Nicotine Exposure Augments Renal Toxicity of 5-aza-cytidine Through p66shc: Prevention by Resveratrol.

abstract：AIM:The aim of the present study was to investigate the prognostic impact of central nervous system metastases (CNS) after acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in EGFR-mutant non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We defined CNS-collapse as de...

journal_title：Anticancer research

authors： Hata A,Katakami N,Yoshioka H,Takeshita J,Tanaka K,Masago K,Fujita S,Kaji R,Imai Y,Monden K,Matsumoto T,Nagata K,Otsuka K,Tachikawa R,Tomii K,Kunimasa K,Iwasaku M,Nishiyama A,Ishida T,Nishimura Y

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) have been linked to a number of cancer types including breast cancer. The rate of brain metastases is 10-30% in patients with advanced breast cancer which is associated with poor prognosis. The potential application of miRNAs in the diagnostics and therapeutics of breast cancer with brain ...

journal_title：Anticancer research

authors： Li Z,Peng Z,Gu S,Zheng J,Feng D,Qin Q,He J

更新日期：2017-08-01 00:00:00

abstract：:Novel treatment strategies for cancer that are based on a more detailed understanding over the tumor biology are based on the latest new technology and are expected to improve the current treatment outcome for patients with cancer. However, many of these strategies still have one common and critical problem, being the...

journal_title：Anticancer research

authors： Kuroki M,Shirasu N

更新日期：2014-08-01 00:00:00

abstract：AIM:To assess whether prognostic factors in male (MBC) and female (FBC) breast cancer have similar impact on survival. PATIENTS AND METHODS:Charts for men and women diagnosed with breast cancer referred to the London Regional Cancer Program (LRCP) were reviewed. Patients with distant metastatic diseases were excluded....

journal_title：Anticancer research

authors： Yu E,Stitt L,Vujovic O,Joseph K,Assouline A,Au J,Younus J,Perera F,Tai P

更新日期：2013-05-01 00:00:00

abstract：:Mast cells are frequently found in close proximity to blood vessels and have been implicated in tumour angiogenesis. The aim of the present ultrastructural study was to characterize, in detail, the mutual association between mast cells and microvasculature in 9 cases of advanced gastric carcinoma. Perivascular mast ce...

journal_title：Anticancer research

authors： Caruso RA,Ieni A,Fabiano V,Basile G,Inferrera C

更新日期：2004-07-01 00:00:00

abstract：:A large number of different papillomavirus types have been identified. Several viruses often infect the same species and each virus is associated with a defined tissue. Recent evidence has shown that certain benign lesions can undergo malignant transformation in both animals and humans in response to genetic or enviro...

journal_title：Anticancer research

authors： Smith KT,Campo MS

更新日期：1985-01-01 00:00:00

abstract：:Independently of tumour and treatment modulation, the host immune response status plays an important role in the clinical outcome of patients with cancer. The influence of single nucleotide polymorphisms (SNPs) and adjuvant radiotherapy (RT) on the systemic immune response status of patients with breast cancer was inv...

journal_title：Anticancer research

authors： Lewin NL,Luetragoon T,Andersson BÅ,Oliva D,Nilsson M,Strandeus M,Löfgren S,Rutqvist LE,Lewin F

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Multidrug resistance, the principal mechanism by which cancer cells develop resistance to chemotherapy drugs, is a major factor in the failure of many forms of chemotherapies. AIM:The aim of the study was to investigate the effect of K-2-11 on the reversal of multidrug resistance. MATERIALS AND METHODS:The...

journal_title：Anticancer research

authors： Cindric M,Cipak A,Serly J,Plotniece A,Jaganjac M,Mrakovcic L,Lovakovic T,Dedic A,Soldo I,Duburs G,Zarkovic N,Molnár J

更新日期：2010-10-01 00:00:00

abstract：:Consumption of dietary fat has been linked to the high incidence of certain cancers. However, recent research has stimulated interest in conjugated linoleic acid (CLA), a newly recognized anticarcinogenic fatty acid. Human MCF-7 breast cancer cells were incubated for 12 d in culture medium supplemented with various co...

journal_title：Anticancer research

authors： Shultz TD,Chew BP,Seaman WR

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Epstein-Barr virus-associated gastric carcinoma (EBV-GC) has been characterized as a special gastric cancer subset. Lifestyle and other major factors that may contribute to EBV-GC and non-EBV-GC were investigated here. MATERIALS AND METHODS:A total of 247 patients with gastric cancer were interviewed, clini...

