Prognostic factors in patients with locally advanced (unresectable) or metastatic pancreatic adenocarcinoma: a retrospective analysis.

abstract：BACKGROUND:Stimulation of inducible nitric oxide synthase (iNOS) and release of nitric oxide by tumor cells may play a critical role in cancer development, either by exhibiting tumoricidal effects or by promoting tumor progression. MATERIALS AND METHODS:In the present study, we investigated four ovarian carcinoma cell...

journal_title：Anticancer research

authors： Rieder J,Marth C,Totzke G,Smolny M,Seibel M,Hoffmann G

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Selective estrogen receptor modulators (SERMS) like Tamoxifen and Raloxifen are used for menopausal symptoms, prevention of cardio-vascular diseases, osteoporosis and mammary carcinoma. Tamoxifen acts as an estrogen inhibitor on the mammary gland, but stimulates postmenopausal uterine mucosa in about 25% of ...

journal_title：Anticancer research

authors： Willèn R,Willèn H,Lindahl B

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND/AIM:Combining an anticancer agent fenretinide (HPR) or C6-pyridinium ceramide (LCL29) with Foscan-mediated photodynamic therapy (FoscanPDT) is expected to augment anticancer benefits of each substance. We showed that treatment with FoscanPDT+HPR enhanced accumulation of C16-dihydroceramide, and that fumonisi...

journal_title：Anticancer research

authors： Boppana NB,Kraveka JM,Rahmaniyan M,Li LI,Bielawska A,Bielawski J,Pierce JS,Delor JS,Zhang K,Korbelik M,Separovic D

更新日期：2017-02-01 00:00:00

abstract：:A 70-year-old man with a growing liver tumor had undergone subtotal gastrectomy with pancreaticoduodenectomy for gastric cancer (T4b P0 H0 N1, Stage IIIB) 30 months before admission to our hospital. Enhanced computed tomography revealed two hypervascular nodules in segments 4 and 8. After histological diagnosis of sma...

journal_title：Anticancer research

authors： Kinoshita K,Beppu T,Miyata T,Kuramoto K,Yoshida Y,Umesaki N,Kitano Y,Nakagawa S,Okabe H,Nitta H,Imai K,Hayashi H,Yamashita YI,Komori H,Horino K,Misumi A,Baba H

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:DNA topoisomerase II alpha (topo II alpha) is associated with active cell proliferation of mammalian cells. Topo II alpha overexpression has been reported in a number of human malignancies and is considered to be related to their biological behaviors. MATERIALS AND METHODS:We examined the expression of topo...

journal_title：Anticancer research

authors： Ohashi Y,Sasano H,Yamaki H,Shizawa S,Kikuchi A,Shineha R,Akaishi T,Satomi S,Nagura H

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Docetaxel is a very active drug against breast cancer, but at the standard dose causes severe myelosuppression. In order to reduce the toxicity while maintaining the activity, weekly docetaxel administration was tested. PATIENTS AND METHODS:We enrolled 30 patients with metastatic breast cancer, who had been...

journal_title：Anticancer research

authors： Maisano R,Mare M,Zavettieri M,Caristi N,Mesiti M,Scisca C,La Torre F

更新日期：2003-03-01 00:00:00

abstract：:We report a case of renal cell carcinoma with solitary metachronous metastasis to contralateral adrenal gland occurring 9 months after radical nephrectomy. The patient was treated with a contralateral adrenalectomy and is alive for 87 months. The literature was reviewed and 5-year survival of solitary metachronous met...

journal_title：Anticancer research

authors： Yamasaki Y,Koga S,Nishikido M,Noguchi M,Kanetake H,Saito Y

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:To further evaluate lung cancer risk associated with rare Hras1 VNTR alleles and possible biological mechanisms. MATERIALS AND METHODS:The Hras1 VNTR was genotyped in 295 lung cancer patients and 500 healthy controls by PCR and high resolution electrophoresis. Microsatellite alterations were examined in 168 tu...

journal_title：Anticancer research

authors： Lindstedt BA,Ryberg D,Zienolddiny S,Khan H,Haugen A

更新日期：1999-11-01 00:00:00

abstract：AIM:To determine the maximally tolerated dose (MTD), recommended phase II dose (RPTD) and toxicity profile of gemcitabine plus irinotecan combination. PATIENTS AND METHODS:Thirty-nine evaluable patients with advanced solid tumors were treated with gemcitabine (Gem) and irinotecan (Iri) on days 1, 8 and 15 of a 28-day ...

journal_title：Anticancer research

authors： Dugan E,Truax R,Meadows KL,Blobe GC,Morse MA,Fernando NH,Gockerman JP,Petros WP,Hurwitz HI

