Cyclooxygenase-2 expression correlates with apoptosis and angiogenesis in endometrial cancer tissue.

abstract：BACKGROUND:The rearrangement of actin cytoskeleton is being increasingly considered a marker of cancer cell activity, but the fine structure and remodeling of microfilaments within tumor tissue still remains unclear. MATERIALS AND METHODS:We used the recently introduced silicon-rhodamine (SiR)-actin dye to visualize e...

journal_title：Anticancer research

authors： Klementieva NV,Snopova LB,Prodanets NN,Furman OE,Dudenkova VV,Zagaynova EV,Lukyanov KA,Mishin AS

更新日期：2016-10-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) ranks as a leading cause of cancer-related death globally. Brain metastases are a frequent complication of NSCLC, with 25-40% of patients developing brain metastases during the course of the disease, often within the first 2 years after diagnosis of the primary tumor. Improvements in...

journal_title：Anticancer research

authors： Dempke WC,Edvardsen K,Lu S,Reinmuth N,Reck M,Inoue A

更新日期：2015-11-01 00:00:00

abstract：:Combined treatment of interleukin-2 (IL-2), 5-fluorouracil (5-FU) and mitomycin C (MMC) is reported to be effective against hepatic metastasis of colon carcinoma. To clarify this modality, we investigated lymphokine activated killer (LAK) activity of human peripheral lymphocytes on colon cancer cell lines by 51Cr rele...

journal_title：Anticancer research

authors： Ishihara M,Kubota T,Watanabe M,Kawano Y,Narai S,Yasui N,Otani Y,Teramoto T,Kitajima M

更新日期：1999-01-01 00:00:00

abstract：:A relationship was established between estradiol 16 alpha-hydroxylation, papillomavirus and its malignant sequelae. In this study, we determined that 16 alpha-hydroxylation was substantial in normal larynx and further increased in laryngeal papillomas. Estradiol or 16 alpha-hydroxyestrone stimulated proliferation in b...

journal_title：Anticancer research

authors： Newfield L,Goldsmith A,Bradlow HL,Auborn K

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:The different clinical evolution of breast cancer with similar pathological characteristics prompted the authors to investigate the prognostic significance of different biological markers. METHODS:Seventy-one primary breast carcinoma specimens obtained by mastectomy or quadrantectomy were examined for the d...

journal_title：Anticancer research

authors： Midulla C,De Iorio P,Nagar C,Pisani T,Cenci M,Valli C,Nofroni I,Vecchione A

更新日期：1999-09-01 00:00:00

abstract：AIM:The evaluation of toxicity after high-dose-rate interstitial brachytherapy (HDR-ISBT) as monotherapy for localized prostate cancer. MATERIALS AND METHODS:We analyzed early and late toxicities in 100 patients treated by HDR-ISBT as monotherapy at the National Hospital Organization Osaka National Hospital using both...

journal_title：Anticancer research

authors： Yoshida K,Yamazaki H,Nakamara S,Masui K,Kotsuma T,Akiyama H,Tanaka E,Yoshioka Y

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic chemicals that have been associated with increased risk of hepatic cancer, melanoma, non-Hodgkin lymphoma and cancer of many other body organs. Structural binding analyses of PCB 77 and PCB 118 with peroxisome proliferator-ac...

journal_title：Anticancer research

authors： Sheikh IA,Khweek AA,Beg MA

更新日期：2016-11-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare neoplasm with a poor prognosis. Prognostic factors are needed to identify patients who should be treated aggressively and those for which a less aggressive approach is warranted. As a result of advances within the field of immunohistochemistry, investigations of Ki-67, PCNA, IG...

journal_title：Anticancer research

authors： Edgren M,Eriksson B,Wilander E,Westlin JE,Nilsson S,Oberg K

更新日期：1997-03-01 00:00:00

abstract：:The most active fraction (Fr. VI) of antitumor and antiviral pine cone extract was subjected to chemical structure analysis. IR, UV, and ESR spectroscopies, in addition to chromatographic analysis on cellulose-TLC plates, reveal that the major component of Fr. VI includes structures belonging to the lignin family. A c...

journal_title：Anticancer research

authors： Sakagami H,Oh-Hara T,Kaiya T,Kawazoe Y,Nonoyama M,Konno K

更新日期：1989-11-01 00:00:00

abstract：:We have previously shown that oral administration of PSK not only exerts antitumor activity, but also restores immune response in tumor-bearing mice. In order to analyze the immunomodulative effect of PSK, we investigated the effects of oral PSK on the intestinal immune systems in ICR mice bearing sarcoma 180. Oral ad...