journal_title：Anticancer research

authors： Kim RH,Chang MS,Kim HJ,Song KS,Kim YS,Choi BY,Kim WH

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The different clinical evolution of breast cancer with similar pathological characteristics prompted the authors to investigate the prognostic significance of different biological markers. METHODS:Seventy-one primary breast carcinoma specimens obtained by mastectomy or quadrantectomy were examined for the d...

journal_title：Anticancer research

authors： Midulla C,De Iorio P,Nagar C,Pisani T,Cenci M,Valli C,Nofroni I,Vecchione A

更新日期：1999-09-01 00:00:00

abstract：:Growth inhibitory activity of YM881 (SMANCS) against 3 human cultured cell lines and one rat cultured cell line derived from glioma cells was assessed quantitatively. YM881 showed potent cytotoxicity against all glioma cell lines tested; the IC50 of this drug was 1.9-8.4 micrograms/ml. YM881 may be classified as a con...

journal_title：Anticancer research

authors： Kuratsu J,Takaki S,Kochi M,Mihara Y,Ushio Y

更新日期：1991-11-01 00:00:00

abstract：:SQM1, a membrane protein associated with methotrexate (MTX) transport was incorporated into unilamellar vesicles, forming. SQM1-Liposome. Human squamous carcinoma of the head and neck (SqCHN) cells resistant to MTX with defective MTX transport and low SQM1 expression were treated with SQM1-Liposome. SQM1 content was f...

journal_title：Anticancer research

authors： Wong YC,Bernal SD

更新日期：1999-01-01 00:00:00

abstract：:Human vaginal malignant melanoma represents rare gynecological malignancies of poor prognosis. We have established a melanoma tumor line in nude mice, designated Mela-1, and have examined the histological and biological characteristics of this tumor. The Mela-1 tumor has preserved the histological, histochemical and b...

journal_title：Anticancer research

authors： Sawada M,Terada N,Nishizawa Y,Ito S,Wakamatsu K,Takemura K,Yamamoto T,Ozaki M,Sakamoto H,Tanizawa O

更新日期：1994-07-01 00:00:00

abstract：:Wet ashing of K562 cell suspensions by means of a sulphonitroperchloric acid digestion for electrothermal atomic absorption spectrometry of platinum has been achieved. The limit of detection was about 1 ng platinum per 10(6) cells. Platinum concentrations in K562 cells were measured after exposure to platinum coordina...

journal_title：Anticancer research

authors： Tabary T,Millart H

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Taxane-based chemotherapy is useful for peritoneal dissemination control in advanced/recurrent gastric cancer; however, insufficient relative dose intensity (RDI) may preclude disease control achievement. Nab-paclitaxel, with high tumour permeability, is a promising second- or later-line treatment. PATIENTS...

journal_title：Anticancer research

authors： Kanazawa Y,Fujita I,Kakinuma D,Arai H,Matsuno K,Shimoda T,Ko K,Kato S,Uchida E

更新日期：2017-05-01 00:00:00

abstract：:The aim of the study was to investigate tumor suppressor genes (TSGs) which play a role in the pathogenesis of prostate cancer. Additionally, different prostate tumors were immunohistochemically related to their potential precursor cells, the basal cells and the glandular secretory epithelium, which differ in their ho...

journal_title：Anticancer research

authors： Wernert N,Bieroff E,Hügel A

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Cyclin D1 is a key protein involved in cell cycle regulation. A common A870G single nucleotide polymorphism in exon 4 of the cyclin D1 gene (CCND1) has an effect on the transcription of two different cyclin D1 mRNAs. Association of the genetic polymorphism of A870G of CCND1 with several cancer risks has been...

journal_title：Anticancer research

authors： Koike H,Suzuki K,Satoh T,Ohtake N,Takei T,Nakata S,Yamanaka H

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND/AIM:The hormonally-active form of vitamin D, 1,25(OH)2D3, demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D3 and 1,20(OH)2D3, have overlapping beneficial effects with 1,25(OH)2D3 without causing hypercalcemia....

journal_title：Anticancer research

authors： Oak ASW,Bocheva G,Kim TK,Brożyna AA,Janjetovic Z,Athar M,Tuckey RC,Slominski AT

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Giant cell tumor of the bone (GCTB) is a benign or sometimes semi-malignant neoplasm accounting for 5% of all primary bone tumors. This type of tumor has been historically considered as radioresistant, but nowadays radiotherapy (RT) is used in unresectable, recurrent or incompletely resected cases. Since the...

journal_title：Anticancer research

authors： Kriz J,Eich HT,Mücke R,Büntzel J,Müller RP,Bruns F,Seegenschmiedt MH,Gosheger G,Micke O,German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD).

