Prognostic value of increased lung tumor tissue cathepsin B.

abstract：:The pattern of cytoplasmic membrane gangliosides and two cellular features which have been reported to be related to the expression of different membrane gangliosides, namely adhesion to solid substrates and susceptibility to the lytic activity of immune effector cells, have been investigated in drug sensitive A2780 h...

journal_title：Anticancer research

authors： Mazzoni A,Trave F,Fabbri M,Leto G,Ghidoni R

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND AND AIM:The Seventh American Joint Committee on Cancer (AJCC)/TNM classification defined that the classification for adenocarcinoma of the esophagogastric junction (AEG) was included in the esophageal category. However, there still remain various classifications in AEG such as the Seventh AJCC/TNM of the eso...

journal_title：Anticancer research

authors： Kawaguchi T,Komatsu S,Ichikawa D,Kubota T,Okamoto K,Shiozaki A,Fujiwara H,Konishi H,Morimura R,Murayama Y,Kuriu Y,Ikoma H,Nakanishi M,Sakakura C,Otsuji E

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Lung resistance-related protein (LRP) was first detected in a non-P-glycoprotein-mediated multidrug-resistant lung cancer cell line and has been shown to be the major human vault protein. The aim of this study was to evaluate the expression of LRP in germ cell testicular tumors (GCT) and to determine the cor...

journal_title：Anticancer research

authors： Mándoky L,Géczi L,Doleschall Z,Bodrogi I,Csuka O,Kásler M,Bak M

更新日期：2004-03-01 00:00:00

abstract：:Around 1970 it was assumed that tumour cells are due to a single specific oncogenic mutation. This implied that daily many thousands of tumour cells would arise de novo and that most of these tumour cells were killed by immune surveillance or natural resistance mechanisms. Recent findings on immune surveillance and na...

journal_title：Anticancer research

authors： Den Otter W,Koten JW,Derkinderen DJ

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND/AIM:Prognosis for patients with head and neck squamous cell carcinoma (HNSCC) is poor in most cases and has not improved despite advances in therapy. Novel therapeutic approaches are mandatory in order to improve the situation. Everolimus, an inhibitor of mammalian target of rapamycin, as well as the multi-t...

journal_title：Anticancer research

authors： Aderhold C,Faber A,Umbreit C,Chakraborty A,Bockmayer A,Birk R,Sommer JU,Hörmann K,Schultz JD

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Previously, the antitumour activity of some flavone-8-acetic acid (FAA) derivatives substituted with an acid function in position 2 of the benzene ring was evaluated. The most active compound resulted the one bearing a fluorine atom in position 7 of the flavone nucleus. In this paper, we evaluated new mono- ...

journal_title：Anticancer research

authors： Carrara M,Zampiron A,Barbera M,Caputo A,Bisi A,Gobbi S,Belluti F,Piazzi L,Rampa A,Valenti P

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Recently, we reported on the existence of activated protein kinase Cα (PKCα) in blood and the possibility for its use in cancer diagnosis. MATERIALS AND METHODS:In the present study, serum samples collected from patients with different lung cancer types (small-cell cancer, adenocarcinoma, and anaplastic can...

journal_title：Anticancer research

authors： Kang JH,Mori T,Kitazaki H,Niidome T,Takayama K,Nakanishi Y,Katayama Y

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND/AIM:Anthracyclines, such as doxorubicin, though widely used in anticancer therapy, they are associated with cardiotoxic side-effects. The aim of this trial was to investigate long-term follow-up cardiotoxicity findings in patients treated with doxorubicin and concomitant metoprolol or enalapril 10 years earl...

journal_title：Anticancer research

authors： Georgakopoulos P,Kyriakidis M,Perpinia A,Karavidas A,Zimeras S,Mamalis N,Kouvela M,Charpidou A

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The genetic basis of sinonasal inverted papilloma (SNIP)-derived squamous cell carcinoma (SCC) has not yet been well characterized. AIM:To characterize the genetic abnormalities of SNIP and SNIP-derived SCC and to uncover their differences. MATERIALS AND METHODS:Mutations of 409 genes were analyzed using a...

journal_title：Anticancer research

authors： Uchi R,Jiromaru R,Yasumatsu R,Yamamoto H,Hongo T,Manako T,Sato K,Hashimoto K,Wakasaki T,Matsuo M,Nakagawa T

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The BCL2 proto-oncogene in non-Hodgkin's lymphoma is a dominant inhibitor of apoptosis. The goal of this work was to develop a (177)Lu-labeled anti-BCL2-peptide nucleic acid (PNA) conjugate designed for dual modality NHL therapy, i.e., simultaneous down-regulation of BCL2-mediated resistance to apoptosis and...