更新日期：2009-12-01 00:00:00

abstract：AIM:Hepatic resection has become the standard treatment for patients with primary or metastatic liver malignancies. The aim of our study was to evaluate the clinical outcome of hepatic resection in patients with advanced ovarian cancer (AOC). PATIENTS AND METHODS:All patients undergoing hepatic resection for AOC in ou...

journal_title：Anticancer research

authors： Neumann UP,Fotopoulou C,Schmeding M,Thelen A,Papanikolaou G,Braicu EI,Neuhaus P,Sehouli J

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND/AIM:Patients with metastatic head-and-neck cancer require individual therapies facilitated by prognostic tools. A tool to estimate the risk of recurrent or new cerebral metastases following whole-brain irradiation (WBI) is presented. PATIENTS AND METHODS:Age, gender, performance status, cancer site, number ...

journal_title：Anticancer research

authors： Staackmann C,Janssen S,Schild SE,Rades D

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:The successful use of clonal selection through fluctuation analysis of human cancer cells as a means for studying tumor progression has been previously reported. MATERIALS AND METHODS:Three clones derived from a parental population of human prostate cancer (LNCaP) cells were selected based on proliferation,...

journal_title：Anticancer research

authors： Ware JH,Zhou Z,Kopelovich L,Kennedy AR

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Malignant melanoma is a life-threatening disease with a poor prognosis due to its capacity for rapid metastasis and resistance to radio- and chemo-therapy. A pharmacological compound, CP-31398, was recently found to be able to stabilize wild-type p53 and rescue mutant p53 to enhance its transcriptional activ...

journal_title：Anticancer research

authors： Luu Y,Li G

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIM:This study aimed to investigate the effect of a new 7-(4-(N-substituted carbamoylmethyl) piperazin-1-yl) ciprofloxacin-derivative on the proliferation and migration abilities of HeLa cells. MATERIALS AND METHODS:Cell viability and morphological alterations were examined. Changes in migration were detect...

journal_title：Anticancer research

authors： Fathy M,Sun S,Zhao QL,Abdel-Aziz M,Abuo-Rahma GEA,Awale S,Nikaido T

更新日期：2020-09-01 00:00:00

abstract：:Smoking is the primary factor responsible for the epidemic of squamous cell lung cancer (SqLC) and small cell lung cancer (SCLC), however, there have been few studies which reported the relationship between smoking and SCLC in female patients. To examine the relationship between smoking and SCLC and SqLC in female pat...

journal_title：Anticancer research

authors： Satoh H,Yamashita YT,Ishikawa H,Kamma H,Ohtsuka M,Sekizawa K

更新日期：1999-11-01 00:00:00

abstract：UNLABELLED:The diagnostic accuracy of fused positron emission tomography/computed tomography (PET/CT) was compared with CT alone and PET alone in the staging and re-staging of nasopharyngeal carcinoma (NPC) patients. PATIENTS AND METHODS:Eighty-six fluorine-18-2-fluoro-2-deoxy-D-glucose (FDG) PET/CT studies were retro...

journal_title：Anticancer research

authors： Chen YK,Su CT,Ding HJ,Chi KH,Liang JA,Shen YY,Chen LK,Yeh CL,Liao AC,Kao CH

更新日期：2006-03-01 00:00:00

abstract：:We herein report a case of locally advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer that achieved a pathological complete response (pCR) with pertuzumab, trastuzumab and docetaxel therapy. A 70-year-old female presented with an elastic hard mass, 5.0 cm in diameter with broad redness and...

journal_title：Anticancer research

authors： Inoue Y,Yamashita N,Tokunaga E,Tanaka K,Ueo H,Saeki H,Oki E,Yamamoto H,Maehara Y

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor of the parafollicular C-cells, accounting for 5-10% of all thyroid tumors. To date, the only effective treatment is the early and total surgical removal of all neoplastic tissue. As the prognosis of patients with advanced MTC, unresectable or ...

journal_title：Anticancer research

authors： Pfragner R,Skofitsch G,Höger H,Jech M,Rinner B,Siegl V,Niederle B,Gnant M,Friedl J,Stift A

更新日期：2005-11-01 00:00:00

abstract：:Matrix metalloproteinase-7 (MMP-7), MMP-9, MMP-13, and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are considered to have important roles in the invasiveness and outcomes of colorectal cancer (CRC). This study examined the clinicopathological significance of the relative expression of these genes in patien...

journal_title：Anticancer research

authors： Yamada T,Oshima T,Yoshihara K,Tamura S,Kanazawa A,Inagaki D,Yamamoto N,Sato T,Fujii S,Numata K,Kunisaki C,Shiozawa M,Morinaga S,Akaike M,Rino Y,Tanaka K,Masuda M,Imada T

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:TZT-1027 (Soblidotin), a microtubule (MT)-depolymerizing agent, has antivascular activity through the disruption of microtubules in vascular endothelial cells. Our aim was to elucidate the mechanism of TZT-1027-induced antivascular activity by investigating the impact of various inhibitors. MATERIALS AND ME...

