Potentiation by dipyridamole of 5-fluorouridine antitumor activity against a rat adenocarcinoma in vivo.

abstract：:Herein we report on a case of synchronous large gastrointestinal stromal tumor (GIST) and adenocarcinoma of the stomach treated with radical surgery following neoadjuvant therapy with imatinib mesylate. A 58-year-old man was referred to our hospital with a large mass in the peritoneal cavity. Abdominal computed tomogr...

journal_title：Anticancer research

authors： Namikawa T,Munekage E,Munekage M,Maeda M,Yatabe T,Kitagawa H,Sakamoto K,Obatake M,Kobayashi M,Hanazaki K

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND/AIM:Non-pegylated liposomal doxorubicin (NPLD) has demonstrated antitumour activity equivalent to conventional doxorubicin and a significantly lower risk of cardiotoxicity. This phase II trial was performed to evaluate the activity and the safety of NPLD and ifosfamide combination in patients with metastatic...

journal_title：Anticancer research

authors： De Sanctis R,Bertuzzi A,Basso U,Comandone A,Marchetti S,Marrari A,Colombo P,Lutman RF,Giordano L,Santoro A

更新日期：2015-01-01 00:00:00

abstract：:Prostatic 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase) is up-regulated by epidermal growth factor (EGF) and down-regulated by 1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D] at the promoter level in an autocrine/paracrine fashion, suggesting that local production of 1alpha,25(OH)2D could provide an important c...

journal_title：Anticancer research

authors： Wang L,Persons KS,Jamieson D,Flanagan JN,Hsu HH,Holick MF,Luo Z,Sakaki T,Urushino N,Faller DV,Chen TC

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND/AIM:Hepatitis B virus-encoded X protein (HBx) plays a pivotal role in hepatocellular carcinoma (HCC) progression and treatment resistance. Interestingly, our previous study unexpectedly showed that full-length HBx sensitized HCC cells to lapatinib by up-regulating erb-b2 receptor tyrosine kinase 3 (ERBB3). W...

journal_title：Anticancer research

authors： Chen JY,Huang WC,Wei CT,Chien PH,Chen YJ

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Primary serous-papillary peritoneal carcinoma is able to spread to the retroperitoneal lymph nodes, but there is no evidence of the pattern of lymphatic metastasis. Because of the fact that this tumor entity is indistinguishable histologically from primary serous-papillary ovarian carcinoma, its taxonomic po...

journal_title：Anticancer research

authors： Steinhagen PR,Sehouli J

更新日期：2011-04-01 00:00:00

abstract：:We present a new approach towards the detection of the mRNAs in formalin-fixed, paraffin-embedded samples using a reverse transcriptase (RT)-polymerase chain reaction (PCR). The total RNAs were extracted from 10-micron-thick sections and were reverse-transcribed, then the RT-products were subjected to PCR amplificatio...

journal_title：Anticancer research

authors： Tachibana M,Shinagawa Y,Kawamata H,Omotehara F,Horiuchi H,Ohkura Y,Kubota K,Imai Y,Fujibayashi T,Fujimori T

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Big Endothelin-1 levels increase significantly in patients with various tumors, and raised plasma concentrations are associated with worse outcome. The aim of this study was to investigate plasma Big Endothelin-1 levels in patients with gastric carcinoma before and after radical gastrectomy and to explore it...

journal_title：Anticancer research

authors： Teng XJ,Shen ZX,Xiang JJ,Shen L,Yuan L,Guo J,Wang XL

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND/AIM:Phenothiazines constitute a versatile family of compounds in terms of biological activity, which have also gained a considerable attention in cancer research. MATERIALS AND METHODS:Three phenothiazines (promethazine, chlorpromazine and thioridazine) have been tested in combination with 11 active selenoc...

journal_title：Anticancer research

authors： GajdÁcs M,NovÉ M,Csonka Á,Varga B,SanmartÍn C,DomÍnguez-Álvarez E,Spengler G

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND/AIM:This study aimed to identify the survival benefit of intrahepatic tumour control by hepatic arterial infusion chemotherapy (HAIC) in hepatocellular carcinoma (HCC) patients with portal vein tumour thrombus (PVTT) or extrahepatic metastasis. PATIENTS AND METHODS:Between 2010 and 2017, a total of 187 cons...

journal_title：Anticancer research

authors： Sung PS,Yang K,Bae SH,Oh JS,Chun HJ,Nam HC,Jang JW,Choi JY,Yoon SK

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Lung cancer tissues are often infiltrated by B lymphocytes, but it is not clear whether these infiltrations represent tumor-specific immune response or a nonspecific reaction. MATERIALS AND METHODS:The serological analysis of recombinant cDNA expression libraries (SEREX) were previously modified using a sev...

