Abstract:
BACKGROUND:Recently, we reported on the existence of activated protein kinase Cα (PKCα) in blood and the possibility for its use in cancer diagnosis. MATERIALS AND METHODS:In the present study, serum samples collected from patients with different lung cancer types (small-cell cancer, adenocarcinoma, and anaplastic cancer) were phosphorylated with a PKCα-specific peptide substrate and the phosphorylation ratio was detected by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. RESULTS:When 13 patient serum samples were phosphorylated with peptide substrates, phosphorylated peaks were obtained in eight samples. However, no peak associated with the phosphorylated peptide was observed using serum samples obtained from 10 healthy persons. Moreover, broadly used cancer biomarkers (progastrin-releasing peptide, carcinoembryonic antigen, and cytokeratin-19 fragment) were identified in eight samples among the 13 samples studied. CONCLUSION:These results suggest that serum activated PKCα is a reliable biomarker, applicable to lung cancer diagnosis.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kang JH,Mori T,Kitazaki H,Niidome T,Takayama K,Nakanishi Y,Katayama Ysubject
Has Abstractpub_date
2013-02-01 00:00:00pages
485-8issue
2eissn
0250-7005issn
1791-7530pii
33/2/485journal_volume
33pub_type
杂志文章abstract::To overcome 5-Fluorouracil (5FU) infusion-related problems, oral 5FU precursors and inhibitors of 5FU degradation have been developed. Capecitabine is one of these new oral fluoropyrimidines. Capecitabine treatment of advanced colorectal carcinoma, when compared to 5FU, results in superior response rates (26.6% versus...
journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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doi:
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:
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pub_type: 杂志文章,随机对照试验
doi:
更新日期:2015-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2013-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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更新日期:2020-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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