journal_title：Anticancer research

authors： Watanabe J,Natsume T,Kobayashi M

更新日期：2007-11-01 00:00:00

abstract：:The expression of the protooncogene encoded proteins (c-erbB1, c-erb B2, c-myc, c-fos) and the suppressor gene product p53 was analyzed in 81 human squamous cell carcinomas of the lung and correlated with clinical parameters of the patients (patient survival, presence of metastases and tumor stage) and with biological...

journal_title：Anticancer research

authors： Volm M,Efferth T,Mattern J

更新日期：1992-01-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare neoplasm with a poor prognosis. Prognostic factors are needed to identify patients who should be treated aggressively and those for which a less aggressive approach is warranted. As a result of advances within the field of immunohistochemistry, investigations of Ki-67, PCNA, IG...

journal_title：Anticancer research

authors： Edgren M,Eriksson B,Wilander E,Westlin JE,Nilsson S,Oberg K

更新日期：1997-03-01 00:00:00

abstract：:Amifostine (Ethyol, WR-2721) has been clinically used in combination with high dose therapy of neuroblastoma stage 4 with melphalan, carboplatin and VP-16 in 14 patients. The amifostine group was compared to a historical control group of 24 comparably-treated patients. There were no significant differences regarding t...

journal_title：Anticancer research

authors： Renner S,Krümpelmann S,Bruchelt G,Wiesinger H,Niethammer D,Klingebiel T

更新日期：2000-11-01 00:00:00

abstract：:S-1 is a new oral formulation of 5-fluorouracil (5-FU) containing 1 M tegafur and 0.4 M 5-chloro-2,4-dihydroxypyridine (CDHP) and 1 M potassium oxonate (Oxo). It has been reported to have a high antitumor activity and low gastrointestinal toxicity in rats bearing murine and human tumors. We further studied the possibl...

journal_title：Anticancer research

authors： Kato T,Shimamoto Y,Uchida J,Ohshimo H,Abe M,Shirasaka T,Fukushima M

更新日期：2001-05-01 00:00:00

abstract：AIM:Late oral mucosa changes after radiotherapy for head and neck cancer have been poorly studied. This study aimed to determine long-term effects of radiotherapy on oral mucosa using exfoliative oral cytology. PATIENTS AND METHODS:Fifty patients with cancer were enrolled, five of whom in order to validate microscopic...

journal_title：Anticancer research

authors： Massaro P,Corbella F,DI Liberto R,Paolini A,Pasi F,Tinelli C,DE Silvestri A,Nano R

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The size of colorectal polyps is important in the clinical management of these lesions. When using a conventional ruler (the tool of pathologists worldwide), we have previously found unacceptably high intra- and inter-observer variations in assessing the size of phantom polyps. The aim of this study was to a...

journal_title：Anticancer research

authors： Suzuki C,Matsson L,Rubio CA

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Due to the longer life expectancy of the world's population, the number of elderly cirrhotic patients undergoing surgery for hepatocellular carcinoma (HCC) is increasing. Our study evaluates the benefits of hepatic resections for HCC in cirrhotic patients aged over 65, analysing the early and long-term surgi...

journal_title：Anticancer research

authors： Mercantini P,Corigliano N,Lucandri G,Balducci G,Amodio PM,Ramacciato G,Ziparo V

更新日期：2002-11-01 00:00:00

abstract：:P-glycoprotein (P-gp) actively pumps out a number of anticancer drugs, such as epirubicin, from tumor cells. P-gp is also expressed in the small intestine under normal physiological conditions. Inhibition of intestinal P-gp function using MDR reversing agents may enhance the oral bioavailability of some chemotherapeut...

journal_title：Anticancer research

authors： Lo YL,Hsu CY,Huang JD

更新日期：1998-07-01 00:00:00

abstract：:Analysis of the overall patterns of gene expression at the polypeptide synthesis level has revealed two S-phase specific, proliferation sensitive nuclear proteins [cyclin (PCNA) and dividin (phosphoprotein)] whose rate of synthesis increases at the G1/S transition border of the cell cycle. All available evidence sugge...

journal_title：Anticancer research

authors： Celis JE,Madsen P,Nielsen S,Rasmussen HH

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:To clarify the pathogenicity of multiple human papilloma virus (HPV) infection, we applied SSCP (single-strand DNA conformation polymorphism) analysis for cervical neoplastic lesions. MATERIALS AND METHODS:Two hundred and sixty-six cervical swab specimens from normal cervix (n=64), cervical dysplasia (n=95)...

journal_title：Anticancer research

authors： Nakagawa H,Sugano K,Fujii T,Kubushiro K,Tsukazaki K,Nozawa S

更新日期：2002-05-01 00:00:00