journal_title：Anticancer research

authors： Yasuda M,Mizukami M,Hanagiri T,Shigematsu Y,Fukuyama T,Nagata Y,So T,Ichiki Y,Sugaya M,Takenoyama M,Sugio K,Yasumoto K

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIM:High-mobility group box 1 (HMGB1) is a nuclear DNA-binding protein that exerts a range of proinflammatory actions when it is secreted extracellularly. We hypothesized that HMGB1 released from damaged cells in pituitary apoplexy would exacerbate the neurological symptoms due to acute inflammation. PATIEN...

journal_title：Anticancer research

authors： Okuda T,Fujita M,Kato A

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:As a majority of ovarian cancer patients will ultimately develop recurrent disease, there is an urgent need for alternative or additional approaches in the treatment of this cancer. MATERIALS AND METHODS:The antitumour effect of i.p. administered cisplatin, liposomal muramyltripeptide phosphatidylethanulami...

journal_title：Anticancer research

authors： Klimp AH,De Vries EG,Scherphof GL,Daemen T

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Bipolar radiofrequency ablation (RFA) can avoid complications such as thermal tissue damage, a possible consequence of monopolar RFA. However, basic studies about the dosage/effect relationship of bipolar systems are missing. This is systematic research on ex vivo beef livers to find which capacity parameter...

journal_title：Anticancer research

authors： Zurbuchen U,Frericks B,Roggan A,Lehmann K,Bössenroth D,Buhr HJ,Ritz JP

更新日期：2009-04-01 00:00:00

abstract：:A possible influence of tamoxifen (TAM) treatment on the measurable content of some steroid hormone receptors (i.e. ER, PgR, AR) from primary breast cancers has been evaluated. In eleven postmenopausal women, two biopsies were taken from the same tumor, the first biopsy before starting endocrine treatment, and a secon...

journal_title：Anticancer research

authors： Lundgren S,Søreide JA,Lea OA

更新日期：1994-05-01 00:00:00

abstract：:The in vitro antioxidative activity of benzylideneascorbate (SBA) and the in vivo effect on adriamycin (ADR)-induced cardiotoxicity in a mouse model were investigated. The radical-scavenging activity of SBA was assayed in terms of reduction of chemiluminescence induced by O2-, generated in xanthine/xanthine oxidase an...

journal_title：Anticancer research

authors： Kojima S,Iizuka H,Yamaguchi H,Tanuma S,Kochi M,Ueno Y

更新日期：1994-09-01 00:00:00

abstract：:Selective delivery of a high level of Mitomycin C (MMC) in intraperitoneal disseminated lesions was studied using a new dosage form of MMC, called MMC-CH. Intracavitary MMC-CH delivered a much higher level of MMC selectively to intraperitoneal tissues, with a much lower level of MMC in the whole body, in comparison wi...

journal_title：Anticancer research

authors： Hagiwara A,Takahashi T,Lee R,Ueda T,Takeda M,Itoh T

更新日期：1986-09-01 00:00:00

abstract：:The production of DNA interstrand crosslinks (ISC) by BCNU and other bifunctional alkylators and the effects of these drugs on the repair of radiation-induced DNA-single strand breaks (SSB) were studied in two human glioblastoma used to assess both DNA-ISCs and DNA-SSBs. BCNU-treated UWR2 and UWR3 cells showed a signi...

journal_title：Anticancer research

authors： Ali-Osman F,Srivenugopal K,Berger MS,Stein DE

更新日期：1990-05-01 00:00:00

abstract：:The present study was undertaken to evaluate the significance of grooved nuclei as an additional diagnostic criterion for primary breast carcinoma as well as their association with tumor grade in cytologic material obtained by fine needle aspiration (FNA). Cytologic slides of 105 cases of breast carcinoma (89 ductal, ...

journal_title：Anticancer research

authors： Labropoulou P,Psachoulia C,Batistatou A,Kardari M,Scopa CD

更新日期：1996-11-01 00:00:00

abstract：:The effects of the oral administration of 100 mg/kg/day egg-white lysozyme (EWL) on the expression of CD3, CD4, CD8 and CD25 antigens of lymphocytes harvested from IEL and mesenteric lymph nodes (MLNL) were tested in mice bearing MCa mammary carcinoma. Lysozyme, after oral administration, retains its enzymatic activit...

journal_title：Anticancer research

authors： Pacor S,Giacomello E,Bergamo A,Gagliardi R,Cocchietto M,Sava G

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:We previously showed the usefulness of a fused protein of human pancreatic ribonuclease1 (hRNase1) with human epidermal growth factor (hEGF) for molecular targeting of EGF receptor (EGFR)-overexpressing cells. In this study, the mechanisms underlying the inhibition of cell growth by RNase-EGF fused proteins ...