journal_title：Anticancer research

authors： Matsunaga K,Morita I,Oguchi Y,Fujii T,Yoshikumi C,Nomoto K

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Oxidised ferrocenium compounds often possess antineoplastic activity. In contrast, reduced ferrocene derivatives frequently only show activity if cell components can oxidise them inside cells to the ferrocenium species. Ferrocene compounds having the lowest formal reduction potential are normally expected to...

journal_title：Anticancer research

authors： Swarts JC,Vosloo TG,Cronje SJ,Du Plessis WC,Van Rensburg CE,Kreft E,Van Lier JE

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Bipolar radiofrequency ablation (RFA) can avoid complications such as thermal tissue damage, a possible consequence of monopolar RFA. However, basic studies about the dosage/effect relationship of bipolar systems are missing. This is systematic research on ex vivo beef livers to find which capacity parameter...

journal_title：Anticancer research

authors： Zurbuchen U,Frericks B,Roggan A,Lehmann K,Bössenroth D,Buhr HJ,Ritz JP

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND/AIM:To describe real clinical outcomes when using systemic therapy to treat non-small cell lung cancer (NSCLC) patients who have anaplastic lymphoma kinase (ALK) fusion gene mutation. PATIENTS AND METHODS:We performed a retrospective chart review from April 2008 to March 2019 sourced from 16 medical institu...

journal_title：Anticancer research

authors： Okauchi S,Numata T,Nawa T,Ichimura H,Saito T,Hayashihara K,Yamada H,Satoh H,Endo T,Inage Y,Kaburagi T,Kiyoshima M,Yamada Y,Tamura T,Saito K,Inagaki M,Hizawa N,Sato Y,Shiozawa T,Sekine I,Ishikawa H,Kurihima K,S

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND AIM:The Seventh American Joint Committee on Cancer (AJCC)/TNM classification defined that the classification for adenocarcinoma of the esophagogastric junction (AEG) was included in the esophageal category. However, there still remain various classifications in AEG such as the Seventh AJCC/TNM of the eso...

journal_title：Anticancer research

authors： Kawaguchi T,Komatsu S,Ichikawa D,Kubota T,Okamoto K,Shiozaki A,Fujiwara H,Konishi H,Morimura R,Murayama Y,Kuriu Y,Ikoma H,Nakanishi M,Sakakura C,Otsuji E

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND/AIM:Kallikrein-related peptidases (KLKs) comprise a serine protease family with prominent roles in tissue physiology and disease pathogenesis, including cancer. Previously, we have characterized canine Klk4-10 and -14. Herein, we continue our efforts by characterizing three novel members of the canine family...

journal_title：Anticancer research

authors： Angelopoulou K,Karagiannis GS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/AIM:Neuroendocrine neoplasms (NEN) of the female genital tract account for 2% of gynecological cancers. The aim of this study was to share our experience of 11 primary neuroendocrine neoplasms of the ovary. PATIENTS AND METHODS:All patients who presented and/or were treated at our Institution with histologi...

journal_title：Anticancer research

authors： Sehouli J,Woopen H,Pavel M,Richter R,Lauterbach LK,Taube E,Darb-Esfahani S,Fotopoulou C,Pietzner K

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that adjuvant systemic chemotherapy is necessary for the survival of breast cancer patients. Antitumor agents are more effective when used in combination with drugs exhibiting different mechanisms of action than when used alone. Previous studies from this laboratory have shown th...

journal_title：Anticancer research

authors： Das JR,Fryar EB,Epie NN,Southerland WM,Bowen D

更新日期：2006-05-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are important therapeutic drugs for postmenopausal women with hormone receptor-positive breast cancer. However, adverse effects of AIs such as arthralgia have been extensively reported. We performed a joint prospective, multi-institutional investigation to find out whether a low-dose and sho...

journal_title：Anticancer research

authors： Kubo M,Onishi H,Kuroki S,Okido M,Shimada K,Yokohata K,Umeda S,Ogawa T,Tanaka M,Katano M

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the outcomes of laparoscopic surgery in colorectal cancer patients with dialysis. PATIENTS AND METHODS:Fourteen dialysis (dialysis group) and 567 non-dialysis (non-dialysis group) patients who underwent laparoscopic and open surgery for colorectal cancer between April 2008 and December 20...

journal_title：Anticancer research

authors： Higashino N,Matsuda T,Hasegawa H,Yamashita K,Sakamoto H,Fujikawa M,Yamamoto M,Kanaji S,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

更新日期：2020-04-01 00:00:00

abstract：:This study was undertaken to investigate the role of the human ras family gene product [P21] in various benign, precancerous and malignant skin lesions. A streptavidin-biotin peroxidase method was performed using the monoclonal antibody (Mab)Y13259 in paraffin tissue sections of a total of 69 skin lesions (5 benign hy...

