Abstract：
BACKGROUND/AIM:Phenothiazines constitute a versatile family of compounds in terms of biological activity, which have also gained a considerable attention in cancer research. MATERIALS AND METHODS:Three phenothiazines (promethazine, chlorpromazine and thioridazine) have been tested in combination with 11 active selenocompounds against MDR (ABCB1-overexpressing) mouse T-lymphoma cells to investigate their activity as combination chemotherapy and as antitumor adjuvants in vitro with a checkerboard combination assay. RESULTS:Seven selenocompounds showed toxicity on mouse embryonic fibroblasts, while three showed selectivity towards tumor cells. Two compounds showed synergism with all tested phenothiazines in low concentration ranges (1.46-11.25 μM). Thioridazine was the most potent among the three phenothiazines. CONCLUSION:Phenothiazines belonging to different generations showed different levels of adjuvant activities. All the tested phenothiazines are already approved medicines with known pharmacological and toxicity profiles, therefore, their use as adjuvants in cancer may be considered as a potential drug repurposing strategy.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
GajdÁcs M,NovÉ M,Csonka Á,Varga B,SanmartÍn C,DomÍnguez-Álvarez E,Spengler Gdoi
10.21873/anticanres.14495subject
Has Abstractpub_date
2020-09-01 00:00:00pages
4921-4928issue
9eissn
0250-7005issn
1791-7530pii
40/9/4921journal_volume
40pub_type
杂志文章abstract：BACKGROUND/AIM:The Glasgow Prognostic Score (GPS), an inflammation-based prognostic score, has been shown to predict the clinical outcomes of a variety of cancer types. The aim of this study was to determine whether the GPS predicts clinical outcomes of patients with pancreatic cancer treated with adjuvant chemotherapy...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2015-09-01 00:00:00
abstract：AIM:To investigate the discordance in the programmed cell death-ligand 1 (PD-L1) expression between primary and metastatic tumors and analyze the association between the discordance and the clinical factors in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:Twenty-one NSCLC patients who underwent sur...
journal_title：Anticancer research
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doi：10.21873/anticanres.11813
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1991-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
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更新日期：2004-05-01 00:00:00
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journal_title：Anticancer research
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更新日期：2006-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
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doi：10.21873/anticanres.14663
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journal_title：Anticancer research
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doi：
更新日期：2009-02-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2006-09-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1999-09-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2001-09-01 00:00:00
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doi：10.21873/anticanres.11908
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更新日期：2000-09-01 00:00:00
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doi：
更新日期：2015-11-01 00:00:00
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doi：
更新日期：1996-09-01 00:00:00
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更新日期：2012-04-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2006-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
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journal_title：Anticancer research
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doi：10.21873/anticanres.11938
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