journal_title：Anticancer research

authors： Hoshimoto S,Ueda M,Jinno H,Kitajima M,Futami J,Seno M

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND/AIM:Ras-related associated with diabetes (RRAD), a member of the Ras-related GTPase superfamily, is frequently methylated in several human cancers, though its methylation profile remains unclear in esophageal cancer. MATERIALS AND METHODS:We examined RRAD promoter hypermethylation using real-time quantitati...

journal_title：Anticancer research

authors： Jin Z,Feng X,Jian Q,Cheng Y,Gao Y,Zhang X,Wang L,Zhang Y,Huang W,Fan X,Chen S,Yu H,Zhao Z,Dong M,Liu J,Mori Y,Meltzer SJ

更新日期：2013-11-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to clarify the role and the predictive strength of the adhesion molecule CD44s (standard isoform) in colorectal carcinogenesis. MATERIALS AND METHODS:CD44s immunohistochemical expression was evaluated in 100 patients with colon adenoma and 100 patients with colon adenocarcinoma...

journal_title：Anticancer research

authors： Visca P,Del Nonno F,Botti C,Marandino F,Sebastiani V,Di Tondo U,Donnorso RP,Trombetta G,Filippi S,Alo PL

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid to prostaglandins and other eicosanoids. A recent report has indicated a selective COX-2 inhibitor resulted in increased apoptosis and down-regulated bcl-2 expression in the androgen-sensitive human prostate cancer cell. We investigat...

journal_title：Anticancer research

authors： Tanji N,Kikugawa T,Yokoyama M

更新日期：2000-07-01 00:00:00

abstract：:We have reported the presence of a CD4+ subpopulation of Natural Killer cells (NK) in humans. These cells also express HIV coreceptors CCR5 or CXCR4 and are infectable by HIV-1. Infection is productive and persistent in vitro and in vivo. Infected people under therapy have evidence of viral DNA in their NK pool. In vi...

journal_title：Anticancer research

authors： Valentin A,Pavlakis GN

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND/AIM:Hypoxia offers resistance to therapy in human solid tumors. The aim of the study was to investigate whether SN-38, the active metabolite of irinotecan, acts as a radiosensitizer through inhibition of hypoxia-inducible factor (HIF)-1α in the human colorectal cancer (CRC) cells. MATERIALS AND METHODS:HT29...

journal_title：Anticancer research

authors： Okuno T,Kawai K,Hata K,Murono K,Emoto S,Kaneko M,Sasaki K,Nishikawa T,Tanaka T,Nozawa H

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND/AIM:Small cell lung cancer (SCLC) is still a deadly type of cancer for which there are few effective therapeutic strategies. Development of a new molecule targeting agent is urgently desired. Previously we showed that recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and mastermin...

journal_title：Anticancer research

authors： Onishi H,Ichimiya S,Yanai K,Umebayashi M,Nakamura K,Yamasaki A,Imaizumi A,Nagai S,Murahashi M,Ogata H,Morisaki T

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND/AIM:Patients with metastatic head-and-neck cancer require individual therapies facilitated by prognostic tools. A tool to estimate the risk of recurrent or new cerebral metastases following whole-brain irradiation (WBI) is presented. PATIENTS AND METHODS:Age, gender, performance status, cancer site, number ...

journal_title：Anticancer research

authors： Staackmann C,Janssen S,Schild SE,Rades D

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast tumors and these breast tumors are usually aggressive and highly metastatic. Unfortunately, treatment options for TNBCs are limited; we have identified a novel molecule, 2'-3'-dehydrosalannol (DHS) and in this study we investigated the an...

journal_title：Anticancer research

authors： Boopalan T,Arumugam A,Damodaran C,Rajkumar L

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND/AIM:We have shown that either chronic nicotine (NIC) exposure or 5-aza-cytidine (AZA) augments oxidative stress-dependent injury through stimulating p66shc in renal cells. Hence, NIC could exacerbate adverse effects of AZA while antioxidants such as resveratrol (RES) could prevent it. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Arany I,Hall S,Faisal A,Dixit M

更新日期：2017-08-01 00:00:00

abstract：:In long term culture of N-ethyl-N-nitrosourea (ENU) exposed fetal BD IX-rat brains, cells proliferate and form aggregates (nodules) in vitro, starting 2-3 months after the transplacental carcinogen injection in vivo. Cell nodules of cultures from 3-6 months after ENU exposure were investigated for the presence of orga...

journal_title：Anticancer research

authors： Mørk SJ

更新日期：1984-05-01 00:00:00