A Tool to Predict the Probability of Intracerebral Recurrence or New Cerebral Metastases After Whole-brain Irradiation in Patients with Head-and-Neck Cancer.

abstract：BACKGROUND:The recent availability of a monoclonal antibody against human telomerase reverse transcriptase (hTERT) has enabled us to investigate the telomerase activity of tissue specimens more easily than by classical TRAP assay. In this study, we studied teromerase activity in thyroid tumors using this antibody. MAT...

journal_title：Anticancer research

authors： Ito Y,Yoshida H,Tomoda C,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：:We have previously reported that lignin carbohydrate complex and E. coli lipopolysaccharide (LPS), but not their precursors or (-)-epigallocatechin-3-gallate (EGCG), enhanced the nitric oxide (NO), citrulline and asparagines production by the mouse-macrophage-like cell line Raw264.7. Here the EGCG inhibition of NO pro...

journal_title：Anticancer research

authors： Hashimoto K,Sakagami H

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:The optimal palliative chemotherapy in endometrial cancer is unknown. CASE REPORT:A patient was diagnosed to have primary endometrioid endometrial cancer metastatic to the pelvic, paraaortic and right inguinal lymph nodes (FIGO IVb). After radical surgery, she received 6 adjuvant cycles of cisplatin and epi...

journal_title：Anticancer research

authors： Idris T,Winter R,Lang U,Petru E

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:It has been demonstrated that 2-Methoxyestradiol (2-ME), one of the estrogen metabolites, induces apoptosis in many different tumor cell lines. In the present study, the effects of 2-ME on human cervical cancer HeLaS3 cells and on normal cervical epithelial cells were evaluated. MATERIALS AND METHODS:Acridi...

journal_title：Anticancer research

authors： Li L,Bu S,Bäckström T,Landström M,Ulmsten U,Fu X

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:The use of prophylactic cranial irradiation (PCI) to treat brain metastases (BM) in non-small cell lung cancer (NSCLC) is restricted due to the potential associated toxicity and lack of survival benefit. BM can have a negative impact on neurocognitive function (NF) and quality of life (QOL). The aim of this ...

journal_title：Anticancer research

authors： Precival C,Landy M,Poole C,Mullaney L

更新日期：2018-01-01 00:00:00

abstract：AIM:To report our experience on implementation and preliminary results of a decision-making model based on the recommendations of an Interdisciplinary Oncological Care Group developed for the management of colorectal cancer. PATIENTS AND METHODS:The multidisciplinary team identified a reference guideline using apprais...

journal_title：Anticancer research

authors： Genovesi D,Mazzilli L,Trignani M,DI Tommaso M,Nuzzo A,Biondi E,Tinari N,Martino MT,Innocenti P,DI Sebastiano P,Mazzola L,Lanci C,Neri M,Laterza F,Marino M,Ferrini G,Spadaccini A,Filippone A,DI Giandomenico E,Marulli

更新日期：2014-05-01 00:00:00

abstract：:An in vitro pilot study was conducted of the possible utility of combining low doses of cytosine arabinoside (araC) and GM-CSF to stimulate leukemic cell differentiation. Cytosine arabinoside induced macrophage differentiation in some cultures but only when the drug produced substantial cytostatic effects. GM-CSF, whe...

journal_title：Anticancer research

authors： Gao XZ,Yin MY,Preisler HD

更新日期：1989-07-01 00:00:00

abstract：:Three monoclonal antiidiotypic antibodies (AIA) to MOPC 315 IgA, G3 (IgG2b), A2 (IgG1) and D10 (a hybrid molecule consisting of gamma 1 and gamma 2a heavy chains), were characterized with respect to their binding constants (Ka) to MOPC 315 mouse myeloma cells. The Ka of G3 and A2 was 10(8)/mole; and that of D10 was 3 ...

journal_title：Anticancer research

authors： Marks A,Baumal R,Lei M,Ahmad A,Liu E

更新日期：1985-07-01 00:00:00

abstract：:The oxazaphosphorines cyclophosphamide (CP) and ifosfamide (IF) are alkylating agents that require bioactivation via cytochrome (CYP) P450 isoenzymes including CYP2C9 enzymes. The present study investigated CYP2C9 in regard to its allelic variants in 23 tumor samples (10 breast tumors, 1 breast tumor cell line, 5 brai...

journal_title：Anticancer research

authors： Knüpfer H,Stanitz D,Preiss R

更新日期：2006-01-01 00:00:00

abstract：:The magnetic resonance (MR) findings in malignant melanoma of soft tissues, also called clear cell sarcoma of tendons and aponeuroses, have been described as a focal abnormality with a specific MR pattern of increased signal intensity (relative to normal muscle) on T1 weighted sequences and variably decreased signal i...