journal_title：Anticancer research

authors： Zioga C,Malamou-Mitsis VD,Kamina S,Agnantis NJ

更新日期：1995-05-01 00:00:00

abstract：:Gynaecologic oncology day surgery deals primarily with the diagnosis of endometrial, cervical, vulvar and vaginal tumors. Conscious sedation is an important technique used in gynaecologic oncology day surgery. It is often associated with regional anaesthesia. The goals of conscious sedation are to provide effective pa...

journal_title：Anticancer research

authors： Pace MC,Palagiano A,Pace L,Passavanti MB,Iannotti M,Sorrentino R,Aurilio C

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND/AIM:Tumor angiogenesis has been the subject of intensive research in recent years in many tumor types. Studies involving epithelial skin tumors are few to date. We evaluated tumor angiogenesis and lymphangiogenesis in cancerous and pre-cancerous lesions of the eyelids using immunohistochemical techniques. M...

journal_title：Anticancer research

authors： Tzoutzos K,Batistatou A,Kitsos G,Liasko R,Stefanou D

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The number of patients with second malignancies is growing and they represent about one in six out of all new cancers. Second malignancies can be categorized into three major groups according to the predominant etiological factor(s): (i) treatment-related, (ii) part of a syndrome and (iii) those due to share...

journal_title：Anticancer research

authors： Mahmood S,Vu K,Tai P,Joseph K,Koul R,Dubey A,Yu E

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND/AIM:Variations in cell phenotype in a single-cell-derived clone may result from asymmetric cell divisions that lead to different cell fate in a homogenous microenvironment. The aim of this study was to demonstrate the extent of cell variety in single-cell-derived clones and propose a different strategy in tr...

journal_title：Anticancer research

authors： Khan GN,Kim EJ,Shin TS,Lee SH

更新日期：2017-05-01 00:00:00

abstract：:A new cell line, designated CC2/CUHK2, was established from a squamous carcinoma of the uterine cervix from a Chinese patient. The cell line grew well without interruption for over 12 months and over 90 passages. The doubling time of CC2/CUHK2 was 72 hours at passage 57. When seeded at a density of 1.5 x 10(3) cells p...

journal_title：Anticancer research

authors： Ho TH,Chew EC,Tam JS,Hou HJ,Yam HF,Chew-Cheng SB,Wong FW

更新日期：1993-07-01 00:00:00

abstract：AIM:To investigate the possibility of enhancing an anti-metastatic effect of 5-fluorouracil (5-FU) on colorectal cancer (CRC) cells by combining it with continuous calcium supplementation. MATERIALS AND METHODS:Optimal doses of 5-FU with/without lactate salt (CaLa) were determined via clonogenicity and 3-(4,5-dimethyl...

journal_title：Anticancer research

authors： Park M,Sundaramoorthy P,Sim JJ,Jeong KY,Kim HM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Few investigators have focused on possible interactions among several MMPs collectively. MATERIALS AND METHODS:Immunostaining for MMP-7, MMP-2 and MT1-MMP was performed on 51 early invasive (T1) colorectal carcinomas, and correlations between the expressions of pairs of MMPs were examined. RESULTS:MMP-7 ex...

journal_title：Anticancer research

authors： Masaki T,Sugiyama M,Matsuoka H,Abe N,Izumisato Y,Sakamoto A,Atomi Y

更新日期：2003-09-01 00:00:00

abstract：:Mast cells are frequently found in close proximity to blood vessels and have been implicated in tumour angiogenesis. The aim of the present ultrastructural study was to characterize, in detail, the mutual association between mast cells and microvasculature in 9 cases of advanced gastric carcinoma. Perivascular mast ce...

journal_title：Anticancer research

authors： Caruso RA,Ieni A,Fabiano V,Basile G,Inferrera C

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Cervical cancer constitutes the second most common cancer in women. Estrogen promotes development of cervical cancer in cells infected with high risk human papillomaviruses (HPVs). We asked whether the phytochemical indole-3-carbinol (I3C) has anti-estrogenic activities in cervical cells with the goal of pre...

journal_title：Anticancer research

authors： Yuan F,Chen DZ,Liu K,Sepkovic DW,Bradlow HL,Auborn K

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND/AIM:In addition to its cytocidal effects as a microtubule dynamics inhibitor, eribulin mesylate (eribulin) regulates the tumour microenvironment. We examined the clinical significance of tumour infiltrating lymphocytes (TILs) and transforming growth factor-β (TGF-β), which are local markers of host immunity,...

journal_title：Anticancer research

authors： Kashiwagi S,Asano Y,Goto W,Takada K,Morisaki T,Kouhashi R,Yabumoto A,Tanaka S,Takashima T,Ohsawa M,Hirakawa K,Ohira M

更新日期：2020-06-01 00:00:00