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND/AIM:RASA1 (p120RasGAP), encodes Ras GTPase-activating protein 1 and, is a potent tumor suppressor gene that is frequently inactivated in several human cancer types. However, its precise role in hepatocellular carcinoma (HCC) has been blurred. MATERIALS AND METHODS:We hypothesized that RASA1 plays a crucial ...

journal_title：Anticancer research

authors： Chen YL,Huang WC,Yao HL,Chen PM,Lin PY,Feng FY,Chu PY

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Genomic imprinting is associated with many human diseases, including various types of cancers, however, no studies on gene imprinting are related to squamous cell carcinoma of the head and neck (SCCHN) directly. MATERIALS AND METHODS:In this study, the expression of a panel of 15 imprinted genes in cancerou...

journal_title：Anticancer research

authors： Hsu CM,Lin PM,Lin HC,Lai CC,Yang CH,Lin SF,Yang MY

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignant soft-tissue tumor and often shows extracompartmental tumoral invasion. The aim of our study was to investigate the clinical features, especially extracompartmental tumoral invasion (ETI) of EMC. PATIENTS AND METHODS:A total of 35 operative patien...

journal_title：Anticancer research

authors： Minami Y,Matsumoto S,Ae K,Tanizawa T,Hayakawa K,Funauchi Y,Saito M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Melanoma is among the top three cancers to present with brain metastasis. The risk of brain metastases in advanced melanoma increases with disease duration. Cytotoxic chemotherapy does not have a significant role in the management of melanoma patients with brain metastases, neither alone nor in conjunction w...

journal_title：Anticancer research

authors： Basnet A,Saad N,Benjamin S

更新日期：2016-09-01 00:00:00

abstract：:The present study was undertaken to evaluate the significance of grooved nuclei as an additional diagnostic criterion for primary breast carcinoma as well as their association with tumor grade in cytologic material obtained by fine needle aspiration (FNA). Cytologic slides of 105 cases of breast carcinoma (89 ductal, ...

journal_title：Anticancer research

authors： Labropoulou P,Psachoulia C,Batistatou A,Kardari M,Scopa CD

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND/AIM:Chemotherapy-associated toxicity is one of the limiting factors regarding treatment efficacy, patient outcome and quality of life in this collective. Underweight or obese patients represent a major group in which the therapy seems to be more challenging. The aim of this analysis was to evaluate the impac...

journal_title：Anticancer research

authors： Grabowski JP,Richter R,Rittmeister H,Chekerov R,Woopen H,Sehouli J

更新日期：2018-10-01 00:00:00

abstract：AIM:To comprehensively summarize the most important literature regarding the late effects of radiotherapy to the abdomen in childhood and adolescence. MATERIALS AND METHODS:Published trials, studies and series were identified using the PubMed database. The key words late effects, late sequelae, child, radiation, radio...

journal_title：Anticancer research

authors： Bölling T,Willich N,Ernst I

更新日期：2010-01-01 00:00:00

abstract：:In order to estimate the environmental risk of the use of Alachlor, experiments on laboratory animals were conducted. Alachlor and 2,6 diethylaniline content in blood serum was quantified. Three groups of male ACI/T rats and C3H/FEJ mice were treated with three different doses of Alachlor. Six hours after the intraper...

journal_title：Anticancer research

authors： Galati R,Federico A,Cortese G,Zito R

更新日期：1998-03-01 00:00:00

abstract：:Matrix metalloproteinase-7 (MMP-7), MMP-9, MMP-13, and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are considered to have important roles in the invasiveness and outcomes of colorectal cancer (CRC). This study examined the clinicopathological significance of the relative expression of these genes in patien...

journal_title：Anticancer research

authors： Yamada T,Oshima T,Yoshihara K,Tamura S,Kanazawa A,Inagaki D,Yamamoto N,Sato T,Fujii S,Numata K,Kunisaki C,Shiozawa M,Morinaga S,Akaike M,Rino Y,Tanaka K,Masuda M,Imada T

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the historical cohort of 61 patients with carcinoma of the vulva, treated with radiation therapy from 1986 to 1997. PATIENTS AND METHODS:Twenty-seven patients were submitted to radiation therapy alone and 34 received radiotherapy post limited surgery in early stages and...

journal_title：Anticancer research

authors： Tombolini V,Raffetto N,Santarelli M,Valeriani M,Necozione S,Masedu F,Enrici RM

更新日期：2005-07-01 00:00:00