journal_title：Anticancer research

authors： Gandolfo N,Martinoli C,Cafiero F,Peressini A,Nicolò M,Dellachà A,Derchi LE

更新日期：2000-09-01 00:00:00

abstract：:Squamous cell carcinomas (SCC) make up 96% of all oral cancers. Most laboratory SCC studies grow cells as a monolayer, which does not accurately represent the disease in vivo. We used a more relevant multicellular spheroid (MCS) model to study this disease. The SCC9β6KDFyn cell line, which expresses full-length β6 and...

journal_title：Anticancer research

authors： Lee C,Lee C,Atakilit A,Siu A,Ramos DM

更新日期：2014-12-01 00:00:00

abstract：AIM:To investigate the protein kinase B (Akt) signalling proteins phosphatase and tensin homolog (PTEN), phosphorylated-Akt (p-Akt) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in non-seminomatous germ cell tumors (NST) with a view to future investigative approaches. MATERIALS AND METHODS:The expressions of PT...

journal_title：Anticancer research

authors： Hennenlotter J,Amend B,Vogel U,Renninger M,Springer C,Kuehs U,Stenzl A,Bedke J

更新日期：2011-11-01 00:00:00

abstract：:Human epidemiological studies suggest an association between N-acetyltransferase (NAT) activity and the incidence of bladder and colorectal cancers. In this study, paclitaxel was selected to examine the inhibition of arylamine NAT activity, gene expression and 2-aminofluorene-DNA adduct formation in a human osteogenic...

journal_title：Anticancer research

authors： Lu KH,Wang DY,Lue KH,Hsiao YM,Chou MC,Chen YS,Chung JG

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Cyclooxygenases (COXs) and prostanoids play pivotal roles in colon carcinogenesis. This study was designed to determine the chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP1 antagonist, on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in male F344...

journal_title：Anticancer research

authors： Kawamori T,Uchiya N,Kitamura T,Ohuchida S,Yamamoto H,Maruyama T,Sugimura T,Wakabayashi K

更新日期：2001-11-01 00:00:00

abstract：:We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurr...

journal_title：Anticancer research

authors： Fujimoto N,Ueoka H,Kiura K,Tabata M,Bessho A,Takata I,Sunami K,Hiramatsu Y,Ikeda K,Tanimoto M,Harada M

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Because of the low chemosensitivity of gastric cancer to conventional antitumor agents, the role of adjuvant chemotherapy for patients with advanced gastric cancer is controversial. We have previously proposed the necessity to evaluate the appropriateness of particular adjuvant cancer chemotherapies in indiv...

journal_title：Anticancer research

authors： Kubota T,Egawa T,Otani Y,Furukawa T,Saikawa Y,Yoshida M,Watanabe M,Kumai K,Kitajima M

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND/AIM:Cisplatin nephrotoxicity includes early activation of the pro-apoptotic p66Shc and disorganization of the actin cytoskeleton, integrity which is regulated by heat-shock protein-27 (Hsp27). Here we determined the potential role of p66Shc in abrogating the Hsp27 function. MATERIALS AND METHODS:Effects of ...

journal_title：Anticancer research

authors： Arany I,Clark JS,Reed DK,Ember I,Juncos LA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Lysozyme is a natural antimicrobial enzyme that is up-regulated in inflammatory diseases of the gastrointestinal tract. Pathogenic microbes have recently been identified in the esophageal mucosa in patients with Barrett's esophagus (BE). Lysozyme expression was evaluated in biopsies from patients with BE. M...

journal_title：Anticancer research

authors： Rubio CA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The BCL2 proto-oncogene in non-Hodgkin's lymphoma is a dominant inhibitor of apoptosis. The goal of this work was to develop a (177)Lu-labeled anti-BCL2-peptide nucleic acid (PNA) conjugate designed for dual modality NHL therapy, i.e., simultaneous down-regulation of BCL2-mediated resistance to apoptosis and...

journal_title：Anticancer research

authors： Balkin ER,Jia F,Miller WH,Lewis MR

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Prognosis of renal cell carcinoma (RCC) differs within the same stage and grade. Our aim was to investigate the incidence of COX-2 in primary RCC tumors at different stages according to the occurrence of metastasis, and the impact of this biomarker on the survival of RCC patients. PATIENTS AND METHODS:The c...

journal_title：Anticancer research

authors： Kankuri-Tammilehto MK,Söderström KO,Pelliniemi TT,Vahlberg T,Pyrhönen SO,Salminen EK

