHODS:The amount of ascites was evaluated, preferably, using diffusion-weighted MRI at primary diagnosis in a retrospective cohort of 214 women with ovarian cancer, in an ordinal manner (amount of ascites: none, limited, moderate, abundant). In a prospective cohort comprising 45 women with ovarian cancer, IL-10 (interleukin), VEGF (vascular endothelial growth factor), TGF-β (transforming growth factor) and CCL-2 [chemokine (C-C) motif ligand 2] were measured at diagnosis (and at interval debulking, when available). RESULTS:Gradually increasing amounts of ascites were correlated significantly, even after correction for FIGO stage, with reduced survival (p<0.0001) and stronger immunosuppression (IL10 and VEGF). Neoadjuvant chemotherapy reduced immunosuppression, which was observed as a reduction in CCL-2, IL-10 and VEGF. CONCLUSION:The amount of ascites is an independent predictor of survival and correlates with increased immunosuppression.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Coosemans AN,Baert T,D'Heygere V,Wouters R,DE Laet L,VAN Hoylandt A,Thirion G,Ceusters J,Laenen A,Vandecaveye V,Vergote Idoi
10.21873/anticanres.13800subject
Has Abstractpub_date
2019-11-01 00:00:00pages
5953-5962issue
11eissn
0250-7005issn
1791-7530pii
39/11/5953journal_volume
39pub_type
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