journal_title：Anticancer research

authors： Balkin ER,Jia F,Miller WH,Lewis MR

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND/AIM:We aimed to investigate the efficacy of immune-cell therapy in terms of the survival of patients with neuroendocrine carcinoma of the uterine cervix (NECC), which lacks standardized therapeutic approaches. PATIENTS AND METHODS:We identified 17 patients who were diagnosed as having NECC and treated with ...

journal_title：Anticancer research

authors： Goto S,Terao Y,Kamigaki T,Takimoto R,Naitoh K,Makita K,Yasumoto K,Okada S,Takizawa K,Yokomichi N,Suzuki N,Takeda S

更新日期：2020-08-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal tumor entity of the gastrointestinal tract. In fewer than 5% of cases, primary GISTs are located in the duodenum. Surgery represents the treatment of choice for localized tumor disease and remains challenging in GISTs located at the duodenum...

journal_title：Anticancer research

authors： Mrak K,Liegl-Atzwanger B,Haybaeck J,Petritsch W,Mischinger HJ,Kornprat P

更新日期：2015-11-01 00:00:00

abstract：:The requirements on sunscreens have essentially changed, since some years ago it was demonstrated that approximately 50% of free radicals, that are formed in the skin by solar radiation, originate from the visible and infrared regions of the solar spectrum. In addition, a critical radical concentration threshold could...

journal_title：Anticancer research

authors： Zastrow L,Lademann J

更新日期：2016-03-01 00:00:00

abstract：:The dimers bis-EUG, bis-MMP, bis-BHA, bis-BMP and bis-DBP were synthesized from the monomers 4-allyl-2-methoxyphenol (EUG), 2-methoxy-4-methylphenol (MMP), 2-t-butyl-4-methoxyphenol (BHA), 2-t-butyl-4-methylphenol (BMP) and 2,4-di-t-butylphenol (DBP), respectively. The stoichiometric factors (n; number of free radical...

journal_title：Anticancer research

authors： Fujisawa S,Atsumi T,Kadoma Y,Ishihara M,Ito S,Yokoe I

更新日期：2004-09-01 00:00:00

abstract：:Rats were inoculated subcutaneously into both flanks with a transplantable adenocarcinoma of the colon. They were treated intravenously with either 5-FUrd (5-fluorouridine) or 5-FdUrd (5-fluoro-2'-deoxyuridine) with or without addition of dipyridamole 20 and 30 min later, respectively, for 3 consecutive days. Dipyrida...

journal_title：Anticancer research

authors： el Hag IA,Roos G,Jönsson PE,Stenram U

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIM:It is unknown whether hypoxia regulates aurora kinase A (AURKA), a serine/threonine kinase, in neuroblastoma to stimulate cell growth or migration. We sought to determine whether AURKA mediates hypoxia-induced regulation of neuroblastoma tumorigenicity. MATERIALS AND METHODS:Human neuroblastoma BE(2)-C ...

journal_title：Anticancer research

authors： Romain CV,Paul P,Lee S,Qiao J,Chung DH

更新日期：2014-05-01 00:00:00

abstract：:We examined the optimal timing for the enhancement of antitumor effects of CDDP analogues, cis- diammine-1,1- cyclobutane dicarboxylate platinum (II); CBDCA combined with hyperthermia against the CD-1 mice bearing Ehrlich ascites tumor (EAT) cells in vivo. The prolonged tumor doubling time was observed when two modali...

journal_title：Anticancer research

authors： Mizuuchi H,Yoshiga K,Sakurai K,Tsumura M,Takada K

更新日期：1996-01-01 00:00:00

abstract：:The purpose of this study was to elucidate the behavior of signal transduction activity in rat and human carcinoma cells. Signal transduction activity was measured by the steady-state activity of the three enzymes involved in the conversion of 1-phosphatidylinositol (PI) to IP3, PI 4-kinase, PI 4-phosphate 5-kinase, a...

journal_title：Anticancer research

authors： Weber G,Shen F,Prajda N,Yeh YA,Yang H,Herenyiova M,Look KY

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms of carcinogen-metabolizing enzyme genes have been associated with the risk of oral squamous cell carcinoma and oral leukoplakia. The overexpression of p53 protein is the most common genetic alteration in head and neck cancer. In the present study the combined or isolated presence of glu...

journal_title：Anticancer research

authors： Duarte EC,Ribeiro DC,Gomez MV,Ramos-Jorge ML,Gomez RS

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The antitumor growth and antimetastatic actions of celecoxib [a selective cyclooxygenase-2 (COX-2) inhibitor] were investigated in a metastatic murine mammary cancer model. MATERIALS AND METHODS:Mice bearing mammary tumors, developed after inoculation of syngeneic BALBIc mice with a mammary carcinoma cell l...

