Abstract:
AIM:The evaluation of toxicity after high-dose-rate interstitial brachytherapy (HDR-ISBT) as monotherapy for localized prostate cancer. MATERIALS AND METHODS:We analyzed early and late toxicities in 100 patients treated by HDR-ISBT as monotherapy at the National Hospital Organization Osaka National Hospital using both Common Terminology Criteria for Adverse Events version 3.0 (CTCAE v3.0) and Radiation Therapy Oncology Group (RTOG) score. The median follow-up was 72 (range=12-109) months. RESULTS:Late-gastrointestinal (GI) toxicities were 4% grade 1 and 2% grade 2 in CTCAE v3.0 and 5% grade 1 in RTOG score. Late genitourinary (GU) toxicities grade 1: grade 2: grade 3 were 29%: 5%: 2% in RTOG and 47%: 10%: 2% in CTCAE v3.0. CTCAE v3.0 GU score identified more grade 1-2 adverse reactions than the RTOG score (p=0.01). Early RTOG GI toxicity-positive patients showed 13% of late RTOG GI toxicity, whereas early RTOG GI negative patients showed 0% of RTOG (p=0.0172) and CTCAE v3.0 late-GI toxicity (p=0.007). CONCLUSION:CTCAE v3.0 GU score identified more grade 1-2 adverse reactions than the RTOG score. Early RTOG GI toxicity is well-correlated to late GI toxicity and absence of RTOG acute GI toxicity is a safe surrogate for late GI toxicity after HDR-ISBT as monotherapy for prostate cancer.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Yoshida K,Yamazaki H,Nakamara S,Masui K,Kotsuma T,Akiyama H,Tanaka E,Yoshioka Ysubject
Has Abstractpub_date
2014-04-01 00:00:00pages
2015-8issue
4eissn
0250-7005issn
1791-7530pii
34/4/2015journal_volume
34pub_type
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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pub_type: 临床试验,杂志文章
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更新日期:2014-02-01 00:00:00
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doi:
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journal_title:Anticancer research
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doi:
更新日期:1994-05-01 00:00:00
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journal_title:Anticancer research
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doi:
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doi:
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更新日期:2014-12-01 00:00:00
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更新日期:2014-07-01 00:00:00
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doi:
更新日期:2006-11-01 00:00:00
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