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Alterations of mitochondrial DNA (mtDNA) have been found in cancer patients, therefore informative mtDNA mutations could serve as biomarkers for the disease. MATERIALS AND METHODS:The two hypervariable regions HVR1 and HVR2 in the D-Loop region were sequenced in ten paired tissue and plasma samples from bre...

journal_title：Anticancer research

authors： Cai FF,Kohler C,Zhang B,Chen WJ,Barekati Z,Garritsen HS,Lenner P,Toniolo P,Zhang JJ,Zhong XY

更新日期：2011-12-01 00:00:00

abstract：:In a retrospective study, immunohistochemical determinations of p53 were performed on paraffinised tissue sections of 243 patients with node negative breast cancer. These patients were primary treated in the years 1980-1986 at the UFK-Würzburg. A complete follow up could be performed in 92% of all cases. The median fo...

journal_title：Anticancer research

authors： Kristen P,Müller JG,Caffier H

更新日期：1997-07-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death worldwide, with approximately 1.2 million deaths annually. The standard-of-care in patients with advanced disease is platinum-based doublet chemotherapy. Recent advances in the understanding of biological mechanisms of tumor growth have allowed for identificatio...

journal_title：Anticancer research

authors： Lauro S,Onesti CE,Righini R,Marchetti P

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND/AIM:To predict pCR during neoadjuvant chemotherapy is still difficult. The aim of this study was to evaluate the optimal tumor reduction rate and modalities for predicting pCR after two cycles of docetaxel. PATIENTS AND METHODS:We analyzed 52 patients with HER2-positive or triple-negative breast cancer. The...

journal_title：Anticancer research

authors： Kuba S,Maeda S,Matsumoto M,Yamanouchi K,Iwata T,Morita M,Sakimura C,Otsubo R,Yano H,Sato S,Kanetaka K,Nagayasu T,Eguchi S

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:It is hypothesised that hypermethylation of the CpG island in the promoter region in several tumour suppressor genes contributes one of the mechanisms for silencing or down-regulating the expression of the tumour suppressor genes. One of the putative tumour suppressor genes, the E-cadherin gene, has shown do...

journal_title：Anticancer research

authors： Kao RH,Huang LC,Hsu YH

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Parathyroid hormone-related protein (PTHrP) is a key regulator of osteolytic metastasis of breast cancer (BC) cells, but its targets and mechanisms of action are not fully understood. This study investigated whether/how PTHrP (1-34) signaling regulates expression of vascular endothelial growth factor (VEGF) ...

journal_title：Anticancer research

authors： Isowa S,Shimo T,Ibaragi S,Kurio N,Okui T,Matsubara K,Hassan NM,Kishimoto K,Sasaki A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIM:HER2-positive breast cancers eventually relapse in about one third of patients. Is anti-HER2-directed therapy with Herceptin® (trastuzumab) effective in re-treatment? Between 2008 and 2018, 216 patients with recurrent HER2-positive breast cancer (BC) were re-treated with Herceptin (HER) during first-line...

journal_title：Anticancer research

authors： Hanker LC,FÖrster F,SchrÖder J,Grafe A,Hitschold T,Hesse T,Lattrich CR,Rody A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND/AIM:To investigate whether surgical margin (SM) status would affect the biochemical recurrence (BCR) after robot-associated RP (RARP). PATIENTS AND METHODS:We evaluated BCR after RARP and the association between pre- and postoperative predictive factors and BCR. RESULTS:Positive SM (PSM) was observed in 97...

journal_title：Anticancer research

authors： Kano H,Kadono Y,Kadomoto S,Iwamoto H,Yaegashi H,Iijima M,Kawaguchi S,Nohara T,Shigehara K,Izumi K,Ikeda H,Mizokami A

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:We examined the anti-tumor effect of 5-S-GAD, a novel potent inhibitor of protein tyrosine kinases, isolated from the flesh fly in order to investigate the potential use of this compound as an anti-tumor agent. METHODS:In vitro growth inhibition was evaluated using the alamarBlue assay kit. In vivo anti-tumor ...

journal_title：Anticancer research

authors： Akiyama N,Hijikata M,Kobayashi A,Yamori T,Tsuruo T,Natori S

更新日期：2000-01-01 00:00:00

abstract：:The cytotoxicity of beta-cyclodextrin benzaldehyde inclusion compound (CDBA) against human normal and cancer cell lines was investigated. CDBA showed slightly higher cytotoxicity against human tumor cell lines, as compared to normal cells, with a tumor-specificity index of 2.2. Human myelogenous leukemia cell lines (H...

journal_title：Anticancer research

authors： Liu Y,Sakagami H,Hashimoto K,Kikuchi H,Amano O,Ishihara M,Kanda Y,Kunii S,Kochi M,Zhang W,Yu G

更新日期：2008-01-01 00:00:00