journal_title：Anticancer research

authors： Yoshinaka R,Shibata MA,Morimoto J,Tanigawa N,Otsuki Y

更新日期：2006-11-01 00:00:00

abstract：:Intravenous administration of sodium benzylideneascorbate (SBA) rapidly necrotized inoperable human lung cancer, and induced degeneration of 3'-methyl-4-dimethylaminoazobenzene-induced rat hepatocellular carcinoma (vacuolar, eosinophilic degeneration, nuclear debris) without affecting the serum glutamic oxaloacetic tr...

journal_title：Anticancer research

authors： Sakagami H,Asano K,Fukuchi K,Gomi K,Ota H,Kazama K,Tanuma S,Kochi M

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Hyaluronan is one of the main components of the extracellular matrix. It is synthesized at the cell plasma membrane by specific hyaluronan synthases (HAS). Although a large number of studies have described hyaluronan in pleural effusion from malignant mesothelioma, the source of hyaluronan in malignant mesot...

journal_title：Anticancer research

authors： Liu Z,Dobra K,Hauzenberger D,Klominek J

更新日期：2004-03-01 00:00:00

abstract：:A rat rhabdomyosarcoma clonal line RMS/8 was cotransfected with genomic DNA of procaryotic or eucaryotic origin and neomycin resistance plasmid pKOneo. The lung colonizing and metastatic capacity of transfected cells was evaluated. When col- meta- RMS/8 cells were transfected, an increase in lung colonizing but not in...

journal_title：Anticancer research

authors： Verrelle P,Lascaut V,Poupon MF,Hillova J

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:5-Fluoro-2'-deoxyuridine (5-FdU), a drug against gastric cancer, was covalently linked via its nucleobase with the amino-bisphosphonate alendronate (Ale), resulting in a new antimetabolite-bisphosphonate conjugate (5-FdU-Ale), designed for bone-targeting. MATERIALS AND METHODS:The cytostatic effect of 5-FdU...

journal_title：Anticancer research

authors： Weinreich J,Schott TC,Königsrainer I,Küper M,Königsrainer A,Schott H

更新日期：2012-10-01 00:00:00

abstract：:The accumulation of vincristine in leukemic cells and normal mononuclear cells and the effect of verapamil on cellular drug accumulation were studied. Leukemic cells were isolated from 10 patients with chronic lymphocytic leukemia, immunocytoma and prolymphocytic leukemia. Normal mononuclear cells were collected from ...

journal_title：Anticancer research

authors： Gruber A,Reizenstein P,Peterson C

更新日期：1989-01-01 00:00:00

abstract：:Although cancer belongs to one of the leading causes of death around the world, fortunately studies have shown that tumor cells have various targets that are susceptible to attack. Interestingly, tumor cells are comprised of cellular membranes, which are altered in chemical composition relative to non-neoplastic cells...

journal_title：Anticancer research

authors： Oelkrug C,Hartke M,Schubert A

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The effects of resveratrol (a natural polyphenol) on angiogenesis in rat gliomas were investigated by color Doppler ultrasound (CDUS). The correlation among the tumor growth rate, macroscopic angiogenesis measured by CDUS and microscopic angiogenesis was assessed by immunohistochemical staining. MATERIALS A...

journal_title：Anticancer research

authors： Chen JC,Chen Y,Lin JH,Wu JM,Tseng SH

更新日期：2006-03-01 00:00:00

abstract：:From 1980 to 1987, 243 evaluable patients with pT1, pT2 (less than 3 centimeters in diameter), N0, M0, invasive breast cancer were treated with "quadrantectomy" with axillary dissection followed by electron beam radiation therapy (QUART) at the St. Bortolo Hospital, Vicenza. Stage II patients received adjuvant chemoth...

journal_title：Anticancer research

authors： Gasparini G,Panizzoni GA,Dal Fior S,Germani B,Dall'Antonia F,Segato G,Meli S,Pozza F

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND/AIM:For cases of musculoskeletal sarcoma of the knee presenting to our institute, we prioritize joint preservation whenever possible. To investigate patient satisfaction and desire for joint preservation, a questionnaire survey was performed. PATIENTS AND METHODS:Surveys were mailed to 62 patients with musc...

journal_title：Anticancer research

authors： Abe K,Yamamoto N,Hayashi K,Takeuchi A,Kato S,Miwa S,Igarashi K,Inatani H,Aoki YU,Higuchi T,Taniguchi Y,Tsuchiya H

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Various localized side effects which accompany head and neck irradiation [IR] have been widely reported. However, systemic side effects/have been only sparsely reported in the short-term period post-IR in an animal model. The potential modulatory role of zinc-desferrioxamine [Zn-DFO] on IR effects was examin...

journal_title：Anticancer research

authors： Nagler RM,Barak V,Nagler A

更新日期：2000-05-01 00:00:00